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Article ; Online: Fear, misinformation, and pharmaceutical messianism in the promotion of compounded bioidentical hormone therapy.

Kauffman, Robert P / MacLaughlin, Eric J / Courtney, Lindsay A / Vineyard, David D

Frontiers in reproductive health

2024 Volume 6, Page(s) 1378644

Abstract: Compounded bioidentical hormone therapy (cBHT) for menopausal symptoms maintains popularity in western countries despite the availability of hormone products in different formulations and dosages produced by pharmaceutical companies with federal ... ...

Abstract	Compounded bioidentical hormone therapy (cBHT) for menopausal symptoms maintains popularity in western countries despite the availability of hormone products in different formulations and dosages produced by pharmaceutical companies with federal oversight. Akin to many populist therapeutic trends in the history of medicine, cBHT advocates tend to capitalize on consumer fears about existing FDA-approved hormone treatments. Unsubstantiated, exaggerated, or outright false claims are commonplace in promoting cBHT. Given these elements, the basic elements of pharmaceutical messianism continue to drive the cBHT movement.
Language	English
Publishing date	2024-02-29
Publishing country	Switzerland
Document type	Journal Article
ISSN	2673-3153
ISSN (online)	2673-3153
DOI	10.3389/frph.2024.1378644
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Article ; Online: The Impact of Posttreatment Imaging in Peptide Receptor Radionuclide Therapy.

Yadav, Surekha / Lawhn-Heath, Courtney / Paciorek, Alan / Lindsay, Sheila / Mirro, Rebecca / Bergsland, Emily K / Hope, Thomas A

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

2024 Volume 65, Issue 3, Page(s) 409–415

Abstract: Posttreatment imaging of γ-emissions after peptide receptor radionuclide therapy (PRRT) can be used to perform quantitative dosimetry as well as assessment response using qualitative measures. We aimed to assess the impact of qualitative posttreatment ... ...

Abstract	Posttreatment imaging of γ-emissions after peptide receptor radionuclide therapy (PRRT) can be used to perform quantitative dosimetry as well as assessment response using qualitative measures. We aimed to assess the impact of qualitative posttreatment imaging on the management of patients undergoing PRRT.
MeSH term(s)	Humans ; Octreotide/therapeutic use ; Retrospective Studies ; Neuroendocrine Tumors/diagnostic imaging ; Neuroendocrine Tumors/radiotherapy ; Neuroendocrine Tumors/pathology ; Radioisotopes ; Receptors, Peptide
Chemical Substances	Octreotide (RWM8CCW8GP) ; Radioisotopes ; Receptors, Peptide
Language	English
Publishing date	2024-03-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	80272-4
ISSN	1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
ISSN (online)	1535-5667
ISSN	0097-9058 ; 0161-5505 ; 0022-3123
DOI	10.2967/jnumed.123.266614
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Zs.A 114: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Using Serum Specimens for Real-Time PCR-Based Diagnosis of Human Granulocytic Anaplasmosis, Canada.

Boodman, Carl / Loomer, Courtney / Dibernardo, Antonia / Hatchette, Todd / LeBlanc, Jason J / Waitt, Brooks / Lindsay, L Robbin

Emerging infectious diseases

2023 Volume 29, Issue 1, Page(s) 175–178

Abstract: Whole blood is the optimal specimen for anaplasmosis diagnosis but might not be available in all cases. We PCR tested serum samples collected in Canada for Anaplasma serology and found 84.8%-95.8% sensitivity and 2.8 average cycle threshold elevation. ... ...

Abstract	Whole blood is the optimal specimen for anaplasmosis diagnosis but might not be available in all cases. We PCR tested serum samples collected in Canada for Anaplasma serology and found 84.8%-95.8% sensitivity and 2.8 average cycle threshold elevation. Serum can be acceptable for detecting Anaplasma spp. when whole blood is unavailable.
MeSH term(s)	Animals ; Humans ; Anaplasmosis/diagnosis ; Real-Time Polymerase Chain Reaction ; Anaplasma phagocytophilum/genetics ; Canada/epidemiology
Language	English
Publishing date	2023-01-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	1380686-5
ISSN	1080-6059 ; 1080-6040
ISSN (online)	1080-6059
ISSN	1080-6040
DOI	10.3201/eid2901.220988
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Article: Chronic Obstructive Pulmonary Disease, Part 5: Clinical Pearls for Comorbid COPD.

Clifford, Kalin M / Klein, Mary S / Courtney, Lindsay A / Van Dyke, Alaina / Sigler, Meredith / Basinger, Rachel L

The Senior care pharmacist

2023 Volume 38, Issue 10, Page(s) 404–415

Abstract: Chronic obstructive pulmonary disease (COPD) is often diagnosed with other comorbid conditions. This can complicate therapy overall by contributing to adverse events leading to poor outcomes to not only COPD, but other comorbid conditions. This ... ...

Abstract	Chronic obstructive pulmonary disease (COPD) is often diagnosed with other comorbid conditions. This can complicate therapy overall by contributing to adverse events leading to poor outcomes to not only COPD, but other comorbid conditions. This manuscript will discuss common comorbid conditions often seen with COPD, update vaccination recommendations for COPD patients, and provide information regarding smoking cessation in COPD. The senior care pharmacist has an important role where they can recommend medication adjustments to potentially avoid these adverse events, immunize their patients appropriately, and provide assistance with smoking cessation to improve not only COPD outcomes but outcomes associated with other comorbid conditions.
MeSH term(s)	Humans ; Pulmonary Disease, Chronic Obstructive/epidemiology ; Pulmonary Disease, Chronic Obstructive/diagnosis ; Comorbidity ; Smoking Cessation
Language	English
Publishing date	2023-09-28
Publishing country	United States
Document type	Journal Article
ISSN	2639-9636
ISSN	2639-9636
DOI	10.4140/TCP.n.2023.404
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Article ; Online: Evaluation of the Clinical Impact of Thromboprophylaxis in Patients With COVID-19 Following Hospital Discharge.

Courtney, Lindsay A / Trujillo, Toby C / Saseen, Joseph J / Wright, Garth / Palkimas, Surabhi

The Annals of pharmacotherapy

2022 Volume 56, Issue 9, Page(s) 981–987

Abstract: Background: Data are limited regarding the incidence of thromboembolism post-hospital discharge among COVID-19 patients. Guidelines addressing the role of extended thromboprophylaxis for COVID-19 patients are limited and conflicting.: Objective: The ... ...

Abstract	Background: Data are limited regarding the incidence of thromboembolism post-hospital discharge among COVID-19 patients. Guidelines addressing the role of extended thromboprophylaxis for COVID-19 patients are limited and conflicting. Objective: The purpose of this study was to evaluate the incidence of post-discharge thromboembolic and bleeding events and the role of thromboprophylaxis among COVID-19 patients. Methods: A retrospective analysis was conducted of hospitalized patients with symptomatic COVID-19 infection who were discharged from a University of Colorado Health (UCHealth) hospital between March 1, 2020, and October 31, 2020. The primary outcome was objectively confirmed thromboembolism within 35 days post-discharge. The main secondary outcome was the incidence of bleeding events within 35 days post-discharge. Outcomes were compared between those who received extended prophylaxis and those who did not. Results: A total of 1171 patients met the study criteria. A total of 13 (1.1%) of patients had a documented thromboembolic event and 10 (0.9%) patients had a documented bleeding event within 35 days post-discharge. None of the 132 patients who received extended prophylaxis had a thromboembolic event compared to 13 of 1039 who did not receive extended prophylaxis (0 and 1.3%, respectively; Conclusions and relevance: These results suggest that post-discharge extended prophylaxis may be beneficial for select COVID-19 patients, while carefully weighing the risk of bleeding. Application of our findings may assist institutions in development of thromboprophylaxis protocols for discharged COVID-19 patients.
MeSH term(s)	Aftercare ; Anticoagulants/adverse effects ; COVID-19/complications ; Hemorrhage/chemically induced ; Hospitals ; Humans ; Patient Discharge ; Retrospective Studies ; Venous Thromboembolism/prevention & control
Chemical Substances	Anticoagulants
Language	English
Publishing date	2022-01-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	1101370-9
ISSN	1542-6270 ; 1060-0280
ISSN (online)	1542-6270
ISSN	1060-0280
DOI	10.1177/10600280211064306
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Article: Development of a survey instrument to assess individual and organizational use of climate adaptation science

Courtney, Steph L. / Hyman, Amanda A. / McNeal, Karen S. / Maudlin, Lindsay C. / Armsworth, Paul R.

Environmental science & policy. 2022 Nov., v. 137

2022

Abstract: Research that can improve the resilience of social and natural systems to climate change has become more common. Many climate adaptation science organizations and agencies now focus on actionable science, a model that aims to have greater impacts on ... ...

Abstract	Research that can improve the resilience of social and natural systems to climate change has become more common. Many climate adaptation science organizations and agencies now focus on actionable science, a model that aims to have greater impacts on policy and practice than traditionally produced and distributed science. However, evaluations of research projects are needed to examine and verify the impact of climate science on adaptation and society. Better understanding the types and mechanisms of impact will allow organizations to design, fund, and facilitate more useful climate adaptation science. Many existing actionable science evaluation approaches are qualitative in nature and take considerable time and effort for funders and administrators to implement. Quantitative methods could provide a valuable option for evaluation, specifically for making comparisons across many projects. Thus, we have designed a quantitative survey instrument for measuring the use of climate adaptation science. We designed the survey using best practices and iterative input from social scientists as well as climate adaptation scientists and practitioners. We then distributed the survey to a sample of users of climate adaptation science and analyzed those responses to further refine the survey. Quantitative and qualitative results show that use of climate adaptation science may be described as either individual use or organizational use, which contrasts with popular models of use in existing evaluation literature. The survey is made available for future efforts to evaluate and improve climate adaptation science and to advance efforts to measure different kinds of use.
Keywords	climate ; climate change ; environmental science ; issues and policy ; models ; society ; surveys
Language	English
Dates of publication	2022-11
Size	p. 271-279.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	1454687-5
ISSN	1462-9011
ISSN	1462-9011
DOI	10.1016/j.envsci.2022.08.023
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Midpoint Reflections on USAID HIV Local Partner Transition Efforts.

Kaliel, Deborah / Knight, Christy / Avery, Latham / White, Lauren A / Bonanno, Lindsay / Porter, Jason / Hoeflich, Kathryn / Irwin, Courtney / Nikola, Christopher / Paul, Amy / Hijazi, Mai / Cavanaugh, Clint / Raulfs-Wang, E Callie

Global health, science and practice

2023 Volume 11, Issue 3

MeSH term(s)	United States ; Humans ; United States Agency for International Development ; Government Agencies ; HIV Infections/prevention & control
Language	English
Publishing date	2023-06-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	2710875-2
ISSN	2169-575X ; 2169-575X
ISSN (online)	2169-575X
ISSN	2169-575X
DOI	10.9745/GHSP-D-22-00338
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Article ; Online: Feasibility of cord blood collection for autologous cell therapy applications in extremely preterm infants.

Zhou, Lindsay / McDonald, Courtney A / Yawno, Tamara / Penny, Tayla / Miller, Suzanne L / Jenkin, Graham / Malhotra, Atul

Cytotherapy

2023 Volume 25, Issue 5, Page(s) 458–462

Abstract: Background aims: Umbilical cord blood (UCB)-derived cells show strong promise as a treatment for neonatal brain injury in pre-clinical models and early-phase clinical trials. Feasibility of UCB collection and autologous administration is reported for ... ...

Abstract	Background aims: Umbilical cord blood (UCB)-derived cells show strong promise as a treatment for neonatal brain injury in pre-clinical models and early-phase clinical trials. Feasibility of UCB collection and autologous administration is reported for term infants, but data are limited for preterm infants. Here the authors assessed the feasibility of UCB-derived cell collection for autologous use in extremely preterm infants born at less than 28 weeks, a population with a high incidence of brain injury and subsequent neurodisability. Methods: In a prospective study at a tertiary hospital in Melbourne, Australia, UCB was collected from infants born at less than 28 weeks and processed to obtain total nucleated cells (TNCs), CD34+ cells, mononuclear cells and cell viability via fluorescence-activated cell sorting prior to cryopreservation. Feasibility was pre-defined as volume adequate for cryopreservation (>9 mL UCB collected) and >25 × 10 Results: Thirty-eight infants (21 male, 17 female) were included in the study. Twenty-four (63.1%) were delivered via cesarean section, 30 (78.9%) received delayed cord clamping before collection and 11 (28.9%) were a multiple birth. Median (interquartile range [IQR]) gestational age was 26.0 weeks (24.5-27.5) and mean (standard deviation) birth weight was 761.5 g (221.5). Median (IQR) UCB volume collected was 19.1 mL/kg (10.5-23.5), median (IQR) TNC count was 105.2 × 10 Conclusions: UCB-derived cell collection adequate for cryopreservation and subsequent autologous reinfusion was achieved in 70% of extremely preterm infants. Extremely preterm UCB demonstrated a higher CD34+:TNC ratio compared with published full-term values. Recruitment to demonstrate safety of UCB cell administration in extremely premature infants is ongoing in the CORD-SAFE study (trial registration no. ACTRN12619001637134).
MeSH term(s)	Humans ; Infant, Newborn ; Male ; Pregnancy ; Female ; Infant ; Infant, Extremely Premature ; Fetal Blood ; Cesarean Section ; Prospective Studies ; Feasibility Studies
Language	English
Publishing date	2023-02-04
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2039821-9
ISSN	1477-2566 ; 1465-3249
ISSN (online)	1477-2566
ISSN	1465-3249
DOI	10.1016/j.jcyt.2023.01.001
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Article: The Evolution of Agrarian Landscapes in the Tropical Andes.

Shadik, Courtney R / Bush, Mark B / Valencia, Bryan G / Rozas-Davila, Angela / Plekhov, Daniel / Breininger, Robert D / Davin, Claire / Benko, Lindsay / Peterson, Larry C / VanValkenburgh, Parker

Plants (Basel, Switzerland)

2024 Volume 13, Issue 7

Abstract: Changes in land-use practices have been a central element of human adaptation to Holocene climate change. Many practices that result in the short-term stabilization of socio-natural systems, however, have longer-term, unanticipated consequences that ... ...

Abstract	Changes in land-use practices have been a central element of human adaptation to Holocene climate change. Many practices that result in the short-term stabilization of socio-natural systems, however, have longer-term, unanticipated consequences that present cascading challenges for human subsistence strategies and opportunities for subsequent adaptations. Investigating complex sequences of interaction between climate change and human land-use in the past-rather than short-term causes and effects-is therefore essential for understanding processes of adaptation and change, but this approach has been stymied by a lack of suitably-scaled paleoecological data. Through a high-resolution paleoecological analysis, we provide a 7000-year history of changing climate and land management around Lake Acopia in the Andes of southern Peru. We identify evidence of the onset of pastoralism, maize cultivation, and possibly cultivation of quinoa and potatoes to form a complex agrarian landscape by c. 4300 years ago. Cumulative interactive climate-cultivation effects resulting in erosion ended abruptly c. 2300 years ago. After this time, reduced sedimentation rates are attributed to the construction and use of agricultural terraces within the catchment of the lake. These results provide new insights into the role of humans in the manufacture of Andean landscapes and the incremental, adaptive processes through which land-use practices take shape.
Language	English
Publishing date	2024-04-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704341-1
ISSN	2223-7747
ISSN	2223-7747
DOI	10.3390/plants13071019
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Article ; Online: Umbilical Cord Blood and Cord Tissue-Derived Cell Therapies for Neonatal Morbidities: Current Status and Future Challenges.

Zhou, Lindsay / McDonald, Courtney / Yawno, Tamara / Jenkin, Graham / Miller, Suzanne / Malhotra, Atul

Stem cells translational medicine

2022 Volume 11, Issue 2, Page(s) 135–145

Abstract: Cell therapies are an emerging focus for neonatal research, with benefits documented for neonatal respiratory, neurological, and cardiac conditions in pre-clinical studies. Umbilical cord blood (UCB) and umbilical cord (UC) tissue-derived cell therapy is ...

Abstract	Cell therapies are an emerging focus for neonatal research, with benefits documented for neonatal respiratory, neurological, and cardiac conditions in pre-clinical studies. Umbilical cord blood (UCB) and umbilical cord (UC) tissue-derived cell therapy is particularly appealing for preventative or regenerative treatment of neonatal morbidities; they are a resource that can be collected at birth and used as an autologous or allogeneic therapy. Moreover, UCB contains a diverse mix of stem and progenitor cells that demonstrate paracrine actions to mitigate damaging inflammatory, immune, oxidative stress, and cell death pathways in several organ systems. In the past decade, published results from early-phase clinical studies have explored the use of these cells as a therapeutic intervention in neonates. We present a systematic review of published and registered clinical trials of UCB and cord tissue-derived cell therapies for neonatal morbidities. This search yielded 12 completed clinical studies: 7 were open-label phase I and II safety and feasibility trials, 3 were open-label dose-escalation trials, 1 was a open-label placebo-controlled trial, and 1 was a phase II randomized controlled trial. Participants totaled 206 infants worldwide; 123 (60%) were full-term infants and 83 (40%) were preterm. A majority (64.5%) received cells via an intravenous route; however, 54 (26.2%) received cells via intratracheal administration, 10 (4.8%) intraoperative cardiac injection, and 9 (4.3%) by direct intraventricular (brain) injection. Assessment of efficacy to date is limited given completed studies have principally been phase I and II safety studies. A further 24 trials investigating UCB and UC-derived cell therapies in neonates are currently registered.
MeSH term(s)	Cell- and Tissue-Based Therapy ; Clinical Trials, Phase I as Topic ; Clinical Trials, Phase II as Topic ; Fetal Blood ; Hematopoietic Stem Cell Transplantation ; Humans ; Infant, Newborn ; Morbidity ; Randomized Controlled Trials as Topic ; Transplantation, Autologous/methods ; Umbilical Cord
Language	English
Publishing date	2022-03-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Systematic Review
ZDB-ID	2642270-0
ISSN	2157-6580 ; 2157-6580
ISSN (online)	2157-6580
ISSN	2157-6580
DOI	10.1093/stcltm/szab024
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