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Article ; Online: Determination of Region-Specific Roles of the M

Igarashi-Hisayoshi, Yoko / Ihara, Eikichi / Bai, Xiaopeng / Higashi, Chika / Ikeda, Hiroko / Tanaka, Yoshimasa / Hirano, Mayumi / Ogino, Haruei / Chinen, Takatoshi / Taguchi, Yasushi / Ogawa, Yoshihiro

Digestive diseases and sciences

2022 Volume 68, Issue 2, Page(s) 439–450

Abstract: Background: The specific role of the M: Aims: The objective of this study was to determine ... the region-specific role of the M: Methods: We developed a novel positive allosteric modulator (PAM ... for the M: Results: PAM-369 selectively potentiated the M: Conclusions: This study provided the first ...

Abstract	Background: The specific role of the M Aims: The objective of this study was to determine the region-specific role of the M Methods: We developed a novel positive allosteric modulator (PAM) for the M Results: PAM-369 selectively potentiated the M Conclusions: This study provided the first direct evidence that the M
MeSH term(s)	Animals ; Humans ; Mice ; Rats ; Carbachol/pharmacology ; Gastrointestinal Motility/genetics ; Gastrointestinal Motility/physiology ; Muscle Contraction ; Receptor, Muscarinic M2/genetics ; Receptor, Muscarinic M2/metabolism ; Receptor, Muscarinic M3/genetics ; Receptor, Muscarinic M3/metabolism ; Receptors, Muscarinic/physiology ; Swine
Chemical Substances	Carbachol (8Y164V895Y) ; Receptor, Muscarinic M2 ; Receptor, Muscarinic M3 ; Receptors, Muscarinic
Language	English
Publishing date	2022-08-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	304250-9
ISSN	1573-2568 ; 0163-2116
ISSN (online)	1573-2568
ISSN	0163-2116
DOI	10.1007/s10620-022-07637-y
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Article ; Online: Splash M-knife versus Flush Knife BT in the technical outcomes of endoscopic submucosal dissection for early gastric cancer: a propensity score matching analysis.

Esaki, Mitsuru / Suzuki, Sho / Hayashi, Yasuyo / Yokoyama, Azusa / Abe, Shuichi / Hosokawa, Taizo / Ogino, Haruei / Akiho, Hirotada / Ihara, Eikichi / Ogawa, Yoshihiro

BMC gastroenterology

2018 Volume 18, Issue 1, Page(s) 35

Abstract: ... to compare the technical outcomes of ESD for early gastric cancer using the Splash M-Knife® with those using ... 2016 at Kitakyushu Municipal Medical Center. Lesions treated with ESD using the Splash M-knife (ESD-M ... in the ESD-M group, and 76 patients in the ESD-F group. Propensity score matching analysis created 45 matched ...

Abstract	Background: Endoscopic submucosal dissection (ESD) is a standard treatment for early gastric cancer. A new multi-functional ESD device was developed to achieve complete ESD with a single device. A metal plate attached to its distal sheath achieves better hemostasis during the procedure than the other needle-knife device, Flush Knife BT®, that has been conventionally used. The aim of this study was to compare the technical outcomes of ESD for early gastric cancer using the Splash M-Knife® with those using the Flush Knife BT. Methods: We conducted a retrospective review of the case records of 149 patients with early gastric cancer treated with ESD using the needle-type ESD knives between January 2012 and August 2016 at Kitakyushu Municipal Medical Center. Lesions treated with ESD using the Splash M-knife (ESD-M) and the Flush Knife BT (ESD-F) were compared. Multivariate analyses and propensity score matching were used to compensate for the differences in age, gender, underlying disease, antithrombotic drug use, lesion location, lesion position, macroscopic type, tumor size, presence of ulceration, operator level and types of electrosurgical unit used. The primary endpoint was the requirement to use hemostatic forceps in the two groups. The secondary endpoints of procedure time, en bloc and complete resection rates, and adverse events rates were evaluated for the two groups. Results: There were 73 patients in the ESD-M group, and 76 patients in the ESD-F group. Propensity score matching analysis created 45 matched pairs. Adjusted comparisons between the two groups showed a significantly lower usage rate of hemostatic forceps in the ESD-M group than in the ESD-F group (6.7% vs 84.4%, p < 0.001). Treatment outcomes showed an en bloc resection rate of 100% in both groups; complete resection rate of 95.6% vs 100%, p = 0.49; median procedure time of 74.0 min vs 71.0 min, p = 0.90; post-procedure bleeding of 2.2% vs 2.2%, p = 1, in the ESD-M and ESD-F groups, respectively. There were no perforations in either group. Conclusions: ESD-M appeared to reduce the usage of hemostatic forceps during ESD for early gastric cancer without increasing the adverse effects. Thus, it may contribute to a reduction in the total ESD cost.
MeSH term(s)	Aged ; Endoscopic Mucosal Resection/instrumentation ; Female ; Hemostasis, Surgical/instrumentation ; Humans ; Male ; Propensity Score ; Retrospective Studies ; Stomach Neoplasms/surgery ; Treatment Outcome
Language	English
Publishing date	2018-02-27
Publishing country	England
Document type	Comparative Study ; Journal Article
ISSN	1471-230X
ISSN (online)	1471-230X
DOI	10.1186/s12876-018-0763-5
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Article ; Online: Urinary PGE-M levels are associated with risk of colorectal adenomas and chemopreventive response to anti-inflammatory drugs.

Bezawada, Navya / Song, Mingyang / Wu, Kana / Mehta, Raaj S / Milne, Ginger L / Ogino, Shuji / Fuchs, Charles S / Giovannucci, Edward L / Chan, Andrew T

Cancer prevention research (Philadelphia, Pa.)

2014 Volume 7, Issue 7, Page(s) 758–765

Abstract: ... can be assessed by measuring its major metabolite, PGE-M, in urine. We examined the potential role of PGE ... M as a biomarker for colorectal adenoma risk and chemopreventive response to anti-inflammatory drugs ... up and matched them to 420 endoscopy-negative controls. We measured urinary PGE-M using an LC/MS ...

Abstract	Prostaglandin E2 (PGE2) promotes colorectal carcinogenesis. Overall, systemic PGE2 production can be assessed by measuring its major metabolite, PGE-M, in urine. We examined the potential role of PGE-M as a biomarker for colorectal adenoma risk and chemopreventive response to anti-inflammatory drugs. We conducted a prospective case-control study nested within the Nurses' Health Study. Among women who previously provided a urine sample, we identified 420 cases diagnosed with colorectal adenoma during follow-up and matched them to 420 endoscopy-negative controls. We measured urinary PGE-M using an LC/MS assay. Compared with women in the lowest quartile of urinary PGE-M, women in the highest quartile had a multivariate OR of 1.40 (95% confidence interval (CI), 0.92-2.14) for any adenoma; 0.91 (95% CI, 0.48-1.72) for low-risk adenoma (solitary adenoma <1 cm in greatest diameter with tubular/unspecified histology); and 1.66 (95% CI, 1.04-2.67) for high-risk adenoma (adenoma ≥1 cm in greatest diameter and/or tubulovillous, villous or high-grade dysplasia histology or multiple adenomas of any size or histology). Regular use of anti-inflammatory drugs (≥2 standard tablets of aspirin/NSAIDs per week) was associated with a significant reduction in adenoma risk (multivariate OR, 0.61; 95% CI, 0.43-0.87) in women with high baseline PGE-M (quartiles 2-4), but not low PGE-M (quartile 1).Urinary PGE-M is associated with an increased risk of high-risk adenoma. Anti-inflammatory drugs seem to reduce adenoma risk among women with high, but not low PGE-M. Urinary PGE-M may serve as a biomarker to define subsets of the population who may obtain differential chemopreventive benefit from anti-inflammatory drugs.
MeSH term(s)	Adenoma/etiology ; Adenoma/prevention & control ; Adenoma/urine ; Adult ; Aged ; Anti-Inflammatory Agents/therapeutic use ; Biomarkers, Tumor/urine ; Case-Control Studies ; Colorectal Neoplasms/etiology ; Colorectal Neoplasms/prevention & control ; Colorectal Neoplasms/urine ; Female ; Follow-Up Studies ; Humans ; Middle Aged ; Prognosis ; Prospective Studies ; Prostaglandins/urine ; Risk Factors
Chemical Substances	Anti-Inflammatory Agents ; Biomarkers, Tumor ; Prostaglandins ; 7-hydroxy-5,11-dioxotetranorprostane-1,16-dioic acid (73303-30-7)
Language	English
Publishing date	2014-05-13
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2434717-6
ISSN	1940-6215 ; 1940-6207
ISSN (online)	1940-6215
ISSN	1940-6207
DOI	10.1158/1940-6207.CAPR-14-0120
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Article: [Drugs for Amyotrophic Lateral Sclerosis].

Ogino, Mieko

Brain and nerve = Shinkei kenkyu no shinpo

2023 Volume 75, Issue 5, Page(s) 503–506

Abstract: Riluzole and edaravone for the treatment of amyotrophic lateral sclerosis (ALS) are currently covered by insurance in Japan. Both have been shown to prolong survival and/or inhibit progression, but neither is a cure-all treatment, and the effects are ... ...

Abstract	Riluzole and edaravone for the treatment of amyotrophic lateral sclerosis (ALS) are currently covered by insurance in Japan. Both have been shown to prolong survival and/or inhibit progression, but neither is a cure-all treatment, and the effects are difficult to realize. The data presented in clinical trials are not applicable to all patients with ALS; the risks and benefits should be explained carefully before use. So far, edaravone has been administered intravenously, but an oral form became available in Japan on April 17, 2023. For symptomatic treatment, morphine hydrochloride and morphine sulfate are insurance-covered alternatives.
MeSH term(s)	Humans ; Amyotrophic Lateral Sclerosis/drug therapy ; Edaravone/therapeutic use ; Neuroprotective Agents/therapeutic use ; Riluzole/therapeutic use ; Japan
Chemical Substances	Edaravone (S798V6YJRP) ; Neuroprotective Agents ; Riluzole (7LJ087RS6F)
Language	Japanese
Publishing date	2023-03-07
Publishing country	Japan
Document type	English Abstract ; Journal Article
ZDB-ID	390389-8
ISSN	1344-8129 ; 1881-6096 ; 0006-8969
ISSN (online)	1344-8129
ISSN	1881-6096 ; 0006-8969
DOI	10.11477/mf.1416202367
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Article: Discovery of 2-aminothiazole-4-carboxamides, a novel class of muscarinic M(3) selective antagonists, through solution-phase parallel synthesis.

Sagara, Yufu / Mitsuya, Morihiro / Uchiyama, Minaho / Ogino, Yoshio / Kimura, Toshifumi / Ohtake, Norikazu / Mase, Toshiaki

Chemical & pharmaceutical bulletin

2005 Volume 53, Issue 4, Page(s) 437–440

Abstract: Synthesis and structure-activity relationship of a new class of muscarinic M(3) selective ... antagonists were described. In the course of searching for a muscarinic M(3) antagonist with a structure ... Since this compound (1) showed relatively low binding affinity (K(i)=140 nM) for M(3) receptors in the human binding ...

Abstract	Synthesis and structure-activity relationship of a new class of muscarinic M(3) selective antagonists were described. In the course of searching for a muscarinic M(3) antagonist with a structure distinct from those of the 2-(4,4-difluorocyclopentyl)-2-phenylacetamide derivatives, we identified a thiazole-4-carboxamide derivative (1) as a lead compound in our in-house chemical collection. Since this compound (1) showed relatively low binding affinity (K(i)=140 nM) for M(3) receptors in the human binding assays, we tried to improve its potency and selectivity for M(3) over M(1) and M(2) receptors by derivatization of 1 through a combinatorial approach. A solution-phase parallel synthesis effectively contributed to the optimization of each segment of 1. Thus, we have identified a cyclooctenylmethyl derivative (3e) and a cyclononenylmethyl derivative (3f) as representative M(3) selective antagonists in this class.
MeSH term(s)	Amides/chemical synthesis ; Amides/pharmacology ; Animals ; CHO Cells ; Cricetinae ; Humans ; Indicators and Reagents ; Kinetics ; Muscarinic Antagonists/chemical synthesis ; Muscarinic Antagonists/pharmacology ; Receptor, Muscarinic M3/drug effects ; Spectrometry, Mass, Fast Atom Bombardment ; Structure-Activity Relationship ; Thiazoles/chemical synthesis ; Thiazoles/pharmacology
Chemical Substances	Amides ; Indicators and Reagents ; Muscarinic Antagonists ; Receptor, Muscarinic M3 ; Thiazoles
Language	English
Publishing date	2005-04
Publishing country	Japan
Document type	Journal Article
ZDB-ID	213307-6
ISSN	1347-5223 ; 0009-2363
ISSN (online)	1347-5223
ISSN	0009-2363
DOI	10.1248/cpb.53.437
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Article: [Video Works on Amyotrophic Lateral Sclerosis].

Ogino, Mieko

Brain and nerve = Shinkei kenkyu no shinpo

2022 Volume 74, Issue 12, Page(s) 1384–1387

Abstract: Amyotrophic lateral sclerosis (ALS) is known to many as a disease that is infrequent but causes progressive disability and death within three to five years if a tracheostomy ventilator are not used. The patient must choose whether to live with a crippled ...

Abstract	Amyotrophic lateral sclerosis (ALS) is known to many as a disease that is infrequent but causes progressive disability and death within three to five years if a tracheostomy ventilator are not used. The patient must choose whether to live with a crippled body or die, and is faced with the question of what kind of condition is considered "living". By watching a video that addresses this theme, we can grasp this question even more deeply.
Language	Japanese
Publishing date	2022-12-08
Publishing country	Japan
Document type	English Abstract ; Journal Article
ZDB-ID	390389-8
ISSN	1344-8129 ; 1881-6096 ; 0006-8969
ISSN (online)	1344-8129
ISSN	1881-6096 ; 0006-8969
DOI	10.11477/mf.1416202254
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Article: Interaction of cellular tubulin with Sendai virus M protein regulates transcription of viral genome.

Ogino, Tomoaki / Iwama, Minako / Ohsawa, Yuki / Mizumoto, Kiyohisa

Biochemical and biophysical research communications

2003 Volume 311, Issue 2, Page(s) 283–293

Abstract: ... We showed that tubulin dissociates viral matrix (M) protein, which acts as a negative regulator ... tubulin subunits demonstrated that M protein is released from the RNP as a complex with each tubulin ... subunit. In vitro-binding analyses revealed that M protein directly interacts with tubulin as well ...

Abstract	Cellular tubulin has been shown to activate in vitro transcription with Sendai virus (SeV) particles. In this study, the molecular basis for the transcriptional activation by tubulin was investigated. We showed that tubulin dissociates viral matrix (M) protein, which acts as a negative regulator for transcription, from viral ribonucleoprotein (RNP) consisting of L, P, N proteins, and the genome RNA. Both alpha and beta subunits of human tubulin, which were expressed as GST fusion proteins, were found to stimulate viral mRNA synthesis similar to native alpha/beta-heterodimer tubulin. Pull-down assay using GST-tubulin subunits demonstrated that M protein is released from the RNP as a complex with each tubulin subunit. In vitro-binding analyses revealed that M protein directly interacts with tubulin as well as microtubules. These findings suggest that interaction of M protein with tubulin may have an important role in the regulation of SeV transcription.
MeSH term(s)	Binding Sites ; Cells, Cultured ; Gene Expression Regulation, Viral/physiology ; Genome, Viral ; Humans ; Microtubules/chemistry ; Microtubules/genetics ; Microtubules/metabolism ; Protein Binding ; Protein Subunits ; Sendai virus/chemistry ; Sendai virus/genetics ; Sendai virus/metabolism ; Structure-Activity Relationship ; Transcriptional Activation/physiology ; Tubulin/chemistry ; Tubulin/metabolism ; Viral Matrix Proteins/chemistry ; Viral Matrix Proteins/metabolism
Chemical Substances	M protein, Sendai virus ; Protein Subunits ; Tubulin ; Viral Matrix Proteins
Language	English
Publishing date	2003-10-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	205723-2
ISSN	0006-291X ; 0006-291X
ISSN (online)	0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2003.09.205
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Article: A potent, long-acting, orally active (2R)-2-[(1R)-3, 3-difluorocyclopentyl]-2-hydroxy-2-phenylacetamide: novel muscarinic M(3) receptor antagonist with high selectivity for M(3) over M(2) receptors.

Mitsuya, M / Kobayashi, K / Kawakami, K / Satoh, A / Ogino, Y / Kakikawa, T / Ohtake, N / Kimura, T / Hirose, H / Sato, A / Numazawa, T / Hasegawa, T / Noguchi, K / Mase, T

Journal of medicinal chemistry

2000 Volume 43, Issue 26, Page(s) 5017–5029

Abstract: ... of our prototype muscarinic M(3) receptor selective antagonist 1, to develop a potent, long-acting, orally active M ... of 15a revealed that this acid moiety was a versatile template for improving the selectivity for M(3 ... over M(2) receptors in comparison with the corresponding cyclopentylphenylacetic acid group ...

Abstract	A novel series of (2R)-2-[(1R)-3, 3-difluorocyclopentyl]-2-hydroxy-2-phenylacetamides was designed and synthesized based on the structure and biological profiles of an active metabolite 2 of our prototype muscarinic M(3) receptor selective antagonist 1, to develop a potent, long-acting, orally active M(3) antagonist for the treatment of urinary tract disorders, irritable bowel syndrome, and respiratory disorders. Investigation of (2R)-2-[(1R)-3, 3-difluorocyclopentyl]-2-hydroxy-2-phenylacetamides containing a phenyl or heterocyclic ring as the piperidinyl side chain in place of the 4-methyl-3-pentenyl moiety of 15a revealed that this acid moiety was a versatile template for improving the selectivity for M(3) over M(2) receptors in comparison with the corresponding cyclopentylphenylacetic acid group. However, since the in vitro metabolic stability of these analogues was insufficient compared with that of 2, further derivatization was performed by introducing an appropriate hydrophilic group into the phenyl or 2-pyridyl ring. Thus, the 1-(6-aminopyridin-2-ylmethyl)piperidine analogue 15y exhibiting 190-fold selectivity for M(3) receptors (K(i) = 2.8 nM) over M(2) receptors (K(i) = 530 nM) in a human binding assay and good in vitro metabolic stability in dog and human hepatic microsomes was identified. This compound has excellent oral activity at 4 h after oral dosing (1 mg/kg), inhibiting methacholine-induced bronchoconstriction in dogs, and may be useful in clinical situations in which M(3) over M(2) selectivity is desirable.
MeSH term(s)	Acetamides/chemical synthesis ; Acetamides/chemistry ; Acetamides/metabolism ; Acetamides/pharmacology ; Acetanilides ; Administration, Oral ; Animals ; Bronchoconstriction/drug effects ; Bronchodilator Agents/chemical synthesis ; Bronchodilator Agents/chemistry ; Bronchodilator Agents/metabolism ; Bronchodilator Agents/pharmacology ; CHO Cells ; Cricetinae ; Dogs ; Drug Stability ; Humans ; Microsomes, Liver/metabolism ; Muscarinic Antagonists/chemical synthesis ; Muscarinic Antagonists/chemistry ; Muscarinic Antagonists/metabolism ; Muscarinic Antagonists/pharmacology ; Piperidines/chemical synthesis ; Piperidines/chemistry ; Piperidines/metabolism ; Piperidines/pharmacology ; Receptor, Muscarinic M2 ; Receptor, Muscarinic M3 ; Receptors, Muscarinic/drug effects ; Receptors, Muscarinic/metabolism ; Structure-Activity Relationship ; Transfection
Chemical Substances	Acetamides ; Acetanilides ; Bronchodilator Agents ; Muscarinic Antagonists ; N-(1-(6-aminopyridin-2-ylmethyl)piperidin-4-yl)-2-(3,3-difluorocyclopentyl)-2-hydroxy-2-phenylacetamide ; Piperidines ; Receptor, Muscarinic M2 ; Receptor, Muscarinic M3 ; Receptors, Muscarinic
Language	English
Publishing date	2000-12-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	218133-2
ISSN	1520-4804 ; 0022-2623
ISSN (online)	1520-4804
ISSN	0022-2623
DOI	10.1021/jm0003135
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Zs.MB 1: Show issues

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Article: [Sports-Related Concussion:Update beyond the Japanese Guidelines for the Treatment and Management of Head Trauma].

Ogino, Masahiro

No shinkei geka. Neurological surgery

2021 Volume 49, Issue 5, Page(s) 1032–1039

Abstract: All the statements regarding sports-related concussion(SRC)in our guidelines are generally simple but somewhat unfavorable. SRC is diagnosed solely by symptoms, without any definitive diagnostic measures. Various pathophysiologies are suspected to ... ...

Abstract	All the statements regarding sports-related concussion(SRC)in our guidelines are generally simple but somewhat unfavorable. SRC is diagnosed solely by symptoms, without any definitive diagnostic measures. Various pathophysiologies are suspected to underlie SRC, making single diagnostic biomarker or neuroimaging unreliable. It is widely acknowledged that casualties of SRC should return to play gradually in a stepwise fashion; however, effective treatment and rehabilitation need to be determined. Although the pathological findings of chronic traumatic encephalopathy(CTE), possibly the result of repetitive injuries, have been elucidated, further research is needed to establish a clinical diagnosis and testing modalities for CTE.
MeSH term(s)	Craniocerebral Trauma/diagnostic imaging ; Craniocerebral Trauma/therapy ; Humans ; Japan/epidemiology ; Sports
Language	Japanese
Publishing date	2021-10-06
Publishing country	Japan
Document type	Journal Article
ZDB-ID	197053-7
ISSN	1882-1251 ; 0301-2603
ISSN (online)	1882-1251
ISSN	0301-2603
DOI	10.11477/mf.1436204486
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Article: Quantitative Assessment of the Heat Transfer Capacity of Ice Bags and their Cooling Effects on the Skin Surface and Core Temperature.

Ichikawa, Yukiko / Ogino, Tetsuya

Acta medica Okayama

2024 Volume 78, Issue 1, Page(s) 53–61

Abstract: ... the non-cooling period, 31.4-53.6 kJ·m-2 of energy was dissipated over 10 min, whereas during the cooling ... period, the range increased to 180.0-218.7 kJ·m-2 over 10 min. Skin surface temperature decreased by 3.2 ... 180 kJ·m-2 over 10 min, but this was insufficient for rapid whole body cooling due to the small skin ...

Abstract	Ice bags are frequently used in medical care settings for pain relief, comfort, and in some cases, whole-body cooling. This study quantifies heat energy transfer capacity of ice bags and evaluates their cooling effects on body temperature. Forty-eight healthy adults in their 20s were recruited. An ice bag wrapped in two layers of dry towel was applied to the forehead, neck, or palm of each participant for 10 min. The skin surface temperature, heat flow, and core temperature were recorded during the cooling and non-cooling periods, with energy transfer calculated by integrating heat flow over time. Over the non-cooling period, 31.4-53.6 kJ·m-2 of energy was dissipated over 10 min, whereas during the cooling period, the range increased to 180.0-218.7 kJ·m-2 over 10 min. Skin surface temperature decreased by 3.2-5.7°C, whereas core temperature was unchanged. Ice bag use augmented energy transfer by about 150-180 kJ·m-2 over 10 min, but this was insufficient for rapid whole body cooling due to the small skin-surface area in contact with the ice bag. The measured energy transfer indicated that topical ice bag application absorbs insufficient energy to affect core temperature. Quantitative assessment of energy transfer was shown to inform the safe and appropriate use of thermotherapy.
MeSH term(s)	Adult ; Humans ; Hot Temperature ; Temperature ; Cold Temperature
Language	English
Publishing date	2024-02-29
Publishing country	Japan
Document type	Journal Article
ZDB-ID	188415-3
ISSN	0386-300X ; 0001-6152
ISSN	0386-300X ; 0001-6152
DOI	10.18926/AMO/66671
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