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Article ; Online: Bile Carriage of

Deng, Li / Zhen, Wendong / Wang, Jing / Lin, Dachuan

2023 , Page(s) e0285222

Abstract: We isolated one Enterococcus faecium isolate SZ21B15 from a bile sample of a patient with choledocholith in Shenzhen, China in 2021. It was positive for oxazolidinone resistance ... ...

Abstract	We isolated one Enterococcus faecium isolate SZ21B15 from a bile sample of a patient with choledocholith in Shenzhen, China in 2021. It was positive for oxazolidinone resistance gene
Language	English
Publishing date	2023-03-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	2807133-5
ISSN	2165-0497 ; 2165-0497
ISSN (online)	2165-0497
ISSN	2165-0497
DOI	10.1128/spectrum.02852-22
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Low levels of humoral response to monkeypox virus-specific antigens in healthy individuals.

Zhang, Kehong / Xu, Yuzhong / Zhang, Huihua / Zheng, Huanwei / Chen, Xinchun / Lin, Dachuan

The Journal of infection

2023 Volume 86, Issue 6, Page(s) e156–e157

MeSH term(s)	Humans ; Monkeypox virus ; Vaccinia virus ; Antibodies, Viral
Chemical Substances	Antibodies, Viral
Language	English
Publishing date	2023-04-11
Publishing country	England
Document type	Letter ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	424417-5
ISSN	1532-2742 ; 0163-4453
ISSN (online)	1532-2742
ISSN	0163-4453
DOI	10.1016/j.jinf.2023.04.002
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Zs.A 1501: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 48: Show issues

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Article ; Online: Clinical and immunological features of COVID-19 in patients with anti-MDA5 dermatomyositis during the omicron wave in Chongqing, China.

Wu, Na / Chen, Zhiwei / Zha, Guanhua / Deng, Zhiling / Huang, Wenhan / Cai, Dachuan / Peng, Mingli / Hu, Peng / Tang, Lin / Ren, Hong

Journal of medical virology

2024 Volume 96, Issue 3, Page(s) e29493

Abstract: Patients with anti-melanoma differentiation-associated gene 5 (anti-MDA5) dermatomyositis (DM) have a higher risk of coronavirus disease 2019 (COVID-19) infection. In this longitudinal observational study, we aimed to investigate the clinical and ... ...

Abstract	Patients with anti-melanoma differentiation-associated gene 5 (anti-MDA5) dermatomyositis (DM) have a higher risk of coronavirus disease 2019 (COVID-19) infection. In this longitudinal observational study, we aimed to investigate the clinical and immunological features of these patients after COVID-19 infection. A total of 73 patients with anti-MDA5 DM were recruited from the Second Affiliated Hospital of Chongqing Medical University during the Omicron wave epidemic. Clinical data were collected by questionnaire survey and electronic medical records. Blood samples were used to determine the immunity responses. From December 9, 2022 to March 31, 2023, 67 patients were eligible for final analysis; 68.7% of them were infected with COVID-19. The most common symptoms observed in COVID-19 were upper respiratory symptoms, most cases were mild or moderate (97.8%). The clinical laboratory indexes were relativity stable in patients after infection (all p > 0.05). Vaccination is not a protective factor against the Omicron infection (odds ratio: 2.69, 95% confidence interval: 0.81-8.93, p = 0.105). Both wildtype (WT) neutralizing antibodies titer and BA.5-specific immunoglobulin G titer were significantly enhanced after infection (all p < 0.01), which was as high as healthy controls (HCs). The memory B-cell responses were similar between the patients with anti-MDA5 DM and HCs (p > 0.05). However, both the WT-specific CD8
MeSH term(s)	Humans ; Antibodies, Neutralizing ; CD8-Positive T-Lymphocytes ; China/epidemiology ; COVID-19 ; Dermatomyositis/immunology ; Interferon-Induced Helicase, IFIH1/immunology
Chemical Substances	Antibodies, Neutralizing ; IFIH1 protein, human (EC 3.6.1.-) ; Interferon-Induced Helicase, IFIH1 (EC 3.6.4.13)
Language	English
Publishing date	2024-03-04
Publishing country	United States
Document type	Observational Study ; Journal Article
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.29493
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Zs.A 1320: Show issues

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Article ; Online: RT-nestRPA is a new technology for the rapid and sensitive detection of nucleic acid detection of pathogens used for a variety of medical application scenarios.

Huang, Wanqiu / Zhang, Zhaoqi / Lin, Dachuan / Deng, Yuliang / Chen, Xinchun / Huang, Jian

Analytica chimica acta

2023 Volume 1262, Page(s) 341263

Abstract: Background: The effective detection of pathogens is of great importance for the diagnosis and treatment of infectious diseases. We have proposed the novel RT-nestRPA technique for SARS-CoV-2 detection, which is a rapid RNA detection technique with ultra- ...

Abstract	Background: The effective detection of pathogens is of great importance for the diagnosis and treatment of infectious diseases. We have proposed the novel RT-nestRPA technique for SARS-CoV-2 detection, which is a rapid RNA detection technique with ultra-high sensitivity. Results: The RT-nestRPA technology has a sensitivity of 0.5 copies/uL of synthetic RNA targeting the ORF7a/7b/8 gene or 1 copy/uL synthetic RNA targeting the N gene of SARS-CoV-2. The entire detection process of RT-nestRPA only takes only 20 min, which is significantly shorter than RT-qPCR (nearly 100 min). Additionally, RT-nestRPA is capable of detecting dual genes of SARS-CoV-2 and human RPP30 simultaneously in one reaction tube. The excellent specificity of RT-nestRPA was verified by analyzing twenty-two SARS-CoV-2 unrelated pathogens. Furthermore, RT-nestRPA had great performance in detecting samples treated with cell lysis buffer without RNA extraction. The innovative double-layer reaction tube for RT-nestRPA can prevent aerosol contamination and simplify the reaction operation. Moreover, the ROC analysis revealed that RT-nestRPA had high diagnostic value (AUC = 0.98), while the AUC of RT-qPCR was 0.75. Significance: Our current findings suggested that RT-nestRPA could serve as a novel technology for nucleic acid detection of pathogens with rapid and ultrahigh sensitive features used in various medical application scenarios.
MeSH term(s)	Humans ; SARS-CoV-2/genetics ; COVID-19/diagnosis ; COVID-19 Testing ; Clinical Laboratory Techniques/methods ; Sensitivity and Specificity ; RNA, Viral/genetics ; RNA, Viral/analysis ; Nucleic Acid Amplification Techniques/methods
Chemical Substances	RNA, Viral
Language	English
Publishing date	2023-04-24
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1483436-4
ISSN	1873-4324 ; 0003-2670
ISSN (online)	1873-4324
ISSN	0003-2670
DOI	10.1016/j.aca.2023.341263
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Article ; Online: Impact of High Lipoprotein(a) on Long-Term Survival Following Coronary Artery Bypass Grafting.

Yuan, Shuo / Li, Fangzhou / Zhang, Heng / Zeng, Juntong / Su, Xiaoting / Qu, Jianyu / Lin, Shen / Gu, Dachuan / Rao, Chenfei / Zhao, Yan / Zheng, Zhe

Journal of the American Heart Association

2024 Volume 13, Issue 3, Page(s) e031322

Abstract: Background: Lipoprotein(a) is a possible causal risk factor for atherosclerosis and related complications. The distribution and prognostic implication of lipoprotein(a) in patients undergoing coronary artery bypass grafting remain unknown. This study ... ...

Abstract	Background: Lipoprotein(a) is a possible causal risk factor for atherosclerosis and related complications. The distribution and prognostic implication of lipoprotein(a) in patients undergoing coronary artery bypass grafting remain unknown. This study aimed to assess the impact of high lipoprotein(a) on the long-term prognosis of patients undergoing coronary artery bypass grafting. Methods and results: Consecutive patients with stable coronary artery disease who underwent isolated coronary artery bypass grafting from January 2013 to December 2018 from a single-center cohort were included. The primary outcome was all-cause death. The secondary outcome was a composite of major adverse cardiovascular and cerebrovascular events. Of the 18 544 patients, 4072 (22.0%) were identified as the high-lipoprotein(a) group (≥50 mg/dL). During a median follow-up of 3.2 years, primary outcomes occurred in 587 patients. High lipoprotein(a) was associated with increased risk of all-cause death (high lipoprotein(a) versus low lipoprotein(a): adjusted hazard ratio [aHR], 1.31 [95% CI, 1.09-1.59]; Conclusions: More than 1 in 5 patients with stable coronary artery disease who underwent coronary artery bypass grafting were exposed to high lipoprotein(a), which is associated with higher risks of death and major adverse cardiovascular and cerebrovascular events. The adverse effects of lipoprotein(a) were more pronounced in patients with clinically low-risk profiles or not receiving arterial grafts.
MeSH term(s)	Humans ; Coronary Artery Disease ; Lipoprotein(a) ; Treatment Outcome ; Coronary Artery Bypass ; Atherosclerosis/complications ; Risk Factors ; Retrospective Studies
Chemical Substances	Lipoprotein(a)
Language	English
Publishing date	2024-01-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2653953-6
ISSN	2047-9980 ; 2047-9980
ISSN (online)	2047-9980
ISSN	2047-9980
DOI	10.1161/JAHA.123.031322
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Article ; Online: Location-specific co-benefits of carbon emissions reduction from coal-fired power plants in China

Pu Wang / Cheng-Kuan Lin / Yi Wang / Dachuan Liu / Dunjiang Song / Tong Wu

Nature Communications, Vol 12, Iss 1, Pp 1-

2021 Volume 11

Abstract: Spatially nuanced policies are necessary for maximising co-benefits of carbon-emissions reduction from coal-fired power plants. Here the authors present an approach integrating costs of CO2 and air pollution emissions to better understand social costs of ...

Abstract	Spatially nuanced policies are necessary for maximising co-benefits of carbon-emissions reduction from coal-fired power plants. Here the authors present an approach integrating costs of CO2 and air pollution emissions to better understand social costs of electricity generation from coal burning in China.
Keywords	Science ; Q
Language	English
Publishing date	2021-11-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Combination of the triglyceride-glucose index and EuroSCORE II improves the prediction of long-term adverse outcomes in patients undergoing coronary artery bypass grafting.

Wu, Zhenguo / Guo, Dachuan / Chen, Sha / Sun, Xiangfei / Zhang, Yerui / Liu, Xiaoyu / Liu, Li / Lin, Zongwei / Yang, Jianmin

Diabetes/metabolism research and reviews

2023 Volume 39, Issue 8, Page(s) e3710

Abstract: Aims: We aimed to investigate the independent and combined association of the triglyceride-glucose (TyG) index and EuroSCORE II with major adverse cardiovascular event (MACE) after coronary artery bypass grafting (CABG), and examine whether the addition ...

Abstract	Aims: We aimed to investigate the independent and combined association of the triglyceride-glucose (TyG) index and EuroSCORE II with major adverse cardiovascular event (MACE) after coronary artery bypass grafting (CABG), and examine whether the addition of the TyG index improves the predictive performance of the EuroSCORE II. Materials and methods: This study included 1013 patients who underwent CABG. The primary endpoint was MACE, which was defined as the composite of all-cause death, repeat coronary artery revascularisation, non-fatal myocardial infarction and non-fatal stroke. The patients were grouped by the TyG index and EuroSCORE II tertiles and the combination of these risk indicators. Results: During the follow-up, 211 individuals developed MACE. Elevated levels of the TyG index and EuroSCORE II were associated with an increased risk of MACE. The hazard ratio [95% confidence interval (CI)] was 3.66 (2.34-5.73) in patients with the highest tertile of the TyG index and EuroSCORE II. Compared with the EuroSCORE II alone, combining the TyG index with EuroSCORE II achieved a better predictive performance [C-statistic increased 0.032, p < 0.001; continuous net reclassification improvement (NRI) (95% CI): 0.364 (0.215-0.514), p < 0.001; integrated discrimination improvement (IDI) (95% CI): 0.015 (0.007-0.023), p < 0.001, Akaike's information criteria (AIC) and Bayesian information criterion (BIC) decreased, and the likelihood ratio test, p < 0.001]. Conclusions: The TyG index and EuroSCORE II are independently associated with poor prognosis. Furthermore, the TyG index is an important adjunct to the EuroSCORE II for improving risk stratification and guiding early intervention among post-CABG patients.
MeSH term(s)	Humans ; Glucose ; Triglycerides ; Bayes Theorem ; Risk Assessment ; Coronary Artery Bypass/adverse effects ; Risk Factors ; Blood Glucose ; Biomarkers ; Retrospective Studies
Chemical Substances	Glucose (IY9XDZ35W2) ; Triglycerides ; Blood Glucose ; Biomarkers
Language	English
Publishing date	2023-08-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1470192-3
ISSN	1520-7560 ; 1520-7552
ISSN (online)	1520-7560
ISSN	1520-7552
DOI	10.1002/dmrr.3710
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Zs.A 2119: Show issues

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Article ; Online: Location-specific co-benefits of carbon emissions reduction from coal-fired power plants in China.

Wang, Pu / Lin, Cheng-Kuan / Wang, Yi / Liu, Dachuan / Song, Dunjiang / Wu, Tong

Nature communications

2021 Volume 12, Issue 1, Page(s) 6948

Abstract: Climate policies that achieve air quality co-benefits can better align developing countries' national interests with global climate mitigation. Since the effects of air pollutants are highly dependent on source locations, spatially nuanced policies are ... ...

Abstract	Climate policies that achieve air quality co-benefits can better align developing countries' national interests with global climate mitigation. Since the effects of air pollutants are highly dependent on source locations, spatially nuanced policies are crucial to maximizing the achievement of co-benefits. Using the coal power industry as a case study, this study presents an interdisciplinary approach to assessing facility level co-benefits at every specific source location in China. We find that co-benefits range from US$51-$278 per ton CO
Language	English
Publishing date	2021-11-29
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-021-27252-1
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Article ; Online: In vitro activity of tetracycline analogs against multidrug-resistant and extensive drug resistance clinical isolates of Mycobacterium tuberculosis.

Zhang, Chi / Ouyang, Qi / Zhou, Xianyuan / Huang, Yingfeng / Zeng, Yu / Deng, Li / Lin, Dachuan / Zheng, Weidong

Tuberculosis (Edinburgh, Scotland)

2023 Volume 140, Page(s) 102336

Abstract: Background: Multidrug-resistant tuberculosis (MDR-TB) has become a big threaten to global health. The current strategy for treatment of MDR-TB and extensive drug resistant tuberculosis (XDR-TB) is with low efficacy and high side effect. While new drug ... ...

Abstract	Background: Multidrug-resistant tuberculosis (MDR-TB) has become a big threaten to global health. The current strategy for treatment of MDR-TB and extensive drug resistant tuberculosis (XDR-TB) is with low efficacy and high side effect. While new drug is fundamental for cure MDR-TB, repurposing the Food and Drug Administration (FDA)-approved drugs represents an alternative soluation with less cost. Methods: The activity of 8 tetracycline-class antibiotics against mycobacterium tuberculosis (M.tb) were determined by Minimum Inhibitory Concentration (MIC) in vitro. A transposon M.smeg libraries was generated by using the Harm phage and then used to isolate the conditional growth mutants in doxycycline containing plate. Eleven mutants were isolated and genomic DNAs were extracted using the cetyltrimethyl ammonium bromide (CTAB) method and analyzed by whole genome sequencing. Results: We found that three of eight drugs efficiently inhibited mycobacteria growth under the peak plasma concentration in the human body. Further tests showed these three tetracycline analogs (demeclocycline, doxycycline and methacycline) had antimicrobial activity against seven clinical isolates, including MDR and XDR strains. Among them, Doxycycline had the lowest MICs in all mycobacteria strains tested in this study. By using a transposon library, we identify the insertion of transposon in two genes, porin and MshA, associatewith the resistant to doxycycline. Conclusions: Our findings show that tetracycline analogs such as doxycycline, has bactericidal activity against not only drug sensitive M.tb, but also clinical MDR and XDR strains, provided proof of concept to repurpose doxycycline to fight MDR-TB and XDR-TB. Further investigations are warranted to clarify the underlying mechanism and optimize the strategy in combination with other anti-TB drugs.
MeSH term(s)	Humans ; Mycobacterium tuberculosis ; Antitubercular Agents/pharmacology ; Antitubercular Agents/therapeutic use ; Extensively Drug-Resistant Tuberculosis/microbiology ; Doxycycline/pharmacology ; Doxycycline/therapeutic use ; Tuberculosis, Multidrug-Resistant/drug therapy ; Tuberculosis, Multidrug-Resistant/microbiology ; Tetracycline/pharmacology ; Tetracycline/therapeutic use ; Drug Resistance ; Microbial Sensitivity Tests ; Drug Resistance, Multiple, Bacterial/genetics
Chemical Substances	Antitubercular Agents ; Doxycycline (N12000U13O) ; Tetracycline (F8VB5M810T)
Language	English
Publishing date	2023-03-11
Publishing country	Scotland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2046804-0
ISSN	1873-281X ; 1472-9792
ISSN (online)	1873-281X
ISSN	1472-9792
DOI	10.1016/j.tube.2023.102336
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Uh II Zs.221: Show issues

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Article: Elimination of Fusarium mycotoxin deoxynivalenol (DON) via microbial and enzymatic strategies: Current status and future perspectives

Tian, Ye / Zhang, Dachuan / Cai, Pengli / Lin, Huikang / Ying, Hao / Hu, Qian-Nan / Wu, Aibo

Trends in food science & technology. 2022 June, v. 124

2022

Abstract: Deoxynivalenol (DON) is an important Fusarium mycotoxin commonly detected in foods and feeds, which has drawn global attention because of its high contamination level and frequency. Applying microbial antagonists to inhibit fungal DON synthesis and ... ...

Abstract	Deoxynivalenol (DON) is an important Fusarium mycotoxin commonly detected in foods and feeds, which has drawn global attention because of its high contamination level and frequency. Applying microbial antagonists to inhibit fungal DON synthesis and detoxification of DON into low toxic metabolites are biological approaches to eliminate DON via an environment friendly manner. Therefore, it is essential to review the latest research work on Fusarium biocontrol and DON bio-detoxification. We summarized recent reported microbial and enzymatic methods for DON elimination. The microbial antagonists on Fusarium control and DON detoxification microbes/enzymes, as well as their control mechanisms were systematically reviewed. In addition, we highlighted the potentials of biological methods for DON elimination and discussed novel approaches for DON detoxification enzymes discovery guided by computational strategy. Successful cases of controlling DON producing fungi by microbial antagonists and detoxifying DON by microbes and enzymes were reported in the past several years, which would provide new opportunities to eliminate mycotoxin DON and promote large-scale usage of bio control-based methods. On the other hand, registration and technical difficulties in practical application should be comprehensively considered and solved in future. Additionally, we proposed a conceptual framework of combining the computational tools with multi omics approaches for DON detoxification enzymes discovery, which could provide a new foundation for future mycotoxin detoxification research.
Keywords	Fusarium ; biological control ; deoxynivalenol ; food science ; fungi ; metabolites ; toxicity
Language	English
Dates of publication	2022-06
Size	p. 96-107.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	1049246-x
ISSN	1879-3053 ; 0924-2244
ISSN (online)	1879-3053
ISSN	0924-2244
DOI	10.1016/j.tifs.2022.04.002
Database	NAL-Catalogue (AGRICOLA)

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