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  1. Article ; Online: Genetic risks of Alzheimer's by

    Huang, Weijie / Zeng, Jianmin / Jia, Lina / Zhu, Dajiang / O'Brien, John / Ritchie, Craig / Shu, Ni / Su, Li

    Brain communications

    2023  Volume 5, Issue 5, Page(s) fcad234

    Abstract: Genetic risk factors such ... ...

    Abstract Genetic risk factors such as
    Language English
    Publishing date 2023-09-08
    Publishing country England
    Document type Journal Article
    ISSN 2632-1297
    ISSN (online) 2632-1297
    DOI 10.1093/braincomms/fcad234
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  2. Article ; Online: Exploration of Spatio-Temporal Evolution and Threshold Effect of Shrinking Cities

    Song, Yuanzhen / He, Weijie / Zeng, Jian

    Land. 2023 July 24, v. 12, no. 7

    2023  

    Abstract: Shrinking cities are a global issue with regional characteristics. This paper focuses on the county-level administrative units in the Three Northeastern Provinces in China to identify and classify shrinking cities using a two-step identification method ... ...

    Abstract Shrinking cities are a global issue with regional characteristics. This paper focuses on the county-level administrative units in the Three Northeastern Provinces in China to identify and classify shrinking cities using a two-step identification method and explores their spatial-temporal evolution. The paper utilizes the panel threshold regression model for empirical testing. The results indicate the following: (1) The number of shrinking cities in the region is large and deep. Quantitatively, the shrinking cities account for about 50% of the whole; spatially, there are six major shrinking city “groups”, showing the distribution trend around the “Ha-Da” urban corridor. (2) The threshold effect test reveals that GDP is a critical threshold variable influencing the formation of shrinking cities. Moreover, cities are classified into three types based on the threshold values: Type I (GDP > 2,270,731 yuan), Type II (434,832 < GDP ≤ 2,270,731), and Type III (GDP < 434,832). (3) The results of the dual-threshold and grouped regression models show significant variations in the dominant factors of shrinking cities of different scales. Variables such as impervious area, fiscal revenue, and grass area demonstrate relatively stable promoting effects.
    Keywords evolution ; grasses ; income ; land ; regression analysis ; China
    Language English
    Dates of publication 2023-0724
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2682955-1
    ISSN 2073-445X
    ISSN 2073-445X
    DOI 10.3390/land12071474
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Mode-pairing quantum key distribution.

    Zeng, Pei / Zhou, Hongyi / Wu, Weijie / Ma, Xiongfeng

    Nature communications

    2022  Volume 13, Issue 1, Page(s) 3903

    Abstract: Quantum key distribution - the establishment of information-theoretically secure keys based on quantum physics - is mainly limited by its practical performance, which is characterised by the dependence of the key rate on the channel transmittance R(η). ... ...

    Abstract Quantum key distribution - the establishment of information-theoretically secure keys based on quantum physics - is mainly limited by its practical performance, which is characterised by the dependence of the key rate on the channel transmittance R(η). Recently, schemes based on single-photon interference have been proposed to improve the key rate to [Formula: see text] by overcoming the point-to-point secret key capacity bound with interferometers. Unfortunately, all of these schemes require challenging global phase locking to realise a stable long-arm single-photon interferometer with a precision of approximately 100 nm over fibres that are hundreds of kilometres long. Aiming to address this problem, we propose a mode-pairing measurement-device-independent quantum key distribution scheme in which the encoded key bits and bases are determined during data post-processing. Using conventional second-order interference, this scheme can achieve a key rate of [Formula: see text] without global phase locking when the local phase fluctuation is mild. We expect this high-performance scheme to be ready-to-implement with off-the-shelf optical devices.
    Language English
    Publishing date 2022-07-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-022-31534-7
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  4. Article ; Online: Synergy of VN and Fe

    Zhou, Hao / Alam, Mahfooz / Wu, Yuncheng / Zeng, Ye / Gandi, Appala N / Zheng, Jiaxian / Zhu, Weijie / Wang, Zhoucheng / Liang, Hanfeng

    ACS applied materials & interfaces

    2023  Volume 15, Issue 15, Page(s) 18819–18827

    Abstract: ... ...

    Abstract Fe
    Language English
    Publishing date 2023-04-06
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.2c22848
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  5. Article ; Online: Activated AMPK Protects Against Chronic Cerebral Ischemia in Bilateral Carotid Artery Stenosis Mice.

    Xie, Weijie / Zeng, Yanqin / Zheng, Yunqiu / Cai, Bin

    Cellular and molecular neurobiology

    2022  Volume 43, Issue 5, Page(s) 2325–2335

    Abstract: AMP-activated protein kinase (AMPK) is a regulator of cellular energy metabolism. Long-term use of metformin, an AMPK activator, was previously reported to be neuroprotective, as it promotes behavioral improvement and angiogenesis following an acute ... ...

    Abstract AMP-activated protein kinase (AMPK) is a regulator of cellular energy metabolism. Long-term use of metformin, an AMPK activator, was previously reported to be neuroprotective, as it promotes behavioral improvement and angiogenesis following an acute ischemic injury of the brain. However, only a few studies have demonstrated the role of AMPK in alleviating chronic cerebral ischemia (CCI) in mice models in the long-term (over 3 months). Therefore, we established a mouse model of CCI via bilateral carotid artery stenosis (BCAS) to explore the effect of AMPK on CCI. We used four groups of 3-month-old male C57BL/6 mice labeled as Sham, BCAS, BCAS + metformin treatment (BCAS + Met) and BCAS + AMPKα2 gene knockout (BCAS + KO). Three months after BCAS, we measured the AMPK protein expression, spatial learning and memory, Nissl bodies, cell apoptosis, astrocyte activation, and oligodendrocyte maturation. Additionally, we observed the brain tissues for changes in cell morphology. We observed that mice in the BCAS group had impaired spatial learning and memory compared with those in the sham group. The brain tissues of mice with CCI injury showed altered cell morphology, fewer Nissl bodies, cerebral cells apoptosis, and astrocyte activation. Interestingly, compared with mice from the BCAS group, the brains of mice from BCAS + Met group suffered lesser damage, whereas those of mice from the BCAS + KO group suffered more damage. The activation of AMPK, especially AMPKα2, plays a neuroprotective role during CCI in a mouse model of BCAS.
    MeSH term(s) Mice ; Male ; Animals ; Carotid Stenosis/complications ; AMP-Activated Protein Kinases ; Mice, Inbred C57BL ; Brain Ischemia/complications ; Brain Ischemia/drug therapy ; Disease Models, Animal ; Metformin
    Chemical Substances AMP-Activated Protein Kinases (EC 2.7.11.31) ; Metformin (9100L32L2N)
    Language English
    Publishing date 2022-11-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 283404-2
    ISSN 1573-6830 ; 0272-4340
    ISSN (online) 1573-6830
    ISSN 0272-4340
    DOI 10.1007/s10571-022-01312-6
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1727: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  6. Article ; Online: Use of Capillary Electrophoresis Migration Position for the Presumptive Identification of Hemoglobin Variants Prevalent in China.

    Xu, Miao / Li, Ming-Yang / Zeng, Yu / Xie, Weijie / Xu, An-Ping / Ji, Ling

    Hemoglobin

    2023  Volume 46, Issue 6, Page(s) 330–334

    Abstract: Capillary electrophoresis (CE) is increasingly being used to screen for hemoglobinopathies. We here report the migration position of hemoglobin (Hb) variants prevalent in China determined by CE. The CE migration position showed excellent precision and ... ...

    Abstract Capillary electrophoresis (CE) is increasingly being used to screen for hemoglobinopathies. We here report the migration position of hemoglobin (Hb) variants prevalent in China determined by CE. The CE migration position showed excellent precision and minor inter-individual variation. We conclude that the CE migration position can be used as a reliable indicator for identifying Hb variants and can also help to establish a well-characterized library of Hb variants for their refined presumptive identification.
    MeSH term(s) Humans ; Hemoglobins/analysis ; Hemoglobinopathies ; Electrophoresis, Capillary/methods ; China ; Hemoglobins, Abnormal/analysis
    Chemical Substances Hemoglobins ; Hemoglobins, Abnormal
    Language English
    Publishing date 2023-01-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 750615-6
    ISSN 1532-432X ; 0363-0269
    ISSN (online) 1532-432X
    ISSN 0363-0269
    DOI 10.1080/03630269.2022.2151463
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1345: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Association of admission blood glucose level and clinical outcomes in elderly community-acquired pneumonia patients with or without diabetes.

    Zeng, Weijian / Huang, Xiaoxing / Luo, Weijie / Chen, Mingqian

    The clinical respiratory journal

    2022  Volume 16, Issue 8, Page(s) 562–571

    Abstract: Introduction: Community-acquired pneumonia (CAP) is the major cause of infection-related mortality worldwide. Patients with CAP frequently present with admission hyperglycemia.: Objectives: The aim of this study was to evaluate the association ... ...

    Abstract Introduction: Community-acquired pneumonia (CAP) is the major cause of infection-related mortality worldwide. Patients with CAP frequently present with admission hyperglycemia.
    Objectives: The aim of this study was to evaluate the association between admission blood glucose (ABG) level and clinical outcomes in elderly CAP patients (≥80 years of age) with or without diabetes.
    Methods: In this single center retrospective study, 290 elderly patients diagnosed with CAP were included. Demographic and clinical information were collected and compared. The associations between admission blood glucose level and the 30-day mortality as well as intensive care unit (ICU) admission and invasive mechanical ventilation (IMV) in elderly CAP patients with or without diabetes were assessed.
    Results: Of the 290 eligible patients with CAP, 159 (66.5%) patients were male, and 64 (22.1%) had a known history of diabetes at hospital admission. After adjusting for age and sex, the logistic regression analysis had identified several risk factors that might be associated with clinical outcomes in elderly patients with CAP. Multivariable logistic regression analysis revealed that admission glucose level > 11.1 mmol/L was significant associated with ICU admission, IMV, and 30-day mortality both in non-diabetic and diabetic patients. Furthermore, Kaplan-Meier analysis indicated that patients with higher admission glucose level were correlated statistically significantly with 30-day mortality in patients with CAP (P < 0.001).
    Conclusion: Admission blood glucose is correlated with 30-day hospital mortality, ICU admission, and IMV of CAP in elderly patients with and without diabetes. Specially, admission glucose > 11.1 mmol/L was a significant risk factor for 30-day hospital mortality.
    MeSH term(s) Aged ; Blood Glucose ; Community-Acquired Infections ; Diabetes Mellitus/epidemiology ; Female ; Humans ; Male ; Pneumonia/complications ; Prognosis ; Retrospective Studies
    Chemical Substances Blood Glucose
    Language English
    Publishing date 2022-07-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2442214-9
    ISSN 1752-699X ; 1752-6981
    ISSN (online) 1752-699X
    ISSN 1752-6981
    DOI 10.1111/crj.13526
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  8. Article ; Online: Exploring the Molecular Tumor Microenvironment and Translational Biomarkers in Brain Metastases of Non-Small-Cell Lung Cancer.

    Wen, Jiexi / Yu, Jie-Zeng / Liu, Catherine / Ould Ismail, A Aziz O / Ma, Weijie

    International journal of molecular sciences

    2024  Volume 25, Issue 4

    Abstract: Brain metastases represent a significant clinical challenge in the treatment of non-small-cell lung cancer (NSCLC), often leading to a severe decline in patient prognosis and survival. Recent advances in imaging and systemic treatments have increased the ...

    Abstract Brain metastases represent a significant clinical challenge in the treatment of non-small-cell lung cancer (NSCLC), often leading to a severe decline in patient prognosis and survival. Recent advances in imaging and systemic treatments have increased the detection rates of brain metastases, yet clinical outcomes remain dismal due to the complexity of the metastatic tumor microenvironment (TME) and the lack of specific biomarkers for early detection and targeted therapy. The intricate interplay between NSCLC tumor cells and the surrounding TME in brain metastases is pivotal, influencing tumor progression, immune evasion, and response to therapy. This underscores the necessity for a deeper understanding of the molecular underpinnings of brain metastases, tumor microenvironment, and the identification of actionable biomarkers that can inform multimodal treatment approaches. The goal of this review is to synthesize current insights into the TME and elucidate molecular mechanisms in NSCLC brain metastases. Furthermore, we will explore the promising horizon of emerging biomarkers, both tissue- and liquid-based, that hold the potential to radically transform the treatment strategies and the enhancement of patient outcomes.
    MeSH term(s) Humans ; Carcinoma, Non-Small-Cell Lung/pathology ; Lung Neoplasms/pathology ; Tumor Microenvironment ; Biomarkers, Tumor ; Brain Neoplasms/pathology
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2024-02-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25042044
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  9. Article ; Online: Mn

    Ling, Kai / Zheng, Jintao / Jiang, Xiaohong / Huang, Weijie / Mai, Youqing / Liao, Chuanghong / Fan, Shuting / Bu, Jianlan / Li, Rui / Zeng, Bingchun / Zheng, Qiunuan / Huang, Ruibin / Li, Zhiyang / Wong, Nai-Kei / Jiang, Hongyan

    ACS nano

    2024  Volume 18, Issue 4, Page(s) 2841–2860

    Abstract: Manganese ions ( ... ...

    Abstract Manganese ions (Mn
    MeSH term(s) Humans ; Oligodeoxyribonucleotides/pharmacology ; Combined Modality Therapy ; Nanoparticles ; Immunotherapy ; Neoplasms/drug therapy ; Tumor Microenvironment
    Chemical Substances Oligodeoxyribonucleotides
    Language English
    Publishing date 2024-01-22
    Publishing country United States
    Document type Journal Article
    ISSN 1936-086X
    ISSN (online) 1936-086X
    DOI 10.1021/acsnano.3c07123
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  10. Article: Changes of bile acids and resting energy expenditure after laparoscopic cholecystectomy in type 2 diabetes patients: a prospective study.

    Yin, Haixin / Chen, Weijie / He, Xiaodong / Zeng, Jianping

    Diabetology & metabolic syndrome

    2022  Volume 14, Issue 1, Page(s) 108

    Abstract: Background: We aimed to investigate changes of bile acids and resting energy expenditure (REE) in patients with type 2 diabetes mellitus (T2DM) after laparoscopic cholecystectomy (LC) and the role in metabolic homeostasis.: Methods: From December ... ...

    Abstract Background: We aimed to investigate changes of bile acids and resting energy expenditure (REE) in patients with type 2 diabetes mellitus (T2DM) after laparoscopic cholecystectomy (LC) and the role in metabolic homeostasis.
    Methods: From December 2019 to December 2021, a total of 77 T2DM patients with gallbladder polyps were included in our study. Among them, 40 patients who underwent LC were enrolled into the cholecystectomy group, and 37 patients who did not undergo LC were enrolled into the control group. Preoperative and 6-months postoperative demographic data, body weight, food intake, effects on diabetes control, and biomedical variables were recorded and compared.
    Results: The mean level of total bile acids (TBA) was higher than that in the control group (P = 0.033) and increased significantly after LC compared to baseline (P = 0.029). The REE level in the cholecystectomy group was higher than that in the control group (P = 0.032) and increased compared to the baseline (P = 0.011). The utilization of carbohydrates increased significantly after LC (P < 0.001) while the utilization of fat decreased (P < 0.001). The mean level of fasting plasma glucose (P = 0.004), hemoglobin A1C (P < 0.001), and homeostasis model assessment-insulin resistance (P = 0.045) decreased after LC. The mean level of total cholesterol (P = 0.003) and low-density lipoprotein cholesterol significantly decreased (P = 0.021), whereas the level of high-density lipoprotein cholesterol increased (P < 0.001).
    Conclusions: The level of REE and TBA increased after LC in patients with T2DM, and the glucose and lipid metabolism improved. Trial registration This study was registered in the Chinese Clinical Trial Registry on November 30, 2018, registered number: ChiCTR1900027823.
    Language English
    Publishing date 2022-07-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2518786-7
    ISSN 1758-5996
    ISSN 1758-5996
    DOI 10.1186/s13098-022-00880-3
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