LIVIVO - Search results -

Search results

Result 1 - 10 of total 34

Search options

Book ; Thesis: Klinische und radiologische Beurteilung des ARDS

Hirt, Stephan W.

Vergl. von konventionellen Röntgenbildern u. Computertomogramm bei Intensivpatienten

1985

Size	145 S. : Ill., graph. Darst.
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Bonn, Univ., Diss., 1985
HBZ-ID	HT003141563
Database	Catalogue ZB MED Medicine, Health

In stock of ZB MED Cologne/Königswinter

Shelf mark	Loan status	Location
87 D 2646	order for loan	Magazin

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: European Reflections on New Indications for Extracorporeal Photopheresis in Solid Organ Transplantation.

Ahrens, Norbert / Geissler, Edward K / Witt, Volker / Berneburg, Mark / Wolff, Daniel / Hirt, Stephan W / Banas, Bernhard / Schlitt, Hans J / Hutchinson, James A

Transplantation

2018 Volume 102, Issue 8, Page(s) 1279–1283

MeSH term(s)	Animals ; Apoptosis ; Dendritic Cells/cytology ; Europe ; Graft vs Host Disease/immunology ; Humans ; Immunosuppressive Agents ; Mice ; Mice, Inbred C57BL ; Monocytes/cytology ; Organ Transplantation/methods ; Photopheresis/instrumentation ; Photopheresis/methods ; Photopheresis/standards ; Quality Control ; T-Lymphocytes/cytology ; United States
Chemical Substances	Immunosuppressive Agents
Language	English
Publishing date	2018-04-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	208424-7
ISSN	1534-6080 ; 0041-1337
ISSN (online)	1534-6080
ISSN	0041-1337
DOI	10.1097/TP.0000000000002244
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 488: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 509: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Synergism of imatinib, vatalanib and everolimus in the prevention of chronic lung allograft rejection after lung transplantation (LTx) in rats.

Keil, Laura / Schaub, Anna-Lena / Hirt, Stephan W / Schmid, Christof / Lehle, Karla / von Suesskind-Schwendi, Marietta

Histology and histopathology

2019 Volume 34, Issue 7, Page(s) 821–834

Abstract: Chronic lung allograft dysfunction (CLAD) still remains a major drawback in the outcome following lung transplantation (LTx). New therapeutic strategies are warranted. Growth factors and their receptors like platelet-derived growth factor-receptor (PDGFR) ...

Abstract	Chronic lung allograft dysfunction (CLAD) still remains a major drawback in the outcome following lung transplantation (LTx). New therapeutic strategies are warranted. Growth factors and their receptors like platelet-derived growth factor-receptor (PDGFR) and vascular endothelial growth factor-receptor (VEGFR), may play a crucial role in the development of CLAD, especially bronchiolitis obliterans (BO) and vasculopathy. In this study, we used an orthotopic left lung transplantation model from Fischer (F344) to Wystar Kyoto (WKY) rats to investigate the effect of the receptor tyrosine kinase inhibitor (RTKI) vatalanib alone, the dual combination of vatalanib and imatinib and a triple therapy consisting of vatalanib, imatinib and the mammalian target of rapamycin inhibitor (mTORI) everolimus on the development of CLAD after LTx in rats. With this trial we demonstrated that monotherapy with vatalanib attenuated mild and severe chronic vascular rejection, whereas dual therapy (vatalanib and imatinib) after LTx also showed a significant reduction of chronic bronchiolar rejection and interstitial fibrosis. By adding everolimus, the effect of vatalanib and imatinib could additionally be increased. In conclusion, the combination of mTORI and RTKIs might be a possible strategy in the prevention of CLAD and BO.
MeSH term(s)	Animals ; Bronchiolitis Obliterans/pathology ; Bronchiolitis Obliterans/prevention & control ; Drug Synergism ; Everolimus/therapeutic use ; Fibrosis ; Graft Rejection/pathology ; Graft Rejection/prevention & control ; Imatinib Mesylate/therapeutic use ; Immunohistochemistry ; Lung Transplantation ; Phthalazines/therapeutic use ; Protein Kinase Inhibitors/therapeutic use ; Pyridines/therapeutic use ; Rats ; Rats, Inbred F344 ; Rats, Inbred WKY ; Receptor Protein-Tyrosine Kinases/antagonists & inhibitors ; Receptor, Platelet-Derived Growth Factor alpha/metabolism ; TOR Serine-Threonine Kinases/antagonists & inhibitors ; Transplantation, Homologous ; Vascular Endothelial Growth Factor Receptor-2/metabolism
Chemical Substances	Phthalazines ; Protein Kinase Inhibitors ; Pyridines ; vatalanib (5DX9U76296) ; Imatinib Mesylate (8A1O1M485B) ; Everolimus (9HW64Q8G6G) ; TOR Serine-Threonine Kinases (EC 2.7.1.1) ; Kdr protein, rat (EC 2.7.10.1) ; Receptor Protein-Tyrosine Kinases (EC 2.7.10.1) ; Receptor, Platelet-Derived Growth Factor alpha (EC 2.7.10.1) ; Vascular Endothelial Growth Factor Receptor-2 (EC 2.7.10.1)
Language	English
Publishing date	2019-02-01
Publishing country	Spain
Document type	Journal Article
ZDB-ID	83911-5
ISSN	1699-5848 ; 0213-3911
ISSN (online)	1699-5848
ISSN	0213-3911
DOI	10.14670/HH-18-088
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 3013: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: The activity of nintedanib in an animal model of allogenic left lung transplantation resembling aspects of allograft rejection.

von Suesskind-Schwendi, Marietta / Boxhammer, Elke / Hirt, Stephan W / Schreml, Stephan / Schmid, Christof / Wollin, Lutz / Lehle, Karla

Experimental lung research

2017 Volume 43, Issue 6-7, Page(s) 259–270

Abstract: Aim of the study: The prevention and treatment of chronic lung allograft dysfunction (CLAD) after lung transplantation (LTx) remain unsatisfactory. Growth factors may play an important role in the development of CLAD. This study evaluated the effects of ...

Abstract	Aim of the study: The prevention and treatment of chronic lung allograft dysfunction (CLAD) after lung transplantation (LTx) remain unsatisfactory. Growth factors may play an important role in the development of CLAD. This study evaluated the effects of nintedanib, a receptor tyrosine kinase inhibitor, in the treatment of CLAD after experimental LTx. Materials and methods: A rat model of left lung allo-transplantation (Fisher 344 to Wistar Kyoto) was used to evaluate the effect of nintedanib (50 mg/kg per day) on the development of CLAD. Therapy with nintedanib began 2 days before LTx and ended on postoperative day (POD) 20 (n = 6) or 60 (n = 6). Nontreated animals who underwent LTx (n = 12) were used as controls, whereas naïve lungs (n = 24) served as reference for physiological healthy organs without transplantation damage or medical effects. Acute and chronic rejection were evaluated on POD 20 and 60, respectively. Results: Immunohistologic analysis showed a decrease in growth factors/receptors on POD 60 (nintedanib-treated vs. nontreated controls: platelet-derived growth factor (PDGF) A: [P ≤ 0.001]; PDGF receptor-α: [P ≤ 0.001]; vascular endothelial growth factor (VEGF) A: [P ≤ 0.001]; VEGF receptor-2: [P ≤ 0.001]). However, no reductions in fibrotic changes were observed in nintedanib-treated allografts compared with nontreated allografts. Although nintedanib treatment started before LTx none of the animals showed impaired wound healing. No dehiscence of the sutures of the bronchus, vessels or skin, or stenosis of the bronchus was found. Conclusion: In conclusion, while nintedanib reduced the expression of growth factors/receptors in a rat LTx model, a reduction in fibrotic alterations was not observed at POD 60.
MeSH term(s)	Allografts/drug effects ; Allografts/metabolism ; Animals ; Disease Models, Animal ; Graft Rejection/drug therapy ; Graft Rejection/metabolism ; Immunosuppressive Agents/pharmacology ; Indoles/pharmacology ; Lung/drug effects ; Lung/metabolism ; Lung Transplantation/adverse effects ; Platelet-Derived Growth Factor/metabolism ; Rats ; Rats, Inbred F344 ; Rats, Inbred WKY ; Vascular Endothelial Growth Factor A/metabolism
Chemical Substances	Immunosuppressive Agents ; Indoles ; Platelet-Derived Growth Factor ; Vascular Endothelial Growth Factor A ; platelet-derived growth factor A ; nintedanib (G6HRD2P839)
Language	English
Publishing date	2017-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	603791-4
ISSN	1521-0499 ; 0190-2148
ISSN (online)	1521-0499
ISSN	0190-2148
DOI	10.1080/01902148.2017.1354408
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 1568: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Comparing everolimus-based immunosuppression with reduction or withdrawal of calcineurin inhibitor reduction from six months after heart transplantation: the randomized MANDELA study.

Barten, Markus J / Hirt, Stephan W / Garbade, Jens / Bara, Christoph / Doesch, Andreas O / Knosalla, Christoph / Grinninger, Carola / Stypmann, Jörg / Sieder, Christian / Lehmkuhl, Han B / Porstner, Martina / Schulz, Uwe

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

2019

Abstract: In the 12-month, open-label MANDELA study, patients were randomized at month 6 after heart transplantation to (i) convert to calcineurin inhibitor (CNI)-free immunosuppression with everolimus (EVR), mycophenolic acid and steroids (CNI-free, n=71), or to ( ...

Abstract	In the 12-month, open-label MANDELA study, patients were randomized at month 6 after heart transplantation to (i) convert to calcineurin inhibitor (CNI)-free immunosuppression with everolimus (EVR), mycophenolic acid and steroids (CNI-free, n=71), or to (ii) continue reduced-exposure CNI, with EVR and steroids (EVR/redCNI, n=74). Tacrolimus was administered in 48.8% of EVR/redCNI patients and 52.6% of CNI-free patients at radomization. Both strategies improved and stabilized renal function based on the primary endpoint (estimated GFR at month 18 post-transplant post-randomization) with superiority of the CNI-free group versus EVR/redCNI : mean 64.1mL/min/1.73m
Language	English
Publishing date	2019-03-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2060594-8
ISSN	1600-6143 ; 1600-6135
ISSN (online)	1600-6143
ISSN	1600-6135
DOI	10.1111/ajt.15361
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 5542: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Impact of Elevated Donor Troponin I as Predictor of Adverse Outcome in Adult Heart Transplantation: A Single-center Experience.

Freundt, Miriam / Philipp, Alois / Kolat, Philipp / Rupprecht, Leopold / Friedrich, Christine / Hirt, Stephan W / Haneya, Assad

The Thoracic and cardiovascular surgeon

2017 Volume 66, Issue 5, Page(s) 417–424

Abstract: Background: Due to globally increasing donor organ shortage, investigation of previously described risk factors for utilizing marginal donor hearts is needed. The aim of this study was to determine the impact of elevated donor serum troponin I (TnI) ... ...

Abstract	Background: Due to globally increasing donor organ shortage, investigation of previously described risk factors for utilizing marginal donor hearts is needed. The aim of this study was to determine the impact of elevated donor serum troponin I (TnI) levels on outcome after heart transplantation (HTx). Methods: Between January 1996 and August 2013, 161 patients were reviewed for donor TnI serum levels (>0.3 ng/mL was considered elevated), postoperative outcome parameters, 30-day mortality, and 1-, 3-, and 5-year survival. Results: TnI levels were elevated in 45 (28.0%) donors. Recipients of hearts with elevated TnI had higher incidence of postoperative systolic dysfunction, prolonged inotropic support, prolonged mechanical ventilation, and longer intensive care unit (ICU) stay ( Conclusions: Elevated donor TnI serum concentration seems to be a marker for adverse outcome and increased short- and long-term mortality after HTx. Nevertheless, many other perioperative variables and parameters can be associated with outcome.
MeSH term(s)	Adult ; Biomarkers/blood ; Donor Selection ; Female ; Germany ; Heart Transplantation/adverse effects ; Heart Transplantation/mortality ; Humans ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Postoperative Complications/etiology ; Postoperative Complications/mortality ; Postoperative Complications/physiopathology ; Postoperative Complications/therapy ; Retrospective Studies ; Risk Factors ; Time Factors ; Tissue Donors ; Treatment Outcome ; Troponin I/blood ; Up-Regulation
Chemical Substances	Biomarkers ; Troponin I
Language	English
Publishing date	2017-09-18
Publishing country	Germany
Document type	Journal Article
ZDB-ID	800050-5
ISSN	1439-1902 ; 0171-6425 ; 0946-4778 ; 0172-6137
ISSN (online)	1439-1902
ISSN	0171-6425 ; 0946-4778 ; 0172-6137
DOI	10.1055/s-0037-1606363
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uk I Zs.186: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Minimized extracorporeal circulation is improving outcome of coronary artery bypass surgery in the elderly.

Freundt, Miriam / Ried, Michael / Philipp, Alois / Diez, Claudius / Kolat, Philipp / Hirt, Stephan W / Schmid, Christof / Haneya, Assad

Perfusion

2016 Volume 31, Issue 2, Page(s) 143–148

Abstract: Advanced age is a known risk factor for morbidity and mortality after coronary artery bypass grafting (CABG). Minimized extracorporeal circulation (MECC) has been shown to reduce the negative effects associated with conventional extracorporeal ... ...

Abstract	Advanced age is a known risk factor for morbidity and mortality after coronary artery bypass grafting (CABG). Minimized extracorporeal circulation (MECC) has been shown to reduce the negative effects associated with conventional extracorporeal circulation (CECC). This trial assesses the impact of MECC on the outcome of elderly patients undergoing CABG. Eight hundred and seventy-five patients (mean age 78.35 years) underwent isolated CABG using CECC (n=345) or MECC (n=530). The MECC group had a significantly shorter extracorporeal circulation time (ECCT), cross-clamp time and reperfusion time and lower transfusion needs. Postoperatively, these patients required significantly less inotropic support, fewer blood transfusions, less postoperative hemodialysis and developed less delirium compared to CECC patients. In the MECC group, intensive care unit (ICU) stay was significantly shorter and 30-day mortality was significantly reduced [2.6% versus 7.8%; p<0.001]. In conclusion, MECC improves outcome in elderly patients undergoing CABG surgery.
MeSH term(s)	Aged ; Aged, 80 and over ; Coronary Artery Bypass/adverse effects ; Coronary Artery Bypass/methods ; Disease-Free Survival ; Extracorporeal Circulation/adverse effects ; Extracorporeal Circulation/methods ; Female ; Humans ; Male ; Retrospective Studies ; Survival Rate
Language	English
Publishing date	2016-03
Publishing country	England
Document type	Clinical Trial ; Journal Article
ZDB-ID	645038-6
ISSN	1477-111X ; 0267-6591
ISSN (online)	1477-111X
ISSN	0267-6591
DOI	10.1177/0267659115588634
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2424: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Everolimus's influence on persistent acute rejection after experimental lung transplantation.

Brunner, Elisabeth / Lehle, Karla / Hirt, Stephan W / Schmid, Christof / von Suesskind-Schwendi, Marietta

Advances in clinical and experimental medicine : official organ Wroclaw Medical University

2013 Volume 22, Issue 3, Page(s) 355–359

Abstract: Background: In lung transplantation, acute rejection episodes increase the risk of chronic rejection. Therefore treatment of acute rejection needs to be optimized for better long-term outcome of lung-transplantation and patient survival.: Objectives: ...

Abstract	Background: In lung transplantation, acute rejection episodes increase the risk of chronic rejection. Therefore treatment of acute rejection needs to be optimized for better long-term outcome of lung-transplantation and patient survival. Objectives: The aim was to verify whether an inhibitor of the mammalian target of rapamycin (Everolimus) contained the extent of persistent acute rejection after left lung allo-transplantation in rats. Material and methods: Rats (F344-to-WKY) with a high grade of acute rejection were treated with methylprednisolone (10mg/kg, postoperative days 14-16) alone or in combination with everolimus (2.5 mg/kg, postoperative days 14-30). The rats were killed on postoperative day 20 and 30. Infiltration of inflammatory cells (ED1, CD11a, CD18) and activation of endothelial cells (ICAM-1) were measured by immunohistochemistry Results: Everolimus treatment significantly reduced the number of ICAM-1 positive small vessels (66%; p<0.05) and suppressed the infiltration of leucocytes (CD11a (64%), CD18 (42%); p<0.05) and macrophages (ED1; 22%) in the allografts on POD 30. Despite this clear anti-inflammatory effects, lung allografts still showed severe acute vascular rejection in combination with high grade small airway inflammation. Conclusions: The shown anti-inflammatory effects of Everolimus could not delay the progression of acute rejection in rat lung allografts.
MeSH term(s)	Acute Disease ; Animals ; Bronchiolitis/drug therapy ; Bronchiolitis/immunology ; Everolimus ; Graft Rejection/drug therapy ; Graft Rejection/immunology ; Lung Transplantation ; Lymphocytes/drug effects ; Lymphocytes/immunology ; Rats ; Rats, Inbred F344 ; Sirolimus/analogs & derivatives ; Sirolimus/pharmacology ; Sirolimus/therapeutic use
Chemical Substances	Everolimus (9HW64Q8G6G) ; Sirolimus (W36ZG6FT64)
Language	English
Publishing date	2013-05
Publishing country	Poland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2270257-X
ISSN	1899-5276 ; 1230-025X
ISSN	1899-5276 ; 1230-025X
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6489: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Re-exploration for bleeding or tamponade after cardiac surgery: impact of timing and indication on outcome.

Haneya, Assad / Diez, Claudius / Kolat, Philipp / Suesskind-Schwendi, Marietta von / Ried, Michael / Schmid, Christof / Hirt, Stephan W

The Thoracic and cardiovascular surgeon

2015 Volume 63, Issue 1, Page(s) 51–57

Abstract: Objectives: Re-exploration after cardiac surgery remains a frequent complication with adverse outcomes. The aim of this study was to evaluate the impact of timing and indication of re-exploration on outcome.: Methods: A retrospective, observational ... ...

Abstract	Objectives: Re-exploration after cardiac surgery remains a frequent complication with adverse outcomes. The aim of this study was to evaluate the impact of timing and indication of re-exploration on outcome. Methods: A retrospective, observational study on a cohort of 209 patients, who underwent re-exploration after cardiac surgery between January 2005 and December 2011, was performed. The cohort was matched for age, gender, and procedure with patients who were not re-explored during the same period. Results: The intraoperative and postoperative transfusion requirements were higher in the re-exploration group (p < 0.01). Patients in the re-exploration group had significantly higher incidences of postoperative acute renal injury (10.0 vs. 3.3%), sternal wound (9.1 vs. 2.4%) and pulmonary (13.4 vs. 4.3%) infections, longer ventilation time (22 [range, 14-52] vs. 12 [range, 9-16] hours) and intensive care unit stay (5 [range, 3-7] vs. 2 [range, 2-4] days), and higher mortality rate (9.6 vs. 3.3%). However, the multivariate logistic regression analysis demonstrated that not the re-exploration itself, but the deleterious effects of re-exploration (blood loss and transfusion requirement) were independent risk factors for mortality. Mortality was 5.3% for patients who were re-explored within the first 12 hours and 20.3% for patients who were re-explored after 12 hours (p = 0.003). Mortality was 3.6% for patients with bleeding and 31.4% for patients with cardiac tamponade for indication of re-exploration (p < 0.001). Conclusions: This study suggests that re-exploration after cardiac surgery is associated with increased mortality and morbidity. Patients with delayed re-exploration and suffering from cardiac tamponade have adverse outcome.
MeSH term(s)	Aged ; Blood Transfusion ; Cardiac Surgical Procedures ; Cardiac Tamponade/complications ; Cardiac Tamponade/etiology ; Female ; Humans ; Intraoperative Care ; Logistic Models ; Male ; Postoperative Care ; Postoperative Complications/mortality ; Postoperative Hemorrhage/etiology ; Reoperation ; Retrospective Studies ; Risk Factors ; Treatment Outcome
Language	English
Publishing date	2015-02
Publishing country	Germany
Document type	Journal Article ; Observational Study
ZDB-ID	800050-5
ISSN	1439-1902 ; 0171-6425 ; 0946-4778 ; 0172-6137
ISSN (online)	1439-1902
ISSN	0171-6425 ; 0946-4778 ; 0172-6137
DOI	10.1055/s-0034-1390154
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uk I Zs.186: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Impact of Elevated Donor Troponin I as Predictor of Adverse Outcome in Adult Heart Transplantation: A Single-center Experience

Freundt, Miriam / Philipp, Alois / Kolat, Philipp / Rupprecht, Leopold / Friedrich, Christine / Hirt, Stephan W. / Haneya, Assad

The Thoracic and Cardiovascular Surgeon

2017 Volume 66, Issue 05, Page(s) 417–424

Abstract	Background: Due to globally increasing donor organ shortage, investigation of previously described risk factors for utilizing marginal donor hearts is needed. The aim of this study was to determine the impact of elevated donor serum troponin I (TnI) levels on outcome after heart transplantation (HTx). Methods: Between January 1996 and August 2013, 161 patients were reviewed for donor TnI serum levels (>0.3 ng/mL was considered elevated), postoperative outcome parameters, 30-day mortality, and 1-, 3-, and 5-year survival. Results: TnI levels were elevated in 45 (28.0%) donors. Recipients of hearts with elevated TnI had higher incidence of postoperative systolic dysfunction, prolonged inotropic support, prolonged mechanical ventilation, and longer intensive care unit (ICU) stay ( p < 0.001). This group had higher 30-day mortality (22.2% vs 8.6%, p = 0.03) and lower 1-, 3-, and 5-year survival (56%, 53%, and 50% versus 82%, 76%, and 69%, p = 0.032). Elevated TnI was the only independent risk factor for 30-day mortality (odds ratio [OR] 3.63, 95% confidence interval [CI] 1.28–10.27, p = 0.015). Conclusions: Elevated donor TnI serum concentration seems to be a marker for adverse outcome and increased short- and long-term mortality after HTx. Nevertheless, many other perioperative variables and parameters can be associated with outcome.
Keywords	heart transplantation ; organ donor selection ; transplant outcome ; troponin I
Language	English
Publishing date	2017-09-18
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	800050-5
ISSN	1439-1902 ; 0171-6425 ; 0946-4778 ; 0172-6137
ISSN (online)	1439-1902
ISSN	0171-6425 ; 0946-4778 ; 0172-6137
DOI	10.1055/s-0037-1606363
Database	Thieme publisher's database

In stock of ZB MED Cologne/Königswinter

Uk I Zs.186: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito