LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 54

Search options

  1. Article ; Online: A Potential Role of Cytomegalovirus Reactivation in the Severity of COVID-19 in the Elderly

    Shabnam Tehrani / Amirreza Keyvanfar

    Novelty in Biomedicine, Vol 10, Iss 2, Pp 142-

    2022  Volume 143

    Abstract: In late 2019, severe acute respiratory syndrome- coronavirus-2 (SARS-CoV-2) was reported in Wuhan, China. This virus spread quickly worldwide, with millions of victims until now. The clinical manifestations of the novel coronavirus disease (COVID-19) are ...

    Abstract In late 2019, severe acute respiratory syndrome- coronavirus-2 (SARS-CoV-2) was reported in Wuhan, China. This virus spread quickly worldwide, with millions of victims until now. The clinical manifestations of the novel coronavirus disease (COVID-19) are a broad spectrum, from asymptomatic and mild cases with a flu-like syndrome to severe cases requiring intensive care1. The severity of diseases and risk of mortality is higher in the elderly, which most authorities attribute to underlying conditions, including diabetes, hypertension, cardiovascular diseases, and respiratory diseases. However, some neglected factors, such as cytomegalovirus (CMV) reactivation, can affect patient outcomes2.
    Keywords covid-19 ; cytomegalovirus ; opportunistic infections ; prognosis ; sars-cov-2 ; Medicine (General) ; R5-920
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher Shahid Beheshti University of Medical Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

  2. Article ; Online: Immunogenicity and safety of a quadrivalent recombinant influenza vaccine manufactured in Iran (FluGuard) in volunteers aged 18-60 years: A double-blind, non-inferiority, randomized controlled trial.

    Yadegarynia, Davood / Keyvanfar, Amirreza / Keyvani, Hossein / Tehrani, Shabnam / Sali, Shahnaz / Abolghasemi, Sara

    Vaccine

    2024  Volume 42, Issue 9, Page(s) 2254–2259

    Abstract: Background: This study aimed to evaluate the non-inferiority of the FluGuard (a quadrivalent recombinant vaccine manufactured by Nivad Pharmed Salamat Company in Iran) by comparing its immunogenicity and safety with Vaxigrip Tetra (a quadrivalent ... ...

    Abstract Background: This study aimed to evaluate the non-inferiority of the FluGuard (a quadrivalent recombinant vaccine manufactured by Nivad Pharmed Salamat Company in Iran) by comparing its immunogenicity and safety with Vaxigrip Tetra (a quadrivalent inactivated vaccine manufactured by Sanofi Pasteur in France).
    Materials and methods: In this double-blind, randomized controlled trial, eligible volunteers aged 18-60 were randomized to receive either FluGuard or Vaxigrip Tetra vaccines. Immunogenicity was evaluated using the Hemagglutination Inhibition (HAI) assay and reported with the geometric mean titer (GMT), seroprotection, and seroconversion. In addition, vaccine safety was assessed by interviewing participants through phone calls.
    Results: Out of 110 randomized volunteers, 51 and 53 were entered into the final analysis in the Vaxigrip and FluGuard groups, respectively. Vaxigrip had a higher seroprotection rate for the H1N1 strain compared with FluGuard (98 % vs. 91 %). Besides, FluGuard had higher seroprotection rates for H3N2 (74 % vs. 69 %), B-Yamagata (87 % vs. 84 %), and B-Victoria (66 % vs. 41 %) strains compared with Vaxigrip. In all four strains, FluGuard was non-inferior to Vaxigrip with the upper bounds of the 95 % CI on the ratio of the GMTs < 1.5: H1N1 (1.25), H3N2 (0.94), B-Yamagata (0.62), and B-Victoria (0.59). Furthermore, FluGuard was non-inferior to Vaxigrip with the upper bounds of the 95 % CI on the difference between the seroconversion rates < 10 %: H1N1 (2 %), H3N2 (10 %), B-Yamagata (-10 %), and B-Victoria (-29 %). The prevalence of solicited adverse drug reactions did not differ between groups. Furthermore, participants did not experience serious adverse events.
    Conclusion: Our findings support the non-inferiority of the FluGuard vaccine to the Vaxigrip vaccine regarding immunogenicity and safety.
    Clinical trial registry: The study protocol was approved by the Iranian Registry of Clinical Trials (IRCT20210901052358N5).
    MeSH term(s) Humans ; Antibodies, Viral ; Double-Blind Method ; Hemagglutination Inhibition Tests ; HIV Seropositivity ; Immunogenicity, Vaccine ; Influenza A Virus, H1N1 Subtype ; Influenza A Virus, H3N2 Subtype ; Influenza Vaccines/adverse effects ; Influenza, Human/prevention & control ; Iran ; Vaccines, Combined ; Vaccines, Inactivated ; Volunteers ; Adolescent ; Young Adult ; Adult ; Middle Aged
    Chemical Substances Antibodies, Viral ; Influenza Vaccines ; Vaccines, Combined ; Vaccines, Inactivated
    Language English
    Publishing date 2024-02-29
    Publishing country Netherlands
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2024.02.073
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article: Translation, cross-cultural adaptation, and psychometric evaluation of the Persian version of the Symptom Distress Scale (SDS) in heart failure patients.

    Farahani, Mansoureh A / Shariatpanahi, Shabnam / Tehrani, Fereshteh J / Boozaripour, Mahsa

    Journal of education and health promotion

    2023  Volume 12, Page(s) 2

    Abstract: Background: Patients with heart failure experience severe and chronic physical and psychological manifestations while the disease progresses. Assessing the degree of distress caused by manifestations of the disease in patients is the first step in ... ...

    Abstract Background: Patients with heart failure experience severe and chronic physical and psychological manifestations while the disease progresses. Assessing the degree of distress caused by manifestations of the disease in patients is the first step in designing and evaluating intervention programs to improve patients' symptoms. The aim of this study was to investigate the psychometric properties of the Persian version of the Symptom Distress Scale in HF patients.
    Materials and methods: This study was conducted via methodological research design from March to November 2019. The translation process and cross-cultural adaptation were performed using a process recommended by the World Health Organization. The face and content validity and internal consistency were used to evaluate the validity and reliability of the instrument. The scale was evaluated by exploratory and confirmatory factor analysis in 300 patients with heart failure, and the obtained data were analyzed using SPSS-22 and AMOS-22 software.
    Results: The content validity of the scale was approved based on the results of the study. One-factor scale with 13 items was used in the confirmatory factor analysis, and the results showed that the instrument had high goodness-of-fit indices. Spearman correlation test for convergent validity showed a correlation between the score obtained by the Scale of Symptoms of Disease and the scores of The European Heart Failure Self-care Behavior scale (9 items) (
    Conclusion: The Persian version of the Symptom Distress Scale can be used as a valid instrument for people with heart failure due to its desirable psychometric properties.
    Language English
    Publishing date 2023-01-31
    Publishing country India
    Document type Journal Article
    ZDB-ID 2715449-X
    ISSN 2319-6440 ; 2277-9531
    ISSN (online) 2319-6440
    ISSN 2277-9531
    DOI 10.4103/jehp.jehp_1505_21
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article ; Online: Translation, cross-cultural adaptation, and psychometric evaluation of the Persian version of the Symptom Distress Scale (SDS) in heart failure patients

    Mansoureh A Farahani / Shabnam Shariatpanahi / Fereshteh J Tehrani / Mahsa Boozaripour

    Journal of Education and Health Promotion, Vol 12, Iss 1, Pp 2-

    2023  Volume 2

    Abstract: BACKGROUND: Patients with heart failure experience severe and chronic physical and psychological manifestations while the disease progresses. Assessing the degree of distress caused by manifestations of the disease in patients is the first step in ... ...

    Abstract BACKGROUND: Patients with heart failure experience severe and chronic physical and psychological manifestations while the disease progresses. Assessing the degree of distress caused by manifestations of the disease in patients is the first step in designing and evaluating intervention programs to improve patients' symptoms. The aim of this study was to investigate the psychometric properties of the Persian version of the Symptom Distress Scale in HF patients. MATERIALS AND METHODS: This study was conducted via methodological research design from March to November 2019. The translation process and cross-cultural adaptation were performed using a process recommended by the World Health Organization. The face and content validity and internal consistency were used to evaluate the validity and reliability of the instrument. The scale was evaluated by exploratory and confirmatory factor analysis in 300 patients with heart failure, and the obtained data were analyzed using SPSS-22 and AMOS-22 software. RESULTS: The content validity of the scale was approved based on the results of the study. One-factor scale with 13 items was used in the confirmatory factor analysis, and the results showed that the instrument had high goodness-of-fit indices. Spearman correlation test for convergent validity showed a correlation between the score obtained by the Scale of Symptoms of Disease and the scores of The European Heart Failure Self-care Behavior scale (9 items) (P < 0.0001). CONCLUSION: The Persian version of the Symptom Distress Scale can be used as a valid instrument for people with heart failure due to its desirable psychometric properties.
    Keywords cross-cultural adaptation ; factor analysis ; heart failure ; psychometrics ; Special aspects of education ; LC8-6691 ; Public aspects of medicine ; RA1-1270
    Subject code 150
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

  5. Article ; Online: Detection of Carbapenems and Colistin Resistance Genes in Pseudomonas aeruginosa and Acinetobacter baumannii

    Shabnam Tehrani / Hamed Samami / Amirreza Keyvanfar / Ali Hashemi

    Novelty in Biomedicine, Vol 10, Iss 3, Pp 178-

    A Single-center Study in Iran

    2022  Volume 183

    Abstract: Background: This study aimed to determine carbapenems, colistin resistance genes, and antimicrobial susceptibility profiles of Pseudomonas aeruginosa and Acinetobacter baumannii isolates. Materials and Methods: In this cross-sectional study, specimens of ...

    Abstract Background: This study aimed to determine carbapenems, colistin resistance genes, and antimicrobial susceptibility profiles of Pseudomonas aeruginosa and Acinetobacter baumannii isolates. Materials and Methods: In this cross-sectional study, specimens of patients with bloodstream, urinary tract, and surgical site nosocomial infections were enrolled. P. aeruginosa and A. baumannii isolates were identified using conventional methods. Antimicrobial susceptibility testing (AST) on isolates was performed using the disk diffusion method and minimum inhibitory concentration (MIC) for colistin as recommended by the Clinical and Laboratory Standards Institute (CLSI). The combination meropenem disk method was used to detect metallo-β-lactamases (MBLs). The blaNDM, blaVIM, blaIMP, and mcr-1 genes were identified using the polymerase chain reaction (PCR) method and Sequencing. Results: Forty strains of P. aeruginosa and forty strains of A. baumannii were isolated from hospitalized patients. The overall prevalence of multidrug-resistance (MDR) was 50% and 95% in P. aeruginosa and A. baumannii isolates, respectively. Almost all the MDR isolates were resistant to cefepime and piperacillin. Colistin had significant inhibitory activity against the isolates. MBL was detected in 25.0% and 15.0% of clinical isolates of P. aeruginosa and A. baumannii, respectively. We detected no blaNDM, blaVIM, blaIMP, and mcr-1 genes in our A. baumannii isolates. Moreover, only three P. aeruginosa isolates were positive for blaIMP gene. Conclusion: The alarming proportion of MDR P. aeruginosa and A. baumannii isolates was reported in the current study. Effective infection prevention practices are required and AST should guide patients' treatment.
    Keywords acinetobacter baumannii ; pseudomonas aeruginosa ; multidrug-resistance ; metallo-β-lactamase ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2022-08-01T00:00:00Z
    Publisher Shahid Beheshti University of Medical Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

  6. Article ; Online: Comparison of the Efficacy of Cefazolin with and without Naproxen in Patients with Cellulitis Admitted to a Tertiary Hospital

    Shabnam TEHRANI / Behnood HATAMI / Sadaf SAKET / Amirreza KEYVANFAR

    Mediterranean Journal of Infection, Microbes and Antimicrobials, Vol 11, Iss

    2019-2020

    2022  Volume 1

    Abstract: Introduction: It is pertinent to carefully monitor the clinical course of patients with cellulitis. If not treated properly, there is a possibility of its extension to other skin surfaces, recurrent infection, risk of systemic spreading, and incidence of ...

    Abstract Introduction: It is pertinent to carefully monitor the clinical course of patients with cellulitis. If not treated properly, there is a possibility of its extension to other skin surfaces, recurrent infection, risk of systemic spreading, and incidence of worse complications, such as sepsis and severe abscesses. Various antibiotic regimens with or without anti-inflammatory drugs have been administered as a treatment against cellulitis. However, there is no proposed standard and selective line of treatment against cellulitis. This study aimed to compare the efficacy and outcome of two medications, cefazolin alone and cefazolin combined with naproxen as a non-steroidal anti-inflammatory drug. Materials and Methods: This open-label randomized clinical trial was conducted on patients with cellulitis who were admitted to Labbafinejad Hospital (Tehran, Iran) from May 2019 to March 2020. The patients were randomly divided into group A (treated with 1-1.5 g of cefazolin alone intravenously every eight hours) and group B (treated with 1-1.5 g of cefazolin intravenously every eight hours combined with 500 mg of naproxen orally every 12 hours). The responses to these medications and the side effects were evaluated during hospitalizations. Results: The mean age of the 64 patients included in the study was 50.52±2.10 years and 51.56% of the patients were male. There were no significant differences between the control (n=33) and intervention (n=31) groups in terms of history of diabetes mellitus (p=0.666), antibiotic use (p=0.594), trauma (p=0.722), cellulitis (p=0.529), and smoking (p=0.705). The mean body temperatures of the two groups were not different in any of the first (p=0.762), third (p=0.789), and fifth (p=0.893) days. The improvement of clinical symptoms on the third day was significantly (p=0.045) more in group B (90.3%) than in group A (51.5%). Also, the clinical improvement on the fifth day was significantly (p=0.036) higher in group B (100%) than in group A (69.7%). In addition, the mean hospitalization periods ...
    Keywords cellulitis ; treatment outcome ; cefazolin ; naproxen ; Medicine ; R ; Infectious and parasitic diseases ; RC109-216
    Subject code 616
    Language Turkish
    Publishing date 2022-04-01T00:00:00Z
    Publisher Galenos Yayinevi
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

  7. Article ; Online: Vitamin D deficiency and oral candidiasis in patients with HIV infection: A case‒control study.

    Tehrani, Shabnam / Abbasian, Ladan / Dehghan Manshadi, Seyed Ali / Hasannezhad, Malihe / Ghaderkhani, Sara / Keyvanfar, Amirreza / Darvishi, Azar / Aghdaee, AmirHossein

    BMC infectious diseases

    2024  Volume 24, Issue 1, Page(s) 217

    Abstract: Background: Oral candidiasis is a common opportunistic infection in patients with human immunodeficiency virus (HIV). In addition, most of these patients suffer from vitamin D deficiency. This study aimed to investigate the association between vitamin D ...

    Abstract Background: Oral candidiasis is a common opportunistic infection in patients with human immunodeficiency virus (HIV). In addition, most of these patients suffer from vitamin D deficiency. This study aimed to investigate the association between vitamin D levels and oral candidiasis in patients with HIV infection.
    Methods: This case‒control study was conducted on HIV-infected patients. Cases were patients with oral candidiasis diagnosed based on physical examinations. Controls were age- and sex-matched individuals without oral candidiasis. The levels of 25-OH vitamin D and other laboratory markers (CD4 count and viral load) were compared between the case and control groups.
    Results: A total of 104 cases and 102 controls were included in the study. The cases had significantly lower 25-OH vitamin D
    Conclusions: Based on the findings, most patients with HIV infection suffer from vitamin D deficiency, especially those with oral candidiasis. Hypovitaminosis D was significantly associated with an increased risk of oral candidiasis. Thus, vitamin D supplementation may assist HIV-positive patients in improving their oral health and preventing oral candidiasis.
    MeSH term(s) Humans ; HIV Infections/complications ; HIV Infections/drug therapy ; Candidiasis, Oral/epidemiology ; Candidiasis, Oral/complications ; Case-Control Studies ; Vitamin D Deficiency/complications ; Vitamin D ; HIV ; Vitamins ; CD4 Lymphocyte Count
    Chemical Substances Vitamin D (1406-16-2) ; Vitamins
    Language English
    Publishing date 2024-02-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041550-3
    ISSN 1471-2334 ; 1471-2334
    ISSN (online) 1471-2334
    ISSN 1471-2334
    DOI 10.1186/s12879-024-09065-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article ; Online: Investigating Ethical Skills in Dentists and Dental Students

    Sahar Vardian Tehrani / Shabnam Bazmi

    International Journal of Medical Toxicology and Forensic Medicine, Vol 10, Iss

    A Comparative Study

    2020  Volume 3

    Abstract: Background: Commitment to professional ethics is important for all medical practitioners, including dentists. This skill should be taught to students during their studies. The purpose of this study was to investigate the moral skills of dentistry ... ...

    Abstract Background: Commitment to professional ethics is important for all medical practitioners, including dentists. This skill should be taught to students during their studies. The purpose of this study was to investigate the moral skills of dentistry students and dentists. Methods: This cross-sectional study was performed on 160 dentistry students and dentists. The Moral skills Inventory (MSI) Questionnaire was cross-culturally adapted and used in this study. The MSI was developed by Chamber’s and has 40 items covering four domains including: moral sensitivity, moral reasoning, moral integrity, and moral courage. Each domain’s scores ranged from zero to 20. The results were analyzed using SPSS software version 21. Results: comparing with dentists, dentistry students got higher score in moral sensitivity domain (5.5 ± 3.64 vs. 3.87 ± 2.22) and moral integrity (6.4 ± 3.2 vs. 5.78 ± 2.72). However, in moral reasoning, dentists got higher score than students (15.40 ± 2.11 vs. 13.92 ± 2.35). In the moral courage domain, students’ score was 13.47 ± 3.10 and dentists’ was 13.62 ± 2.96. The mean±SD of total score of moral skills in all domains was 39.3± 4.50 for dental students, 38.68 ± 4.48 for dentists, and 38.99 ± 4.49 for all participants. Conclusion: The professional ethics skills are relatively low in all four domains among dentistry students and dentists. Workshops, reviewing the syllables of medical ethics course, and practicing moral skills during training courses and monitoring professional performance can help to improve moral skill.
    Keywords professional ethics ; dentists ; dental students ; Medicine (General) ; R5-920 ; Toxicology. Poisons ; RA1190-1270
    Subject code 170
    Language English
    Publishing date 2020-09-01T00:00:00Z
    Publisher Shaheed Beheshti University of Medical Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

  9. Article: The First Reported Case of Ocular Syphilis in an Iranian Patient.

    Fekri, Sahba / Salehi-Rad, Shahram / Nouri, Hosein / Tehrani, Shabnam / Shalbafan, Bita / Abtahi, Seyed-Hossein

    Journal of ophthalmic & vision research

    2023  Volume 18, Issue 4, Page(s) 452–457

    Abstract: Purpose: To report the first case of ocular syphilis in an Iranian patient and discuss its diagnostic challenges.: Case report: A man in his mid-70s presented with progressive bilateral visual and auditory decline. He had previously lived in a ... ...

    Abstract Purpose: To report the first case of ocular syphilis in an Iranian patient and discuss its diagnostic challenges.
    Case report: A man in his mid-70s presented with progressive bilateral visual and auditory decline. He had previously lived in a Southeast Asian country for 10 years. Prior steroid therapies entailed no inflammation subsidence. His visual acuity at presentation was light perception OU. Funduscopic findings included severe vitritis, severe optic atrophy, diffuse retinal vascular occlusion, and diffuse retinal atrophy OU. Angiography demonstrated diffuse areas of retinal and choriocapillaris atrophy with no active choroiditis. Scaly cutaneous lesions were noted on his palms and soles - atypical findings of secondary syphilis. Serum analysis revealed an underlying syphilis infection. The cerebrospinal fluid sample was reactive to anti-syphilis antibodies, securing a neurosyphilis diagnosis. Two weeks of antibiotic therapy resulted in cutaneous lesions resolution and relative visual improvement despite extensive baseline retinal atrophic damage.
    Conclusion: Ocular syphilis can mimic numerous ocular inflammatory scenarios. In cases of ocular inflammation that is unresponsive to steroids, reconsidering alternative diagnoses, especially infections with the highest clinical relevance, is necessary. We stress the importance of acquiring patients' sexual history, regardless of cultural barriers and the rarity of the entity in some regions.
    Language English
    Publishing date 2023-11-30
    Publishing country United Arab Emirates
    Document type Case Reports
    ISSN 2008-2010
    ISSN 2008-2010
    DOI 10.18502/jovr.v18i4.14559
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Article ; Online: A Randomized Controlled Trial

    Davood Yadegarynia / Shabnam Tehrani / Amirreza Keyvanfar / Latif Gachkar / Behnaz Najafi

    Novelty in Biomedicine, Vol 10, Iss 4, Pp 213-

    Colistin Alone or Colistin and Meropenem: Which Is More Effective for the Management of Urinary Tract Infections?

    2022  Volume 218

    Abstract: Background: Colistin is a common antibiotic used to treat urinary tract infections (UTIs) caused by gramnegative bacteria. In recent years, due to the increasing resistance, consumption of colistin alone could lead to treatment failures. This study aimed ...

    Abstract Background: Colistin is a common antibiotic used to treat urinary tract infections (UTIs) caused by gramnegative bacteria. In recent years, due to the increasing resistance, consumption of colistin alone could lead to treatment failures. This study aimed to compare the effectiveness of colistin alone with colistin and meropenem to treat patients with urinary tract infections. Materials and Methods: In this randomized, open-label, parallel groups controlled trial, hospitalized patients with urinary tract infections were included. Patients were randomly allocated to the control group (n=35) that received colistin (1 mIU every 12 hours) and the intervention group (n=35) that received colistin (1 mIU every 12 hours) with meropenem (1gr every 8 hours). An infectious disease specialist evaluated the therapeutic responses 48-72 hours after admission. Cessation of fever, improvement of symptoms and signs, and negative urine culture within 48 hours were considered successful therapeutic responses. Results: The mean length of hospitalization was longer in the control group (4.74±0.78 days) compared with the intervention group (4.26±0.56 days) (P=0.004). The prevalence of fever cessation had no significant difference between the two groups at any time (P>0.05). Also, there was no significant difference between the two groups at any time, considering vital signs, irritative urinary symptoms, nausea and vomiting, and flank pain (P>0.05). Conclusion: The administration of colistin and meropenem to treat UTIs was associated with a shorter length of hospital stay. However, regarding response to treatment, it did not matter if they were treated with colistin alone or with combination therapy (colistin and meropenem)
    Keywords colistin ; drug resistance ; gram-negative bacteria ; meropenem ; urinary tract infections ; Medicine (General) ; R5-920
    Subject code 610 ; 630
    Language English
    Publishing date 2022-12-01T00:00:00Z
    Publisher Shahid Beheshti University of Medical Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

To top