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  1. Article ; Online: Endothelium Seeing Red: Should We Redefine eNOS as the Endothelial and Erythrocytic NOS?

    Gladwin, Mark T

    Circulation

    2021  Volume 144, Issue 11, Page(s) 890–892

    MeSH term(s) Endothelium ; Erythrocytes ; Humans ; Nitric Oxide Synthase Type III/genetics
    Chemical Substances Nitric Oxide Synthase Type III (EC 1.14.13.39)
    Language English
    Publishing date 2021-09-13
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.121.055679
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: "Severity" in adult sickle cell disease.

    Steinberg, Martin H / Gladwin, Mark T

    American journal of hematology

    2023  Volume 98, Issue 10, Page(s) 1508–1511

    MeSH term(s) Adult ; Humans ; Anemia, Sickle Cell/complications ; Anemia, Sickle Cell/therapy ; Severity of Illness Index
    Language English
    Publishing date 2023-07-14
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 196767-8
    ISSN 1096-8652 ; 0361-8609
    ISSN (online) 1096-8652
    ISSN 0361-8609
    DOI 10.1002/ajh.27024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Revisiting Arginine Therapy for Sickle Cell Acute Vasoocclusive Painful Crisis.

    Hopper, Rachel K / Gladwin, Mark T

    American journal of respiratory and critical care medicine

    2022  Volume 206, Issue 1, Page(s) 6–7

    MeSH term(s) Anemia, Sickle Cell/complications ; Anemia, Sickle Cell/drug therapy ; Arginine/therapeutic use ; Child ; Child, Hospitalized ; Hemodynamics ; Humans ; Pain ; Prospective Studies
    Chemical Substances Arginine (94ZLA3W45F)
    Language English
    Publishing date 2022-05-11
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202204-0673ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Inhaled NO in COVID-19 Acute Respiratory Distress Syndrome: Yes or No?

    Lal, Amos / Gladwin, Mark T / Gajic, Ognjen

    American journal of respiratory and critical care medicine

    2023  Volume 208, Issue 12, Page(s) 1259–1261

    MeSH term(s) Humans ; Nitric Oxide ; COVID-19 ; Respiratory Distress Syndrome/drug therapy ; Respiratory Insufficiency
    Chemical Substances Nitric Oxide (31C4KY9ESH)
    Language English
    Publishing date 2023-11-07
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202310-1823ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Flipping Off and On the Redox Switch in the Microcirculation.

    Katona, Máté / Gladwin, Mark T / Straub, Adam C

    Annual review of physiology

    2023  Volume 85, Page(s) 165–189

    Abstract: Resistance arteries and arterioles evolved as specialized blood vessels serving two important functions: ( ...

    Abstract Resistance arteries and arterioles evolved as specialized blood vessels serving two important functions: (
    MeSH term(s) Humans ; Microcirculation ; Vasodilation/physiology ; Vasoconstriction/physiology ; Oxidation-Reduction ; Oxygen
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2023-02-10
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 207933-1
    ISSN 1545-1585 ; 0066-4278
    ISSN (online) 1545-1585
    ISSN 0066-4278
    DOI 10.1146/annurev-physiol-031522-021457
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  6. Article ; Online: How Red Blood Cells Process Nitric Oxide: Evidence for the Nitrite Hypothesis.

    Gladwin, Mark T

    Circulation

    2017  Volume 135, Issue 2, Page(s) 177–179

    MeSH term(s) Erythrocytes ; Hemoglobins ; Nitric Oxide ; Nitrites ; Vasodilation
    Chemical Substances Hemoglobins ; Nitrites ; Nitric Oxide (31C4KY9ESH)
    Language English
    Publishing date 2017-01-07
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.116.024752
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Translational Advances in the Field of Pulmonary Hypertension Bench to Bedside: How Fundamental Discoveries in Science Are Advancing Our Understanding and Therapy of Pulmonary Arterial Hypertension.

    Gladwin, Mark T

    American journal of respiratory and critical care medicine

    2017  Volume 195, Issue 1, Page(s) 1–3

    Language English
    Publishing date 2017-01-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.201608-1637ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Carbon Monoxide Poisoning: From Microbes to Therapeutics.

    Dent, Matthew R / Rose, Jason J / Tejero, Jesús / Gladwin, Mark T

    Annual review of medicine

    2023  Volume 75, Page(s) 337–351

    Abstract: Carbon monoxide (CO) poisoning leads to 50,000-100,000 emergency room visits and 1,500-2,000 deaths each year in the United States alone. Even with treatment, survivors often suffer from long-term cardiac and neurocognitive deficits, highlighting a clear ...

    Abstract Carbon monoxide (CO) poisoning leads to 50,000-100,000 emergency room visits and 1,500-2,000 deaths each year in the United States alone. Even with treatment, survivors often suffer from long-term cardiac and neurocognitive deficits, highlighting a clear unmet medical need for novel therapeutic strategies that reduce morbidity and mortality associated with CO poisoning. This review examines the prevalence and impact of CO poisoning and pathophysiology in humans and highlights recent advances in therapeutic strategies that accelerate CO clearance and mitigate toxicity. We focus on recent developments of high-affinity molecules that take advantage of the uniquely strong interaction between CO and heme to selectively bind and sequester CO in preclinical models. These scavengers, which employ heme-binding scaffolds ranging from organic small molecules to hemoproteins derived from humans and potentially even microorganisms, show promise as field-deployable antidotes that may rapidly accelerate CO clearance and improve outcomes for survivors of acute CO poisoning.
    MeSH term(s) Humans ; United States ; Carbon Monoxide Poisoning/therapy ; Carbon Monoxide Poisoning/epidemiology ; Heme
    Chemical Substances Heme (42VZT0U6YR)
    Language English
    Publishing date 2023-08-15
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 207930-6
    ISSN 1545-326X ; 0066-4219
    ISSN (online) 1545-326X
    ISSN 0066-4219
    DOI 10.1146/annurev-med-052422-020045
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  9. Article ; Online: Cardiovascular complications in patients with sickle cell disease.

    Gladwin, Mark T

    Hematology. American Society of Hematology. Education Program

    2017  Volume 2017, Issue 1, Page(s) 423–430

    Abstract: Sickle cell disease (SCD) is an autosomal recessive disease in which homozygosity for a single point mutation in the gene encoding the β-globin chain produces hemoglobin S molecules that polymerize within the erythrocyte during deoxygenation; the result ... ...

    Abstract Sickle cell disease (SCD) is an autosomal recessive disease in which homozygosity for a single point mutation in the gene encoding the β-globin chain produces hemoglobin S molecules that polymerize within the erythrocyte during deoxygenation; the result is sustained hemolytic anemia and vaso-occlusive events. As patients live to adulthood, the chronic impact of sustained hemolytic anemia and episodic vaso-occlusive episodes leads to progressive end-organ complications. This scenario culminates in the development of 1 or more major cardiovascular complications of SCD for which there are no approved or consensus therapies. These complications include elevated pulmonary artery systolic pressure, pulmonary hypertension, left ventricular diastolic heart disease, dysrhythmia, sudden death, and chronic kidney disease with associated proteinuria, microalbuminuria, and hemoglobinuria. In patients with advancing age, cardiopulmonary organ dysfunction and chronic kidney injury have significant effects on morbidity and premature mortality. Over the last 15 years, a number of tests have been validated in multiple replicate cohort studies that identify patients with SCD at the highest risk of experiencing pulmonary and systemic vasculopathy and death, providing for screening strategies tied to targeted, more aggressive diagnostic and therapeutic interventions.
    MeSH term(s) Anemia, Sickle Cell/complications ; Anemia, Sickle Cell/therapy ; Anemia, Sickle Cell/urine ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/therapy ; Cardiovascular Diseases/urine ; Humans ; Proteinuria/etiology ; Proteinuria/therapy ; Proteinuria/urine ; Renal Insufficiency, Chronic/etiology ; Renal Insufficiency, Chronic/therapy ; Renal Insufficiency, Chronic/urine
    Language English
    Publishing date 2017-12-06
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1520-4383
    ISSN (online) 1520-4383
    DOI 10.1182/asheducation-2017.1.423
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Cardiovascular complications and risk of death in sickle-cell disease.

    Gladwin, Mark T

    Lancet (London, England)

    2016  Volume 387, Issue 10037, Page(s) 2565–2574

    Abstract: In sickle-cell disease, a point mutation in the β-globin chain causes haemoglobin to polymerise within erythrocytes during deoxygenation, altering red blood cell rheology and causing haemolysis. Improvements in health infrastructure, preventive care, and ...

    Abstract In sickle-cell disease, a point mutation in the β-globin chain causes haemoglobin to polymerise within erythrocytes during deoxygenation, altering red blood cell rheology and causing haemolysis. Improvements in health infrastructure, preventive care, and clinical treatments have reduced the morbidity and mortality of sickle-cell disease in developed countries. However, as these patients live longer, the chronic effects of sustained haemolytic anaemia and episodic vaso-occlusive events drive the development of end-organ complications. Cardiopulmonary organ dysfunction and chronic kidney injury have a large effect on morbidity and premature mortality, and typically accelerate in the second decade of life. These processes culminate in the development of pulmonary hypertension, left ventricular diastolic heart disease, dysrhythmia, and sudden death. In this Series paper, we review the mechanisms, clinical features, and epidemiology of major cardiovascular complications in patients with sickle-cell disease and discuss how screening and intervention could reduce their incidence.
    MeSH term(s) Anemia, Sickle Cell/complications ; Anemia, Sickle Cell/mortality ; Death, Sudden, Cardiac/etiology ; Death, Sudden, Cardiac/prevention & control ; Early Diagnosis ; Heart Diseases/diagnosis ; Heart Diseases/etiology ; Heart Diseases/mortality ; Hemolysis/physiology ; Humans ; Hypertension, Pulmonary/diagnosis ; Hypertension, Pulmonary/etiology ; Hypertension, Pulmonary/mortality ; Risk Factors
    Language English
    Publishing date 2016-06-18
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(16)00647-4
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