LIVIVO - Search results -

Search results

Result 1 - 10 of total 95

Search options

Article ; Online: Opinion paper on the systematic application of integrated bioinformatic tools to actuate routine precision medicine in poly-treated patients.

Borro, Marina / Salerno, Gerardo / Gentile, Giovanna / Simmaco, Maurizio

Clinical chemistry and laboratory medicine

2023 Volume 61, Issue 4, Page(s) 662–665

Abstract: Precision Medicine is a reality in selected medical areas, as oncology, or in excellent healthcare structures, but it is still far to reach million patients who could benefit from this medical concept. Here, we sought to highlight how the time is ripe to ...

Abstract	Precision Medicine is a reality in selected medical areas, as oncology, or in excellent healthcare structures, but it is still far to reach million patients who could benefit from this medical concept. Here, we sought to highlight how the time is ripe to achieve horizontal delivery to a significant larger audience of patients, represented by the poly-treated patients. Combination therapies are frequent (especially in the elderly, to treat comorbidities) and are related to decreased drug safety and efficacy, disease's exacerbation, additional treatments, hospitalization. But the recent development and validation of bioinformatic tools, aimed to automatic evaluation and optimization of poly-therapies, according to the unique individual characteristics (including genotype), is ready to change the daily approach to pharmacological prescription.
MeSH term(s)	Humans ; Aged ; Precision Medicine ; Delivery of Health Care ; Patients ; Hospitalization
Language	English
Publishing date	2023-01-19
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1418007-8
ISSN	1437-4331 ; 1434-6621 ; 1437-8523
ISSN (online)	1437-4331
ISSN	1434-6621 ; 1437-8523
DOI	10.1515/cclm-2022-1293
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 121: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Frequencies of Combined Dysfunction of Cytochromes P450 2C9, 2C19, and 2D6 in an Italian Cohort: Suggestions for a More Appropriate Medication Prescribing Process.

Gentile, Giovanna / De Luca, Ottavia / Del Casale, Antonio / Salerno, Gerardo / Simmaco, Maurizio / Borro, Marina

International journal of molecular sciences

2023 Volume 24, Issue 16

Abstract: Improper drug prescription is a main cause of both drug-related harms (inefficacy and toxicity) and ineffective spending and waste of the healthcare system's resources. Nowadays, strategies to support an improved, informed prescription process may ... ...

Abstract	Improper drug prescription is a main cause of both drug-related harms (inefficacy and toxicity) and ineffective spending and waste of the healthcare system's resources. Nowadays, strategies to support an improved, informed prescription process may benefit from the adequate use of pharmacogenomic testing. Using next-generation sequencing, we analyzed the genomic profile for three major cytochromes P450 (CYP2C9, CYP2C19, CYP2D6) and studied the frequencies of dysfunctional isozymes (e.g., poor, intermediate, or rapid/ultra-rapid metabolizers) in a cohort of 298 Italian subjects. We found just 14.8% of subjects with a fully normal set of cytochromes, whereas 26.5% of subjects had combined cytochrome dysfunction (more than one isozyme involved). As improper drug prescription is more frequent, and more burdening, in polytreated patients, since drug-drug interactions also cause patient harm, we discuss the potential benefits of a more comprehensive PGX testing approach to support informed drug selection in such patients.
MeSH term(s)	Humans ; Cytochrome P-450 CYP2C9/genetics ; Drug Prescriptions ; Cytochrome P-450 CYP2D6 ; Genetic Profile ; High-Throughput Nucleotide Sequencing
Chemical Substances	Cytochrome P-450 CYP2C9 (EC 1.14.13.-) ; Cytochrome P-450 CYP2D6 (EC 1.14.14.1)
Language	English
Publishing date	2023-08-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms241612696
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Inter-individual variation in CYP2A6 activity and chronic obstructive pulmonary disease in smokers: Perspectives for an early predictive marker.

Pezzuto, Aldo / Lionetto, Luana / Ricci, Alberto / Simmaco, Maurizio / Borro, Marina

Biochimica et biophysica acta. Molecular basis of disease

2020 Volume 1867, Issue 1, Page(s) 165990

MeSH term(s)	Cytochrome P-450 CYP2A6/genetics ; Cytochrome P-450 CYP2A6/metabolism ; Female ; Genetic Variation ; Humans ; Male ; Pulmonary Disease, Chronic Obstructive/enzymology ; Pulmonary Disease, Chronic Obstructive/etiology ; Pulmonary Disease, Chronic Obstructive/genetics ; Smokers ; Smoking/adverse effects ; Smoking/genetics
Chemical Substances	CYP2A6 protein, human (EC 1.14.14.1) ; Cytochrome P-450 CYP2A6 (EC 1.14.14.1)
Language	English
Publishing date	2020-10-19
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	60-7
ISSN	1879-260X ; 1879-2596 ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
ISSN (online)	1879-260X ; 1879-2596 ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
ISSN	0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
DOI	10.1016/j.bbadis.2020.165990
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uc I Zs.247: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: SARS-CoV-2 Transmission Control Measures in the Emergency Department: The Role of Rapid Antigenic Testing in Asymptomatic Subjects.

Borro, Marina / Salerno, Gerardo / Montori, Andrea / Petrucca, Andrea / Anibaldi, Paolo / Marcolongo, Adriano / Bonfini, Rita / Simmaco, Maurizio / Santino, Iolanda

Healthcare (Basel, Switzerland)

2022 Volume 10, Issue 5

Abstract: Limiting transmission of SARS-CoV-2 from asymptomatic people assumes the paramount importance of keeping fragile subjects protected. We evaluated the utility of rapid SARS-CoV-2 antigen testing in asymptomatic subjects attending emergency departments in ... ...

Abstract	Limiting transmission of SARS-CoV-2 from asymptomatic people assumes the paramount importance of keeping fragile subjects protected. We evaluated the utility of rapid SARS-CoV-2 antigen testing in asymptomatic subjects attending emergency departments in non-COVID-19 areas, using a single nasopharyngeal swab specimen collected in universal transport medium to perform both rapid antigen testing and rRT-PCR (used as reference standard) in a cohort of 899 patients. In the overall sample, the rapid antigen test had 43.9% sensitivity, 100% specificity, 100% positive predictive value, 93.6% negative predictive value. Considering subjects with rRT-PCR cycle threshold ≤30, the test had 80.4% sensitivity, 100% specificity, 100% positive predictive value, 98.8% negative predictive value. Considering subjects with rRT-PCR cycle threshold ≤25, the test had 94.7% sensitivity, 100% specificity, 100% positive predictive value and 99.7% negative predictive value. Despite low sensitivity, routine application of rapid antigen testing in the emergency department can lead to isolation in less than 30 min of about a half of asymptomatic COVID-19 subjects assigned to non-COVID-19 areas by clinical triage. The rapid test correctly identified 94.7% of asymptomatic patients with cycle threshold ≤ 25 that are supposed to be more infective; thus, it could be a useful measure to contain viral transmission in non-COVID-19 areas.
Language	English
Publishing date	2022-04-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2721009-1
ISSN	2227-9032
ISSN	2227-9032
DOI	10.3390/healthcare10050790
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Predicting Dihydropyrimidine Dehydrogenase Deficiency and Related 5-Fluorouracil Toxicity: Opportunities and Challenges of

De Luca, Ottavia / Salerno, Gerardo / De Bernardini, Donatella / Torre, Maria Simona / Simmaco, Maurizio / Lionetto, Luana / Gentile, Giovanna / Borro, Marina

International journal of molecular sciences

2022 Volume 23, Issue 22

Abstract: Deficiency of dihydropyrimidine dehydrogenase (DPD), encoded by the DPYD gene, is associated with severe toxicity induced by the anti-cancer drug 5-Fluorouracil (5-FU). DPYD genotyping of four recommended polymorphisms is widely used to predict toxicity, ...

Abstract	Deficiency of dihydropyrimidine dehydrogenase (DPD), encoded by the DPYD gene, is associated with severe toxicity induced by the anti-cancer drug 5-Fluorouracil (5-FU). DPYD genotyping of four recommended polymorphisms is widely used to predict toxicity, yet their prediction power is limited. Increasing availability of next generation sequencing (NGS) will allow us to screen rare variants, predicting a larger fraction of DPD deficiencies. Genotype−phenotype correlations were investigated by performing DPYD exon sequencing in 94 patients assessed for DPD deficiency by the 5-FU degradation rate (5-FUDR) assay. Association of common variants with 5-FUDR was analyzed with the SNPStats software. Functional interpretation of rare variants was performed by in-silico analysis (using the HSF system and PredictSNP) and literature review. A total of 23 rare variants and 8 common variants were detected. Among common variants, a significant association was found between homozygosity for the rs72728438 (c.1974+75A>G) and decreased 5-FUDR. Haplotype analysis did not detect significant associations with 5-FUDR. Overall, in our sample cohort, NGS exon sequencing allowed us to explain 42.5% of the total DPD deficiencies. NGS sharply improves prediction of DPD deficiencies, yet a broader collection of genotype−phenotype association data is needed to enable the clinical use of sequencing data.
MeSH term(s)	Humans ; Dihydrouracil Dehydrogenase (NADP)/genetics ; Dihydrouracil Dehydrogenase (NADP)/metabolism ; Dihydropyrimidine Dehydrogenase Deficiency/diagnosis ; Dihydropyrimidine Dehydrogenase Deficiency/genetics ; Fluorouracil/adverse effects ; Fluorouracil/metabolism ; Floxuridine ; Antimetabolites, Antineoplastic/adverse effects ; Antimetabolites, Antineoplastic/metabolism ; Exons
Chemical Substances	Dihydrouracil Dehydrogenase (NADP) (EC 1.3.1.2) ; Fluorouracil (U3P01618RT) ; Floxuridine (039LU44I5M) ; Antimetabolites, Antineoplastic
Language	English
Publishing date	2022-11-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms232213923
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Hard-to-heal peripheral wounds infected with

Virgilio, Edoardo / Solmone, Mariacarmela / Scardigno, Alessandro / Fradiani, Piera / Ceci, Diego / Teggi, Antonella / Enea Di Domenico, Gino / Cavallo, Ilaria / Ensoli, Fabrizio / Borro, Marina / Simmaco, Maurizio / Santino, Iolanda / Cavallini, Marco

Journal of wound care

2023 Volume 32, Issue 12, Page(s) 811–820

Abstract: Objective: To investigate : Method: In this study, two groups of patients with similar lesions which were infected were compared: one group with the presence of the coryneform rod, the other without.: Results: In total, : Conclusion: In view of ...

Abstract	Objective: To investigate Method: In this study, two groups of patients with similar lesions which were infected were compared: one group with the presence of the coryneform rod, the other without. Results: In total, Conclusion: In view of the findings of our study,
MeSH term(s)	Humans ; Prospective Studies ; Corynebacterium ; Corynebacterium Infections/microbiology ; Wound Healing ; Cross Infection/microbiology
Language	English
Publishing date	2023-12-07
Publishing country	England
Document type	Journal Article
ZDB-ID	1353951-6
ISSN	0969-0700
ISSN	0969-0700
DOI	10.12968/jowc.2023.32.12.811
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4572: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 4: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: The Impact of Non-Andrological Medications on Semen Characteristics, Oxidative Stress and Inflammatory Parameters.

Salerno, Gerardo / Borro, Marina / Visco, Vincenzo / Olana, Soraya / Gargano, Francesca / Raffa, Salvatore / Zamponi, Virginia / Mancini, Camilla / Faggiano, Antongiulio / Simmaco, Maurizio / Mazzilli, Rossella

Medicina (Kaunas, Lithuania)

2023 Volume 59, Issue 5

Abstract: Background and ... ...

Abstract	Background and Objectives
MeSH term(s)	Male ; Humans ; Semen ; Interleukin-1alpha/metabolism ; Tumor Necrosis Factor-alpha/analysis ; Interleukin-10/metabolism ; Infertility, Male/drug therapy ; Oxidative Stress ; Oxygen/metabolism
Chemical Substances	Interleukin-1alpha ; Tumor Necrosis Factor-alpha ; Interleukin-10 (130068-27-8) ; Oxygen (S88TT14065)
Language	English
Publishing date	2023-05-08
Publishing country	Switzerland
Document type	Observational Study ; Journal Article
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina59050903
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6270: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Integrated OMICS tools for personalised medicine.

Borro, Marina / Gentile, Giovanna / Lionetto, Luana / Simmaco, Maurizio

The journal of headache and pain

2017 Volume 16, Issue Suppl 1, Page(s) A9

Language	English
Publishing date	2017-01-26
Publishing country	England
Document type	Journal Article
ZDB-ID	2036768-5
ISSN	1129-2377 ; 1129-2369
ISSN (online)	1129-2377
ISSN	1129-2369
DOI	10.1186/1129-2377-16-S1-A9
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 5464: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: The future of pharmacogenetics in the treatment of migraine.

Borro, Marina / Guglielmetti, Martina / Simmaco, Maurizio / Martelletti, Paolo / Gentile, Giovanna

Pharmacogenomics

2019 Volume 20, Issue 16, Page(s) 1159–1173

Abstract: Migraine is considered one of the most disabling neurological disorder with a high socioeconomic burden. Pharmacological management includes many classes of drugs which in the most cases, are administrated in polytherapy. The therapeutic scheme of ... ...

Abstract	Migraine is considered one of the most disabling neurological disorder with a high socioeconomic burden. Pharmacological management includes many classes of drugs which in the most cases, are administrated in polytherapy. The therapeutic scheme of migraineurs is often affected by comorbidities which need concomitant medications, thus increasing the risk of side effects related to drug-drug interactions. Pharmacogenetics is a promising tool to achieve a personalized cure based on individual genetic profile while the availability of free online knowledge bases allows to check the potential DDIs of selected medications. Combining, these approaches may offer to clinicians a useful tool to improve the appropriateness of migraine polytherapy choice, aiming to increase the efficacy and reduce the toxicity of pharmacological treatments.
MeSH term(s)	Anti-Inflammatory Agents, Non-Steroidal/adverse effects ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Drug Interactions/genetics ; Drug-Related Side Effects and Adverse Reactions/genetics ; Drug-Related Side Effects and Adverse Reactions/pathology ; Humans ; Migraine Disorders/drug therapy ; Migraine Disorders/genetics ; Migraine Disorders/pathology ; Pharmacogenetics ; Precision Medicine
Chemical Substances	Anti-Inflammatory Agents, Non-Steroidal
Language	English
Publishing date	2019-10-22
Publishing country	England
Document type	Journal Article
ZDB-ID	2019513-8
ISSN	1744-8042 ; 1462-2416
ISSN (online)	1744-8042
ISSN	1462-2416
DOI	10.2217/pgs-2019-0069
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 5247: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Optimising migraine treatment: from drug-drug interactions to personalized medicine.

Pomes, Leda Marina / Guglielmetti, Martina / Bertamino, Enrico / Simmaco, Maurizio / Borro, Marina / Martelletti, Paolo

The journal of headache and pain

2019 Volume 20, Issue 1, Page(s) 56

Abstract: Migraine is the most disabling and expensive chronic disorders, the etiology of which is still not fully known. The neuronal systems, (glutammatergic, dopaminergic, serotoninergic and GABA-ergic) whose functionality is partly attributable to genetically ... ...

Abstract	Migraine is the most disabling and expensive chronic disorders, the etiology of which is still not fully known. The neuronal systems, (glutammatergic, dopaminergic, serotoninergic and GABA-ergic) whose functionality is partly attributable to genetically determined factors, has been suggested to play an important role. The treatment of acute attacks and the prophylactic management of chronic forms include the use of different category of drugs, and it is demonstrated that not each subject has the same clinical answer to them. The reason of this is to be searched in different functional capacity and quantity of phase I enzymes (such as different isoforms of CYP P450), phase II enzymes (such as UDP-glucuronosyltransferases), receptors (such as OPRM1 for opioids) and transporters (such as ABCB1) involved in the metabolic destiny of each drug, all of these dictated by DNA and RNA variations. The general picture is further exacerbated by the need for polytherapies, often also to treat comorbidities, which may interfere with the pharmacological action of anti-migraine drugs. Personalized medicine has the objective of setting the optimal therapies in the light of the functional biochemical asset and of the comorbidities of the individual patient, in order to obtain the best clinical response. Novel therapeutic perspectives in migraine includes biotechnological drugs directed against molecules (such as CGRP and its receptor) that cause vasodilatation at the peripheral level of the meningeal blood vessels and reflex stimulation of the parasympathetic system. Drug-drug interactions and the possible competitive metabolic destiny should be studied by the application of pharmacogenomics in large scale. Drug-drug interactions and their possible competitive metabolic destiny should be studied by the application of pharmacogenomics in large scale.
MeSH term(s)	Analgesics, Opioid/therapeutic use ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Antidepressive Agents, Tricyclic/therapeutic use ; Calcitonin Gene-Related Peptide/antagonists & inhibitors ; Calcitonin Gene-Related Peptide/metabolism ; Calcitonin Gene-Related Peptide Receptor Antagonists/therapeutic use ; Drug Interactions ; Humans ; Migraine Disorders/drug therapy ; Migraine Disorders/genetics ; Migraine Disorders/metabolism ; Pharmacogenetics ; Precision Medicine/methods ; Tryptamines/therapeutic use
Chemical Substances	Analgesics, Opioid ; Anti-Inflammatory Agents, Non-Steroidal ; Antidepressive Agents, Tricyclic ; Calcitonin Gene-Related Peptide Receptor Antagonists ; Tryptamines ; Calcitonin Gene-Related Peptide (JHB2QIZ69Z)
Language	English
Publishing date	2019-05-17
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2036768-5
ISSN	1129-2377 ; 1129-2369
ISSN (online)	1129-2377
ISSN	1129-2369
DOI	10.1186/s10194-019-1010-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 5464: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito