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  1. Article: Validation of Diagnostic Coding for Asthma in an Electronic Health Record System in Hong Kong.

    Kwok, Wang Chun / Tam, Terence Chi Chun / Sing, Chor Wing / Chan, Esther Wai Yin / Cheung, Ching-Lung

    Journal of asthma and allergy

    2023  Volume 16, Page(s) 315–321

    Abstract: Background: Electronic health record (EHR) databases can facilitate epidemiology research into various diseases including asthma. Given the diagnostic challenges of asthma, the validity of the coding in EHR requires clarification. We aimed to assess the ...

    Abstract Background: Electronic health record (EHR) databases can facilitate epidemiology research into various diseases including asthma. Given the diagnostic challenges of asthma, the validity of the coding in EHR requires clarification. We aimed to assess the validity of International Classification of Diseases, 9th Revision (ICD-9) code algorithms for identifying asthma in the territory-wide electronic medical health record system of the Clinical Data Analysis and Reporting System (CDARS) in Hong Kong.
    Methods: Adult patients who had the diagnosis of asthma input from all public hospitals in Hong Kong and those from Queen Mary Hospital in 2011-2020 were identified using the ICD-9 code of 493 (493.0, 493.1, 493.2, and 493.9) by CDARS. Patients' clinical record and spirometry were reviewed by two respiratory specialists to confirm the presence of asthma in the randomly selected cases.
    Results: There were 43,454 patients who had the diagnostic code of asthma among all public hospitals in Hong Kong and 1852 in Queen Mary Hospital in the same period. A total of 200 cases were randomly selected and validated using medical record and spirometry review by a respiratory specialist. The overall positive predictive value (PPV) was 85.0% (95% CI 80.1-89.9%).
    Conclusion: This was the first ICD-9 code validation for CDARS (EHR) in Hong Kong on asthma. Our study demonstrated that using ICD-9 code (493.0, 493.1, 493.2 and 493.9) to identify asthma can result in a PPV that was reliable to support the utility of the CDARS database for further research on asthma among the Hong Kong population.
    Language English
    Publishing date 2023-03-27
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2494877-9
    ISSN 1178-6965
    ISSN 1178-6965
    DOI 10.2147/JAA.S405297
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Validation of diagnostic coding for bronchiectasis in an electronic health record system in Hong Kong.

    Kwok, Wang Chun / Tam, Terence Chi Chun / Sing, Chor Wing / Chan, Esther Wai Yin / Cheung, Ching-Lung

    Pharmacoepidemiology and drug safety

    2023  Volume 32, Issue 10, Page(s) 1077–1082

    Abstract: Background and objective: Electronic medical record (EMR) databases can facilitate epidemiology research in various diseases including bronchiectasis. Given the diagnostic challenges of bronchiectasis, the validity of the coding in EMR requires ... ...

    Abstract Background and objective: Electronic medical record (EMR) databases can facilitate epidemiology research in various diseases including bronchiectasis. Given the diagnostic challenges of bronchiectasis, the validity of the coding in EMR requires clarification. We aimed to assess the validity of International Classification of Diseases, 9th Revision (ICD-9) code algorithms for identifying bronchiectasis in the territory-wide electronic medical health record system of Clinical Data Analysis and Reporting System (CDARS) in Hong Kong.
    Materials and methods: Adult patients who had the diagnosis of bronchiectasis input from Queen Mary Hospital in 2011-2020 were identified using the ICD-9 code of 494 by CDARS. All patients who had high resolution computed tomography (HRCT) were reviewed by respiratory specialists to confirm the presence of bronchiectasis on HRCT.
    Results: A total of 19 617 patients who had the diagnostic code of bronchiectasis among all public hospitals in Hong Kong and 1866 in Queen Mary Hospital in the same period. Six hundred and forty-eight cases were randomly selected and validated using medical record and HRCT review by a respiratory specialist. The overall positive predictive value (PPV) was 92.7% (95% CI 90.7-94.7).
    Conclusions: This was the first ICD-9 coding validation for bronchiectasis in Hong Kong CDARS. Our study demonstrated that using ICD-9 code of 494 was reliable to support utility of CDARS database for further clinical research on bronchiectasis.
    MeSH term(s) Adult ; Humans ; Hong Kong/epidemiology ; Electronic Health Records ; Clinical Coding ; Software ; Algorithms ; International Classification of Diseases
    Language English
    Publishing date 2023-05-28
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1099748-9
    ISSN 1099-1557 ; 1053-8569
    ISSN (online) 1099-1557
    ISSN 1053-8569
    DOI 10.1002/pds.5638
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Evaluation of a Commercial Point-of-Care RT-LAMP Assay for Rapid Detection of SARS-CoV-2.

    Law, Janet Hei Yin / Chan, Wai Sing / Chan, Tsun Leung / Ma, Edmond Shiu Kwan / Tang, Bone Siu Fai

    Biomedicines

    2023  Volume 11, Issue 9

    Abstract: The goal of this study was to evaluate the performance of a commercial reverse transcription loop-mediated isothermal amplification (RT-LAMP) assay (Detect COVID-19 Test) in the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A ...

    Abstract The goal of this study was to evaluate the performance of a commercial reverse transcription loop-mediated isothermal amplification (RT-LAMP) assay (Detect COVID-19 Test) in the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A total of 202 human respiratory and viral culture specimens were tested retrospectively. The performance of the Detect COVID-19 Test was comparable to that of commercial real-time polymerase chain reaction assays (sensitivity: 93.42%; specificity: 100%), and better than that of the rapid antigen test (sensitivity: 48.00%; specificity: 100%) for specimens with threshold cycle (Ct) values of less than 30. The Beta, Delta, and Omicron variants of concern were successfully detected. With their simplicity of use and good assay sensitivity, point-of-care RT-LAMP assays may be a viable option for SARS-CoV-2 testing at home, or in regions without sophisticated laboratory facilities.
    Language English
    Publishing date 2023-08-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines11092344
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: A Chinese help-seeking model for psychological distress in primary care: An adaptation of Andersen's Behavioral Model of Health Services Use.

    Sun, Kai Sing / Lam, Tai Pong / Wu, Dan / Chan, Tak Hon / Browne, Graeme / Chan, Sally Wai Chi

    Transcultural psychiatry

    2024  Volume 61, Issue 2, Page(s) 182–193

    Abstract: Help-seeking for depression and anxiety disorders from primary care physicians in Western countries is at three times the rate of China. Western help-seeking models for common mental disorders have limitations in the Chinese settings. This article argues ...

    Abstract Help-seeking for depression and anxiety disorders from primary care physicians in Western countries is at three times the rate of China. Western help-seeking models for common mental disorders have limitations in the Chinese settings. This article argues that an adapted model based on Andersen's Behavioral Model of Health Services Use could be an appropriate tool to better understand patients' help-seeking behaviors and improve outcomes. We applied a narrative review approach to integrate research findings from China into Andersen's model to generate a model that fits the Chinese context. We found 39 relevant articles in PubMed, MEDLINE, and Chinese journal databases from 1999 to 2022. Findings were mapped onto predisposing, enabling, and need factors of the model. This model emphasizes that predisposing factors including demographics, social norms, and health beliefs influence help-seeking preferences. Mental health service users in China tend to be older and female. Chinese generally have high concern about psychotropic medications, and social norms that consider psychological distress a personal weakness may discourage help-seeking. However, help-seeking can be enhanced by enabling factors in the health system, including training of primary care physicians, longer consultation time, and continuity of care. Need factors for treatment increase with the severity of distress symptoms, and doctor's skills and attitudes in recognizing psychosomatic symptoms. While predisposing factors are relatively hard to change, enabling factors in the health system and need factors for treatment can be targeted by enhancing the role of family doctors and training in mental health.
    MeSH term(s) Female ; Humans ; Attitude ; Mental Health ; Mental Health Services ; Patient Acceptance of Health Care/psychology ; Primary Health Care ; Psychological Distress ; Male
    Language English
    Publishing date 2024-01-17
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 1378978-8
    ISSN 1461-7471 ; 1363-4615
    ISSN (online) 1461-7471
    ISSN 1363-4615
    DOI 10.1177/13634615231225130
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Endovascular Management of Hepatic Artery Pseudoaneurysms: A Case Series.

    Cheung, Pui Lam / Lee, Yat Sing / Tan, Chong Boon / Lau, Hin Yue / Siu, Chi Wai / Chan, Chik Xing / Chan, Wai Tat / Ho, Cheuk Him

    Vascular specialist international

    2023  Volume 39, Page(s) 1

    Abstract: Although rare, hepatic artery aneurysms are associated with a high morbidity and mortality, necessitating a prompt diagnosis. A significant proportion of hepatic artery aneurysms are pseudoaneurysms, and the major risk factors of which have already been ... ...

    Abstract Although rare, hepatic artery aneurysms are associated with a high morbidity and mortality, necessitating a prompt diagnosis. A significant proportion of hepatic artery aneurysms are pseudoaneurysms, and the major risk factors of which have already been identified in previous literatures. Presentation can be variable, but diagnosis almost relies entirely on computed tomography and digital subtraction angiography. The endovascular approach has progressively become the preferred option due to its better performance when compared to the traditional surgical approach. However, formulation of an endovascular treatment plan for these lesions remains difficult as multiple factors should be considered to identify the best endovascular treatment modality. Five cases of pseudoaneurysm due to recent Whipple operation, hepatobiliary infections, and underlying malignancy are presented in this article to illustrate the effectiveness and complexity of endovascular treatment in this disease entity.
    Language English
    Publishing date 2023-02-13
    Publishing country Korea (South)
    Document type Case Reports
    ISSN 2288-7970
    ISSN 2288-7970
    DOI 10.5758/vsi.220053
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  6. Article ; Online: Systemic Lupus Erythematosus and Immunodeficiency.

    Chan, Shirley Chiu Wai / Lau, Chak Sing

    Rheumatology and immunology research

    2021  Volume 2, Issue 3, Page(s) 131–138

    Abstract: Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease caused by a combination of genetic, epigenetic, and environmental factors. Recent advances in genetic analysis coupled with better understanding of different immune regulatory and ... ...

    Abstract Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease caused by a combination of genetic, epigenetic, and environmental factors. Recent advances in genetic analysis coupled with better understanding of different immune regulatory and signaling pathways have revealed the complex relationship between autoimmunity, including SLE, and immunodeficiency. Furthermore, the expanding therapeutic armamentarium has led to the increasing awareness of secondary immunodeficiency in these patients. This article serves to update the current understanding of SLE and immunodeficiency by discussing the shared genetic factors and immunobiology. We also summarize the effects of immunosuppressive therapies with a focus on secondary antibody deficiency (SAD) after B-cell targeted therapies.
    Language English
    Publishing date 2021-12-15
    Publishing country Germany
    Document type Journal Article ; Review
    ISSN 2719-4523
    ISSN (online) 2719-4523
    DOI 10.2478/rir-2021-0019
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  7. Article: Clinical Evaluation of Xpert Xpress CoV-2/Flu/RSV

    Chan, Wai-Sing / Wong, Kan-Pui / Yau, Siu-Kei / Wong, Ching-Yan / Chan, Tsz-Ching / Hung, Jeffrey / Lai, Kristi Tsz-Wan / Leung, Chin-Pang / Wang, Candy Ling-Na / Au, Chun-Hang / Wan, Thomas Shek-Kong / Ma, Edmond Shiu-Kwan / Tang, Bone Siu-Fai

    Diagnostics (Basel, Switzerland)

    2024  Volume 14, Issue 7

    Abstract: The performance of the Xpert Xpress CoV-2/Flu/ ... ...

    Abstract The performance of the Xpert Xpress CoV-2/Flu/RSV
    Language English
    Publishing date 2024-03-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics14070683
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  8. Article ; Online: Young children's motivations and social cognitions toward swimming: Testing direct and moderation effects of sport competence in two large-scale studies.

    Chan, Derwin King Chung / Lee, Alfred Sing Yeung / Tang, Tracy Chor Wai / Leung, Kiko / Chung, Joan Sau Kwan / Hagger, Martin S / Hamilton, Kyra

    Journal of sports sciences

    2023  Volume 41, Issue 9, Page(s) 859–873

    Abstract: Direct and moderation effects of swimming competence using an integrated model of self-determination theory (SDT) and theory of planned behaviour (TPB) were examined in two large-scale studies among young children. Specifically, we examined whether ... ...

    Abstract Direct and moderation effects of swimming competence using an integrated model of self-determination theory (SDT) and theory of planned behaviour (TPB) were examined in two large-scale studies among young children. Specifically, we examined whether swimming competence had direct and moderation effects on social psychological variables of perceived need support, autonomous motivation, TPB social cognition constructs, and intention. In Study 1, using a cross-sectional survey of 4959 primary school children, swimming competence formed significant positive relationships with all model variables (β =.061 to.330,
    Language English
    Publishing date 2023-07-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 995528-8
    ISSN 1466-447X ; 0264-0414
    ISSN (online) 1466-447X
    ISSN 0264-0414
    DOI 10.1080/02640414.2023.2241782
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  9. Article ; Online: Persistence in risk and effect of COVID-19 vaccination on long-term health consequences after SARS-CoV-2 infection.

    Lam, Ivan Chun Hang / Zhang, Ran / Man, Kenneth Keng Cheung / Wong, Carlos King Ho / Chui, Celine Sze Ling / Lai, Francisco Tsz Tsun / Li, Xue / Chan, Esther Wai Yin / Lau, Chak Sing / Wong, Ian Chi Kei / Wan, Eric Yuk Fai

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 1716

    Abstract: The persisting risk of long-term health consequences of SARS-CoV-2 infection and the protection against such risk conferred by COVID-19 vaccination remains unclear. Here we conducted a retrospective territory-wide cohort study on 1,175,277 patients with ... ...

    Abstract The persisting risk of long-term health consequences of SARS-CoV-2 infection and the protection against such risk conferred by COVID-19 vaccination remains unclear. Here we conducted a retrospective territory-wide cohort study on 1,175,277 patients with SARS-CoV-2 infection stratified by their vaccination status and non-infected controls to evaluate the risk of clinical sequelae, cardiovascular and all-cause mortality using a territory-wide public healthcare database with population-based vaccination records in Hong Kong. A progressive reduction in risk of all-cause mortality was observed over one year between patients with SARS-CoV-2 infection and controls. Patients with complete vaccination or have received booster dose incurred a lower risk of health consequences including major cardiovascular diseases, and all-cause mortality than unvaccinated or patients with incomplete vaccination 30-90 days after infection. Completely vaccinated and patients with booster dose of vaccines did not incur significant higher risk of health consequences from 271 and 91 days of infection onwards, respectively, whilst un-vaccinated and incompletely vaccinated patients continued to incur a greater risk of clinical sequelae for up to a year following SARS-CoV-2 infection. This study provided real-world evidence supporting the effectiveness of COVID-19 vaccines in reducing the risk of long-term health consequences of SARS-CoV-2 infection and its persistence following infection.
    MeSH term(s) Humans ; Cohort Studies ; COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; Disease Progression ; Retrospective Studies ; SARS-CoV-2 ; Vaccination
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2024-02-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-45953-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Genomic characteristics and viral load dynamics of a SARS-CoV-2 Omicron BA.2.2 variant from a hospitalized patient treated with molnupiravir.

    Chan, Wai Sing / Law, Janet Hei Yin / Ho, Matthew Kam Shing / Chan, Tsun Leung / Ma, Edmond Shiu Kwan / Tang, Bone Siu Fai

    Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases

    2022  Volume 105, Page(s) 105376

    Abstract: We sequenced severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genomes from nasal and throat swabs of a hospitalized patient during the fifth wave of coronavirus disease 2019 (COVID-19) pandemic in Hong Kong. Genomic characteristics and viral ... ...

    Abstract We sequenced severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genomes from nasal and throat swabs of a hospitalized patient during the fifth wave of coronavirus disease 2019 (COVID-19) pandemic in Hong Kong. Genomic characteristics and viral load dynamics of an Omicron BA.2.2 variant before and after molnupiravir treatment were presented.
    MeSH term(s) Humans ; SARS-CoV-2/genetics ; Viral Load ; COVID-19 ; Genomics
    Chemical Substances molnupiravir (YA84KI1VEW)
    Language English
    Publishing date 2022-10-08
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2037068-4
    ISSN 1567-7257 ; 1567-1348
    ISSN (online) 1567-7257
    ISSN 1567-1348
    DOI 10.1016/j.meegid.2022.105376
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