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  1. Article: Comprehensive molecular characterizations of stage I-III lung adenocarcinoma with tumor spread through air spaces.

    Ye, Ronghao / Yu, Yongfeng / Zhao, Ruiying / Han, Yuchen / Lu, Shun

    Frontiers in genetics

    2023  Volume 14, Page(s) 1101443

    Abstract: Purpose: ...

    Abstract Purpose:
    Language English
    Publishing date 2023-02-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2023.1101443
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Solar-blind ultraviolet photodetector based on Nb

    Zhang, Yongfeng / Liu, Shuainan / Xu, Ruiliang / Ruan, Shengping / Liu, Caixia / Ma, Yan / Li, Xin / Chen, Yu / Zhou, Jingran

    Nanotechnology

    2024  Volume 35, Issue 16

    Abstract: ... ...

    Abstract β
    Language English
    Publishing date 2024-01-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 1362365-5
    ISSN 1361-6528 ; 0957-4484
    ISSN (online) 1361-6528
    ISSN 0957-4484
    DOI 10.1088/1361-6528/ad18e7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Function and mechanism of exogenous AGR2 in colorectal cancer cells.

    Zheng, Chao / Mao, Yu / Ye, Jianping / Zhang, Miaolong / Chen, Yongfeng

    Heliyon

    2024  Volume 10, Issue 7, Page(s) e28175

    Abstract: Background: Anterior gradient 2 (AGR2) is highly enriched in several malignant tumors and can boost tumor metastasis. Whereas, AGR2 role in colorectal cancer (CRC) is not clear.: Methods: AGR2 expression in the GEPIA database was studied, and the ... ...

    Abstract Background: Anterior gradient 2 (AGR2) is highly enriched in several malignant tumors and can boost tumor metastasis. Whereas, AGR2 role in colorectal cancer (CRC) is not clear.
    Methods: AGR2 expression in the GEPIA database was studied, and the results were confirmed by Western blot in CRC cell lines (SW480, SW620, and HT-29). The impact of AGR2 on the multiplication, migration, invasion and EMT of CRC cells were studied by CCK-8 assay, as well as clone formation, wound healing and transwell assays. The protein concent related to the AKT/β-catenin signaling pathway were accessed via Western blot.
    Results: AGR2 concent in CRC tissues was notablely boosted versus normal colorectal tissues. Exogenous AGR2 boosted the multiplication of CRC cells. In addition, exogenous AGR2 induced EMT, which demonstrated that ZEB1, N-cadherin, Vimentin, Slug, Snail protein concent boosted and E-cadherin protein abated in CRC cells. In terms of mechanism, exogenous AGR2 upgulated
    Conclusion: Exogenous AGR2 enhances the multiplication of CRC cells and induces EMT process, the mechanism of which is related to AKT/β-catenin signal pathway.
    Language English
    Publishing date 2024-03-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e28175
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Effect of ionic groups on the morphology and transport properties in a novel perfluorinated ionomer containing sulfonic and phosphonic acid groups: a molecular dynamics study.

    Zhang, Zongwei / Cui, Rui / Jiang, Xuesong / Yu, Chunyang / Zhou, Yongfeng

    Physical chemistry chemical physics : PCCP

    2024  Volume 26, Issue 16, Page(s) 12806–12819

    Abstract: Combining the phosphonic acid group with the sulfonic acid group in PEMs has been shown to be an effective strategy for improving the fuel cell performance. However, the interplay of two different ionic groups and the resulting effect on the membrane ... ...

    Abstract Combining the phosphonic acid group with the sulfonic acid group in PEMs has been shown to be an effective strategy for improving the fuel cell performance. However, the interplay of two different ionic groups and the resulting effect on the membrane properties have not been fully elucidated. Here, we used classical molecular dynamics simulation to investigate the morphologies, transport properties and effects of ionic groups in a novel perfluorinated PEM containing two ionic groups (PFSA-PFPA) in comparison to the corresponding homopolymers. Phase separations between hydrophilic and hydrophobic domains are confirmed in these PEMs and result from the evolution of water clusters formed around the ionic groups. The combination of both ionic groups brings a complicated morphological feature in PFSA-PFPA, with near-cylindrical aqueous domains of large length scales interconnected by tortuous domains of small sizes. And we found that the self-diffusion coefficients of water molecules are strongly related to morphologies, with the water transport in PFSA-PFPA lying between two analogous homopolymers. At the molecular level, we found that the sulfonic and phosphonic acid groups have distinct effects on the coordination behaviors and the dynamics of water molecules and hydronium ions. Strong electrostatic interactions lead to compact coordination structures and sluggish dynamics of hydronium ions around phosphonic acid groups, which determine the morphological evolution and transport properties in PFSA-PFPA. Our study affords insights into the relationship between molecular characteristics and transport properties bridged by phase-separated morphologies in a novel PEM containing both sulfonic acid and phosphonic acid groups, which deepens the understanding of the interplay between two ionic groups and may inspire the rational design of high-performance PEMs.
    Language English
    Publishing date 2024-04-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 1476244-4
    ISSN 1463-9084 ; 1463-9076
    ISSN (online) 1463-9084
    ISSN 1463-9076
    DOI 10.1039/d4cp00962b
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Demographic patterns of two related desert shrubs with overlapping distributions in response to past climate changes.

    Yu, Qiushi / Hu, Jing / Hu, Xiaoke / Zhou, Yongfeng / Wang, Fanglin / Jiang, Shengxiu / Wang, Yuqi

    Frontiers in plant science

    2024  Volume 15, Page(s) 1345624

    Abstract: Numerous studies have revealed that past geological events and climatic fluctuations had profoundly affected the genetic structure and demographic patterns of species. However, related species with overlapping ranges may have responded to such ... ...

    Abstract Numerous studies have revealed that past geological events and climatic fluctuations had profoundly affected the genetic structure and demographic patterns of species. However, related species with overlapping ranges may have responded to such environmental changes in different ways. In this study, we compared the genetic structure and population dynamics of two typical desert shrubs with overlapping distributions in northern China,
    Language English
    Publishing date 2024-02-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2613694-6
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2024.1345624
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Combination of single-cell and bulk RNA seq reveals the immune infiltration landscape and targeted therapeutic drugs in spinal cord injury.

    Zhang, Qing / Yu, Beibei / Zhang, Yongfeng / Tian, Yunze / Yang, Shijie / Chen, Yongfeng / Wu, Haining

    Frontiers in immunology

    2023  Volume 14, Page(s) 1068359

    Abstract: Background: In secondary spinal cord injury (SCI), the immune microenvironment of the injured spinal cord plays an important role in spinal regeneration. Among the immune microenvironment components, macrophages/microglia play a dual role of pro- ... ...

    Abstract Background: In secondary spinal cord injury (SCI), the immune microenvironment of the injured spinal cord plays an important role in spinal regeneration. Among the immune microenvironment components, macrophages/microglia play a dual role of pro-inflammation and anti-inflammation in the subacute stage of SCI. Therefore, discovering the immune hub genes and targeted therapeutic drugs of macrophages/microglia after SCI has crucial implications in neuroregeneration. This study aimed to identify immune hub genes and targeted therapeutic drugs for the subacute phase of SCI.
    Methods: Bulk RNA sequencing (bulk-RNA seq) datasets (GSE5296 and GSE47681) and single-cell RNA sequencing (scRNA-seq) dataset (GSE189070) were obtained from the Gene Expression Omnibus database. In the bulk RNA-seq, the R package 'limma,' 'WGCNA,' and 'CIBERSORT' were used to jointly screen key immune genes. Subsequently, the R package 'Seurat' and the R package 'celldex' were used to divide and annotate the cell clusters, respectively. After using the Autodock software to dock immune hub genes and drugs that may be combined, the effectiveness of the drug was verified using an
    Results: In the bulk-RNA seq,
    Conclusion: In the subacute phase of SCI,
    MeSH term(s) Animals ; Mice ; Decitabine/therapeutic use ; Macrophages/metabolism ; Molecular Docking Simulation ; RNA-Seq ; Spinal Cord Injuries/drug therapy ; Spinal Cord Injuries/genetics ; Spinal Cord Injuries/complications
    Chemical Substances Decitabine (776B62CQ27)
    Language English
    Publishing date 2023-01-19
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1068359
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: UvVelC is important for conidiation and pathogenicity in the rice false smut pathogen

    Yu, Mina / Song, Tianqiao / Yu, Junjie / Cao, Huijuan / Pan, Xiayan / Qi, Zhongqiang / Du, Yan / Liu, Wende / Liu, Yongfeng

    Virulence

    2024  Volume 15, Issue 1, Page(s) 2301243

    Abstract: Rice false smut disease is one of the most significant rice diseases worldwide. ...

    Abstract Rice false smut disease is one of the most significant rice diseases worldwide.
    MeSH term(s) Oryza/microbiology ; Virulence ; Hypocreales/genetics ; Stress, Physiological/genetics ; Plant Diseases/microbiology
    Language English
    Publishing date 2024-01-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2657572-3
    ISSN 2150-5608 ; 2150-5594
    ISSN (online) 2150-5608
    ISSN 2150-5594
    DOI 10.1080/21505594.2023.2301243
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Chinese multidisciplinary expert consensus on the management of adverse drug reactions associated with savolitinib.

    Zhang, Li / Wang, Yongsheng / Lin, Lizhu / Yu, Yongfeng / Lu, Shun

    Therapeutic advances in medical oncology

    2023  Volume 15, Page(s) 17588359231216089

    Abstract: Savolitinib is a highly selective mesenchymal-epithelial transition (MET) tyrosine kinase inhibitor (TKI). Based on its significant efficacy shown in clinical studies, savolitinib was conditionally approved for marketing in China on 22 June 2021, for the ...

    Abstract Savolitinib is a highly selective mesenchymal-epithelial transition (MET) tyrosine kinase inhibitor (TKI). Based on its significant efficacy shown in clinical studies, savolitinib was conditionally approved for marketing in China on 22 June 2021, for the treatment of advanced non-small cell lung cancer (NSCLC) with MET 14 exon skipping mutation. Additionally, many studies showed that MET TKIs were equally effective in patients with advanced solid tumors with
    Language English
    Publishing date 2023-12-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2503443-1
    ISSN 1758-8359 ; 1758-8340
    ISSN (online) 1758-8359
    ISSN 1758-8340
    DOI 10.1177/17588359231216089
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Retraction notice to "MicroRNA-204-GSDMD interaction regulates pyroptosis of fibroblast-like synoviocytes in ankylosing spondylitis" [Int. Immunopharmacol. 91 (2020) 107227].

    Gu, Guangxue / Huo, Yongfeng / Xu, Gang / Li, Leiming / Yu, Jian / Sheng, Luxin / Yin, Zhaoyang

    International immunopharmacology

    2023  Volume 117, Page(s) 109866

    Language English
    Publishing date 2023-02-21
    Publishing country Netherlands
    Document type Journal Article ; Retraction of Publication
    ZDB-ID 2043785-7
    ISSN 1878-1705 ; 1567-5769
    ISSN (online) 1878-1705
    ISSN 1567-5769
    DOI 10.1016/j.intimp.2023.109866
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5408: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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  10. Article ; Online: Correction to: Exploration of the potential common pathogenic mechanisms in COVID‑19 and silicosis by using bioinformatics and system biology.

    Tian, Yunze / Yu, Beibei / Zhang, Yongfeng / Zhang, Sanpeng / Lv, Boqiang / Gong, Shouping / Li, Jianzhong

    Functional & integrative genomics

    2023  Volume 23, Issue 3, Page(s) 240

    Language English
    Publishing date 2023-07-14
    Publishing country Germany
    Document type Published Erratum
    ZDB-ID 2014670-X
    ISSN 1438-7948 ; 1438-793X
    ISSN (online) 1438-7948
    ISSN 1438-793X
    DOI 10.1007/s10142-023-01165-2
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    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5230: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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