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Article ; Online: Use of CRISPR/Cas9 with Homology-Directed Repair to Gene-Edit Topoisomerase II

Carvajal-Moreno, Jessika / Wang, Xinyi / Hernandez, Victor A / Mondal, Milon / Zhao, Xinyu / Yalowich, Jack C / Elton, Terry S

The Journal of pharmacology and experimental therapeutics

2024 Volume 389, Issue 2, Page(s) 186–196

Abstract: DNA topoisomerase ... ...

Abstract	DNA topoisomerase II
MeSH term(s)	Humans ; Etoposide/pharmacology ; K562 Cells ; DNA Topoisomerases, Type II/genetics ; DNA Topoisomerases, Type II/metabolism ; Mitoxantrone ; CRISPR-Cas Systems/genetics ; Codon, Nonsense ; Antineoplastic Agents/pharmacology ; Leukemia ; DNA ; Phenotype
Chemical Substances	Etoposide (6PLQ3CP4P3) ; DNA Topoisomerases, Type II (EC 5.99.1.3) ; Mitoxantrone (BZ114NVM5P) ; Codon, Nonsense ; Antineoplastic Agents ; DNA (9007-49-2)
Language	English
Publishing date	2024-04-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	3106-9
ISSN	1521-0103 ; 0022-3565
ISSN (online)	1521-0103
ISSN	0022-3565
DOI	10.1124/jpet.123.002038
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Article ; Online: Solubility tuning of alkyl amine functionalized carbon quantum dots for selective detection of nitroexplosive

Mondal, Tapas Kumar / Kapuria, Arijit / Miah, Milon / Saha, Shyamal K.

Carbon. 2023 June, v. 209, p. 117972

2023 , Page(s) 117972

Abstract: The major issue of luminescent carbon quantum dots (CQDs) is the solubility in wide range of solvent and disappearance of luminescence behavior in its solid state due to aggregation caused quenching. To resolve this issue, in the present work, we have ... ...

Abstract	The major issue of luminescent carbon quantum dots (CQDs) is the solubility in wide range of solvent and disappearance of luminescence behavior in its solid state due to aggregation caused quenching. To resolve this issue, in the present work, we have tuned the solubility of carbon quantum dots in different kinds of solvents through surface functionalization technique. Here, we have synthesized three sets of alkyl amine functionalized carbon quantum dots from citric acid and alkyl amine by solvothermal method. We have observed that the solubility of CQDs increases from aqueous medium to organic medium with increasing length of hydrophobic alkyl chains attached at the surface of CQDs. It is seen that n-butyl amine functionalized CQDs (C₄-CQD) are soluble in any type of solvents. Here we have also observed that the C₄-CQD shows aggregation induced emission instead of aggregation caused quenching in solid state and shows bright yellow luminescence color upon excitation. Besides this, we also report selective detection of both dinitroaniline (DNA) and dinitrophenol (DNP) using this C₄-CQD via fluorescence quenching and colorimetric methods. In organic medium both shows significant quenching with emission peak of carbon quantum dots is red shifted (∼30 nm) in presence of DNP whereas no significant peak shift is observed for DNA. CQDs containing paper strip shows yellow spot in presence of DNP but no such characteristic color is appeared after addition of DNA. Using these two techniques, we have selectively identified both DNA and DNP among other nitro compounds by our as-synthesized carbon dots.
Keywords	DNA ; carbon ; citric acid ; color ; colorimetry ; fluorescence ; hydrophobicity ; paper ; solubility ; solvents ; Carbon quantum dots ; Alkyl amine functionalization ; Solid state luminescence ; Fluorescence quenching ; Colorimetric detection
Language	English
Dates of publication	2023-06
Size	p. 117972
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Pre-press version
ISSN	0008-6223
DOI	10.1016/j.carbon.2023.03.047
Database	NAL-Catalogue (AGRICOLA)

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Article: The protective effects of nerol to prevent the toxicity of carbon tetrachloride to the liver in Sprague-Dawley rats.

Mondal, Milon / Bala, Jibanananda / Mondal, Kakoli Rani / Afrin, Sadia / Saha, Protyaee / Saha, Moumita / Jamaddar, Sarmin / Roy, Uttam Kumar / Sarkar, Chandan

Heliyon

2023 Volume 9, Issue 12, Page(s) e23065

Abstract: Introduction: Carbon-tetrachloride (CCl: Materials and methods: For the aim of this experiment, 35 male Sprague-Dawley rats ranging in body weight (BW) from 140 to 180 g were split into five separate groups. With the exception of vehicle control ... ...

Abstract	Introduction: Carbon-tetrachloride (CCl Materials and methods: For the aim of this experiment, 35 male Sprague-Dawley rats ranging in body weight (BW) from 140 to 180 g were split into five separate groups. With the exception of vehicle control group 1, all experimental rats were subjected to carbon tetrachloride exposure through intra-peritoneal injection at a 0.7 mL/kg body weight dose once a week for 4 weeks (28 days). The treatment groups 3 and 4 received oral administration of nerol at 50 and 100 mg/kg BW for 28 days. In the same time period, the standard control group received 100 mg/kg BW silymarin. Results: Serum hepatic markers, lipid profiles, albumin, globulin, bilirubin, and total protein were all substantially improved in nerol-treated rats in a dose-dependent manner that had been exposed to CCl Conclusion: According to the findings of our investigation, nerol has potential as a functional element to shield the liver from harm brought on by ROS that are caused by CCL
Language	English
Publishing date	2023-11-30
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e23065
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Article ; Online: The protective effects of nerol to prevent the toxicity of carbon tetrachloride to the liver in Sprague-Dawley rats

Milon Mondal / Jibanananda Bala / Kakoli Rani Mondal / Sadia Afrin / Protyaee Saha / Moumita Saha / Sarmin Jamaddar / Uttam Kumar Roy / Chandan Sarkar

Heliyon, Vol 9, Iss 12, Pp e23065- (2023)

2023

Abstract: Introduction: Carbon-tetrachloride (CCl4) is well-known to cause liver damage due to severe oxidative stress. Nerol, on the other hand, is a monoterpene that is antioxidant, antiviral, antibacterial, anti-inflammatory, and anxiolytic. This study set out ... ...

Abstract	Introduction: Carbon-tetrachloride (CCl4) is well-known to cause liver damage due to severe oxidative stress. Nerol, on the other hand, is a monoterpene that is antioxidant, antiviral, antibacterial, anti-inflammatory, and anxiolytic. This study set out to determine if nerol may be used as a prophylactic measure against the oxidative stress mediated hepatic injury caused by CCl4. Materials and methods: For the aim of this experiment, 35 male Sprague-Dawley rats ranging in body weight (BW) from 140 to 180 g were split into five separate groups. With the exception of vehicle control group 1, all experimental rats were subjected to carbon tetrachloride exposure through intra-peritoneal injection at a 0.7 mL/kg body weight dose once a week for 4 weeks (28 days). The treatment groups 3 and 4 received oral administration of nerol at 50 and 100 mg/kg BW for 28 days. In the same time period, the standard control group received 100 mg/kg BW silymarin. Results: Serum hepatic markers, lipid profiles, albumin, globulin, bilirubin, and total protein were all substantially improved in nerol-treated rats in a dose-dependent manner that had been exposed to CCl4 compared to the only CCl4-treated group. Carbon tetrachloride-exposed rats had lower glutathione, superoxide dismutase, and catalase levels and higher thio-barbituric acid reactive substances (TBARS) levels than normal rats. In contrast, administration of nerol shown a significant augmentation in the concentrations of these antioxidant compounds, while concurrently inducing a decline in the levels of TBARS in the hepatic tissue. In a similar vein, the histo-pathological examination yielded further evidence indicating that nerol offered protection to the hepatocyte against damage generated by CCl4. Conclusion: According to the findings of our investigation, nerol has potential as a functional element to shield the liver from harm brought on by ROS that are caused by CCL4.
Keywords	Nerol ; Carbon-tetrachloride ; Hepatotoxicity ; Oxidative-stress ; Hepatoprotective ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
Subject code	610
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: UCHL1 as a novel target in breast cancer: emerging insights from cell and chemical biology.

Mondal, Milon / Conole, Daniel / Nautiyal, Jaya / Tate, Edward W

British journal of cancer

2021 Volume 126, Issue 1, Page(s) 24–33

Abstract: Breast cancer has the highest incidence and death rate among cancers in women worldwide. In particular, metastatic estrogen receptor negative (ER-) breast cancer and triple-negative breast cancer (TNBC) subtypes have very limited treatment options, with ... ...

Abstract	Breast cancer has the highest incidence and death rate among cancers in women worldwide. In particular, metastatic estrogen receptor negative (ER-) breast cancer and triple-negative breast cancer (TNBC) subtypes have very limited treatment options, with low survival rates. Ubiquitin carboxyl terminal hydrolase L1 (UCHL1), a ubiquitin C-terminal hydrolase belonging to the deubiquitinase (DUB) family of enzymes, is highly expressed in these cancer types, and several key reports have revealed emerging and important roles for UCHL1 in breast cancer. However, selective and potent small-molecule UCHL1 inhibitors have been disclosed only very recently, alongside chemical biology approaches to detect regulated UHCL1 activity in cancer cells. These tools will enable novel insights into oncogenic mechanisms driven by UCHL1, and identification of substrate proteins deubiquitinated by UCHL1, with the ultimate goal of realising the potential of UCHL1 as a drug target in breast cancer.
MeSH term(s)	Antineoplastic Agents/pharmacology ; Biomarkers, Tumor/metabolism ; Breast Neoplasms/drug therapy ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Female ; Humans ; Molecular Targeted Therapy/methods ; Triple Negative Breast Neoplasms/drug therapy ; Triple Negative Breast Neoplasms/metabolism ; Triple Negative Breast Neoplasms/pathology ; Ubiquitin Thiolesterase/antagonists & inhibitors ; Ubiquitin Thiolesterase/metabolism
Chemical Substances	Antineoplastic Agents ; Biomarkers, Tumor ; UCHL1 protein, human ; Ubiquitin Thiolesterase (EC 3.4.19.12)
Language	English
Publishing date	2021-09-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	80075-2
ISSN	1532-1827 ; 0007-0920
ISSN (online)	1532-1827
ISSN	0007-0920
DOI	10.1038/s41416-021-01516-5
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Article ; Online: Antioxidant mediated protective effect of

Mondal, Milon / Hossen, Md Sakib / Rahman, Mohammad Asikur / Saha, Sushmita / Sarkar, Chandan / Bhoumik, Nikhil Chandra / Kundu, Sukalyan Kumar

Toxicology reports

2021 Volume 8, Page(s) 1369–1380

Abstract: Bridelia tomentosa (B. tomentosa) ...

Abstract	Bridelia tomentosa (B. tomentosa)
Language	English
Publishing date	2021-07-08
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	2805786-7
ISSN	2214-7500 ; 2214-7500
ISSN (online)	2214-7500
ISSN	2214-7500
DOI	10.1016/j.toxrep.2021.07.003
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Article ; Online: In Vitro Antioxidant and In Vivo Hepatoprotective Properties of

Hossain, Kazi Nadim / Islam, Md Shafiqul / Rahman, Sheikh Hasibur / Sarker, Subroto / Mondal, Milon / Rahman, Mohammad Asikur / Alhag, Sadeq K / Al-Shuraym, Laila A / Alghamdi, Othman A / Islam, Muhammad Torequl / Al-Farga, Ammar / El-Shazly, Mohamed / Alam, Md Jahir / El-Nashar, Heba A S

ACS omega

2023 Volume 8, Issue 49, Page(s) 47001–47011

Abstract: Wissadula ... ...

Abstract	Wissadula periplocifolia
Language	English
Publishing date	2023-11-28
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.3c06614
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Article ; Online: Therapeutic perspectives of the black cumin component thymoquinone: A review.

Sarkar, Chandan / Jamaddar, Sarmin / Islam, Tawhida / Mondal, Milon / Islam, Muhammad Torequl / Mubarak, Mohammad S

Food & function

2021 Volume 12, Issue 14, Page(s) 6167–6213

Abstract: The dietary phytochemical thymoquinone (TQ), belonging to the family of quinones, mainly obtained from the black and angular seeds of Nigella sativa, is one of the promising monoterpenoid hydrocarbons, which has been receiving massive attention for its ... ...

Abstract	The dietary phytochemical thymoquinone (TQ), belonging to the family of quinones, mainly obtained from the black and angular seeds of Nigella sativa, is one of the promising monoterpenoid hydrocarbons, which has been receiving massive attention for its therapeutic potential and pharmacological properties. It plays an important role as a chemopreventive and therapeutic agent in the treatment of various diseases and illnesses. The aim of this review is to present a summary of the most recent literature pertaining to the use of TQ for the prevention and treatment of various diseases along with possible mechanisms of action, and the potential use of this natural product as a complementary or alternative medicine. Research findings indicated that TQ exhibits numerous pharmacological activities including antioxidant, anti-inflammatory, cardioprotective, hepatoprotective, antidiabetic, neuroprotective, and anticancer, among others. Conclusions of this review on the therapeutic aspects of TQ highlight the medicinal and folk values of this compound against various diseases and ailments. In short, TQ could be a novel drug in clinical trials, as we hope.
MeSH term(s)	Animals ; Anti-Inflammatory Agents/pharmacology ; Antineoplastic Agents/pharmacology ; Antioxidants/pharmacology ; Benzoquinones/pharmacokinetics ; Benzoquinones/pharmacology ; Benzoquinones/therapeutic use ; Cardiotonic Agents/pharmacology ; Humans ; Hypoglycemic Agents/pharmacology ; Mice ; Neuroprotective Agents/pharmacology ; Nigella sativa/chemistry ; Phytochemicals/pharmacology ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Rats ; Seeds/chemistry
Chemical Substances	Anti-Inflammatory Agents ; Antineoplastic Agents ; Antioxidants ; Benzoquinones ; Cardiotonic Agents ; Hypoglycemic Agents ; Neuroprotective Agents ; Phytochemicals ; Plant Extracts ; thymoquinone (O60IE26NUF)
Language	English
Publishing date	2021-06-04
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2612033-1
ISSN	2042-650X ; 2042-6496
ISSN (online)	2042-650X
ISSN	2042-6496
DOI	10.1039/d1fo00401h
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Article ; Online: Ebselen suitably interacts with the potential SARS-CoV-2 targets: an

Sarkar, Chandan / Abdalla, Mohnad / Mondal, Milon / Khalipha, Abul Bashar Ripon / Ali, Nasir

Journal of biomolecular structure & dynamics

2021 Volume 40, Issue 22, Page(s) 12286–12301

Abstract: Ebselen (SPI-1005) is an active selenoorganic compound that can be found potential inhibitory activity against different types of viral infections such as zika virus, influenza A virus, HCV, and HIV-1; and also be found to exhibit promising antiviral ... ...

Abstract	Ebselen (SPI-1005) is an active selenoorganic compound that can be found potential inhibitory activity against different types of viral infections such as zika virus, influenza A virus, HCV, and HIV-1; and also be found to exhibit promising antiviral activity against SARS-CoV-2 in cell-based assays but its particular target action against specific non-structural and structural proteins of SARS-CoV-2 is unclear to date. The purpose of this study is to evaluate the anti-SARS-CoV-2 efficacy of Ebselen along with the determination of the specific target among the 12 most common target proteins of SARS-CoV-2. AutoDock Vina in PyRx platform was used for docking analysis against the 12 selected SARS-CoV-2 encoded drug targets. ADME profiling was examined by using SwissADME online server. The stability of binding mode in the target active sites was evaluated using molecular dynamics (MD) simulation studies through NAMD and Desmond package software application. In this docking study, we recognized that Ebselen possesses the highest affinity to N protein (C domain) (PDB ID: 6YUN) and PLpro (PDB ID: 6WUU) among the selected SARS-CoV-2 targets showing -7.4 kcal/mol binding energy. The stability of Ebselen-6YUN and Ebselen-6WUU was determined by a 100 ns trajectory of all-atom molecular dynamics simulation. Structural conformation of these two complexes displayed stable root mean square deviation (RMSD), while root mean square fluctuations (RMSF) were also found to be consistent. This molecular docking study may propose the efficiency of Ebselen against SARS-CoV-2 to a significant extent which makes it a candidature of COVID-19 treatment.
MeSH term(s)	Humans ; SARS-CoV-2 ; COVID-19 ; COVID-19 Drug Treatment ; Molecular Docking Simulation ; Antiviral Agents/pharmacology ; Azoles/pharmacology ; Molecular Dynamics Simulation ; Zika Virus ; Zika Virus Infection ; Protease Inhibitors
Chemical Substances	ebselen (40X2P7DPGH) ; Antiviral Agents ; Azoles ; Protease Inhibitors
Language	English
Publishing date	2021-08-30
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	49157-3
ISSN	1538-0254 ; 0739-1102
ISSN (online)	1538-0254
ISSN	0739-1102
DOI	10.1080/07391102.2021.1971562
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Article: Subchronic Toxicity Study of Alternanthera philoxeroides in Swiss Albino Mice Having Antioxidant and Anticoagulant Activities.

Khandker, Shahad Saif / Alam, Morshed / Uddin, Forhad / Shapla, Ummay Mahfuza / Lubna, Nafisa / Mazumder, Tanusree Amy / Marzan, Mahfuza / Mondal, Milon / Khalil, Md Ibrahim / Karim, Nurul / Shakil, Md Salman / Hossen, Md Sakib

Journal of toxicology

2022 Volume 2022, Page(s) 8152820

Abstract: Alternanthera ... ...

Abstract	Alternanthera philoxeroides
Language	English
Publishing date	2022-07-13
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	2495098-1
ISSN	1687-8205 ; 1687-8191
ISSN (online)	1687-8205
ISSN	1687-8191
DOI	10.1155/2022/8152820
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