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Article ; Online: The effect of floating spline parameter on the dynamic characteristic of encased differential planetary gear train.

Che, Xiaoyu / Yu, Hu / Zhang, Chao / Zhu, Rupeng

2024 Volume 14, Issue 1, Page(s) 8349

Abstract: The load sharing performance of encased differential planetary system has a great impact on the operating performance and service life of the transmission system of the coaxial high speed helicopter. In order to improve the load-sharing performance of ... ...

Abstract	The load sharing performance of encased differential planetary system has a great impact on the operating performance and service life of the transmission system of the coaxial high speed helicopter. In order to improve the load-sharing performance of the gear pair, the influence of different floating spline structural parameters on the load sharing characteristics of the system was studied. Considering the manufacturing error, installation error, time varying meshing stiffness and other factors, the Lagrange equation is used to construct the dynamic model of encased differential planetary gear train with floating spline structure. The effects of input torque, spline clearance, spline shaft stiffness and spline friction coefficient on the load sharing performance of gear pairs were analyzed. The results show that the differential stage system has a better load sharing performance than the encased stage system. The increase of input torque helps to improve the load sharing performance of the system, and the improvement of the encased stage system is more obvious. The floating spline of sun gear of the encased stage has a greater impact on the load sharing performance of the system. Furthermore, increasing the floating spline clearance, reducing spline shaft stiffness or increasing the friction coefficient of the spline can improve the load sharing performance of the system overall.
Language	English
Publishing date	2024-04-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-59094-4
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Article: Bayesian Statistics Improves Biological Interpretability of Metabolomics Data from Human Cohorts.

Brydges, Christopher / Che, Xiaoyu / Lipkin, Walter Ian / Fiehn, Oliver

Metabolites

2023 Volume 13, Issue 9

Abstract: Univariate analyses of metabolomics data currently follow a frequentist approach, ... ...

Abstract	Univariate analyses of metabolomics data currently follow a frequentist approach, using
Language	English
Publishing date	2023-08-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662251-8
ISSN	2218-1989
ISSN	2218-1989
DOI	10.3390/metabo13090984
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Article ; Online: In-sample stability and postsampling analysis of 21 illicit drugs, their metabolites and cotinine in wastewater.

Che, Xinfeng / Liu, Peipei / Ding, Yan / Tao, Wenjia / Zheng, Xiaoyu / Di, Bin / Qiao, Hongwei

Ecotoxicology and environmental safety

2024 Volume 270, Page(s) 115900

Abstract: A thorough understanding of the degradation of chemical biomarkers in wastewater after the sampling is critical in the surveillance of illicit drug use based on the back-calculation technique. Herein, three temperatures, eight groups of matrices, and ... ...

Abstract	A thorough understanding of the degradation of chemical biomarkers in wastewater after the sampling is critical in the surveillance of illicit drug use based on the back-calculation technique. Herein, three temperatures, eight groups of matrices, and acidification were applied to simulate the preservation condition of 21 illicit drugs, their metabolites, and cotinine for a 240-day stability study. It was proved that the temperature, matrices, and acidification play vital roles in their stability in wastewater. Most of them demonstrated high stability (transformation rates < 20%) during room temperature for 45 days, and the transformation rates decreased while the storage temperature reduced. The stability of the target compounds such as cocaine (COC), 6-monoacetylmorphine (6-MAM), and amphetamine (AM) is influenced by matrices. Acidification prevented the majority of analytes from transforming, making it a feasible solution for preservation after sampling. A model that combined the effects of temperature and matrix was developed to back-calculate the concentration of target compounds during the postsampling process. The feasibility of this model was validated by correcting the loss of COC and 6-MAM from 24.2% and 16.2% to 2.98% and 2.77%. This study simulated a typical large-scale sampling and storage scenario. The effect of the temperature, pH, and matrix on in-sample stability and the postsampling analysis of selected target compounds was investigated for the first time in this study.
MeSH term(s)	Wastewater ; Illicit Drugs/analysis ; Cotinine ; Amphetamine/analysis ; Cocaine/analysis ; Water Pollutants, Chemical/analysis
Chemical Substances	Wastewater ; Illicit Drugs ; Cotinine (K5161X06LL) ; Amphetamine (CK833KGX7E) ; Cocaine (I5Y540LHVR) ; Water Pollutants, Chemical
Language	English
Publishing date	2024-01-04
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	436536-7
ISSN	1090-2414 ; 0147-6513
ISSN (online)	1090-2414
ISSN	0147-6513
DOI	10.1016/j.ecoenv.2023.115900
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Zs.A 1418: Show issues

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Article ; Online: Maternal Mediterranean-Style Diet Adherence during Pregnancy and Metabolomic Signature in Postpartum Plasma: Findings from the Boston Birth Cohort.

Che, Xiaoyu / Hong, Xiumei / Gross, Susan / Pearson, Colleen / Bartell, Tami / Wang, Xiaobin / Wang, Guoying

The Journal of nutrition

2024 Volume 154, Issue 3, Page(s) 846–855

Abstract: Background: The health benefits of a Mediterranean-style diet (MSD) are well observed, but the underlying mechanisms are unclear. Metabolomic profiling offers a systematic approach for identifying which metabolic biomarkers and pathways might be ... ...

Abstract	Background: The health benefits of a Mediterranean-style diet (MSD) are well observed, but the underlying mechanisms are unclear. Metabolomic profiling offers a systematic approach for identifying which metabolic biomarkers and pathways might be affected by an MSD. Objectives: This study aimed to identify postpartum plasma metabolites that are associated with MSD adherence during pregnancy and to further test whether these identified metabolites may vary by maternal characteristics. Methods: We analyzed data from 1410 mothers enrolled in the Boston Birth Cohort (BBC). A maternal food frequency questionnaire (FFQ) was administered and epidemiologic information was obtained via an in-person standard questionnaire interview within 24-72 h postpartum. Maternal clinical information was extracted from electronic medical records. A Mediterranean-style diet score (MSDS) was calculated using responses to the FFQ. Metabolomic profiling in postpartum plasma was conducted by liquid chromatography-MS. Linear regression models were used to assess the associations of each metabolite with an MSDS, adjusting for covariates. Results: Among the 380 postpartum plasma metabolites analyzed, 24 were associated with MSDS during pregnancy (false discovery rate < 0.05). Of 24 MSDS-associated metabolites, 19 were lipids [for example, triacylglycerols, phosphatidylcholines (PCs), PC plasmalogen, phosphatidylserine, and phosphatidylethanolamine]; others were amino acids (methionine sulfoxide and threonine), tropane (nor-psi-tropine), vitamin (vitamin A), and nucleotide (adenosine). The association of adenosine and methionine sulfoxide with MSDS differed by race (P-interaction = 0.033) and maternal overweight or obesity status (P-interaction = 0.021), respectively. Conclusions: In the BBC, we identified 24 postpartum plasma metabolites associated with MSDS during pregnancy. The associations of the 2 metabolites varied by maternal race and BMI. This study provides a new insight into dietary effects on health under the skin. More studies are needed to better understand the metabolic pathways underlying the short- and long-term health benefits of an MSD during pregnancy.
MeSH term(s)	Pregnancy ; Female ; Humans ; Birth Cohort ; Diet, Mediterranean ; Postpartum Period ; Adenosine ; Methionine/analogs & derivatives
Chemical Substances	methionine sulfoxide (XN1XVI4B2C) ; Adenosine (K72T3FS567) ; Methionine (AE28F7PNPL)
Language	English
Publishing date	2024-01-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	218373-0
ISSN	1541-6100 ; 0022-3166
ISSN (online)	1541-6100
ISSN	0022-3166
DOI	10.1016/j.tjnut.2024.01.022
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Article ; Online: In-sample stability and postsampling analysis of 21 illicit drugs, their metabolites and cotinine in wastewater

Xinfeng Che / Peipei Liu / Yan Ding / Wenjia Tao / Xiaoyu Zheng / Bin Di / Hongwei Qiao

Ecotoxicology and Environmental Safety, Vol 270, Iss , Pp 115900- (2024)

2024

Abstract	A thorough understanding of the degradation of chemical biomarkers in wastewater after the sampling is critical in the surveillance of illicit drug use based on the back-calculation technique. Herein, three temperatures, eight groups of matrices, and acidification were applied to simulate the preservation condition of 21 illicit drugs, their metabolites, and cotinine for a 240-day stability study. It was proved that the temperature, matrices, and acidification play vital roles in their stability in wastewater. Most of them demonstrated high stability (transformation rates < 20%) during room temperature for 45 days, and the transformation rates decreased while the storage temperature reduced. The stability of the target compounds such as cocaine (COC), 6-monoacetylmorphine (6-MAM), and amphetamine (AM) is influenced by matrices. Acidification prevented the majority of analytes from transforming, making it a feasible solution for preservation after sampling. A model that combined the effects of temperature and matrix was developed to back-calculate the concentration of target compounds during the postsampling process. The feasibility of this model was validated by correcting the loss of COC and 6-MAM from 24.2% and 16.2% to 2.98% and 2.77%. This study simulated a typical large-scale sampling and storage scenario. The effect of the temperature, pH, and matrix on in-sample stability and the postsampling analysis of selected target compounds was investigated for the first time in this study.
Keywords	Wastewater ; Matrix ; Postsampling Analysis ; Stability ; Illicit Drugs ; Online-SPE-UPLC3MS/MS ; Environmental pollution ; TD172-193.5 ; Environmental sciences ; GE1-350
Subject code	500
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Formation of pre-metastatic niches induced by tumor extracellular vesicles in lung metastasis.

Liu, Yuping / Mao, Dengxuan / Wang, Hong / Che, Xiaoyu / Chen, Yan

Pharmacological research

2023 Volume 188, Page(s) 106669

Abstract: There are a number of malignant tumors that metastasize into the lung as one of their most common sites of dissemination. The successful infiltration of tumor cells into distant organs is the result of the cooperation between tumor cells and distant host ...

Abstract	There are a number of malignant tumors that metastasize into the lung as one of their most common sites of dissemination. The successful infiltration of tumor cells into distant organs is the result of the cooperation between tumor cells and distant host cells. When tumor cells have not yet reached distant organs, in situ tumor cells secrete extracellular vesicles (EVs) carrying important biological information. In recent years, scholars have found that tumor cells-derived EVs act as the bridge between orthotopic tumors and secondary metastases by promoting the formation of a pre-metastatic niche (PMN), which plays a key role in awakening dormant circulating tumor cells and promoting tumor cell colonization. This review provides an overview of multiple routes and mechanisms underlying PMN formation induced by EVs and summaries study ﬁndings that underline a potential role of EVs in the intervention of lung PMN, both as a target or a carrier for drug design. In this review, the underlying mechanisms of EVs in lung PMN formation are highlighted as well as potential applications to lung metastasis diagnosis and treatment.
MeSH term(s)	Humans ; Lung Neoplasms/pathology ; Extracellular Vesicles ; Lung/pathology ; Neoplastic Cells, Circulating ; Tumor Microenvironment ; Neoplasm Metastasis/pathology
Language	English
Publishing date	2023-01-18
Publishing country	Netherlands
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	1003347-6
ISSN	1096-1186 ; 0031-6989 ; 1043-6618
ISSN (online)	1096-1186
ISSN	0031-6989 ; 1043-6618
DOI	10.1016/j.phrs.2023.106669
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Zs.A 721: Show issues

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Article: Novel αO-conotoxin GeXIVA[1,2] Nonaddictive Analgesic with Pharmacokinetic Modelling-Based Mechanistic Assessment.

Zhu, Xiaoyu / Yuan, Mei / Wang, Huanbai / Zhangsun, Dongting / Yu, Gang / Che, Jinjing / Luo, Sulan

Pharmaceutics

2022 Volume 14, Issue 9

Abstract: αO-conotoxin GeXIVA[1,2] was isolated in our laboratory ... ...

Abstract	αO-conotoxin GeXIVA[1,2] was isolated in our laboratory from
Language	English
Publishing date	2022-08-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics14091789
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Article ; Online: Combination of oxymatrine (Om) and astragaloside IV (As) enhances the infiltration and function of TILs in triple-negative breast cancer (TNBC).

Wang, Hong / Wei, Liangyin / Mao, Dengxuan / Che, Xiaoyu / Ye, Xietao / Liu, Yuping / Chen, Yan

International immunopharmacology

2023 Volume 125, Issue Pt A, Page(s) 111026

Abstract: Triple-negative breast cancer (TNBC) is the most aggressive subtype and has a poor response to treatment due to an immunosuppressive microenvironment. Chinese Medicine effective constituents such as oxymatrine (Om) and astragaloside IV (As) have shown ... ...

Abstract	Triple-negative breast cancer (TNBC) is the most aggressive subtype and has a poor response to treatment due to an immunosuppressive microenvironment. Chinese Medicine effective constituents such as oxymatrine (Om) and astragaloside IV (As) have shown promise in cancer treatment by providing anti-fibrosis and immune-enhancing effects. However, the potential combined effect of Om and As on TNBC and its mechanism is still uncertain. This study focuses on exploring the impact of Om and As on enhancing the immunosuppressive microenvironment of TNBC and uncovering the potential mechanism behind it. In this study, a trans-Cancer associated fibroblasts (CAFs) infiltration system of T cells was utilized to investigate the potential benefits of Om, while the impact of As on the morphology and quantity of mitochondria in T cells was examined in a co-culture system with tumor cells. Further to investigate the combined effects of Om and As on tumor suppression and immunosuppressive microenvironment improvement, this study established an in situ TNBC mouse model with 4 T1-luc. In vitro, our findings indicate that Om can effectively suppress the activation of CAFs by downregulating the expression of FAP and α-SMA, and also promoting the infiltration of T cells trans CAFs. It was discovered that the mitochondrial activity of T cells could be improved by increasing the number of mitochondria and cristae. In vivo, the optimal ratio of Om and As (2:1) was found to increase the apoptosis rate of tumor cells in a co-culture system and enhance the infiltration of CD4
MeSH term(s)	Humans ; Animals ; Mice ; CD8-Positive T-Lymphocytes/metabolism ; Triple Negative Breast Neoplasms/pathology ; Cancer-Associated Fibroblasts ; Tumor Microenvironment
Chemical Substances	astragaloside A (3A592W8XKE) ; oxymatrine (85U4C366QS)
Language	English
Publishing date	2023-10-23
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2043785-7
ISSN	1878-1705 ; 1567-5769
ISSN (online)	1878-1705
ISSN	1567-5769
DOI	10.1016/j.intimp.2023.111026
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Zs.A 5408: Show issues

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Article: Up-regulated serum lactate dehydrogenase could become a poor prognostic marker in patients with bladder cancer by an evidence-based analysis of 2,182 patients.

Wei, Xiaoyu / Chai, Yumeng / Li, Zhouyue / Che, Xuanyan / Zhang, Yong / Zhou, Zhongbao / Wang, Xiang

Frontiers in oncology

2023 Volume 13, Page(s) 1233620

Abstract: Background: A growing number of studies have considered serum lactate dehydrogenase (LDH) as an indicator of bladder cancer (BC) prognosis. However, a meta-analysis of the serum LDH's influence on BC prognosis is still missing.: Methods: PubMed, ... ...

Abstract	Background: A growing number of studies have considered serum lactate dehydrogenase (LDH) as an indicator of bladder cancer (BC) prognosis. However, a meta-analysis of the serum LDH's influence on BC prognosis is still missing. Methods: PubMed, EMBASE, Web of Science and Cochrane Library were exhaustively searched for studies comparing oncological outcomes between high-LDH and low-LDH patients. Standard cumulative analyses using hazard ratios (HR) with 95% confidence intervals (CI) were performed using Review Manager (version 5.3) for overall survival (OS) in patients with BC. Results: Six studies involving 2,182 patients were selected according to predefined eligibility criteria. The results showed that serum LDH level was significantly associated with OS (HR = 1.86, 95%CI = 1.54-2.25, p<0.0001) in BC. Sensitivity analysis showed the stability of the results. Subgroup analysis revealed that the levels of serum LDH had a significant impact on the OS of BC patients among different groups including publication time, research country, sample size, tumor stage, LDH cut-off value, therapy and follow-up time (all HR>1 and p<0.05), revealing that the ability of serum LDH is not affected by other factors. Conclusion: Our findings indicated that a high level of serum LDH was associated with inferior OS in patients with BC. However, caution must be taken before recommendations are given because this interpretation is based upon very few clinical studies and a small sample.
Language	English
Publishing date	2023-08-03
Publishing country	Switzerland
Document type	Systematic Review
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2023.1233620
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Article ; Online: Causes of death in endometrial cancer survivors: A Surveillance, Epidemiology, and End Result-based analysis.

Xue, Qing / Che, Wenqiang / Xue, Lujiadai / Zhang, Xian / Wang, Xiaoyu / Lyu, Jun

Cancer medicine

2023 Volume 12, Issue 9, Page(s) 10917–10930

Abstract: Background: Increasing attention has been paid to the survival of endometrial cancer (EC) patients, but the non-cancer causes of death from EC are rarely reported. This study primarily aimed to investigate the non-cancer causes of death in patients with ...

Abstract	Background: Increasing attention has been paid to the survival of endometrial cancer (EC) patients, but the non-cancer causes of death from EC are rarely reported. This study primarily aimed to investigate the non-cancer causes of death in patients with EC. Methods: The study collected relevant data, including age, tumour stage and treatment mode, on patients diagnosed with endometrial malignancies from 2000 to 2015 in the Surveillance, Epidemiology, and End Results (SEER) Programme. We analysed the standardised mortality ratio (SMR) to determine the cause of death. Results: The study included 135,831 patients with EC. During the follow-up, 46,604 (34.3%) patients died, of whom 42.9%, 15.6% and 41.5% died of EC, other cancers and non-cancer causes, respectively. As the diagnosis time increased, the number of EC-associated mortalities gradually decreased. The most common non-cancer causes of death were heart disease, cerebrovascular disease and diabetes. Regarding the general population of the United States, patients with EC died of heart disease (SMR: 1.06; 95% confidence interval [CI]: 1.03-1.09), diabetes (SMR: 1.56; 95% CI: 1.47-1.65) and septicaemia (SMR: 1.40; 95% CI: 1.28-1.52), which were statistically significant. Conclusions: For patients with EC, the number of deaths from non-cancer causes (mainly heart disease, cerebrovascular disease and diabetes mellitus) is equivalent to that of EC. In addition, compared with the general population, EC survivors have a higher risk of death from sepsis and diabetes. These discoveries support how survivors can avoid future-related health risks. By doing this, clinicians can improve the quality of life and chances of the survival of patients with EC.
MeSH term(s)	Female ; Humans ; United States/epidemiology ; Cause of Death ; Quality of Life ; Endometrial Neoplasms/epidemiology ; Survivors ; Risk Factors ; Heart Diseases ; Diabetes Mellitus ; Cerebrovascular Disorders
Language	English
Publishing date	2023-03-16
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2659751-2
ISSN	2045-7634 ; 2045-7634
ISSN (online)	2045-7634
ISSN	2045-7634
DOI	10.1002/cam4.5804
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