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Article ; Online: HIV-Sheltering Platelets From Immunological Non-Responders Induce a Dysfunctional Glycolytic CD4

Zhu, Aiwei / Real, Fernando / Zhu, Jaja / Greffe, Ségolène / de Truchis, Pierre / Rouveix, Elisabeth / Bomsel, Morgane / Capron, Claude

Frontiers in immunology

2022 Volume 12, Page(s) 781923

Abstract: Immunological non-responders (InRs) are HIV-infected individuals in whom the administration of combination antiretroviral therapy (cART), although successful in suppressing viral replication, cannot properly reconstitute patient circulating ... ...

Abstract	Immunological non-responders (InRs) are HIV-infected individuals in whom the administration of combination antiretroviral therapy (cART), although successful in suppressing viral replication, cannot properly reconstitute patient circulating CD4
MeSH term(s)	Blood Platelets ; CD4 Lymphocyte Count ; CD4-Positive T-Lymphocytes ; Glycolysis ; HIV Infections ; Humans
Language	English
Publishing date	2022-02-11
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2021.781923
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Article: Single cell RNA-sequencing of Ewing sarcoma tumors demonstrates transcriptional heterogeneity and clonal evolution.

Goodspeed, Andrew / Bodlak, Avery / Nelson-Taylor, Sarah / Oike, Naoki / Porfilio, Timothy / Shirai, Ryota / Walker, Deandra / Treece, Amy / Black, Jennifer / Donaldson, Nathan / Cost, Carrye / Garrington, Tim / Greffe, Brian / Luna-Fineman, Sandra / Demedis, Jenna / Lake, Jessica / Danis, Etienne / Verneris, Michael / Hayashi, Masanori

bioRxiv : the preprint server for biology

2024

Abstract: Ewing sarcoma is the second most common bone cancer in children, accounting for 2% of pediatric cancer diagnoses. Patients who present with metastatic disease at the time of diagnosis have a dismal prognosis, compared to the >70% 5-year survival of those ...

Abstract	Ewing sarcoma is the second most common bone cancer in children, accounting for 2% of pediatric cancer diagnoses. Patients who present with metastatic disease at the time of diagnosis have a dismal prognosis, compared to the >70% 5-year survival of those with localized disease. Here, we utilized single cell RNA-sequencing to characterize the transcriptional landscape of primary Ewing sarcoma tumors and surrounding tumor microenvironment (TME). Copy-number analysis identified subclonal evolution within patients even prior to treatment. Primary tumor samples demonstrate a heterogenous transcriptional landscape with several conserved gene expression programs, including those composed of genes related to proliferation and EWS targets. We also were able to identify the composition of the TME and molecularly dissect the transcriptional profile of circulating tumor cells in peripheral blood at the time of diagnosis.
Language	English
Publishing date	2024-01-20
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.01.18.576251
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Article ; Online: Pseudo-hyperkaliémie et thrombocytose.

Le Goff, E / Jondeau, K / Venon, M-D / Greffe, S / Ronez, E / Ngo, S / Kahn, J-E / Hanslik, T

La Revue de medecine interne

2021 Volume 42, Issue 6, Page(s) 438–441

Abstract: Introduction: Hyperkalemia is common in medicine and requires rapid management. Besides the easily evoked causes such as renal failure, adrenal insufficiency, cell lysis or iatrogenic causes, false or pseudo-hyperkalemia should not be forgotten.: ... ...

Title translation	Pseudohyperkalemia and thrombocytosis.
Abstract	Introduction: Hyperkalemia is common in medicine and requires rapid management. Besides the easily evoked causes such as renal failure, adrenal insufficiency, cell lysis or iatrogenic causes, false or pseudo-hyperkalemia should not be forgotten. Observations: Three patients (1 man, 2 women, aged 78, 84, 88) were managed for thrombocytosis (between 1306 and 2404 G/L) and non-symptomatic hyperkalemia (between 6.1 and 7.7mmol/L) are reported. Kalemia on blood collected in heparin tube was normal (4.4-4.6mmol/L). Therefore, no specific treatment for this pseudohyperkalemia was required. Conclusion: The combination of thrombocytosis and non-symptomatic hyperkalemia should suggest the diagnosis of pseudohyperkalemia and should prompt for a control of kalemia on blood collected in heparin tube. The recognition of this diagnosis is important in order to avoid unnecessary and potentially deleterious treatment of hyperkalemia.
MeSH term(s)	Female ; Heparin ; Humans ; Hyperkalemia/diagnosis ; Hyperkalemia/therapy ; Male ; Potassium ; Thrombocytosis/diagnosis ; Thrombocytosis/therapy
Chemical Substances	Heparin (9005-49-6) ; Potassium (RWP5GA015D)
Language	French
Publishing date	2021-01-30
Publishing country	France
Document type	Journal Article
ZDB-ID	604679-4
ISSN	1768-3122 ; 0248-8663
ISSN (online)	1768-3122
ISSN	0248-8663
DOI	10.1016/j.revmed.2020.12.008
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Article ; Online: Influenza-like illness in individuals treated with immunosuppressants, biologics, and/or systemic corticosteroids for autoimmune or chronic inflammatory disease: A crowdsourced cohort study, France, 2017-2018.

Greffe, Ségolène / Guerrisi, Caroline / Souty, Cécile / Vilcu, Ana-Maria / Hayem, Gilles / Costantino, Félicie / Padovano, Ilaria / Bourgault, Isabelle / Trad, Salim / Ponsoye, Matthieu / Vilaine, Eve / Debin, Marion / Turbelin, Clément / Blanchon, Thierry / Hanslik, Thomas

Influenza and other respiratory viruses

2023 Volume 17, Issue 6, Page(s) e13148

Abstract: Background: Influenza-like illness (ILI) incidence estimates in individuals treated with immunosuppressants and/or biologics and/or corticosteroid for an autoimmune or chronic inflammatory disease are scarce. We compared the ILI incidence among ... ...

Abstract	Background: Influenza-like illness (ILI) incidence estimates in individuals treated with immunosuppressants and/or biologics and/or corticosteroid for an autoimmune or chronic inflammatory disease are scarce. We compared the ILI incidence among immunocompromised population and the general population. Method: We conducted a prospective cohort study during the 2017-2018 seasonal influenza epidemic, on the GrippeNet.fr electronic platform, which allows the collection of epidemiological crowdsourced data on ILI, directly from the French general population. The immunocompromised population were adults treated with systemic corticosteroids, immunosuppressants, and/or biologics for an autoimmune or chronic inflammatory disease, recruited directly on GrippeNet.fr and also among patients of the departments of a single university hospital that were asked to incorporate GrippeNet.fr. The general population consisted of adults reporting none of the above treatments or diseases participating in GrippeNet.fr. The incidence of ILI was estimated on a weekly basis and compared between the immunocompromised population and the general population, during the seasonal influenza epidemic. Results: Among the 318 immunocompromised patients assessed for eligibility, 177 were included. During the 2017-2018 seasonal influenza epidemic period, immunocompromised population had 1.59 (95% CI: 1.13-2.20) higher odds to experience an ILI episode, compared to the general population (N = 5358). An influenza vaccination was reported by 58% of the immunocompromised population, compared to 41% of the general population (p < 0.001). Conclusion: During a seasonal influenza epidemic period, the incidence of influenza-like illness was higher in patients treated with immunosuppressants, biologics, and/or corticosteroids for an autoimmune or chronic inflammatory disease, compared to the general population.
MeSH term(s)	Adult ; Humans ; Biological Products ; Immunosuppressive Agents/therapeutic use ; Influenza, Human/drug therapy ; Influenza, Human/epidemiology ; Influenza, Human/prevention & control ; Cohort Studies ; Crowdsourcing ; Prospective Studies ; Adrenal Cortex Hormones/therapeutic use ; Virus Diseases ; Chronic Disease ; France/epidemiology
Chemical Substances	Biological Products ; Immunosuppressive Agents ; Adrenal Cortex Hormones
Language	English
Publishing date	2023-06-26
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2274538-5
ISSN	1750-2659 ; 1750-2640
ISSN (online)	1750-2659
ISSN	1750-2640
DOI	10.1111/irv.13148
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Article ; Online: A Cystic Renal Mass in the Setting of a Pneumothorax: More Than Meets the Eye?

Han, Daniel S / Chalmers, David J / Greffe, Brian / Garrington, Timothy / Partrick, David / Lovell, Mark / Schneider, Kami Wolfe / Cost, Nicholas G

Urology

2021 Volume 154, Page(s) 275–277

Abstract: DICER1 syndrome is a rare hereditary cancer predisposition syndrome that has relevance to pediatric urology providers due to its association with many various pediatric genitourinary malignancies. We describe the case of a pediatric patient who was ... ...

Abstract	DICER1 syndrome is a rare hereditary cancer predisposition syndrome that has relevance to pediatric urology providers due to its association with many various pediatric genitourinary malignancies. We describe the case of a pediatric patient who was eventually diagnosed with a pathogenic DICER1 germline variant after undergoing resection of a cystic nephroma and pleuropulmonary blastoma.
MeSH term(s)	Child, Preschool ; DEAD-box RNA Helicases/genetics ; Genetic Predisposition to Disease/genetics ; Germ-Line Mutation ; Humans ; Kidney Diseases, Cystic/diagnostic imaging ; Kidney Diseases, Cystic/surgery ; Kidney Neoplasms/diagnostic imaging ; Kidney Neoplasms/genetics ; Kidney Neoplasms/surgery ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/genetics ; Lung Neoplasms/surgery ; Male ; Pneumothorax/complications ; Pulmonary Blastoma/diagnostic imaging ; Pulmonary Blastoma/genetics ; Pulmonary Blastoma/surgery ; Ribonuclease III/genetics ; Syndrome ; Tomography, X-Ray Computed
Chemical Substances	DICER1 protein, human (EC 3.1.26.3) ; Ribonuclease III (EC 3.1.26.3) ; DEAD-box RNA Helicases (EC 3.6.4.13)
Language	English
Publishing date	2021-02-09
Publishing country	United States
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	192062-5
ISSN	1527-9995 ; 0090-4295
ISSN (online)	1527-9995
ISSN	0090-4295
DOI	10.1016/j.urology.2021.01.049
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Article ; Online: Infarctus cérébral et tuberculose : rapport d'un cas et analyse de la littérature.

Tala-Ighil, T / Greffe, S / Trad, S / Delaroche, M / Coutte, L / Rouveix, E / Kahn, J-E / Hanslik, T

La Revue de medecine interne

2020 Volume 41, Issue 10, Page(s) 704–707

Abstract: Introduction: Although tuberculous meningitis is an uncommon presentation of tuberculosis, it still remains one of the deadliest forms of this disease. In this context, the occurrence of a cerebral infarct is an aggravating factor.: Observation: A 48- ...

Title translation	Cerebral infarction and tuberculosis: case report and literature review.
Abstract	Introduction: Although tuberculous meningitis is an uncommon presentation of tuberculosis, it still remains one of the deadliest forms of this disease. In this context, the occurrence of a cerebral infarct is an aggravating factor. Observation: A 48-year-old Asian man presented himself in the emergency room for dysarthria and dysphagia of progressive onset. Cerebral CT showed a recent ischemic defect of the right internal capsule. Lumbar puncture showed meningitis with low sugar levels. Pulmonary micronodules on the thoracic CT suggested tuberculosis, which was confirmed by a broncho-alveolar lavage. Anti-tuberculosis treatment and early corticosteroid resulted in an improvement of the patient's state. Conclusion: Cerebral infarctions in patients with tuberculous meningitis are events that cannot be underestimated in terms of frequency or severity. Their poor prognosis is partly the result of insufficiently defined management, which combines anti-tuberculosis treatment and early corticosteroid therapy.
MeSH term(s)	Antitubercular Agents/therapeutic use ; Cerebral Infarction/diagnosis ; Cerebral Infarction/drug therapy ; Cerebral Infarction/etiology ; Glucocorticoids/therapeutic use ; Humans ; Male ; Middle Aged ; Tuberculosis, Meningeal/complications ; Tuberculosis, Meningeal/diagnosis ; Tuberculosis, Meningeal/drug therapy
Chemical Substances	Antitubercular Agents ; Glucocorticoids
Language	French
Publishing date	2020-08-27
Publishing country	France
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	604679-4
ISSN	1768-3122 ; 0248-8663
ISSN (online)	1768-3122
ISSN	0248-8663
DOI	10.1016/j.revmed.2020.05.013
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Article: Electrocardiogram abnormalities and prognosis in COVID-19.

Chevrot, Gabriel / Hauguel-Moreau, Marie / Pépin, Marion / Vieillard-Baron, Antoine / Lot, Anne-Sophie / Ouadahi, Mounir / Hergault, Hélène / Aïdan, Vincent / Greffe, Ségolène / Costantini, Adrien / Dubourg, Olivier / Beaune, Sébastien / Mansencal, Nicolas

Frontiers in cardiovascular medicine

2022 Volume 9, Page(s) 993479

Abstract: Background: COVID-19 is a major pandemic with potential cardiovascular complications. Few studies have focused on electrocardiogram (ECG) modifications in COVID-19 patients.: Method and results: We reviewed from our database all patients referred to ... ...

Abstract	Background: COVID-19 is a major pandemic with potential cardiovascular complications. Few studies have focused on electrocardiogram (ECG) modifications in COVID-19 patients. Method and results: We reviewed from our database all patients referred to our hospital for COVID-19 between January 1st, 2020, and December 31st, 2020: 669 patients were included and 98 patients died from COVID-19 (14.6%). We systematically analyzed ECG at admission and during hospitalization if available. ECG was abnormal at admission in 478 patients (71.4%) and was more frequently abnormal in patients who did not survive (88.8 vs. 68.5%, Conclusion: The presence of abnormal ECG during COVID-19 is frequent. Physicians should be aware of the usefulness of ECG for risk stratification during COVID-19.
Language	English
Publishing date	2022-10-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2022.993479
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Article ; Online: Superinfection is associated with short-term outcome and mortality in viral respiratory tract infections during the fall-winter seasons 2016-2018 in the Greater Paris area: the SUPERFLUOUS study: outcomes of viral infections.

Davido, Benjamin / Lemarie, Benoit / Gault, Elyanne / Pepin, Marion / Jaffal, Karim / Beaune, Sebastien / Dahmane, Lotfi / Dumoulin, Jennifer / Greffe, Segolene / Annane, Djillali / De Truchis, Pierre

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

2022 Volume 119, Page(s) 217–224

Abstract: Background: Following a study of predictors of superinfection in viral respiratory tract infections (VRTIs), this study analyzes the predictors of the outcome.: Methods: Multicenter retrospective study conducted among adults who tested positive for ... ...

Abstract	Background: Following a study of predictors of superinfection in viral respiratory tract infections (VRTIs), this study analyzes the predictors of the outcome. Methods: Multicenter retrospective study conducted among adults who tested positive for VRTIs with reverse-transcription polymerase chain reaction. We compared characteristics between influenza virus, Paramyxoviridae, and Pneumoviridae and identified predictors of favorable short-term outcome, admission to the intensive care unit (ICU), and mortality. Results: A total of 590 patients had VRTI, including 347 (59%) influenza infections. Mean (SD) patient age was 71.0 (18.3) years, with a sex ratio of 0.91. In multivariate analyses, predictors of favorable short-term outcome were age ≤75 years (adjusted odds ratio [aOR] 5.38 [95% confidence interval, 1.59-18.2]), absence of respiratory disease (4.94 [1.01-24.37]), and absence of superinfection (aOR 3.91 [1.37-11.13]). The predictors of ICU admission were age ≤75 years (aOR 3.28 [1.71-6.25]), chronic respiratory disease (aOR 2.49 [1.20-5.19]), and procalcitonin level >0.25 ng/mL (aOR 4.25 [1.55-11.67]). Predictors of mortality were use of inhaled corticosteroids (2.49 [1.10-5.63]), influenza infection (2.73 [1.27-5.85]), Charlson score ≥5 (5.35 [1.90-15.05]), superinfection (2.54 [1.05-6.18]), and eosinophil count <50/µL (4.39 [1.19-16.2]). Certainty of superinfection was significantly associated with mortality (2.23 [1.15-4.3]). Conclusion: Our study revealed that superinfection was significantly related to the outcome, and that virus species affects mortality. These findings emphasize the need for improving the tools used in daily practice to confirm certainty of superinfection and for broader implementation of vaccination of individuals at risk of VRTIs.
MeSH term(s)	Adult ; Aged ; Humans ; Influenza, Human/drug therapy ; Influenza, Human/epidemiology ; Paris ; Respiratory Tract Infections ; Retrospective Studies ; Seasons ; Superinfection/epidemiology ; Virus Diseases/epidemiology
Language	English
Publishing date	2022-04-08
Publishing country	Canada
Document type	Journal Article ; Multicenter Study
ZDB-ID	1331197-9
ISSN	1878-3511 ; 1201-9712
ISSN (online)	1878-3511
ISSN	1201-9712
DOI	10.1016/j.ijid.2022.04.008
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Article ; Online: Central Nervous System Involvement of Rhabdomyosarcoma: A Single Institution Experience.

Moreira, Daniel C / Macy, Margaret E / Cost, Carrye R / Greffe, Brian S / Garrington, Timothy P

Journal of pediatric hematology/oncology

2018 Volume 41, Issue 2, Page(s) 152–154

Abstract: The incidence of central nervous system (CNS) involvement in patients with rhabdomyosarcoma (RMS) is low, and the outcome is dismal. We present a single institution analysis of CNS involvement of pediatric RMS. In 59 patients, the prevalence of CNS ... ...

Abstract	The incidence of central nervous system (CNS) involvement in patients with rhabdomyosarcoma (RMS) is low, and the outcome is dismal. We present a single institution analysis of CNS involvement of pediatric RMS. In 59 patients, the prevalence of CNS involvement was 11.9% (7 patients), higher than prior reports. Of the 6 deaths from disease, all had rapid progression, with a median survival of 14 days. The higher incidence could be secondary to treatment modifications or more sensitive detection. These findings are useful for decisions at the time of CNS involvement and could lead to modifications for future RMS clinical trials.
MeSH term(s)	Adolescent ; Adult ; Central Nervous System Neoplasms/mortality ; Central Nervous System Neoplasms/therapy ; Child ; Child, Preschool ; Disease-Free Survival ; Female ; Humans ; Male ; Prevalence ; Retrospective Studies ; Rhabdomyosarcoma/mortality ; Rhabdomyosarcoma/therapy ; Survival Rate
Language	English
Publishing date	2018-04-18
Publishing country	United States
Document type	Clinical Trial ; Journal Article
ZDB-ID	1231152-2
ISSN	1536-3678 ; 1077-4114 ; 0192-8562
ISSN (online)	1536-3678
ISSN	1077-4114 ; 0192-8562
DOI	10.1097/MPH.0000000000001166
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Article ; Online: Predictors of Hospitalization and Superinfection in Viral Respiratory Tract Infections Between Influenza and Paramyxoviruses: The SUPERFLUOUS Study.

Lemarie, Benoit / Boussaid, Ghilas / Gault, Elyanne / Prigent, Helene / Beaune, Sebastien / Moreau, Frederique / Dumoulin, Jennifer / Pepin, Marion / Greffe, Segolene / De Truchis, Pierre / Davido, Benjamin

The Journal of infectious diseases

2021 Volume 226, Issue 6, Page(s) 1027–1035

Abstract: ... of superinfection and hospitalization.s.: Results: Five hundred ninety patients had VRTI, including 347 (59 ...

Abstract	Background: Viral respiratory tract infections (VRTIs) are among the most common diseases, but the risks of superinfection for different virus species have never been compared. Methods: Multicenter retrospective study conducted among adults who tested positive for VRTIs with reverse-transcription polymerase chain reaction. We compared characteristics between influenza (A or B) and paramyxoviruses (respiratory syncytial virus, parainfluenza virus types 1 and 3, and human metapneumovirus) and identified predictors of superinfection and hospitalization.s. Results: Five hundred ninety patients had VRTI, including 347 (59%) influenza and 243 paramyxovirus infections with comparable rates of superinfections (53% vs 60%). In multivariate analyses, the predictors of superinfections were age >75 years (adjusted odds ratio, 2.37 [95% confidence interval, 1.65-3.40]), chronic respiratory disease (1.79 [1.20-2.67]), and biological abnormalities, including neutrophil count >7000/µL (1.98 [1.34-2.91)], eosinophil count <50/µL (2.53 [1.61-3.98], and procalcitonin level >0.25ng/mL (2.8 [1.65-4.73]). The predictors of hospitalization were age >75 years old (adjusted odds ratio, 3.49 [95% confidence interval, 2.17-5.63]), paramyxovirus infection (2.28 [1.39-3.75]), long-term use of inhaled corticosteroids (2.49 [1.13-5.49]), and biological abnormalities, including neutrophil count >7000/µL (2.38 [1.37-4.12)] and procalcitonin level >0.25ng/mL (2.49 [1.23-5.02]). Kaplan-Meier survival curves showed that influenza-infected patients had a higher mortality rate than those with paramyxovirus infections (8.9% vs 4.5%, respectively; P = .02). Conclusions: Our study revealed a high rate of superinfection (56%), not related to viral species. However influenza virus was associated with a poorer prognosis than paramyxoviruses, pleading for a broader and large-scale vaccination of individual at risk of VRTIs.
MeSH term(s)	Adult ; Aged ; Hospitalization ; Humans ; Influenza, Human ; Paramyxoviridae Infections/epidemiology ; Procalcitonin ; Respiratory Syncytial Virus Infections ; Respiratory Syncytial Virus, Human ; Respiratory Tract Infections ; Retrospective Studies ; Superinfection/epidemiology
Chemical Substances	Procalcitonin
Language	English
Publishing date	2021-10-11
Publishing country	United States
Document type	Journal Article ; Multicenter Study
ZDB-ID	3019-3
ISSN	1537-6613 ; 0022-1899
ISSN (online)	1537-6613
ISSN	0022-1899
DOI	10.1093/infdis/jiab525
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