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  1. Article ; Online: Racial disparities: disruptive genes in prostate carcinogenesis.

    Singh, Savita / Plaga, Alexis / Shukla, Girish C

    Frontiers in bioscience (Scholar edition)

    2017  Volume 9, Issue 2, Page(s) 244–253

    Abstract: Population specific studies in prostate cancer (PCa) reveal a unique heterogeneous etiology. Various factors, such as genetics, environment and dietary regimen seems to determine disease progression, therapeutic resistance and rate of mortality. Enormous ...

    Abstract Population specific studies in prostate cancer (PCa) reveal a unique heterogeneous etiology. Various factors, such as genetics, environment and dietary regimen seems to determine disease progression, therapeutic resistance and rate of mortality. Enormous disparity documented in disease incidences, aggressiveness and mortality in PCa among AAs (African Americans) and CAs (Caucasian Americans) is attributed to the variations in genetics, epigenetics and their association with metabolism. Scientific and clinical evidences have revealed the influence of variations in Androgen Receptor (AR), RNAse L, macrophage scavenger receptor 1 (
    MeSH term(s) African Americans/genetics ; Animals ; Carcinogenesis/genetics ; Health Status Disparities ; Humans ; Male ; Prostatic Neoplasms/ethnology ; Prostatic Neoplasms/genetics ; Receptors, Androgen/genetics ; Whites/genetics
    Chemical Substances AR protein, human ; Receptors, Androgen
    Language English
    Publishing date 2017-06-01
    Publishing country Singapore
    Document type Journal Article ; Review
    ZDB-ID 2565100-6
    ISSN 1945-0524 ; 1945-0516
    ISSN (online) 1945-0524
    ISSN 1945-0516
    DOI 10.2741/S485
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7071: Show issues Location:
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  2. Article ; Online: MicroRNAs in prostate cancer: Functional role as biomarkers.

    Kanwal, Rajnee / Plaga, Alexis R / Liu, Xiaoqi / Shukla, Girish C / Gupta, Sanjay

    Cancer letters

    2017  Volume 407, Page(s) 9–20

    Abstract: MicroRNAs (miRNAs) are small endogenous non-coding molecules that alters gene expression through post-transcriptional regulation of messenger RNA. Compelling evidence suggest the role of miRNA in cancer biology having potential as diagnostic, prognostic ... ...

    Abstract MicroRNAs (miRNAs) are small endogenous non-coding molecules that alters gene expression through post-transcriptional regulation of messenger RNA. Compelling evidence suggest the role of miRNA in cancer biology having potential as diagnostic, prognostic and predictive biomarkers. This review summarizes the current knowledge on miRNA deregulated in prostate cancer and their role as oncogene, tumor suppressor and metastasis regulators. The emerging information elucidating the biological function of miRNA is promising and may lead to their potential usefulness as diagnostic/prognostic markers and development as effective therapeutic tools for management of prostate cancer.
    MeSH term(s) Biomarkers, Tumor/metabolism ; Gene Expression Regulation, Neoplastic ; Humans ; Male ; MicroRNAs/metabolism ; MicroRNAs/physiology ; Prognosis ; Prostatic Neoplasms/diagnosis ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/metabolism
    Chemical Substances Biomarkers, Tumor ; MicroRNAs
    Language English
    Publishing date 2017-10-28
    Publishing country Ireland
    Document type Journal Article ; Review
    ZDB-ID 195674-7
    ISSN 1872-7980 ; 0304-3835
    ISSN (online) 1872-7980
    ISSN 0304-3835
    DOI 10.1016/j.canlet.2017.08.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1177: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Evaluation of the Clinical Performance of 7 Serological Assays for SARS-CoV-2 for Use in Clinical Laboratories.

    Plaga, Alexis / Wei, Ruhan / Olson, Elizabeth / Payto, Drew / Harrington, John / Nwe-Kissig, Pyik That / Strizzi, Michelle / Zilka, Sarah / Ko, Jennifer / Colón-Franco, Jessica M

    The journal of applied laboratory medicine

    2021  Volume 6, Issue 4, Page(s) 998–1004

    Abstract: Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) serological assays have emerged as a response to the global pandemic, warranting studies evaluating their clinical performance. This study investigated 7 commercially available ... ...

    Abstract Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) serological assays have emerged as a response to the global pandemic, warranting studies evaluating their clinical performance. This study investigated 7 commercially available SARS-CoV-2 serological assays in samples from noninfected individuals and hospitalized patients.
    Methods: SARS-CoV-2 qualitative serological assays by Abbott (IgG), Beckman (IgG), DiaSorin (IgG), EUROIMMUN (IgG and IgA), Roche and Bio-Rad (Total) were evaluated using specimens collected pre-December 2019 (n = 393), from nucleic acid amplification testing (NAAT) negative patients (n = 40), and from 53 patients with COVID-19 by NAAT collected 3-21 days post-onset of symptoms (POS) (N = 83). Negative agreement (NA), positive agreement (PA), and positive and negative predictive values (PPV and NPV) at prevalences of 5% and 10% were calculated.
    Results: The overall %NA; 95% CI in the negative samples were: Roche 99.8%; 99.3-100.2, Beckman 99.8%; 98.7-100.0, Abbott and Bio-Rad 99.3%; 98.0-99.9, DiaSorin 98.4; 97.2-99.6, EUROIMMUN IgG 97.5%; 95.5-98.7, and EUROIMMUN IgA 79.7%; 75.9-83.5), accounting for positive/equivocal results as false positives. The %PA; 95% CI in samples collected 14+ days POS (n = 24) were: Bio-Rad 83.3%; 68.4-98.2, Abbott and Roche 79.2%; 62.9-95.4, EUROIMMUN IgA 70.8%; 52.6-89.0, Beckman 58.3%; 38.6-78.1, DiaSorin 54.2; 34.2-74.1, and EUROIMMUN IgG 50.0%; 30.0-70.0, accounting for negative/equivocal results as false negatives. NPVs ranged from 97.4%-98.9% and 94.7%-97.7% for prevalences 5% and 10%, respectively. PPVs ranged from 15.5%-94.8% and 27.9%-97.4% for prevalences 5% and 10%, respectively.
    Conclusion: The Roche and Beckman assays resulted in fewer false positives, followed by the Bio-Rad and Abbott assays. While the Bio-Rad assay demonstrated higher antibody detection in COVID-19-positive patients, PA claims cannot be established with a high level of confidence in our sample population.
    MeSH term(s) Antibodies, Viral/blood ; Antibodies, Viral/immunology ; COVID-19/blood ; COVID-19/diagnosis ; COVID-19/virology ; COVID-19 Serological Testing/methods ; Case-Control Studies ; Clinical Laboratory Services/statistics & numerical data ; Clinical Laboratory Techniques/methods ; Cohort Studies ; Humans ; Laboratories/statistics & numerical data ; Predictive Value of Tests ; SARS-CoV-2/immunology ; SARS-CoV-2/isolation & purification
    Chemical Substances Antibodies, Viral
    Language English
    Publishing date 2021-03-31
    Publishing country England
    Document type Evaluation Study ; Journal Article
    ISSN 2576-9456
    ISSN 2576-9456
    DOI 10.1093/jalm/jfab038
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Tumor histology and location predict deep nuclei toxicity: Implications for late effects from focal brain irradiation.

    Plaga, Alexis / Shields, Lisa B E / Sun, David A / Vitaz, Todd W / Spalding, Aaron C

    Medical dosimetry : official journal of the American Association of Medical Dosimetrists

    2012  Volume 37, Issue 3, Page(s) 276–279

    Abstract: Normal tissue toxicity resulting from both disease and treatment is an adverse side effect in the management of patients with central nervous system malignancies. We tested the hypothesis that despite these improvements, certain tumors place patients at ... ...

    Abstract Normal tissue toxicity resulting from both disease and treatment is an adverse side effect in the management of patients with central nervous system malignancies. We tested the hypothesis that despite these improvements, certain tumors place patients at risk for neurocognitive, neuroendocrine, and neurosensory late effects. Defining patient groups at risk for these effects could allow for development of preventive strategies. Fifty patients with primary brain tumors underwent radiation planning with magnetic resonance imaging scan and computed tomography datasets. Organs at risk (OAR) responsible for neurocognitive, neuroendocrine, and neurosensory function were defined. Inverse-planned intensity-modulated radiation therapy was optimized with priority given to target coverage while penalties were assigned to exceeding normal tissue tolerances. Tumor laterality, location, and histology were compared with OAR doses, and analysis of variance was performed to determine the significance of any observed correlation. The ipsilateral hippocampus exceeded dose limits in frontal (74%), temporal (94%), and parietal (100%) lobe tumor locations. The contralateral hippocampus was at risk in the following tumor locations: frontal (53%), temporal (83%), or parietal (50%) lobe. Patients with high-grade glioma were at risk for ipsilateral (88%) and contralateral (73%) hippocampal damage (P <0.05 compared with other histologies). The pituitary gland and hypothalamus exceeded dose tolerances in patients with pituitary tumors (both 100%) and high-grade gliomas (50% and 75%, P <0.05 compared with other histologies), respectively. Despite application of modern radiation therapy, certain tumor locations and histologies continue to place patients at risk for morbidity. Patients with high-grade gliomas or tumors located in the frontal, temporal, or parietal lobes are at risk for neurocognitive decline, likely because of larger target volumes and higher radiation doses. Data from this study may help to stratify patients at risk for late effects to develop strategies to reduce frequency and severity of radiation sequelae.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Brain/pathology ; Brain/radiation effects ; Brain Injuries/etiology ; Brain Injuries/pathology ; Brain Neoplasms/pathology ; Brain Neoplasms/radiotherapy ; Child ; Female ; Humans ; Male ; Middle Aged ; Radiation Dosage ; Radiation Injuries/etiology ; Radiation Injuries/pathology ; Radiotherapy, Conformal/adverse effects ; Treatment Outcome ; Young Adult
    Language English
    Publishing date 2012
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645065-9
    ISSN 1873-4022 ; 0958-3947 ; 0739-0211
    ISSN (online) 1873-4022
    ISSN 0958-3947 ; 0739-0211
    DOI 10.1016/j.meddos.2011.10.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2448: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: 46-year-old man with a spinal cord mass.

    Sanders, Mary Ann / Vitaz, Todd / Rosenblum, Marc / Plaga, Alexis R / Parker, Joseph C / Parker, John R

    Brain pathology (Zurich, Switzerland)

    2010  Volume 21, Issue 1, Page(s) 109–112

    Abstract: Medulloblastoma accounts for only 1% of all adult CNS tumors. Likewise, recurrence of adult medulloblastoma greater than 20 years after initial diagnosis is extremely rare.We describe a case of adult medulloblastoma with late relapse of disease. The ... ...

    Abstract Medulloblastoma accounts for only 1% of all adult CNS tumors. Likewise, recurrence of adult medulloblastoma greater than 20 years after initial diagnosis is extremely rare.We describe a case of adult medulloblastoma with late relapse of disease. The patient was 24 years old when first diagnosed and was treated with total tumor resection and craniospinal radiation. At the age of 45, an enhancing 1.3 cm intradural extramedullary spinal cord lesion at T5 was discovered on MRI. This was presumed to be recurrent medulloblastoma in the form of drop metastasis and the patient was treated with spinal radiation. Several months following treatment, at the age of 46, a follow-up MRI demonstrated an enhancing 1.4 cm intradural extramedullary spinal cord lesion at T7. The lesion was resected and histopathologic examination was most consistent with medulloblastoma, late drop metastasis. Although rare, adult medulloblastoma recurring 20 years after initial diagnosis should always be considered in the main differential diagnosis when working up CNS lesions at or outside the primary tumor site.
    MeSH term(s) Cranial Fossa, Posterior/pathology ; Cranial Fossa, Posterior/surgery ; Humans ; Magnetic Resonance Imaging ; Male ; Medulloblastoma/secondary ; Medulloblastoma/surgery ; Middle Aged ; Skull Base Neoplasms/pathology ; Skull Base Neoplasms/surgery ; Spinal Cord Neoplasms/secondary ; Spinal Cord Neoplasms/surgery ; Treatment Outcome
    Language English
    Publishing date 2010-12-03
    Publishing country Switzerland
    Document type Case Reports ; Letter
    ZDB-ID 1051484-3
    ISSN 1750-3639 ; 1015-6305
    ISSN (online) 1750-3639
    ISSN 1015-6305
    DOI 10.1111/j.1750-3639.2010.00451.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3585: Show issues Location:
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  6. Article ; Online: Papillary tumor of the pineal region: two case studies and a review of the literature.

    Rickard, Kyle A / Parker, John R / Vitaz, Todd W / Plaga, Alexis R / Wagner, Stephanie / Parker, Joseph C

    Annals of clinical and laboratory science

    2011  Volume 41, Issue 2, Page(s) 174–181

    Abstract: Papillary tumor of the pineal region (PTPR) is a newly recognized distinct entity in the 2007 World Health Organization nomenclature. This tumor is characterized by epithelial-appearing areas with papillary features and more densely cellular areas that ... ...

    Abstract Papillary tumor of the pineal region (PTPR) is a newly recognized distinct entity in the 2007 World Health Organization nomenclature. This tumor is characterized by epithelial-appearing areas with papillary features and more densely cellular areas that often display ependymal-like differentiation. Ultrastructurally, this rare neuroepithelial tumor possesses neuroendocrine, secretory, and ependymal organelles that likely originate from the subcommissural organ (SCO) near the aqueduct of Sylvius. To date, approximately fifty-seven described cases worldwide have been recognized, with ages ranging from 5 years to 66 years (mean age=32 years). Clinical presentation most often includes headache and obstructive hydrocephalus. The tumor, which is well circumscribed, may be cystic and radiographically is often considered to be consistent with the findings of a pineocytoma. Microscopic evaluation often demonstrates a lesion with papillary areas lined by epithelioid tumor cells with eosinophilic cytoplasm and more cellular areas with cells exhibiting clear or vacuolated cytoplasm. Perivascular and true rosettes may be identified. Distinctive immunohistochemical features including reactivity for keratins (AE1/AE3, CAM 5.2, CK18) and only focal GFAP staining help distinguish this neoplasm from an ependymoma. The relative paucity of data compiled for this tumor makes giving an accurate diagnosis and prognosis a daunting task. We discuss two additional cases of PTPR that presented to us within a three-month span in order to more fully elucidate the possible presentations of this rare entity. Furthermore, we examine now 59 reported cases of PTPR in order to review the current diagnostic and treatment modalities in addition to exploring emerging research encompassing this unusual neoplasm.
    MeSH term(s) Adult ; Biomarkers/metabolism ; Brain Neoplasms/metabolism ; Brain Neoplasms/pathology ; Brain Neoplasms/surgery ; Carcinoma, Papillary/metabolism ; Carcinoma, Papillary/pathology ; Carcinoma, Papillary/surgery ; Female ; Humans ; Keratins/metabolism ; Male ; Middle Aged ; Pineal Gland/pathology
    Chemical Substances Biomarkers ; CAM 5.2 antigen ; Keratins (68238-35-7)
    Language English
    Publishing date 2011
    Publishing country United States
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 193092-8
    ISSN 1550-8080 ; 0091-7370 ; 0095-8905
    ISSN (online) 1550-8080
    ISSN 0091-7370 ; 0095-8905
    Database MEDical Literature Analysis and Retrieval System OnLINE

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