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  1. Book: Bioimage analysis linking information at protein and transcriptional level in tissues

    Köhler, Ralf

    2024  

    Abstract: Biobildanalyse, die Informationen auf Protein- und Transkriptionsebene in Geweben verknüpft" -- -- Die optische Auflösung des menschlichen Auges ist begrenzt. Deshalb wurden Mikroskope erfunden, um die Beobachtung kleinerer Objekte durch eine bestimmte ... ...

    Abstract "Biobildanalyse, die Informationen auf Protein- und Transkriptionsebene in Geweben verknüpft" -- -- Die optische Auflösung des menschlichen Auges ist begrenzt. Deshalb wurden Mikroskope erfunden, um die Beobachtung kleinerer Objekte durch eine bestimmte Anordnung optischer Komponenten sowie die Untersuchung biologischer Prozesse im Hinblick auf Krankheit oder Behandlung zu ermöglichen. Mit Hilfe des Auges des Mikroskops, der Kamera, können Bilder von verschiedenen Gewebefärbungen digitalisie...
    Keywords Gewebeprotein ; biology ; Transkription ; Biologie ; fluorescence ; Gewebe ; Fluoreszenz ; gene expression ; Genexpression ; medizinische Daten ; tissue protein ; transcription ; tissues ; medical records ; histology ; Histologie
    Language English
    Size 182 p.
    Edition 1
    Publisher Mensch und Buch
    Document type Book
    Note Hochschulschriften Medizin
    Format 148 x 210
    ISBN 9783967292367 ; 3967292363
    Database PDA

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  2. Book ; Online ; Thesis: Bioimage analysis linking information at protein and transcriptional level in tissues

    Köhler, Ralf [Verfasser]

    2024  

    Author's details Ralf Köhler
    Keywords Landwirtschaft, Veterinärmedizin ; Agriculture, Veterinary Science
    Subject code sg630
    Language English
    Publisher Freie Universität Berlin
    Publishing place Berlin
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  3. Article: Editorial: Mitochondria as a hub for neurodegenerative disorders.

    Kohler, Verena / Braun, Ralf J / Aufschnaiter, Andreas

    Frontiers in molecular neuroscience

    2023  Volume 16, Page(s) 1147468

    Language English
    Publishing date 2023-02-06
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2452967-9
    ISSN 1662-5099
    ISSN 1662-5099
    DOI 10.3389/fnmol.2023.1147468
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  4. Book ; Thesis: Zum Zusammenhang zwischen den Gehalten an Selen und anderen Spurenelementen in Blut, Gewebe und dem Colorektalkarzinom

    Köhler, Ralf

    1994  

    Author's details vorgelegt von Ralf Köhler
    Language German
    Size 77 S. : graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Aachen, Techn. Hochsch., Diss., 1994
    HBZ-ID HT006350319
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    94 D 3506 order for loan Magazin

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  5. Article ; Online: Determination of the Spatial Resolution in the Case of Imaging Magnetic Fields by Polarized Neutrons

    Wolfgang Treimer / Ralf Köhler

    Applied Sciences, Vol 11, Iss 6973, p

    2021  Volume 6973

    Abstract: One of the most important parameters characterizing imaging systems (neutrons, X-rays, etc.) is their spatial resolution. In magnetic field imaging, the spatial resolution depends on the (magnetic) resolution of the depolarization of spin-polarized ... ...

    Abstract One of the most important parameters characterizing imaging systems (neutrons, X-rays, etc.) is their spatial resolution. In magnetic field imaging, the spatial resolution depends on the (magnetic) resolution of the depolarization of spin-polarized neutrons. This should be realized by different methods, but they all have in common that a spin-polarizing and spin-analyzing system is part of the resolution function. First a simple and useful method for determining the spatial resolution for unpolarized neutrons is presented, and then methods in the case of imaging with polarized neutrons. Spatial resolution in the case of polarized neutron imaging is fundamentally different from ‘classical’ spatial resolution. Because of <math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mi>π</mi></semantics></math> -periodicity, the shortest path along which a spin-flip can occur is a measure of ‘magnetic’ spatial resolution. Conversely, the largest detectable magnetic field (B-field) within a given path length is also a measure of magnetic spatial resolution. This refers to the spatial resolution in the flight direction of the neutrons ( <math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mo>Δ</mo><mi>y</mi></mrow></semantics></math> ). The <math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mo>Δ</mo><mi>x</mi></mrow></semantics></math> and <math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mo>Δ</mo><mi>z</mi></mrow></semantics></math> refers to the spatial resolution in x- or z-direction; however, in these cases a different method must be used. Therefore, two independent methods are used to distinguish longitudinal and lateral spatial resolution, one method to determine the modulation transfer ...
    Keywords neutron imaging ; polarized neutrons ; magnetic fields ; spatial resolution ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
    Subject code 530
    Language English
    Publishing date 2021-07-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
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  6. Article ; Online: How water desorbs from calcite.

    Dickbreder, Tobias / Lautner, Dirk / Köhler, Antonia / Klausfering, Lea / Bechstein, Ralf / Kühnle, Angelika

    Physical chemistry chemical physics : PCCP

    2023  Volume 25, Issue 18, Page(s) 12694–12701

    Abstract: Calcite is the most abundant carbonate mineral in Earth's crust. Upon cleavage, the (10.4) plane with a rectangular unit cell is exposed. Interestingly, several experiments suggest a (2 × 1) surface reconstruction. However, clear experimental evidence ... ...

    Abstract Calcite is the most abundant carbonate mineral in Earth's crust. Upon cleavage, the (10.4) plane with a rectangular unit cell is exposed. Interestingly, several experiments suggest a (2 × 1) surface reconstruction. However, clear experimental evidence and a theoretical confirmation were long missing. Recently, convincing indication for a (2 × 1) reconstruction has been given by atomic force microscopies taken at 5 K. Here, we show temperature-programmed desorption (TPD) experiments of water and ethanol desorbing from calcite (10.4) around room temperature. The TPD curves fit excellently to a kinetic model considering two different adsorption sites, as expected in case of a (2 × 1) reconstruction. This finding applies to the desorption of water and ethanol, illustrating that the effect is characteristic for the calcite cleavage plane. Our results thus show that the (2 × 1) reconstruction not only exists at room temperature but has significant impact on the interfacial properties of calcite.
    Language English
    Publishing date 2023-05-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 1476244-4
    ISSN 1463-9084 ; 1463-9076
    ISSN (online) 1463-9084
    ISSN 1463-9076
    DOI 10.1039/d3cp01159c
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  7. Book ; Online: How do different pathways connect the stratospheric polar vortex to its tropospheric precursors?

    Köhler, Raphael Harry / Jaiser, Ralf / Handorf, Dörthe

    eISSN: 2698-4016

    2023  

    Abstract: Processes involving troposphere–stratosphere coupling have been identified as important contributors to an improved subseasonal to seasonal prediction in the mid-latitudes. However, atmosphere models still struggle to accurately predict stratospheric ... ...

    Abstract Processes involving troposphere–stratosphere coupling have been identified as important contributors to an improved subseasonal to seasonal prediction in the mid-latitudes. However, atmosphere models still struggle to accurately predict stratospheric extreme events. Based on a novel approach in this study, we use ERA5 reanalysis data and ensemble simulations with the ICOsahedral Non-hydrostatic atmospheric model (ICON) to investigate tropospheric precursor patterns, localised troposphere–stratosphere coupling mechanisms, and the involved timescales of these processes in the Northern Hemisphere extended winter. We identify two precursor regions: mean sea level pressure in the Ural region is negatively correlated with the strength of the stratospheric polar vortex for the following 5–55 d with a maximum at 25–45 d, and the pressure in the extended Aleutian region is positively correlated with the strength of the stratospheric polar vortex the following 10–50 d with a maximum at 20–30 d. A simple precursor index based on the mean pressure difference of these two regions is very strongly linked to the strength of the stratospheric polar vortex in the following month. The pathways connecting these two regions to the strength of the stratospheric polar vortex, however, differ from one another. Whereas a vortex weakening can be connected to prior increased vertical planetary wave forcing due to high-pressure anomalies in the Ural region, the pathway for the extended Aleutian region is less straightforward. A low-pressure anomaly in this region can trigger a Pacific–North American-related (PNA-related) pattern, leading to geopotential anomalies of the opposite sign in the mid-troposphere over central North America. This positive geopotential anomaly travels upward and westward in time, directly penetrating into the stratosphere and thereby strengthening the stratospheric Aleutian High, a pattern linked to the displacement towards Eurasia and subsequent weakening of the stratospheric polar vortex. Overall, this study ...
    Subject code 551
    Language English
    Publishing date 2023-12-06
    Publishing country de
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Conference proceedings: Patient-Reported Outcome in der orthopädischen Rehabilitation

    Köhler, Matthias / Bürgy, Ralf / Wiederer, Ralf / Schulz, Holger

    2020  , Page(s) 20dkvf136

    Event/congress 19. Deutscher Kongress für Versorgungsforschung (DKVF); sine loco [digital]; Deutsches Netzwerk Versorgungsforschung; 2020
    Keywords Medizin, Gesundheit
    Publishing date 2020-09-25
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/20dkvf136
    Database German Medical Science

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  9. Conference proceedings: CAFOGES – Klimaneutralität im Gesundheitswesen: fallstudiengestützte Carbon-footprint-Bewertung eines Universitätsklinikums nach ‚Greenhouse Gas Protocol‘

    Maun, Andy / Terres, Leonard / Ellensohn, Johanna / Liu, Ran / Köhler, Andreas Ralf

    2023  , Page(s) V–23–03

    Event/congress 57. Kongress für Allgemeinmedizin und Familienmedizin; Berlin; Deutsche Gesellschaft für Allgemeinmedizin und Familienmedizin; 2023
    Keywords Medizin, Gesundheit
    Publishing date 2023-09-27
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/23degam133
    Database German Medical Science

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  10. Article ; Online: Heavy metal to lower the pressure?

    Köhler, Ralf

    Cardiovascular research

    2012  Volume 95, Issue 1, Page(s) 3–4

    MeSH term(s) Animals ; Arteries/physiology ; Humans ; Large-Conductance Calcium-Activated Potassium Channels/drug effects ; Magnesium/physiology ; Male ; Tungsten Compounds/pharmacology ; Vasodilation/drug effects
    Chemical Substances Large-Conductance Calcium-Activated Potassium Channels ; Tungsten Compounds ; Magnesium (I38ZP9992A) ; tungstate (SW0Y0WQ46I)
    Language English
    Publishing date 2012-07-01
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1093/cvr/cvs169
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