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Article ; Online: Long-term outcomes of Baerveldt glaucoma implant surgery in Japanese patients.

Iwasaki, Kentaro / Komori, Ryohei / Arimura, Shogo / Orii, Yusuke / Takamura, Yoshihiro / Inatani, Masaru

2023 Volume 13, Issue 1, Page(s) 14312

Abstract: This study evaluated the long-term surgical outcomes of Baerveldt glaucoma implant (BGI) surgery in patients with refractory glaucoma (204 eyes/204 patients). Surgical failure was defined by: < 20% reduction in preoperative intraocular pressure (IOP), or ...

Abstract	This study evaluated the long-term surgical outcomes of Baerveldt glaucoma implant (BGI) surgery in patients with refractory glaucoma (204 eyes/204 patients). Surgical failure was defined by: < 20% reduction in preoperative intraocular pressure (IOP), or criterion A (IOP > 21 mmHg), criterion B (IOP > 17 mmHg), or criterion C (IOP > 14 mmHg). Reoperation, loss of light perception vision, or hypotony also denoted failure. The probability of success at 5 years postoperatively using criteria A, B, and C was 72.4%, 49.7%, and 24.4%, respectively. The mean IOP decreased significantly from 32.7 ± 9.7 mmHg preoperatively to 13.1 ± 3.9 mmHg at 5 years; the mean number of glaucoma medications also decreased from 3.7 ± 1.2 to 1.8 ± 1.9 (both P < 0.01). The number of previous intraocular surgeries was significantly associated with failure in the multivariable analysis for criterion B (hazard ratio 1.30; P < 0.01) and criterion C (hazard ratio 1.19; P = 0.031). Early and late postoperative complications occurred in 82 (40.2%) and 28 (13.7%) eyes, respectively. Postoperative interventions were performed in 44 eyes (21.6%). BGI surgery resulted in significant long-term decreases in IOP and the number of glaucoma medications. BGI surgery is effective for refractory glaucoma. However, postoperative interventions due to complications are required in numerous cases.
MeSH term(s)	Humans ; East Asian People ; Eye ; Ophthalmologic Surgical Procedures ; Glaucoma/surgery ; Glaucoma Drainage Implants
Language	English
Publishing date	2023-08-31
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-41673-6
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Article ; Online: Randomised clinical trial for morphological changes of trabecular meshwork between Kahook dual-blade goniotomy and ab interno trabeculotomy with a microhook.

Arimura, Shogo / Iwasaki, Kentaro / Orii, Yusuke / Komori, Ryohei / Takamura, Yoshihiro / Inatani, Masaru

Scientific reports

2023 Volume 13, Issue 1, Page(s) 20783

Abstract: We demonstrated whether the difference of trabecular meshwork remodeling occur depending on the incisional cross-sectional area by comparing Kahook dual-blade goniotomy (KDB) and ab interno trabeculotomy with a microhook. Phakic eyes with primary open- ... ...

Abstract	We demonstrated whether the difference of trabecular meshwork remodeling occur depending on the incisional cross-sectional area by comparing Kahook dual-blade goniotomy (KDB) and ab interno trabeculotomy with a microhook. Phakic eyes with primary open-angle or exfoliative glaucoma were randomised into a KDB or a microhook group. The primary outcome was an incisional cross-sectional area quantified by anterior segment optical coherence tomography. In subgroup analysis, the number of patients with the unidentifiable incisional area was compared between the groups. Secondary outcomes were the rate of intraocular pressure changes, the laser flare metre values, corneal endothelial cell densities, the number of glaucoma medications, the usage rate per glaucoma medication type and postoperative complications between the two groups. A total of 29 eyes in 29 patients in the KDB and microhook group were included respectively, with an overall mean age of 72.6 ± 8.1 years. The incisional cross-sectional area of the KDB group was significantly larger at 1 week and at 1, 6 and 12 months (p < 0.01) postoperatively. The number of patients with the nonidentified incisional area was higher at 1, 6 and 12 months postoperatively (p ≤ 0.03) in the microhook group. The flare values in the KDB group were higher than those in the microhook group at 12 months postoperatively (p = 0.02). No significant differences were observed in other secondary outcomes. Incisional cross-sectional area remains larger in eyes treated with KDB goniotomy than in those treated with ab interno trabeculotomy with the microhook, whereas KDB goniotomy did not have an advantage in controlling intraocular pressure postoperatively.Trial registration: UMIN000041290 (UMIN, University Hospital Medical Information Network Clinical Trials Registry of Japan; date of access and registration, 03/08/2020).
MeSH term(s)	Humans ; Middle Aged ; Aged ; Aged, 80 and over ; Trabeculectomy/methods ; Trabecular Meshwork/surgery ; Treatment Outcome ; Retrospective Studies ; Glaucoma/surgery ; Intraocular Pressure
Language	English
Publishing date	2023-11-27
Publishing country	England
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-48121-5
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Article ; Online: Prospective study of corneal endothelial cell loss after trabeculectomy.

Iwasaki, Kentaro / Arimura, Shogo / Takamura, Yoshihiro / Inatani, Masaru

Acta ophthalmologica

2020 Volume 99, Issue 4, Page(s) e614–e615

MeSH term(s)	Aged ; Corneal Endothelial Cell Loss/pathology ; Female ; Humans ; Male ; Middle Aged ; Prospective Studies ; Risk Factors ; Trabeculectomy/adverse effects ; Trabeculectomy/methods
Language	English
Publishing date	2020-08-04
Publishing country	England
Document type	Letter
ZDB-ID	2408333-1
ISSN	1755-3768 ; 1755-375X
ISSN (online)	1755-3768
ISSN	1755-375X
DOI	10.1111/aos.14561
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Article: [110th Scientific Meeting of the Japanese Society of Internal Medicine: Educational lecture: 5. Recent advances in vasculitis].

Arimura, Yoshihiro

Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine

2013 Volume 102, Issue 9, Page(s) 2382–2390

MeSH term(s)	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/therapy ; Antibodies, Antineutrophil Cytoplasmic/analysis ; Humans ; Vasculitis/classification ; Vasculitis/pathology
Chemical Substances	Antibodies, Antineutrophil Cytoplasmic
Language	Japanese
Publishing date	2013-09-30
Publishing country	Japan
Document type	Journal Article
ZDB-ID	952816-7
ISSN	1883-2083 ; 0021-5384
ISSN (online)	1883-2083
ISSN	0021-5384
DOI	10.2169/naika.102.2382
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Article ; Online: Randomised clinical trial for morphological changes of trabecular meshwork between Kahook dual-blade goniotomy and ab interno trabeculotomy with a microhook

Shogo Arimura / Kentaro Iwasaki / Yusuke Orii / Ryohei Komori / Yoshihiro Takamura / Masaru Inatani

Scientific Reports, Vol 13, Iss 1, Pp 1-

2023 Volume 9

Abstract: Abstract We demonstrated whether the difference of trabecular meshwork remodeling occur depending on the incisional cross-sectional area by comparing Kahook dual-blade goniotomy (KDB) and ab interno trabeculotomy with a microhook. Phakic eyes with ... ...

Abstract	Abstract We demonstrated whether the difference of trabecular meshwork remodeling occur depending on the incisional cross-sectional area by comparing Kahook dual-blade goniotomy (KDB) and ab interno trabeculotomy with a microhook. Phakic eyes with primary open-angle or exfoliative glaucoma were randomised into a KDB or a microhook group. The primary outcome was an incisional cross-sectional area quantified by anterior segment optical coherence tomography. In subgroup analysis, the number of patients with the unidentifiable incisional area was compared between the groups. Secondary outcomes were the rate of intraocular pressure changes, the laser flare metre values, corneal endothelial cell densities, the number of glaucoma medications, the usage rate per glaucoma medication type and postoperative complications between the two groups. A total of 29 eyes in 29 patients in the KDB and microhook group were included respectively, with an overall mean age of 72.6 ± 8.1 years. The incisional cross-sectional area of the KDB group was significantly larger at 1 week and at 1, 6 and 12 months (p < 0.01) postoperatively. The number of patients with the nonidentified incisional area was higher at 1, 6 and 12 months postoperatively (p ≤ 0.03) in the microhook group. The flare values in the KDB group were higher than those in the microhook group at 12 months postoperatively (p = 0.02). No significant differences were observed in other secondary outcomes. Incisional cross-sectional area remains larger in eyes treated with KDB goniotomy than in those treated with ab interno trabeculotomy with the microhook, whereas KDB goniotomy did not have an advantage in controlling intraocular pressure postoperatively. Trial registration: UMIN000041290 (UMIN, University Hospital Medical Information Network Clinical Trials Registry of Japan; date of access and registration, 03/08/2020).
Keywords	Medicine ; R ; Science ; Q
Subject code	630
Language	English
Publishing date	2023-11-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
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Article ; Online: Clinical practice preferences for glaucoma surgery in Japan: a survey of Japan Glaucoma Society specialists.

Iwasaki, Kentaro / Arimura, Shogo / Takamura, Yoshihiro / Inatani, Masaru

Japanese journal of ophthalmology

2020 Volume 64, Issue 4, Page(s) 385–391

Abstract: Purpose: This study evaluated the surgical practice patterns of glaucoma management followed by glaucoma specialists in Japan.: Methods: A survey was administered to 50 glaucoma specialists who were councilors in the Japan Glaucoma Society about ... ...

Abstract	Purpose: This study evaluated the surgical practice patterns of glaucoma management followed by glaucoma specialists in Japan. Methods: A survey was administered to 50 glaucoma specialists who were councilors in the Japan Glaucoma Society about surgical preferences and postoperative glaucoma care. Results: All 50 glaucoma specialists participated in the survey. Results show that, in 2019, compared to conventional trabeculotomy (4.6%), the frequency of minimally invasive glaucoma surgery (MIGS), combined with phacoemulsification, remarkably increased (79.0%) for non-operated eyes with mild open-angle glaucoma associated with cataract. Tube-shunt surgery was performed more often for open-angle glaucoma with previously twice failed trabeculectomy (65.8%) and neovascular glaucoma with previously once failed trabeculectomy (63.4%). In addition, during one year post-operatively, MIGS required less frequent follow-up visits compared to filtering surgery. Conclusion: Although glaucoma specialists in the Japan Glaucoma Society usually prefer trabeculectomy, in the past decade they have selected tube-shunt surgery more often to treat refractory glaucoma. MIGS is increasing remarkably as the choice primary glaucoma surgery.
MeSH term(s)	Female ; Glaucoma Drainage Implants/statistics & numerical data ; Glaucoma, Open-Angle/surgery ; Health Care Surveys ; Humans ; Japan ; Male ; Minimally Invasive Surgical Procedures/statistics & numerical data ; Ophthalmology/organization & administration ; Ophthalmology/statistics & numerical data ; Phacoemulsification/statistics & numerical data ; Practice Patterns, Physicians'/statistics & numerical data ; Societies, Medical/organization & administration ; Specialization/statistics & numerical data ; Trabeculectomy/statistics & numerical data
Language	English
Publishing date	2020-05-30
Publishing country	Japan
Document type	Journal Article
ZDB-ID	82032-5
ISSN	1613-2246 ; 0021-5155
ISSN (online)	1613-2246
ISSN	0021-5155
DOI	10.1007/s10384-020-00749-w
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Article: [Tubulointerstitial nephritis associated with ANCA-associated vasculitis].

Arimura, Yoshihiro

Nihon Jinzo Gakkai shi

2011 Volume 53, Issue 4, Page(s) 604–609

MeSH term(s)	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/complications ; Humans ; Kidney/blood supply ; Kidney/pathology ; Nephritis, Interstitial/etiology ; Nephritis, Interstitial/pathology
Language	Japanese
Publishing date	2011
Publishing country	Japan
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1195538-7
ISSN	0385-2385
ISSN	0385-2385
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Article: Long-Term Outcomes of a Kahook Dual Blade Procedure Combined with Phacoemulsification in Japanese Patients with Open-Angle Glaucoma.

Iwasaki, Kentaro / Kakimoto, Hiroshi / Orii, Yusuke / Arimura, Shogo / Takamura, Yoshihiro / Inatani, Masaru

Journal of clinical medicine

2022 Volume 11, Issue 5

Abstract: We retrospectively evaluated the long-term surgical outcomes of phacoemulsification combined with a Kahook dual blade (KDB) procedure in Japanese patients with open-angle glaucoma. The primary outcome was surgical success or failure. Surgical failure was ...

Abstract	We retrospectively evaluated the long-term surgical outcomes of phacoemulsification combined with a Kahook dual blade (KDB) procedure in Japanese patients with open-angle glaucoma. The primary outcome was surgical success or failure. Surgical failure was indicated by a <20% reduction in preoperative intraocular pressure (IOP) or IOP > 18 mmHg (criterion A), IOP > 14 mmHg (criterion B), or requirement for reoperation. Glaucoma medications after surgery and postoperative complications were recorded. Surgical outcomes were compared between primary open-angle glaucoma (POAG) and exfoliation glaucoma (ExG) groups. The probability of success at 36 months postoperation was 52.5% using criterion A and 36.9% using criterion B. Mean IOP decreased significantly from 19.5 ± 6.9 mmHg preoperatively to 11.9 ± 2.7 mmHg at 36 months, and the mean number of glaucoma medications from 2.4 ± 1.4 to 1.6 ± 1.4 (both p < 0.01). IOP spikes were significantly more common in the ExG group (23.7% vs. 9.1%; p = 0.045), as was the need for additional glaucoma surgery (10.5% vs. 1.8%; p = 0.038). A KDB procedure combined with cataract surgery resulted in significant long-term decreases in IOP and the number of glaucoma medications. The complication rate was higher in eyes with ExG. Therefore, these eyes require more careful management after a KDB procedure.
Language	English
Publishing date	2022-03-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm11051354
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Article ; Online: Comparison of 5-year outcomes between trabeculectomy combined with phacoemulsification and trabeculectomy followed by phacoemulsification: a retrospective cohort study.

Arimura, Shogo / Iwasaki, Kentaro / Orii, Yusuke / Takamura, Yoshihiro / Inatani, Masaru

BMC ophthalmology

2021 Volume 21, Issue 1, Page(s) 188

Abstract: Background: We aimed to compare the outcomes of trabeculectomy combined with phacoemulsification and those of trabeculectomy followed by phacoemulsification.: Methods: A total of 141 patients with primary open-angle glaucoma, exfoliation glaucoma, ... ...

Abstract	Background: We aimed to compare the outcomes of trabeculectomy combined with phacoemulsification and those of trabeculectomy followed by phacoemulsification. Methods: A total of 141 patients with primary open-angle glaucoma, exfoliation glaucoma, and glaucoma secondary to uveitis glaucoma who underwent trabeculectomy followed by (n = 48) or combined with (n = 93) phacoemulsification were included. We analyzed data collected from the Collaborative Bleb-Related Infection Incidence and Treatment Study, a prospective cohort study conducted in 34 clinical centers that included 1249 eyes. The main outcome was the cumulative probability of success based on intraocular pressure (IOP) within 5 years. Surgical failure was defined as a case in which additional glaucoma surgery is required or one of the following criteria are met: preoperative IOP > 21 (A), > 18 (B), or > 15 mmHg (C). The secondary outcomes were cumulative probability of success, risk factors of surgical failure, and Δ visual acuity. However, the data on phacoemulsification during the 5-year follow-up were censored. Results: No significant difference was found in the cumulative probability of success as the main outcome. When the data on phacoemulsification during the 5-year follow-up were censored, the probabilities of success of trabeculectomy followed by phacoemulsification were significantly higher for criteria A (p = 0.02), B (p < 0.01), and C (p < 0.01). Lower preoperative IOP, younger age, and trabeculectomy combined with phacoemulsification were associated with poorer outcome. Trabeculectomy followed by phacoemulsification had significantly worse Δ logMAR visual acuity at 6 and 12 months (p < 0.01). Conclusion: The cumulative probability of success after trabeculectomy combined with or followed by phacoemulsification remained unchanged. Combining phacoemulsification with trabeculectomy adversely affected the cumulative probability of success after trabeculectomy. The visual acuity improvements observed in the early postoperative period after combining phacoemulsification with trabeculectomy disappeared within 5 years.
MeSH term(s)	Humans ; Intraocular Pressure ; Phacoemulsification ; Prospective Studies ; Retrospective Studies ; Trabeculectomy ; Treatment Outcome
Language	English
Publishing date	2021-04-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2050436-6
ISSN	1471-2415 ; 1471-2415
ISSN (online)	1471-2415
ISSN	1471-2415
DOI	10.1186/s12886-021-01949-9
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Article ; Online: Chronic Antioxidant Capacity Loss in Anterior Chamber Environment After Iridectomy.

Arimura, Shogo / Iwasaki, Kentaro / Neo, Takuma / Orii, Yusuke / Matsumura, Takehiro / Takamura, Yoshihiro / Oki, Masaya / Inatani, Masaru

Translational vision science & technology

2023 Volume 12, Issue 5, Page(s) 4

Abstract: Purpose: To compare the ascorbic acid concentration and total antioxidant capacity in the aqueous humor of pigmented Rex rabbits after sham operation (control), iridectomy, and trabeculectomy.: Methods: Pigmented Rex rabbits were divided into control, ...

Abstract	Purpose: To compare the ascorbic acid concentration and total antioxidant capacity in the aqueous humor of pigmented Rex rabbits after sham operation (control), iridectomy, and trabeculectomy. Methods: Pigmented Rex rabbits were divided into control, iridectomy, and trabeculectomy groups and followed up for 12 months after surgery. Ascorbic acid concentration and total antioxidant capacity in the aqueous humor, intraocular pressure, and the occurrence of cataracts were examined in each group. Results: The ascorbic acid concentration and total antioxidant capacity after iridectomy and trabeculectomy were significantly lower at one week and at one, six, and 12 months after operation than those in the control group (P ≤ 0.03). Ascorbic acid concentration was positively and significantly correlated with total antioxidant capacity in the aqueous humor (P < 0.01). Compared to the control and the iridectomy groups, intraocular pressure in the trabeculectomy group was significantly lower at one week and at one and six months after surgery (one week: P < 0.01 and P < 0.01, respectively; one month: P < 0.01 and P = 0.03, respectively; six months: P = 0.03). Histological findings in the iridectomy and trabeculectomy groups included the appearance of vacuoles in the lens at six and 12 months after surgery. Conclusions: Iridectomy causes a sustained decrease in ascorbic acid concentration, followed by a long-term decrease in the total antioxidant capacity within the aqueous humor. Translational relevance: The animal model possibly predicts the vulnerability focusing on the antioxidant level in the anterior chamber environment after trabeculectomy and iridectomy per se in clinical settings.
MeSH term(s)	Animals ; Rabbits ; Iridectomy ; Antioxidants ; Anterior Chamber/pathology ; Trabeculectomy ; Ascorbic Acid
Chemical Substances	Antioxidants ; Ascorbic Acid (PQ6CK8PD0R)
Language	English
Publishing date	2023-05-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2674602-5
ISSN	2164-2591 ; 2164-2591
ISSN (online)	2164-2591
ISSN	2164-2591
DOI	10.1167/tvst.12.5.4
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