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  1. Article ; Online: Retraction Note: Development and Evaluation of Icariin-Loaded PLGA-PEG Nanoparticles for Potentiation the Proapoptotic Activity in Pancreatic Cancer Cells.

    Alhakamy, Nabil A

    AAPS PharmSciTech

    2023  Volume 24, Issue 6, Page(s) 153

    Language English
    Publishing date 2023-07-19
    Publishing country United States
    Document type Retraction of Publication
    ZDB-ID 2052070-0
    ISSN 1530-9932 ; 1530-9932
    ISSN (online) 1530-9932
    ISSN 1530-9932
    DOI 10.1208/s12249-023-02614-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Retraction notice to "Exploring cytotoxicity of cordycepin loaded nanovesicles against (HCT116) colon cancer cells: Optimization and cellular evaluation" [Biomed. Pharmacother. 154 (2022) 113619].

    Alhakamy, Nabil A / Fahmy, Usama A

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2024  Volume 172, Page(s) 116200

    Language English
    Publishing date 2024-01-30
    Publishing country France
    Document type Journal Article ; Retraction of Publication
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2024.116200
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.198: Show issues Location:
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  3. Article ; Online: Development and Evaluation of Icariin-Loaded PLGA-PEG Nanoparticles for Potentiation the Proapoptotic Activity in Pancreatic Cancer Cells.

    Alhakamy, Nabil A

    publication RETRACTED

    AAPS PharmSciTech

    2021  Volume 22, Issue 8, Page(s) 252

    Abstract: Therapeutic efficacy of antineoplastic agents possessing a selective target to the nucleus of the cancer cells could be enhanced through novel formulation approaches. Thus, towards improvement of anticancer potential of icariin (ICA) on pancreatic cancer, ...

    Abstract Therapeutic efficacy of antineoplastic agents possessing a selective target to the nucleus of the cancer cells could be enhanced through novel formulation approaches. Thus, towards improvement of anticancer potential of icariin (ICA) on pancreatic cancer, the drug was entrapped into the polymeric poly lactic-co-glycolic acid (PLGA) with polyethylene glycol (PEG) as diblock copolymer. Optimization of the formulation was done using Statgraphics software to standardize percentages of PEG-PLGA and tween 80 (TW80) to obtain the smallest particle size. The optimized formulation was found to be in nanometer size and low PDI (0.321). Optimized formula enhanced cytotoxicity and apoptotic potential, compared with ICA-raw, against pancreatic cancer cell lines (aspc-1). The entrapment efficiency of the polymeric micelles was 72.34 ± 2.3% with 93.1 ± 6.5% release of ICA within 72 h. There was a twofold increase in apoptosis and sevenfold increase in necrosis of aspc-1 cells when incubated with raw ICA compared to control cells. Further, loss of mitochondrial membrane potential (⁓50-fold) by the ICA-loaded PMs and free drug compared to control cells was found to be due to the generation of ROS. Findings of cell cycle analysis revealed the significant arrest of G2-M phase of aspc-1 cells when incubated with the optimized formulation. Simultaneously, a significantly increased number of cells in pre-G1 revealed maximum apoptotic potential of the drug when delivered via micellar formulation. Finally, upregulation of caspase-3 established the superiority of the PMs approach against pancreatic cancer. In summary, the acquired results highlighted the potentiality of PMs delivery tool for controlling the growth of pancreatic cancer cells for improved efficacy.
    MeSH term(s) Cell Line, Tumor ; Drug Carriers/therapeutic use ; Flavonoids ; Humans ; Nanoparticles ; Pancreatic Neoplasms/drug therapy ; Particle Size ; Polyethylene Glycols
    Chemical Substances Drug Carriers ; Flavonoids ; Polyethylene Glycols (3WJQ0SDW1A) ; icariin (VNM47R2QSQ)
    Language English
    Publishing date 2021-10-19
    Publishing country United States
    Document type Journal Article ; Retracted Publication
    ZDB-ID 2052070-0
    ISSN 1530-9932 ; 1530-9932
    ISSN (online) 1530-9932
    ISSN 1530-9932
    DOI 10.1208/s12249-021-02111-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: RETRACTED: Alhakamy et al. Attenuation of Benign Prostatic Hyperplasia by Optimized Tadalafil Loaded Pumpkin Seed Oil-Based Self Nanoemulsion: In Vitro and In Vivo Evaluation.

    Alhakamy, Nabil A / Fahmy, Usama A / Ahmed, Osama A A

    Pharmaceutics

    2023  Volume 15, Issue 12

    Abstract: The journal retracts the article, "Attenuation of Benign Prostatic Hyperplasia by Optimized Tadalafil Loaded Pumpkin Seed Oil-Based Self Nanoemulsion: In Vitro and In Vivo Evaluation" [ ... ]. ...

    Abstract The journal retracts the article, "Attenuation of Benign Prostatic Hyperplasia by Optimized Tadalafil Loaded Pumpkin Seed Oil-Based Self Nanoemulsion: In Vitro and In Vivo Evaluation" [...].
    Language English
    Publishing date 2023-11-22
    Publishing country Switzerland
    Document type Retraction of Publication
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics15122654
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Exploring cytotoxicity of cordycepin loaded nanovesicles against (HCT116) colon cancer cells: Optimization and cellular evaluation.

    Alhakamy, Nabil A / Fahmy, Usama A

    publication RETRACTED

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2022  Volume 154, Page(s) 113619

    Abstract: Numerous researchers have investigated cordycepin (COR) as an anti-tumor compound. COR has been documented to have cytotoxic effects on several cancer cells. The current work used a Box-Behnken mathematical design to minimize COR's size. The design ... ...

    Abstract Numerous researchers have investigated cordycepin (COR) as an anti-tumor compound. COR has been documented to have cytotoxic effects on several cancer cells. The current work used a Box-Behnken mathematical design to minimize COR's size. The design incorporated COR concentration, phospholipid concentration and sonication time as variables to minimize the vesicles of COR emulsomes (COR-EMLs). To evaluate degree of improvement of COR cytotoxicity against colorectal cancer (HCT116) cells, cell viability, cell cycle analysis and apoptosis have been assessed. In addition, wound scratching and mitochondrial membrane potential were evaluated. Results of Box-Behnken design achieved COR-EMLs sizes in range from 91.54 ± 2.3-343.83 ± 3.7 nm. Moreover, the optimized formula morphology's was evaluated using transmission electron microscope and showed nanospheres in range of 100 nm. COR released from COR-EMLs exceeded 80% after 12 h.The half-maximal inhibitory concentration (IC
    MeSH term(s) Apoptosis ; Cell Survival ; Colonic Neoplasms/drug therapy ; Colonic Neoplasms/pathology ; Deoxyadenosines/pharmacology ; HCT116 Cells ; Humans
    Chemical Substances Deoxyadenosines ; cordycepin (GZ8VF4M2J8)
    Language English
    Publishing date 2022-09-05
    Publishing country France
    Document type Journal Article ; Retracted Publication
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2022.113619
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.198: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Retraction Note: Optimization of Thymoquinone-Loaded Coconut Oil Nanostructured Lipid Carriers for the Management of Ethanol-Induced Ulcer.

    Fahmy, Usama A / Alaofi, Ahmed L / Awan, Zuhier A / Alqarni, Hani M / Alhakamy, Nabil A

    AAPS PharmSciTech

    2023  Volume 24, Issue 5, Page(s) 129

    Language English
    Publishing date 2023-06-02
    Publishing country United States
    Document type Retraction of Publication
    ZDB-ID 2052070-0
    ISSN 1530-9932 ; 1530-9932
    ISSN (online) 1530-9932
    ISSN 1530-9932
    DOI 10.1208/s12249-023-02590-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: RETRACTED: Alhakamy et al. Thymoquinone-Loaded Soy-Phospholipid-Based Phytosomes Exhibit Anticancer Potential against Human Lung Cancer Cells.

    Alhakamy, Nabil A / Badr-Eldin, Shaimaa M / Fahmy, Usama A / Alruwaili, Nabil K / Awan, Zuhier A / Caruso, Giuseppe / Alfaleh, Mohamed A / Alaofi, Ahmed L / Arif, Faris O / Ahmed, Osama A A / Alghaith, Adel F

    Pharmaceutics

    2024  Volume 16, Issue 2

    Abstract: The journal retracts the article, "Thymoquinone-Loaded Soy-Phospholipid-Based Phytosomes Exhibit Anticancer Potential against Human Lung Cancer Cells" [ ... ]. ...

    Abstract The journal retracts the article, "Thymoquinone-Loaded Soy-Phospholipid-Based Phytosomes Exhibit Anticancer Potential against Human Lung Cancer Cells" [...].
    Language English
    Publishing date 2024-01-23
    Publishing country Switzerland
    Document type Retraction of Publication
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics16020156
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Nasal Gel Loaded with Amphotericin Nanotransferosomes as Antifungal Treatment for Fungal Sinusitis.

    Hosny, Khaled M / Alhakamy, Nabil A

    Pharmaceutics

    2020  Volume 13, Issue 1

    Abstract: On the basis of fungal involvement, rhinosinusitis is categorized into allergic, mycetoma, chronic, and acute invasive types. The aim of the current study was to evaluate the efficacy of an amphotericin gel in situ loaded with nanotransferosomes ... ...

    Abstract On the basis of fungal involvement, rhinosinusitis is categorized into allergic, mycetoma, chronic, and acute invasive types. The aim of the current study was to evaluate the efficacy of an amphotericin gel in situ loaded with nanotransferosomes against
    Language English
    Publishing date 2020-12-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics13010035
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: RETRACTED: Aldawsari et al. Lipidic Nano-Sized Emulsomes Potentiates the Cytotoxic and Apoptotic Effects of Raloxifene Hydrochloride in MCF-7 Human Breast Cancer Cells: Factorial Analysis and In Vitro Anti-Tumor Activity Assessment.

    Aldawsari, Hibah M / Ahmed, Osama A A / Alhakamy, Nabil A / Neamatallah, Thikryat / Fahmy, Usama A / Badr-Eldin, Shaimaa M

    Pharmaceutics

    2024  Volume 16, Issue 2

    Abstract: The journal retracts the article "Lipidic Nano-Sized Emulsomes Potentiates the Cytotoxic and Apoptotic Effects of Raloxifene Hydrochloride in MCF-7 Human Breast Cancer Cells: Factorial Analysis and In Vitro Anti-Tumor Activity Assessment" [ ... ]. ...

    Abstract The journal retracts the article "Lipidic Nano-Sized Emulsomes Potentiates the Cytotoxic and Apoptotic Effects of Raloxifene Hydrochloride in MCF-7 Human Breast Cancer Cells: Factorial Analysis and In Vitro Anti-Tumor Activity Assessment" [...].
    Language English
    Publishing date 2024-01-30
    Publishing country Switzerland
    Document type Retraction of Publication
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics16020195
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: RETRACTED: Alhakamy et al. Chitosan-Based Microparticles Enhance Ellagic Acid's Colon Targeting and Proapoptotic Activity.

    Alhakamy, Nabil A / Ahmed, Osama A A / Kurakula, Mallesh / Caruso, Giuseppe / Caraci, Filippo / Asfour, Hani Z / Alfarsi, Anas / Eid, Basma G / Mohamed, Amir I / Alruwaili, Nabil K / Abdulaal, Wesam H / Fahmy, Usama A / Alhadrami, Hani A / Eldakhakhny, Basmah M / Abdel-Naim, Ashraf B

    Pharmaceutics

    2024  Volume 16, Issue 2

    Abstract: The journal retracts the article "Chitosan-Based Microparticles Enhance Ellagic Acid's Colon Targeting and Proapoptotic Activity" [ ... ]. ...

    Abstract The journal retracts the article "Chitosan-Based Microparticles Enhance Ellagic Acid's Colon Targeting and Proapoptotic Activity" [...].
    Language English
    Publishing date 2024-01-30
    Publishing country Switzerland
    Document type Retraction of Publication
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics16020196
    Database MEDical Literature Analysis and Retrieval System OnLINE

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