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Article ; Online: An elusive debate on the evidence for RNA editing in SARS-CoV-2.

Mattiuz, Giorgio / Di Giorgio, Salvatore / Conticello, Silvestro G

2024 Volume 21, Issue 1, Page(s) 1–2

MeSH term(s)	Humans ; SARS-CoV-2/genetics ; RNA Editing ; COVID-19 ; RNA, Viral/genetics
Chemical Substances	RNA, Viral
Language	English
Publishing date	2024-03-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2159587-2
ISSN	1555-8584 ; 1555-8584
ISSN (online)	1555-8584
ISSN	1555-8584
DOI	10.1080/15476286.2024.2321032
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Article ; Online: Pediatric Gastroenterology and Hepatology in Italy before and after the COVID-19: Lessons learned and management changes by SIGENP.

Dipasquale, Valeria / Deganello Saccomani, Marco / Di Giorgio, Angelo / Oliva, Salvatore / Salvatore, Silvia / Strisciuglio, Caterina / Tambucci, Renato / Lionetti, Paolo / Romano, Claudio

Italian journal of pediatrics

2023 Volume 49, Issue 1, Page(s) 15

Abstract: Around the world, the 2019 Coronavirus disease (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has raised serious public health problems and major medical challenges. The Italian Society of Pediatric ... ...

Abstract	Around the world, the 2019 Coronavirus disease (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has raised serious public health problems and major medical challenges. The Italian Society of Pediatric Gastroenterology, Hepatology and Nutrition (SIGENP) published several papers on the impact of COVID-19 on the current management, diagnosis, and treatment of acute and chronic gastrointestinal, hepatic, immune-mediated, and functional disorders. The present article summarizes the most relevant SIGENP reports and consensus during and after the peak of the COVID-19 outbreak, including the diagnosis and treatment of inflammatory bowel disease (IBD), indications and timing of digestive endoscopy, and insights into the novel hepatitis.
MeSH term(s)	Child ; Humans ; Gastroenterology ; SARS-CoV-2 ; COVID-19 ; Italy/epidemiology ; Liver Diseases/diagnosis ; Liver Diseases/epidemiology ; Liver Diseases/therapy ; Inflammatory Bowel Diseases/therapy
Language	English
Publishing date	2023-01-26
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2088556-8
ISSN	1824-7288 ; 1720-8424
ISSN (online)	1824-7288
ISSN	1720-8424
DOI	10.1186/s13052-023-01418-7
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Article ; Online: Food Beliefs and the Risk of Orthorexia in Patients with Inflammatory Bowel Disease.

Di Giorgio, Francesca Maria / Modica, Stefania Pia / Saladino, Marica / Muscarella, Stefano / Ciminnisi, Stefania / Almasio, Piero Luigi / Petta, Salvatore / Cappello, Maria

Nutrients

2024 Volume 16, Issue 8

Abstract: Patients with inflammatory bowel disease (IBD) believe that diet plays a significant role in the pathogenesis of their disease and the exacerbation of their symptoms. They often adopt restrictive diets that can lead to malnutrition, anxiety, and stress. ... ...

Abstract	Patients with inflammatory bowel disease (IBD) believe that diet plays a significant role in the pathogenesis of their disease and the exacerbation of their symptoms. They often adopt restrictive diets that can lead to malnutrition, anxiety, and stress. Recent studies have found a correlation between IBD and eating disorders, such as anorexia nervosa and ARFID (Avoidant Restrictive Food Intake Disorder). None of these studies report an association with orthorexia nervosa, which is an obsession with healthy and natural foods. The aim of this study was to assess the risk of orthorexia nervosa in patients with IBD. A total of 158 consecutive subjects were recruited, including 113 patients with IBD and 45 controls. The standardized Donini questionnaire ORTO-15 was administered to assess the risk of orthorexia, and clinical and demographic data were collected. The results showed that patients with IBD had a risk of developing orthorexia nervosa of 77%. This was significantly higher than the 47% observed in the control group. In the patients with IBD, the risk of orthorexia was associated with a lower BMI, at least in patients older than 30 years, and it was also associated with marital status in patients younger than 30. In conclusion, many patients with IBD are at increased risk of developing orthorexia nervosa, which may have a negative impact on their psychological wellbeing and social sphere, expose them to a high risk of nutritional deficiencies, and affect their overall quality of life. Further high-quality studies are needed to assess the clinical impact of orthorexia and its correlation with clinical features and classified eating disorders.
MeSH term(s)	Humans ; Female ; Male ; Adult ; Inflammatory Bowel Diseases/psychology ; Feeding and Eating Disorders/psychology ; Middle Aged ; Surveys and Questionnaires ; Risk Factors ; Young Adult ; Feeding Behavior/psychology ; Diet/psychology ; Body Mass Index ; Case-Control Studies ; Avoidant Restrictive Food Intake Disorder ; Diet, Healthy/psychology
Language	English
Publishing date	2024-04-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu16081193
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Article ; Online: The "Great Lockdown" and cultural consumption in the UK.

Bakhshi, Hasan / Di Novo, Salvatore / Fazio, Giorgio

Journal of cultural economics

2022 , Page(s) 1–33

Abstract: In this paper, we exploit a unique weekly longitudinal survey of adults in the UK purposefully collected to study consumption choices with respect to cultural content types during the first Covid-19 national lockdown (the "Great Lockdown"). We look for ... ...

Abstract	In this paper, we exploit a unique weekly longitudinal survey of adults in the UK purposefully collected to study consumption choices with respect to cultural content types during the first Covid-19 national lockdown (the "Great Lockdown"). We look for changes in the probability of consuming different cultural and creative types of content (Music, Movies, TV, Games, Books, Magazines and Audiobooks), as well as changes in the overall variety of consumption. We find that changes in consumption depend on the type of content. In particular, other things being equal, the likelihood of listening to Music and playing Games went up and the likelihood of reading Books went down. We find little statistically significant evidence of changes in the probability of consumption of the other types of content. We find that, while on average individuals increased the variety of their consumption, the statistical significance of this increase varied depending on the socio-demographic and economic characteristic of interest. In particular, we find evidence of an increase in the variety of consumption for those at the bottom of the distribution of socio-economic status, which speaks to the importance of access to culture and creativity during lockdown for this specific social class.
Language	English
Publishing date	2022-11-17
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1478693-X
ISSN	1573-6997 ; 0885-2545
ISSN (online)	1573-6997
ISSN	0885-2545
DOI	10.1007/s10824-022-09463-6
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Article ; Online: Precise and efficient C-to-U RNA base editing with SNAP-CDAR-S.

Latifi, Ngadhnjim / Mack, Aline Maria / Tellioglu, Irem / Di Giorgio, Salvatore / Stafforst, Thorsten

Nucleic acids research

2023 Volume 51, Issue 15, Page(s) e84

Abstract: Site-directed RNA base editing enables the transient and dosable change of genetic information and represents a recent strategy to manipulate cellular processes, paving ways to novel therapeutic modalities. While tools to introduce adenosine-to-inosine ... ...

Abstract	Site-directed RNA base editing enables the transient and dosable change of genetic information and represents a recent strategy to manipulate cellular processes, paving ways to novel therapeutic modalities. While tools to introduce adenosine-to-inosine changes have been explored quite intensively, the engineering of precise and programmable tools for cytidine-to-uridine editing is somewhat lacking behind. Here we demonstrate that the cytidine deaminase domain evolved from the ADAR2 adenosine deaminase, taken from the RESCUE-S tool, provides very efficient and highly programmable editing when changing the RNA targeting mechanism from Cas13-based to SNAP-tag-based. Optimization of the guide RNA chemistry further allowed to dramatically improve editing yields in the difficult-to-edit 5'-CCN sequence context thus improving the substrate scope of the tool. Regarding editing efficiency, SNAP-CDAR-S outcompeted the RESCUE-S tool clearly on all tested targets, and was highly superior in perturbing the β-catenin pathway. NGS analysis showed similar, moderate global off-target A-to-I and C-to-U editing for both tools.
MeSH term(s)	RNA/genetics ; RNA/metabolism ; Base Sequence ; Gene Editing ; RNA Editing/genetics ; Adenosine Deaminase/metabolism
Chemical Substances	RNA (63231-63-0) ; Adenosine Deaminase (EC 3.5.4.4)
Language	English
Publishing date	2023-07-17
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	186809-3
ISSN	1362-4962 ; 1362-4954 ; 0301-5610 ; 0305-1048
ISSN (online)	1362-4962 ; 1362-4954
ISSN	0301-5610 ; 0305-1048
DOI	10.1093/nar/gkad598
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Zs.A 1067: Show issues

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Article: Correction to "An Unexpected Deuterium-Induced Metabolic Switch in Doxophylline".

Aprile, Silvio / Colombo, Giorgia / Serafini, Marta / Di Paola, Rosanna / Pisati, Federica / Bhela, Irene Preet / Cuzzocrea, Salvatore / Grosa, Giorgio / Pirali, Tracey

ACS medicinal chemistry letters

2023 Volume 14, Issue 12, Page(s) 1891–1892

Abstract: This corrects the article DOI: 10.1021/acsmedchemlett.2c00166.]. ...

Abstract	[This corrects the article DOI: 10.1021/acsmedchemlett.2c00166.].
Language	English
Publishing date	2023-11-27
Publishing country	United States
Document type	Published Erratum
ISSN	1948-5875
ISSN	1948-5875
DOI	10.1021/acsmedchemlett.3c00497
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Article ; Online: Streamlining Large Chemical Library Docking with Artificial Intelligence: the PyRMD2Dock Approach.

Roggia, Michele / Natale, Benito / Amendola, Giorgio / Di Maro, Salvatore / Cosconati, Sandro

Journal of chemical information and modeling

2023 Volume 64, Issue 7, Page(s) 2143–2149

Abstract: The present contribution introduces a novel computational protocol called PyRMD2Dock, which combines the Ligand-Based Virtual Screening (LBVS) tool PyRMD with the popular docking software AutoDock-GPU (AD4-GPU) to enhance the throughput of virtual ... ...

Abstract	The present contribution introduces a novel computational protocol called PyRMD2Dock, which combines the Ligand-Based Virtual Screening (LBVS) tool PyRMD with the popular docking software AutoDock-GPU (AD4-GPU) to enhance the throughput of virtual screening campaigns for drug discovery. By implementing PyRMD2Dock, we demonstrate that it is possible to rapidly screen massive chemical databases and identify those with the highest predicted binding affinity to a target protein. Our benchmarking and screening experiments illustrate the predictive power and speed of PyRMD2Dock and highlight its potential to accelerate the discovery of novel drug candidates. Overall, this study showcases the value of combining AI-powered LBVS tools with docking software to enable effective and high-throughput virtual screening of ultralarge molecular databases in drug discovery. PyRMD and the PyRMD2Dock protocol are freely available on GitHub (https://github.com/cosconatilab/PyRMD) as an open-source tool.
MeSH term(s)	Artificial Intelligence ; Molecular Docking Simulation ; Software ; Proteins/chemistry ; Drug Discovery ; Small Molecule Libraries ; Ligands
Chemical Substances	Proteins ; Small Molecule Libraries ; Ligands
Language	English
Publishing date	2023-08-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	190019-5
ISSN	1549-960X ; 0095-2338
ISSN (online)	1549-960X
ISSN	0095-2338
DOI	10.1021/acs.jcim.3c00647
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Article ; Online: Functions and consequences of AID/APOBEC-mediated DNA and RNA deamination.

Pecori, Riccardo / Di Giorgio, Salvatore / Paulo Lorenzo, J / Nina Papavasiliou, F

Nature reviews. Genetics

2022 Volume 23, Issue 8, Page(s) 505–518

Abstract: The AID/APOBEC polynucleotide cytidine deaminases have historically been classified as either DNA mutators or RNA editors based on their first identified nucleic acid substrate preference. DNA mutators can generate functional diversity at antibody genes ... ...

Abstract	The AID/APOBEC polynucleotide cytidine deaminases have historically been classified as either DNA mutators or RNA editors based on their first identified nucleic acid substrate preference. DNA mutators can generate functional diversity at antibody genes but also cause genomic instability in cancer. RNA editors can generate informational diversity in the transcriptome of innate immune cells, and of cancer cells. Members of both classes can act as antiviral restriction factors. Recent structural work has illuminated differences and similarities between AID/APOBEC enzymes that can catalyse DNA mutation, RNA editing or both, suggesting that the strict functional classification of members of this family should be reconsidered. As many of these enzymes have been employed for targeted genome (or transcriptome) editing, a more holistic understanding will help improve the design of therapeutically relevant programmable base editors.
MeSH term(s)	Cytidine Deaminase/chemistry ; Cytidine Deaminase/genetics ; Cytidine Deaminase/metabolism ; DNA/genetics ; DNA/metabolism ; Deamination ; RNA/genetics ; RNA/metabolism ; RNA Editing
Chemical Substances	RNA (63231-63-0) ; DNA (9007-49-2) ; Cytidine Deaminase (EC 3.5.4.5)
Language	English
Publishing date	2022-03-07
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2035157-4
ISSN	1471-0064 ; 1471-0056
ISSN (online)	1471-0064
ISSN	1471-0056
DOI	10.1038/s41576-022-00459-8
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Zs.A 5474: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Italian guidelines for the management of irritable bowel syndrome in children and adolescents : Joint Consensus from the Italian Societies of: Gastroenterology, Hepatology and Pediatric Nutrition (SIGENP), Pediatrics (SIP), Gastroenterology and Endoscopy (SIGE) and Neurogastroenterology and Motility (SINGEM).

Di Nardo, Giovanni / Barbara, Giovanni / Borrelli, Osvaldo / Cremon, Cesare / Giorgio, Valentina / Greco, Luigi / La Pietra, Michele / Marasco, Giovanni / Pensabene, Licia / Piccirillo, Marisa / Romano, Claudio / Salvatore, Silvia / Saviano, Michele / Stanghellini, Vincenzo / Strisciuglio, Caterina / Tambucci, Renato / Turco, Rossella / Zenzeri, Letizia / Staiano, Annamaria

Italian journal of pediatrics

2024 Volume 50, Issue 1, Page(s) 51

Abstract: The irritable bowel syndrome (IBS) is a functional gastrointestinal disorder (FGID), whose prevalence has widely increased in pediatric population during the past two decades. The exact pathophysiological mechanism underlying IBS is still uncertain, thus ...

Abstract	The irritable bowel syndrome (IBS) is a functional gastrointestinal disorder (FGID), whose prevalence has widely increased in pediatric population during the past two decades. The exact pathophysiological mechanism underlying IBS is still uncertain, thus resulting in challenging diagnosis and management. Experts from 4 Italian Societies participated in a Delphi consensus, searching medical literature and voting process on 22 statements on both diagnosis and management of IBS in children. Recommendations and levels of evidence were evaluated according to the grading of recommendations, assessment, development, and evaluation (GRADE) criteria. Consensus was reached for all statements. These guidelines suggest a positive diagnostic strategy within a symptom-based approach, comprehensive of psychological comorbidities assessment, alarm signs and symptoms' exclusion, testing for celiac disease and, under specific circumstances, fecal calprotectin and C-reactive protein. Consensus also suggests to rule out constipation in case of therapeutic failure. Conversely, routine stool testing for enteric pathogens, testing for food allergy/intolerance or small intestinal bacterial overgrowth are not recommended. Colonoscopy is recommended only in patients with alarm features. Regarding treatment, the consensus strongly suggests a dietary approach, psychologically directed therapies and, in specific conditions, gut-brain neuromodulators, under specialist supervision. Conditional recommendation was provided for both probiotics and specific fibers supplementation. Polyethylene glycol achieved consensus recommendation for specific subtypes of IBS. Secretagogues and 5-HT4 agonists are not recommended in children with IBS-C. Certain complementary alternative therapies, antispasmodics and, in specific IBS subtypes, loperamide and rifaximin could be considered.
MeSH term(s)	Humans ; Child ; Adolescent ; Gastroenterology ; Irritable Bowel Syndrome/diagnosis ; Irritable Bowel Syndrome/therapy ; Consensus ; Endoscopy, Gastrointestinal ; Italy
Language	English
Publishing date	2024-03-14
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2088556-8
ISSN	1824-7288 ; 1720-8424
ISSN (online)	1824-7288
ISSN	1720-8424
DOI	10.1186/s13052-024-01607-y
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Article: Prenatal Diagnosis of Canine and Feline Twins Using Ultrasound: A Retrospective Study.

Pecchia, Fabiana / Di Giorgio, Stefania / Sfacteria, Alessandra / Monti, Salvatore / Vullo, Cecilia / Catone, Giuseppe / Marino, Gabriele

Animals : an open access journal from MDPI

2023 Volume 13, Issue 21

Abstract: Prenatal diagnosis comprises a set of investigations, both instrumental and laboratory-based, which aim to monitor the health of the foetus during pregnancy, from the early stages of embryonic development to the moments preceding delivery. A growing ... ...

Abstract	Prenatal diagnosis comprises a set of investigations, both instrumental and laboratory-based, which aim to monitor the health of the foetus during pregnancy, from the early stages of embryonic development to the moments preceding delivery. A growing interest is emerging for the preterm ultrasound morphological screening of embryos and foetuses, aimed at assessing the integrity and viability of the conceptus, as well as the early diagnosis of anomalies which can cause complications. This study is a retrospective study of the ultrasonographic findings of twins in the authors' clinical activity from 2016 to 2022. Only seven cases of monochorionic twins were recorded, out of the whole number of evaluations performed on 3120 foetuses, with a prevalence of 0.6% and 0.2% in feline and canine foetuses. All the twins had their own amniotic sac and umbilical cord but presented a single placenta and a single allantoic sac. Unfortunately, the three feline cases were not more recognizable at term. In the four canine cases, three were of opposite sex and then necessarily dizygotic. Twins may have an impact on the success of a pregnancy due to the risk of dystocia, as observed in some of the reported cases. Prenatal ultrasound allows early recognition of twins in dogs and cats.
Language	English
Publishing date	2023-10-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606558-7
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani13213309
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