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  1. Article ; Online: Juvenile dermatomyositis with scleroderma features - when skin thickening is not systemic sclerosis.

    Lourenço, Maria Helena / Bento da Silva, Ana / Gago, Laura / Branco, Jaime Cunha / Silva, Inês

    ARP rheumatology

    2024  Volume 2, Issue 4, Page(s) 345–346

    Title translation Juvenile dermatomyositis with scleroderma features - when skin thickening is not systemic sclerosis.
    MeSH term(s) Humans ; Dermatomyositis/complications ; Sclerosis ; Scleroderma, Systemic/complications ; Scleroderma, Localized/complications ; Skin Abnormalities
    Language English
    Publishing date 2024-01-04
    Publishing country Portugal
    Document type Journal Article
    ISSN 2795-4552
    ISSN (online) 2795-4552
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  2. Article: ARDS Mortality Prediction Model Using Evolving Clinical Data and Chest Radiograph Analysis.

    Cysneiros, Ana / Galvão, Tiago / Domingues, Nuno / Jorge, Pedro / Bento, Luis / Martin-Loeches, Ignacio

    Biomedicines

    2024  Volume 12, Issue 2

    Abstract: Introduction: Within primary ARDS, SARS-CoV-2-associated ARDS (C-ARDS) emerged in late 2019, reaching its peak during the subsequent two years. Recent efforts in ARDS research have concentrated on phenotyping this heterogeneous syndrome to enhance ... ...

    Abstract Introduction: Within primary ARDS, SARS-CoV-2-associated ARDS (C-ARDS) emerged in late 2019, reaching its peak during the subsequent two years. Recent efforts in ARDS research have concentrated on phenotyping this heterogeneous syndrome to enhance comprehension of its pathophysiology.
    Methods and results: A retrospective study was conducted on C-ARDS patients from April 2020 to February 2021, encompassing 110 participants with a mean age of 63.2 ± 11.92 (26-83 years). Of these, 61.2% (68) were male, and 25% (17) experienced severe ARDS, resulting in a mortality rate of 47.3% (52). Ventilation settings, arterial blood gases, and chest X-ray (CXR) were evaluated on the first day of invasive mechanical ventilation and between days two and three. CXR images were scrutinized using a convolutional neural network (CNN). A binary logistic regression model for predicting C-ARDS mortality was developed based on the most influential variables: age, PaO
    Conclusion: Integrating data available in all intensive care units enables the prediction of C-ARDS mortality by utilizing evolving P/F ratios and CXR. This approach can assist in tailoring treatment plans and initiating early discussions to escalate care and extracorporeal life support. Machine learning algorithms for imaging classification can uncover otherwise inaccessible patterns, potentially evolving into another form of ARDS phenotyping. The combined features of these algorithms and clinical variables demonstrate superior performance compared to either element alone.
    Language English
    Publishing date 2024-02-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines12020439
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  3. Article ; Online: Author Correction: Disease-economy trade-offs under alternative epidemic control strategies.

    Ash, Thomas / Bento, Antonio M / Kaffine, Daniel / Rao, Akhil / Bento, Ana I

    Nature communications

    2022  Volume 13, Issue 1, Page(s) 3570

    Language English
    Publishing date 2022-06-22
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-022-31307-2
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  4. Article ; Online: Disease-economy trade-offs under alternative epidemic control strategies.

    Ash, Thomas / Bento, Antonio M / Kaffine, Daniel / Rao, Akhil / Bento, Ana I

    Nature communications

    2022  Volume 13, Issue 1, Page(s) 3319

    Abstract: Public policy and academic debates regarding pandemic control strategies note disease-economy trade-offs, often prioritizing one outcome over the other. Using a calibrated, coupled epi-economic model of individual behavior embedded within the broader ... ...

    Abstract Public policy and academic debates regarding pandemic control strategies note disease-economy trade-offs, often prioritizing one outcome over the other. Using a calibrated, coupled epi-economic model of individual behavior embedded within the broader economy during a novel epidemic, we show that targeted isolation strategies can avert up to 91% of economic losses relative to voluntary isolation strategies. Unlike widely-used blanket lockdowns, economic savings of targeted isolation do not impose additional disease burdens, avoiding disease-economy trade-offs. Targeted isolation achieves this by addressing the fundamental coordination failure between infectious and susceptible individuals that drives the recession. Importantly, we show testing and compliance frictions can erode some of the gains from targeted isolation, but improving test quality unlocks the majority of the benefits of targeted isolation.
    MeSH term(s) Humans ; Income ; Pandemics/prevention & control ; Public Policy
    Language English
    Publishing date 2022-06-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-022-30642-8
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  5. Article: Facile preparation of a Pt-ERGO composite modified screen-printed electrode for the sensitive determination of phenolic compounds.

    Lema, Luís / Oliveira, Raquel / Amorim, Isilda / Bettencourt, Ana Paula / Bento, Fátima

    Heliyon

    2023  Volume 9, Issue 12, Page(s) e22521

    Abstract: The mass production of screen-printed electrochemical devices with integrated electrodes has facilitated the widespread adoption of electroanalytical methods. The SPEs (screen-printed electrodes) overcome some obstacles associated with the use of ... ...

    Abstract The mass production of screen-printed electrochemical devices with integrated electrodes has facilitated the widespread adoption of electroanalytical methods. The SPEs (screen-printed electrodes) overcome some obstacles associated with the use of conventional electrochemical cells, making them accessible to untrained operators. Despite their advantages, SPEs require activation/modification of the working electrode (WE) to enhance sensitivity. Nanomaterials, with metal nanoparticles (NPs) dispersed in polymers and/or carbon NPs has gaining popularity for this purpose. In this study, we describe a modification of carbon SPEs (SPCEs) using Pt NPs and reduced graphene oxide (ERGO). The Pt-ERGO@SPCE is prepared by galvanostatic reduction of drop-casted precursors directly onto the WE surface, eliminating complex synthetic steps and high temperatures. After optimizing Pt amount and reduction extent, the modified SPCEs were tested for detecting hydroquinone (HQ) and bisphenol A (BPA). DPV results show significantly increased sensitivity for the quantification of both compounds. The modified SPCEs demonstrates promising performance: precision (5 % HQ, 8 % BPA), detection limits (1.4 μM HQ, 4.6 μM BPA), sensitivity (1688 μA mM
    Language English
    Publishing date 2023-11-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e22521
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  6. Article ; Online: Author Correction

    Thomas Ash / Antonio M. Bento / Daniel Kaffine / Akhil Rao / Ana I. Bento

    Nature Communications, Vol 13, Iss 1, Pp 1-

    Disease-economy trade-offs under alternative epidemic control strategies

    2022  Volume 1

    Keywords Science ; Q
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Disease-economy trade-offs under alternative epidemic control strategies

    Thomas Ash / Antonio M. Bento / Daniel Kaffine / Akhil Rao / Ana I. Bento

    Nature Communications, Vol 13, Iss 1, Pp 1-

    2022  Volume 14

    Abstract: Pandemic control policy requires balancing economic and disease outcomes. This study develops a joint modeling approach that allows both aspects to be considered simultaneously and shows that targeted isolation is superior economically and can achieve ... ...

    Abstract Pandemic control policy requires balancing economic and disease outcomes. This study develops a joint modeling approach that allows both aspects to be considered simultaneously and shows that targeted isolation is superior economically and can achieve similar disease outcomes to voluntary isolation or blanket lockdowns.
    Keywords Science ; Q
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Factors Associated With Long Survival in Patients With Cancer Admitted to Palliative Care: An Exploratory Study.

    Ferraz-Gonçalves, José António / Alves, Adelaide / Silva, Álvaro José / Valente, Ana Carmo / Pina, Ana / Lima, Áurea / Antunes, Daniela / Cubal, Francisco / Costa, Isabel / Rodrigues, Jorge / Costa, Mariana / Ramos, Mariana / Luis, Michael / Soares, Sofia Garcês / Sousa, Sofia / Moreira, Teresa Dias / Sá-Araújo, Vânia / Bento, Maria José

    Journal of palliative care

    2024  , Page(s) 8258597241231005

    Abstract: Objective: ...

    Abstract Objective:
    Language English
    Publishing date 2024-02-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639326-3
    ISSN 2369-5293 ; 0825-8597
    ISSN (online) 2369-5293
    ISSN 0825-8597
    DOI 10.1177/08258597241231005
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    Zs.B 3203: Show issues Location:
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  9. Article ; Online: Comparison of diuretics and fluid expansion in the initial treatment of patients with normotensive acute pulmonary embolism: a systematic review and meta-analysis.

    Febra, Cláudia / Santos, Ana Rita / Cabrita, Isabel / Bento, Joana / Pacheco, João / Mendes, Mariana / Isidro, Michael / Batista, Rafael / Macedo, Ana Margarida André Febra Moita

    Emergency medicine journal : EMJ

    2024  Volume 41, Issue 3, Page(s) 187–192

    Abstract: Background: Right ventricular (RV) dysfunction is the main cause of death in patients with normotensive acute pulmonary embolism (PE). The optimal management for this subset of patients remains uncertain. This systematic review and meta-analysis focused ...

    Abstract Background: Right ventricular (RV) dysfunction is the main cause of death in patients with normotensive acute pulmonary embolism (PE). The optimal management for this subset of patients remains uncertain. This systematic review and meta-analysis focused on the comparison of diuretics and fluid expansion in patients with acute PE presenting with RV dysfunction and haemodynamic stability.
    Methods: A systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines considering only RTCs. The authors searched the traditional and grey literature through 1 November 2022. Meta-analysis used open source packages in R. Inverse variance fixed-effects models with OR as the effect measure were used for primary analyses. The main outcomes defined in this review protocol included pulmonary arterial systolic pressure (PASP), creatinine value changes and N-terminal pro-B-type natriuretic peptide during the first 24 hours.
    Results: Four studies with a total of 452 patients met the inclusion criteria. The baseline characteristics of patients were similar across all studies. Overall, patients receiving diuretics had a significant 24 hours reduction in pro-B-type natriuretic peptide (standard mean difference of -41.97; 95% CI -65.79 to -18.15), and PASP (standard mean difference of -5.96; 95% CI -8.06 to -3.86). This group had significantly higher creatinine levels (standard mean difference of 7.74; 95% CI 5.04 to 10.45). The quality of the studies was heterogeneous; two had a low risk of bias, and the other two had a high risk of bias.
    Conclusions: Very few studies have compared the efficacy and safety of diuretics and fluid expansion in normotensive patients with acute PE with RV failure. Overall, furosemide appears to reduce RV dysfunction in this subset of patients compared with fluid expansion. Further research is required to confirm these findings.
    MeSH term(s) Humans ; Diuretics/therapeutic use ; Natriuretic Peptide, Brain ; Blood Pressure ; Creatinine ; Pulmonary Embolism/drug therapy ; Acute Disease
    Chemical Substances Diuretics ; Natriuretic Peptide, Brain (114471-18-0) ; Creatinine (AYI8EX34EU)
    Language English
    Publishing date 2024-02-20
    Publishing country England
    Document type Meta-Analysis ; Systematic Review ; Journal Article
    ZDB-ID 2040124-3
    ISSN 1472-0213 ; 1472-0205
    ISSN (online) 1472-0213
    ISSN 1472-0205
    DOI 10.1136/emermed-2023-213525
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  10. Article ; Online: A hemlock salad: a case report of super-refractory status epilepticus after accidental hemlock ingestion.

    Parreira, Sara / Antunes, Ana Patrícia / Bento, Henrique / Moniz, Isabel

    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

    2021  Volume 42, Issue 10, Page(s) 4335–4339

    MeSH term(s) Anticonvulsants/therapeutic use ; Eating ; Hemlock ; Humans ; Salads ; Status Epilepticus/chemically induced ; Status Epilepticus/drug therapy
    Chemical Substances Anticonvulsants
    Language English
    Publishing date 2021-06-29
    Publishing country Italy
    Document type Case Reports ; Letter
    ZDB-ID 2016546-8
    ISSN 1590-3478 ; 1590-1874
    ISSN (online) 1590-3478
    ISSN 1590-1874
    DOI 10.1007/s10072-021-05421-w
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