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Book ; Thesis: Stickstoffmonoxidkontamination von Lachgas und komprimierter Luft und deren Auswirkungen auf den Lungenkreislauf

Kruse, Jan Matthias

2001

Author's details	vorgelegt von Jan Matthias Kruse
Language	German
Size	91 Bl., graph. Darst., 29 cm
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Essen, Univ., Diss., 2002 (Nicht für den Austausch)
HBZ-ID	HT013364496
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: Is the routine use of antipseudomonal antibiotics in acutely exacerbated COPD patients indicated: A retrospective analysis in 437 ICU patients.

Schroeder, Tim / Kruse, Jan Matthias / Marcy, Florian / Piper, Sophie K / Storm, Christian / Nee, Jens

Journal of critical care

2021 Volume 65, Page(s) 49–55

Abstract: Purpose: Chronic obstructive pulmonary disease (COPD) is a risk factor for acquiring multiple drug resistant bacteria. The main objective of this analysis was to question a beneficial outcome in the routine use of antipseudomonal antibiotics in the ... ...

Abstract	Purpose: Chronic obstructive pulmonary disease (COPD) is a risk factor for acquiring multiple drug resistant bacteria. The main objective of this analysis was to question a beneficial outcome in the routine use of antipseudomonal antibiotics in the empiric treatment of severe AECOPD in Intensive Care Unit patients. Material and methods: We report a retrospective, observational cohort study in adult patients with severe AECOPD admitted to ICU at a tertiary care university hospital. Antibiotic treatment on admission as well as microbiology samples were analyzed. The influence of SOFA score at admission, age, sex and antibiotic choice upon survival was investigated by multivariable analysis. Results: 437 patients were included. Mean age was 68 years (±10), 46.5% were female. 271/437 patients (62%) were initially treated with antibiotics covering Pseudomonas aeruginosa. Overall, positive microbiology samples were found in 107 patients (24.5%). P. aeruginosa was only found in 3.7%. There was no significant difference in 30-day ICU mortality after adjusting for age, sex and severity of illness (20.4% ± 11.6 in patients with Pseudomonas inactive antibiotics versus 29.3% ± 10.8 in patients with PAA, p=0.113). Conclusions: Empiric use of antipseudomonal antibiotics did not result in improved ICU survival in this retrospective analysis.
MeSH term(s)	Adult ; Aged ; Anti-Bacterial Agents/therapeutic use ; Female ; Humans ; Intensive Care Units ; Pseudomonas aeruginosa ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Retrospective Studies
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2021-05-24
Publishing country	United States
Document type	Journal Article ; Observational Study
ZDB-ID	632818-0
ISSN	1557-8615 ; 0883-9441
ISSN (online)	1557-8615
ISSN	0883-9441
DOI	10.1016/j.jcrc.2021.05.012
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Article ; Conference proceedings: The oral microbiome and its association with taste perception and nutritional patterns after a structured non-surgical weight-loss intervention or bariatric surgery

Schlicht, Kristina / Rabe, Lisa / Griese, Lena / Knappe, Carina / Beckmann, Alexia / Wietzke-Braun, Perdita / Seoudy, Anna Katharina / Rohmann, Nathalie / Kruse, Lucy / Hartmann, Katharina / Geisler, Corinna / Settgast, Ute / Türk, Kathrin / Schulte, Dominik M. / Hollstein, Tim / Beckmann, Jan Henrik / Laudes, Matthias

Diabetologie und Stoffwechsel

(Diabetes Kongress 2024 – 58. Jahrestagung der DDG)

2024 Volume 19, Issue S 01

Event/congress	Diabetes. Umwelt. Leben. Perspektiven aus allen Blickwinkeln, CityCube Berlin, 2024-05-08
Series title	Diabetes Kongress 2024 – 58. Jahrestagung der DDG
Language	German
Publishing date	2024-04-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	2222993-0
ISSN	1861-9010 ; 1861-9002
ISSN (online)	1861-9010
ISSN	1861-9002
DOI	10.1055/s-0044-1785270
Database	Thieme publisher's database

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Zs.A 6479: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.A 6479/X: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)

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Article ; Conference proceedings: Changes in taste sensitivity and eating patterns after a structured non-surgical weight-loss intervention or bariatric surgery.

Griese, Lena / Schlicht, Kristina / Rabe, Lisa / Knappe, Carina / Beckmann, Alexia / Wietzke-Braun, Perdita / Seoudy, Anna Katharina / Rohmann, Nathalie / Kruse, Lucy / Hartmann, Katharina / Geisler, Corinna / Settgast, Ute / Türk, Kathrin / Schulte, Dominik M. / Hollstein, Tim / Beckmann, Jan Henrik / Laudes, Matthias

Diabetologie und Stoffwechsel

(Diabetes Kongress 2024 – 58. Jahrestagung der DDG)

2024 Volume 19, Issue S 01

Event/congress	Diabetes. Umwelt. Leben. Perspektiven aus allen Blickwinkeln, CityCube Berlin, 2024-05-08
Series title	Diabetes Kongress 2024 – 58. Jahrestagung der DDG
Language	German
Publishing date	2024-04-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	2222993-0
ISSN	1861-9010 ; 1861-9002
ISSN (online)	1861-9010
ISSN	1861-9002
DOI	10.1055/s-0044-1785372
Database	Thieme publisher's database

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Zs.A 6479: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.A 6479/X: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Use of Hemoadsorption in Patients With Severe Intoxication Requiring Extracorporeal Cardiopulmonary Support-A Case Series.

Zickler, Daniel / Nee, Jens / Arnold, Tim / Schröder, Tim / Slowinski, Torsten / Eckardt, Kai-Uwe / Körner, Roland / Kruse, Jan Matthias

ASAIO journal (American Society for Artificial Internal Organs : 1992)

2021 Volume 67, Issue 11, Page(s) e186–e190

Abstract: Drugs intoxications often lead to severe vasoplegia and cardiogenic shock, and VA-ECMO represents a viable therapy option. However, as cardiopulmonary support is not contributing to the removal of the causal agent from the blood, detoxification by a new ... ...

Abstract	Drugs intoxications often lead to severe vasoplegia and cardiogenic shock, and VA-ECMO represents a viable therapy option. However, as cardiopulmonary support is not contributing to the removal of the causal agent from the blood, detoxification by a new hemoadsorption device (CytoSorb) could represent a potential therapeutic tool due to its highly efficient elimination capacity of endogenous but also exogenous hydrophobic substances for which otherwise no effective antidote exist. In this case series, four anecdotal cases of acute intoxications requiring VA-ECMO support used as extracorporeal cardiopulmonary resuscitation after intoxication-induced out-of-hospital cardiac arrest (OHCA) are presented, who were additionally treated with CytoSorb hemoadsorption in combination with renal replacement therapy. Combined treatment was associated with a considerable decrease in plasma levels of the overdosed drugs. Additionally, the combination of applied techniques was safe, practical, and technically feasible with no adverse or any device-related side effects documented during or after the treatment sessions. Based on the reported dramatic decline in drug levels during treatment, that fits in the device's characteristics, we strongly suggest to further investigate the potentially lifesaving role of CytoSorb therapy in patients with acute intoxications requiring multiple organ support techniques.
MeSH term(s)	Cardiopulmonary Resuscitation ; Combined Modality Therapy ; Extracorporeal Membrane Oxygenation/adverse effects ; Humans ; Shock, Cardiogenic/chemically induced ; Shock, Cardiogenic/therapy
Language	English
Publishing date	2021-02-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	759982-1
ISSN	1538-943X ; 0162-1432 ; 1058-2916
ISSN (online)	1538-943X
ISSN	0162-1432 ; 1058-2916
DOI	10.1097/MAT.0000000000001362
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Zs.B 2435: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Future unmet medical need as a guiding principle for pharmaceutical R&D.

Vennemann, Matthias / Ruland, Vincent / Kruse, Jan-Philip / Harloff, Christine / Trübel, Hubert / Gielen-Haertwig, Heike

Drug discovery today

2019 Volume 24, Issue 9, Page(s) 1924–1929

Abstract: In pharmaceutical R&D the strategic focus is on addressing areas of high unmet medical need. 'Unmet medical need' is a widely used term in the healthcare sector but a common definition does not exist. The current standard of care determines the current ... ...

Abstract	In pharmaceutical R&D the strategic focus is on addressing areas of high unmet medical need. 'Unmet medical need' is a widely used term in the healthcare sector but a common definition does not exist. The current standard of care determines the current unmet medical need, whereas the future unmet medical need (i.e., the unmet medical need when a new product reaches the market) and the extent to which the unmet need is addressed by the new product significantly impact its value. We have defined six dimensions as key drivers of (future) unmet medical needs of patients in a given setting. In the absence of quantifiable criteria, structured expert assessment techniques, such as the Delphi method, can guide portfolio strategies, especially for early-stage assets.
MeSH term(s)	Health Services Needs and Demand ; Humans ; Pharmaceutical Research
Language	English
Publishing date	2019-06-21
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1324988-5
ISSN	1878-5832 ; 1359-6446
ISSN (online)	1878-5832
ISSN	1359-6446
DOI	10.1016/j.drudis.2019.06.004
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Article: Successful aspiration thrombectomy in a patient with submassive, intermediate-risk pulmonary embolism following COVID-19 pneumonia.

Pohlan, Julian / Kamel, Sarah Nadine / Torsello, Giovanni Federico / Zickler, Daniel / Kruse, Jan Matthias / Eckardt, Kai-Uwe / Gebauer, Bernard

Radiology case reports

2020 Volume 15, Issue 10, Page(s) 1764–1768

Abstract: A 64-year-old female patient presented with severe dyspnea shortly after apparent recovery from COVID-19 disease. Chest computed tomography revealed central pulmonary embolism and ultrasonography showed a deep vein thrombosis of her right leg. The ... ...

Abstract	A 64-year-old female patient presented with severe dyspnea shortly after apparent recovery from COVID-19 disease. Chest computed tomography revealed central pulmonary embolism and ultrasonography showed a deep vein thrombosis of her right leg. The patient was tachycardiac with evidence of right ventricular strain on echocardiography. An interdisciplinary decision for interventional therapy was made. Angiographic aspiration thrombectomy resulted in a significant reduction of thrombus material and improved flow in the pulmonary arteries and immediate marked clinical improvement and subsequent normalization of functional echocardiographic parameters. This case adds to the emerging evidence for severe thromboembolic complications following COVID-19 and suggests aspiration thrombectomy can be considered in pulmonary embolism of intermediate risk.
Keywords	covid19
Language	English
Publishing date	2020-07-16
Publishing country	Netherlands
Document type	Case Reports
ZDB-ID	2406300-9
ISSN	1930-0433
ISSN	1930-0433
DOI	10.1016/j.radcr.2020.07.028
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Article ; Online: Hepatobiliary long-term consequences of COVID-19: dramatically increased rate of secondary sclerosing cholangitis in critically ill COVID-19 patients.

Hepatology international

2023 Volume 17, Issue 6, Page(s) 1610–1625

Abstract: Background: Increasing evidence suggests that secondary sclerosing cholangitis (SSC), which can lead to cirrhosis or liver failure, may be a hepatobiliary long-term complication of COVID-19. The aim of this study was to estimate the frequency and ... ...

Abstract	Background: Increasing evidence suggests that secondary sclerosing cholangitis (SSC), which can lead to cirrhosis or liver failure, may be a hepatobiliary long-term complication of COVID-19. The aim of this study was to estimate the frequency and outcome of this COVID-19 sequela and to identify possible risk factors. Methods: This observational study, conducted at University Hospital Charité Berlin and Unfallkrankenhaus Berlin, Germany, involved hospitalized patients with COVID-19 pneumonia, including 1082 ventilated COVID-19 patients. We compared COVID-19 patients who developed SSC with a COVID-19 control group by univariate and multivariate analyses. Results: SSC occurrence after COVID-19 was observed exclusively in critically ill patients with invasive ventilation, albeit with extreme clustering among them. One in every 43 invasively ventilated COVID-19 patients developed this complication. Risk factors preceding the development of secondary sclerosing cholangitis in critically ill COVID-19 patients (SSC-CIP) were signs of systemic reduced blood oxygen supply (e.g., low PaO Conclusions: COVID-19 causes SSC-CIP in a substantial proportion of critically ill patients. SSC-CIP most likely develops due to severe tissue hypoxia and fibrinogen-associated circulatory disturbances. A significant increase of patients with SSC-CIP is to be expected in the post-COVID era.
MeSH term(s)	Humans ; Cholangitis, Sclerosing/complications ; Cholangitis, Sclerosing/therapy ; Critical Illness ; COVID-19/complications ; Liver Cirrhosis/complications ; Fibrinogen
Chemical Substances	Fibrinogen (9001-32-5)
Language	English
Publishing date	2023-04-29
Publishing country	United States
Document type	Observational Study ; Journal Article
ZDB-ID	2270316-0
ISSN	1936-0541 ; 1936-0533
ISSN (online)	1936-0541
ISSN	1936-0533
DOI	10.1007/s12072-023-10521-0
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Article ; Online: Viscoelastic testing reveals normalization of the coagulation profile 12 weeks after severe COVID-19.

Magomedov, Abakar / Zickler, Daniel / Karaivanov, Stoyan / Kurreck, Annika / Münch, Frédéric H / Kamhieh-Milz, Julian / Ferse, Caroline / Kahl, Andreas / Piper, Sophie K / Eckardt, Kai-Uwe / Dörner, Thomas / Kruse, Jan Matthias

Scientific reports

2021 Volume 11, Issue 1, Page(s) 13325

Abstract: COVID 19 is associated with a hypercoagulable state and frequent thromboembolic complications. For how long this acquired abnormality lasts potentially requiring preventive measures, such as anticoagulation remains to be delineated. We used viscoelastic ... ...

Abstract	COVID 19 is associated with a hypercoagulable state and frequent thromboembolic complications. For how long this acquired abnormality lasts potentially requiring preventive measures, such as anticoagulation remains to be delineated. We used viscoelastic rotational thrombelastometry (ROTEM) in a single center cohort of 13 critical ill patients and performed follow up examinations three months after discharge from ICU. We found clear signs of a hypercoagulable state due to severe hypofibrinolysis and a high rate of thromboembolic complications during the phase of acute illness. Three month follow up revealed normalization of the initial coagulation abnormality and no evidence of venous thrombosis in all thirteen patients. In our cohort the coagulation profile was completely normalized three months after COVID-19. Based on these findings, discontinuation of anticoagulation can be discussed in patients with complete venous reperfusion.
MeSH term(s)	Aged ; Anticoagulants/therapeutic use ; Blood Coagulation ; Blood Coagulation Disorders/drug therapy ; Blood Coagulation Disorders/pathology ; COVID-19/blood ; COVID-19/pathology ; Cohort Studies ; Female ; Humans ; Male ; Middle Aged ; Severity of Illness Index ; Thrombelastography ; Thromboembolism/drug therapy ; Thromboembolism/pathology ; Venous Thrombosis/drug therapy ; Venous Thrombosis/pathology ; COVID-19 Drug Treatment
Chemical Substances	Anticoagulants
Language	English
Publishing date	2021-06-25
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-92683-1
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Article ; Online: Evidence for a thromboembolic pathogenesis of lung cavitations in severely ill COVID-19 patients.

Kruse, Jan Matthias / Zickler, Daniel / Lüdemann, Willie M / Piper, Sophie K / Gotthardt, Inka / Ihlow, Jana / Greuel, Selina / Horst, David / Kahl, Andreas / Eckardt, Kai-Uwe / Elezkurtaj, Sefer

Scientific reports

2021 Volume 11, Issue 1, Page(s) 16039

Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing coronavirus disease 2019 (COVID-19) induces lung injury of varying severity, potentially causing severe acute respiratory distress syndrome (ARDS). Pulmonary injury patterns in COVID-19 ...

Abstract	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing coronavirus disease 2019 (COVID-19) induces lung injury of varying severity, potentially causing severe acute respiratory distress syndrome (ARDS). Pulmonary injury patterns in COVID-19 patients differ from those in patients with other causes of ARDS. We aimed to explore the frequency and pathogenesis of cavitary lung lesions in critically ill patients with COVID-19. Retrospective study in 39 critically ill adult patients hospitalized with severe acute respiratory syndrome coronavirus 2 including lung injury of varying severity in a tertiary care referral center during March and May 2020, Berlin/Germany. We observed lung cavitations in an unusually large proportion of 22/39 (56%) COVID-19 patients treated on intensive care units (ICU), including 3/5 patients without mechanical ventilation. Median interquartile range (IQR) time between onset of symptoms and ICU admission was 11.5 (6.25-17.75) days. In 15 patients, lung cavitations were already present on the first CT scan, performed after ICU admission; in seven patients they developed during a subsequent median (IQR) observation period of 48 (35-58) days. In seven patients we found at least one cavitation with a diameter > 2 cm (maximum 10 cm). Patients who developed cavitations were older and had a higher body mass index. Autopsy findings in three patients revealed that the cavitations reflected lung infarcts undergoing liquefaction, secondary to thrombotic pulmonary artery branch occlusions. Lung cavitations appear to be a frequent complication of severely ill COVID-19 patients, probably related to the prothrombotic state associated with COVID-19.
MeSH term(s)	Aged ; COVID-19/complications ; COVID-19/pathology ; Critical Illness ; Female ; Humans ; Intensive Care Units ; Lung/pathology ; Male ; Middle Aged ; Pulmonary Embolism/etiology ; Pulmonary Embolism/pathology ; Retrospective Studies ; SARS-CoV-2/isolation & purification
Language	English
Publishing date	2021-08-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-95694-0
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