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Article ; Online: Disentangling trust of patients with rare cancer in their healthcare professionals and the healthcare system: a qualitative interview study.

Simons, Barbara C R / Hillen, Marij A / Aarts, Johanna W M / Tromp, Jacqueline M / de Heus, Eline / Duijts, Saskia F A

Journal of cancer survivorship : research and practice

2024

Abstract: Purpose: Patients with a rare cancer face challenges, e.g., delayed diagnosis, that may affect ...

Abstract	Purpose: Patients with a rare cancer face challenges, e.g., delayed diagnosis, that may affect trust in the healthcare system and the healthcare professionals (HCPs) involved. This study aimed to explore trust of patients with a rare cancer in their HCPs and the healthcare system. Methods: Semi-structured interviews were conducted with 20 purposively sampled patients with a rare cancer. The interview guide included topics related to trust, including level, development, barriers and facilitators, importance, and trust dimensions. Thematic analysis was conducted with use of Atlas.ti. Results: The mean age of patients was 50 years, 60% were female, and 70% were highly educated. Three themes were constructed: (1) "Confirmed expertise is a prerequisite of trust." Patients need confirmation of their HCPs' expertise, as it could not be assumed due to the rarity of their cancer; (2) "Trust depends on the adequacy of information and how it is provided." Limited information about rare cancer reduced patients' trust in health care, whereas interpersonal trust was mainly affected by how HCPs provided information; and (3) "Trust is built on properly coordinated and supportive care." Proper organization and cooperation within and between hospitals, and integration of supportive care, enhanced trust. Conclusion: Patients with a rare cancer experience challenges that influence trust in HCPs and the healthcare system. Further research should examine trust among subgroups of patients with a rare cancer, to enable development of tailored interventions. Implications for cancer survivors: HCPs may improve trust by focusing on expertise, effective information provision, proper coordination of care, and provision of adequate supportive care.
Language	English
Publishing date	2024-01-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	2388888-X
ISSN	1932-2267 ; 1932-2259
ISSN (online)	1932-2267
ISSN	1932-2259
DOI	10.1007/s11764-023-01531-w
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Article ; Online: New material of Qatrania from Egypt with comments on the phylogenetic position of the parapithecidae (primates, Anthropoidea).

Simons, E L / Kay, R F

American journal of primatology

2016 Volume 15, Issue 4, Page(s) 337–347

Abstract: New material of the early anthropoid primate Qatrania wingi and a new species of that genus are described. Several features of the dental anatomy show that Qatrania, while quite primitive relative to other anthropoids in many ways, is most likely a ... ...

Abstract	New material of the early anthropoid primate Qatrania wingi and a new species of that genus are described. Several features of the dental anatomy show that Qatrania, while quite primitive relative to other anthropoids in many ways, is most likely a parapithecid primate. The new material suggests that several dental features previously thought to ally parapithecids with the catarrhine primates were actually evolved in parallel in catarrhines and some parapithecids. Furthermore, all nonparapithecid anthropoids (including platyrrhines and catarrhines) share a suite of derived dental and postcranial features not found in parapithecids. Therefore, parapithecid origins may predate the platyrrhine/catarrhine split.
Language	English
Publishing date	2016-03-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	1495834-X
ISSN	1098-2345 ; 0275-2565
ISSN (online)	1098-2345
ISSN	0275-2565
DOI	10.1002/ajp.1350150407
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Article ; Online: A randomized controlled trial of graded exposure treatment (GET living) for adolescents with chronic pain.

Simons, Laura E / Harrison, Lauren E / Boothroyd, Derek B / Parvathinathan, Gomathy / Van Orden, Amanda R / O'Brien, Shannon F / Schofield, Deborah / Kraindler, Joshua / Shrestha, Rupendra / Vlaeyen, Johan W S / Wicksell, Rikard K

Pain

2023 Volume 165, Issue 1, Page(s) 177–191

Abstract: Abstract: Graded exposure treatment (GET) is a theory-driven pain treatment that aims to improve functioning by exposing patients to activities previously feared and avoided. Combining key elements of GET with acceptance-based exposure, GET Living (GL) ... ...

Abstract	Abstract: Graded exposure treatment (GET) is a theory-driven pain treatment that aims to improve functioning by exposing patients to activities previously feared and avoided. Combining key elements of GET with acceptance-based exposure, GET Living (GL) was developed for adolescents with chronic pain (GL). Based on robust treatment effects observed in our single-case experimental design pilot trial of GL (NCT01974791), we conducted a 2-arm randomized clinical trial comparing GL with multidisciplinary pain management (MPM) comprised of cognitive behavioral therapy and physical therapy for pain management (NCT03699007). A cohort of 68 youth with chronic musculoskeletal pain (M age 14.2 years; 81% female) were randomized to GL or MPM. Owing to COVID-19 restrictions, 54% of participants received zoom video delivered care. Assessments were collected at baseline, discharge, as well as at 3-month and 6-month follow-up. Primary outcomes were self-reported pain-related fear and avoidance. Secondary outcomes were child functional disability and parent protective responses to child pain. As hypothesized, GL improved in primary and secondary outcomes at 3-month follow-up. Contrary to our superiority hypothesis, there was no significant difference between GL and MPM. Patients reported both GL and MPM (in person and video) as credible and were highly satisfied with the treatment experience. Next steps will involve examining the single-case experimental design data embedded in this trial to facilitate an understanding of individual differences in treatment responses (eg, when effects occurred, what processes changed during treatment within the treatment arm). The current findings support GET Living and MPM for youth with chronic pain.
MeSH term(s)	Child ; Humans ; Adolescent ; Female ; Male ; Chronic Pain/therapy ; Chronic Pain/psychology ; Treatment Outcome ; Cognitive Behavioral Therapy ; Pain Management/psychology ; Physical Therapy Modalities
Language	English
Publishing date	2023-08-25
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	193153-2
ISSN	1872-6623 ; 0304-3959
ISSN (online)	1872-6623
ISSN	0304-3959
DOI	10.1097/j.pain.0000000000003010
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Article ; Online: Uptake of EpiPen and Allerject (Auvi-Q) epinephrine auto-injectors in Manitoba children.

Tam, Herman / Simons, F Estelle R / Simons, Elinor

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology

2017 Volume 119, Issue 2, Page(s) 192–193

Language	English
Publishing date	2017-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	1228189-x
ISSN	1534-4436 ; 0003-4738 ; 1081-1206
ISSN (online)	1534-4436
ISSN	0003-4738 ; 1081-1206
DOI	10.1016/j.anai.2017.06.010
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Article ; Online: Are dispensing patterns for epinephrine autoinjectors age-appropriate in children?

Tam, Herman / Simons, F Estelle R / Simons, Elinor

The journal of allergy and clinical immunology. In practice

2017 Volume 5, Issue 5, Page(s) 1435–1437.e1

MeSH term(s)	Administrative Claims, Healthcare ; Adolescent ; Adrenergic Agonists/administration & dosage ; Adrenergic Agonists/adverse effects ; Age Factors ; Anaphylaxis/diagnosis ; Anaphylaxis/drug therapy ; Anaphylaxis/epidemiology ; Child ; Child, Preschool ; Databases, Factual ; Drug Delivery Systems/trends ; Epinephrine/administration & dosage ; Epinephrine/adverse effects ; Female ; Humans ; Infant ; Infant, Newborn ; Injections ; Insurance, Pharmaceutical Services ; Male ; Manitoba/epidemiology ; Practice Patterns, Physicians'/trends ; Syringes/trends ; Time Factors
Chemical Substances	Adrenergic Agonists ; Epinephrine (YKH834O4BH)
Language	English
Publishing date	2017-07-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2843237-X
ISSN	2213-2201 ; 2213-2198
ISSN (online)	2213-2201
ISSN	2213-2198
DOI	10.1016/j.jaip.2017.06.012
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Article ; Online: Anaphylaxis and cardiovascular disease: therapeutic dilemmas.

Lieberman, P / Simons, F E R

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology

2015 Volume 45, Issue 8, Page(s) 1288–1295

Abstract: Cardiovascular disease (CVD) increases the risk of severe or fatal anaphylaxis, and some medications for CVD treatment can exacerbate anaphylaxis. The aim of this article is to review the effect of anaphylaxis on the heart, the potential impact of ... ...

Abstract	Cardiovascular disease (CVD) increases the risk of severe or fatal anaphylaxis, and some medications for CVD treatment can exacerbate anaphylaxis. The aim of this article is to review the effect of anaphylaxis on the heart, the potential impact of medications for CVD on anaphylaxis and anaphylaxis treatment, and the cardiovascular effects of epinephrine. The therapeutic dilemmas arising from these issues are also discussed and management strategies proposed. PubMed searches were performed for the years 1990-2014 inclusive, using terms such as angiotensin-converting enzyme (ACE) inhibitors, adrenaline, allergic myocardial infarction, anaphylaxis, angiotensin-receptor blockers (ARBs), beta-adrenergic blockers, epinephrine, and Kounis syndrome. Literature analysis indicated that: cardiac mast cells are key constituents of atherosclerotic plaques; mast cell mediators play an important role in acute coronary syndrome (ACS); patients with CVD are at increased risk of developing severe or fatal anaphylaxis; and medications for CVD treatment, including beta-adrenergic blockers and ACE inhibitors, potentially exacerbate anaphylaxis or make it more difficult to treat. Epinephrine increases myocardial contractility, decreases the duration of systole relative to diastole, and enhances coronary blood flow. Its transient adverse effects include pallor, tremor, anxiety, and palpitations. Serious adverse effects (including ventricular arrhythmias and hypertension) are rare, and are significantly more likely after intravenous injection than after intramuscular injection. Epinephrine is life-saving in anaphylaxis; second-line medications (including antihistamines and glucocorticoids) are not. In CVD patients (especially those with ACS), the decision to administer epinephrine for anaphylaxis can be difficult, and its benefits and potential harms need to be carefully considered. Concerns about potential adverse effects need to be weighed against concerns about possible death from untreated anaphylaxis, but there is no absolute contraindication to epinephrine injection in anaphylaxis.
MeSH term(s)	Anaphylaxis/etiology ; Anaphylaxis/immunology ; Anaphylaxis/pathology ; Anaphylaxis/therapy ; Animals ; Cardiovascular Diseases/complications ; Cardiovascular Diseases/immunology ; Cardiovascular Diseases/pathology ; Cardiovascular Diseases/therapy ; Humans ; Mast Cells/immunology ; Mast Cells/pathology ; Myocardial Contraction/immunology ; Myocardium/immunology ; Myocardium/pathology
Language	English
Publishing date	2015-08
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	645204-8
ISSN	1365-2222 ; 0954-7894 ; 0960-2178
ISSN (online)	1365-2222
ISSN	0954-7894 ; 0960-2178
DOI	10.1111/cea.12520
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Zs.A 767: Show issues

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Article ; Online: Modulating medial prefrontal cortex activity using real-time fMRI neurofeedback: Effects on reality monitoring performance and associated functional connectivity.

Garrison, J R / Saviola, F / Morgenroth, E / Barker, H / Lührs, M / Simons, J S / Fernyhough, C / Allen, P

NeuroImage

2021 Volume 245, Page(s) 118640

Abstract: Neuroimaging studies have found 'reality monitoring', our ability to distinguish internally generated experiences from those derived from the external world, to be associated with activity in the medial prefrontal cortex (mPFC) of the brain. Here we ... ...

Abstract	Neuroimaging studies have found 'reality monitoring', our ability to distinguish internally generated experiences from those derived from the external world, to be associated with activity in the medial prefrontal cortex (mPFC) of the brain. Here we probe the functional underpinning of this ability using real-time fMRI neurofeedback to investigate the involvement of mPFC in recollection of the source of self-generated information. Thirty-nine healthy individuals underwent neurofeedback training in a between groups study receiving either Active feedback derived from the paracingulate region of the mPFC (21 subjects) or Sham feedback based on a similar level of randomised signal (18 subjects). Compared to those in the Sham group, participants receiving Active signal showed increased mPFC activity over the course of three real-time neurofeedback training runs undertaken in a single scanning session. Analysis of resting state functional connectivity associated with changes in reality monitoring accuracy following Active neurofeedback revealed increased connectivity between dorsolateral frontal regions of the fronto-parietal network (FPN) and the mPFC region of the default mode network (DMN), together with reduced connectivity within ventral regions of the FPN itself. However, only a trend effect was observed in the interaction of the recollection of the source of Imagined information compared with recognition memory between participants receiving Active and Sham neurofeedback, pre- and post- scanning. As such, these findings demonstrate that neurofeedback can be used to modulate mPFC activity and increase cooperation between the FPN and DMN, but the effects on reality monitoring performance are less clear.
MeSH term(s)	Brain Mapping/methods ; Female ; Healthy Volunteers ; Humans ; Image Processing, Computer-Assisted ; Magnetic Resonance Imaging/methods ; Male ; Neurofeedback/methods ; Prefrontal Cortex/diagnostic imaging ; Prefrontal Cortex/physiology ; Young Adult
Language	English
Publishing date	2021-10-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1147767-2
ISSN	1095-9572 ; 1053-8119
ISSN (online)	1095-9572
ISSN	1053-8119
DOI	10.1016/j.neuroimage.2021.118640
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Article: Biogenic propane production by a marine

Currie, Felicity / Twigg, Matthew S / Huddleson, Nicholas / Simons, Keith E / Marchant, Roger / Banat, Ibrahim M

Frontiers in microbiology

2022 Volume 13, Page(s) 1000247

Abstract: Propane is a major component of liquefied petroleum gas, a major energy source for off-grid communities and industry. The replacement of fossil fuel-derived propane with more sustainably derived propane is of industrial interest. One potential production ...

Abstract	Propane is a major component of liquefied petroleum gas, a major energy source for off-grid communities and industry. The replacement of fossil fuel-derived propane with more sustainably derived propane is of industrial interest. One potential production route is through microbial fermentation. Here we report, for the first time, the isolation of a marine bacterium from sediment capable of natural propane biosynthesis. Propane production, both in mixed microbial cultures generated from marine sediment and in bacterial monocultures was detected and quantified by gas chromatography-flame ionization detection. Using DNA sequencing of multiple reference genes, the bacterium was shown to belong to the genus
Language	English
Publishing date	2022-10-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2022.1000247
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Article ; Online: A prospective observational study describing severity of acquired diarrhea among U.S. military and Western travelers participating in the Global Travelers' Diarrhea Study.

Ashbaugh, Hayley R / Early, June M / Johnson, Myles E / Simons, Mark P / Graf, Paul C F / Riddle, Mark S / Swierczewski, Brett E

Travel medicine and infectious disease

2021 Volume 43, Page(s) 102139

Abstract: ... by pathogen revealed that, at non-military sites, 17/19 (89%) of enteropathogenic Escherichia coli (E. coli ... EPEC) infections, 28/32 (88%) of enterotoxigenic E. coli (ETEC) infections, and 13/15 (87%) of Shigella ... enteroinvasive E. coli (EIEC) infections resulted in severe AD cases. At the military site, all infections ...

Abstract	Background: Travelers' diarrhea (TD) is one of the most common illnesses affecting modern-day travelers, including military personnel. Previous work has shown that afflicted travelers may alter their itineraries and be confined to bed rest due to symptoms, and military personnel may become incapable of completing operational requirements. Examination of signs, symptoms, and severity of diarrheagenic pathogens can inform clinical diagnosis and prioritization of future surveillance and research activities. Methods: Utilizing a global laboratory network, culture and molecular testing were performed in parallel at each site on a group of core pathogens, and definitions for acute diarrhea (AD), severe AD, acute gastroenteritis (AGE), and severe AGE were determined using data elements in the modified Vesikari scale. We included 210 cases of TD reporting all variables of interest in our severity assessment analysis. Results: Out of all cases, 156/210 (74%) met criteria for severe AD and 35/210 (17%) for severe AGE. Examination of severity by pathogen revealed that, at non-military sites, 17/19 (89%) of enteropathogenic Escherichia coli (E. coli) (EPEC) infections, 28/32 (88%) of enterotoxigenic E. coli (ETEC) infections, and 13/15 (87%) of Shigella/enteroinvasive E. coli (EIEC) infections resulted in severe AD cases. At the military site, all infections of ETEC (6/6), Shigella-EIEC (4/4), and enteroaggregative E. coli (EAEC) resulted in AD. Norovirus infections at non-military and military sites resulted in 27% (14/51) and 33% (3/9) severe AGE cases, respectively. Conclusions: This study found a high percentage of participants enrolled at both military and non-military sites experienced severe AD with concerning numbers of severe cases at non-military sites reporting hospitalization and reductions in performance. Since travelers with mild TD symptoms are less likely to present to health care workers than those with more severe TD, there is a potential selection bias in this study that may have overestimated the proportion of more severe outcomes among all individuals who could have participated in the GTD study. Future research should examine other covariates among pathogen and host, such as treatment and comorbid conditions, that may contribute to the presence of signs and symptoms and their severity.
MeSH term(s)	Diarrhea/epidemiology ; Enteropathogenic Escherichia coli ; Escherichia coli Infections/diagnosis ; Escherichia coli Infections/epidemiology ; Feces ; Humans ; Military Personnel ; Travel
Language	English
Publishing date	2021-07-13
Publishing country	Netherlands
Document type	Journal Article ; Observational Study
ZDB-ID	2170891-5
ISSN	1873-0442 ; 1477-8939
ISSN (online)	1873-0442
ISSN	1477-8939
DOI	10.1016/j.tmaid.2021.102139
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Article ; Online: Myelin regulatory factor is a target of individual and interactive effects of HIV-1 Tat and morphine in the striatum and pre-frontal cortex.

Flounlacker, Kelly M / Hahn, Yun Kyung / Xu, Ruqiang / Simons, Chloe A / Tian, Tao / Hauser, Kurt F / Knapp, Pamela E

Journal of neurovirology

2023 Volume 29, Issue 1, Page(s) 15–26

Abstract: HIV-associated neurocognitive disorders (HAND) remain pervasive even with increased efficacy/use of antiretroviral therapies. Opioid use/abuse among HIV + individuals is documented to exacerbate CNS deficits. White matter (WM) alterations, including ... ...

Abstract	HIV-associated neurocognitive disorders (HAND) remain pervasive even with increased efficacy/use of antiretroviral therapies. Opioid use/abuse among HIV + individuals is documented to exacerbate CNS deficits. White matter (WM) alterations, including myelin pallor, and volume/structural alterations detected by diffusion tensor imaging are common observations in HIV + individuals, and studies in non-human primates suggest that WM may harbor virus. Using transgenic mice that express the HIV-1 Tat protein, we examined in vivo effects of 2-6 weeks of Tat and morphine exposure on WM using genomic and biochemical methods. RNA sequencing of striatal tissue at 2 weeks revealed robust changes in mRNAs associated with oligodendrocyte precursor populations and myelin integrity, including those for transferrin, the atypical oligodendrocyte marker N-myc downstream regulated 1 (Ndrg1), and myelin regulatory factor (Myrf/Mrf), an oligodendrocyte-specific transcription factor with a significant role in oligodendrocyte differentiation/maturation. Western blots conducted after 6-weeks exposure in 3 brain regions (striatum, corpus callosum, pre-frontal cortex) revealed regional differences in the effect of Tat and morphine on Myrf levels, and on levels of myelin basic protein (MBP), whose transcription is regulated by Myrf. Responses included individual and interactive effects. Although baseline and post-treatment levels of Myrf and MBP differed between brain regions, post-treatment MBP levels in striatum and pre-frontal cortex were compatible with changes in Myrf activity. Additionally, the Myrf regulatory ubiquitin ligase Fbxw7 was identified as a novel target in our model. These results suggest that Myrf and Fbxw7 contribute to altered myelin gene regulation in HIV.
MeSH term(s)	Animals ; Mice ; Diffusion Tensor Imaging ; F-Box-WD Repeat-Containing Protein 7/metabolism ; Frontal Lobe/metabolism ; HIV Infections ; HIV-1/metabolism ; Mice, Transgenic ; Morphine ; Transcription Factors/genetics ; tat Gene Products, Human Immunodeficiency Virus/metabolism
Chemical Substances	F-Box-WD Repeat-Containing Protein 7 ; Morphine (76I7G6D29C) ; Transcription Factors ; tat Gene Products, Human Immunodeficiency Virus
Language	English
Publishing date	2023-02-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	1283265-0
ISSN	1538-2443 ; 1355-0284
ISSN (online)	1538-2443
ISSN	1355-0284
DOI	10.1007/s13365-022-01107-x
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