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  1. Article: Exploiting routine data for international benchmarking of quality in mental health care.

    Wahlbeck, Kristian

    World psychiatry : official journal of the World Psychiatric Association (WPA)

    2018  Volume 17, Issue 1, Page(s) 41–42

    Language English
    Publishing date 2018-01-19
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2236130-3
    ISSN 2051-5545 ; 1723-8617
    ISSN (online) 2051-5545
    ISSN 1723-8617
    DOI 10.1002/wps.20485
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Thesis: The brain renin angiotensin system in schizophrenia and pain disorder

    Wahlbeck, Kristian

    1997  

    Author's details by Kristian Wahlbeck
    Language English
    Size Getr. Zählung : graph. Darst.
    Publishing country Finland
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Helsinki, Univ., Diss., 1997
    HBZ-ID HT008496306
    ISBN 952-90-9094-3 ; 978-952-90-9094-5
    Database Catalogue ZB MED Medicine, Health

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    98 E 905 order for loan Magazin

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  3. Article: Public mental health: the time is ripe for translation of evidence into practice.

    Wahlbeck, Kristian

    World psychiatry : official journal of the World Psychiatric Association (WPA)

    2015  Volume 14, Issue 1, Page(s) 36–42

    Abstract: Public mental health deals with mental health promotion, prevention of mental disorders and suicide, reducing mental health inequalities, and governance and organization of mental health service provision. The full impact of mental health is largely ... ...

    Abstract Public mental health deals with mental health promotion, prevention of mental disorders and suicide, reducing mental health inequalities, and governance and organization of mental health service provision. The full impact of mental health is largely unrecognized within the public health sphere, despite the increasing burden of disease attributable to mental and behavioral disorders. Modern public mental health policies aim at improving psychosocial health by addressing determinants of mental health in all public policy areas. Stigmatization of mental disorders is a widespread phenomenon that constitutes a barrier for help-seeking and for the development of health care services, and is thus a core issue in public mental health actions. Lately, there has been heightened interest in the promotion of positive mental health and wellbeing. Effective programmes have been developed for promoting mental health in everyday settings such as families, schools and workplaces. New evidence indicates that many mental disorders and suicides are preventable by public mental health interventions. Available evidence favours the population approach over high-risk approaches. Public mental health emphasizes the role of primary care in the provision of mental health services to the population. The convincing evidence base for population-based mental health interventions asks for actions for putting evidence into practice.
    Language English
    Publishing date 2015-02-04
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2236130-3
    ISSN 2051-5545 ; 1723-8617
    ISSN (online) 2051-5545
    ISSN 1723-8617
    DOI 10.1002/wps.20178
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  4. Article ; Online: Life Conditions as Mediators of Welfare State Effect on Mental Wellbeing among Oldest Old in Europe.

    Cresswell-Smith, Johanna / Wahlbeck, Kristian / Kalseth, Jorid

    International journal of environmental research and public health

    2022  Volume 19, Issue 7

    Abstract: Background: Mental wellbeing is formed by our daily environments, which are, in turn, influenced by public policies, such as the welfare state. This paper looks at how different aspects of life conditions may mediate the welfare state effect on mental ... ...

    Abstract Background: Mental wellbeing is formed by our daily environments, which are, in turn, influenced by public policies, such as the welfare state. This paper looks at how different aspects of life conditions may mediate the welfare state effect on mental wellbeing in oldest old age.
    Methods: Data were extracted from Round 6 of the European Social Survey (2012). The dataset comprised of 2058 people aged 80 years and older from 24 countries. Mediation analyses determined possible links between the welfare state, including eleven intervening variables representing life conditions and five mental wellbeing dimensions.
    Results: Our study confirms that the higher the level of welfare state, the better mental wellbeing, irrespective of dimension. Although several life conditions were found to mediate the welfare state effect on mental wellbeing, subjective general health, coping with income and place in society were the most important intervening variables.
    Conclusions: All three variables centre around supporting autonomy in the oldest old age. By teasing out how the welfare state influences mental wellbeing in the oldest old, we can better understand the many drivers of wellbeing and enable evidence informed age-friendly policy making.
    MeSH term(s) Aged, 80 and over ; Europe ; Humans ; Mental Health ; Social Welfare
    Language English
    Publishing date 2022-04-05
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph19074363
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  5. Article ; Online: Finding the right words: Articulating the value of mental health promotion. A focus group study.

    Cresswell-Smith, Johanna / Mäkikärki, Nonni / Appelqvist-Schmidlechner, Kaija / Wahlbeck, Kristian

    Journal of community psychology

    2022  Volume 50, Issue 7, Page(s) 2857–2874

    Abstract: The Lapinlahti Hospital initiative in Helsinki has transformed a disused psychiatric hospital into an open site for mental health promotion. The current study uses qualitative methods to explore how the initiative may promote population mental health. ... ...

    Abstract The Lapinlahti Hospital initiative in Helsinki has transformed a disused psychiatric hospital into an open site for mental health promotion. The current study uses qualitative methods to explore how the initiative may promote population mental health. The phenomenological study comprised of data from 7 focus group including 28 participants. Resulting data were thematically analysed to articulate how the initiative supports mental wellbeing in different ways. Mental health benefits were categorized into three themes; mental health value, civil values and common values which were comprised of nine subthemes; paradigm shift, social inclusion, personal meaning, regeneration, ambience, stigma, sustainability, democracy and environment. Mental health promotion emphasises the impact of daily environments in which people live their lives. Results from this study support the use of broad based actions which promote different components of mental wellbeing simultaneously. Psychiatric hospitals may offer historically meaningful sites for such actions.
    MeSH term(s) Focus Groups ; Health Promotion ; Humans ; Mental Health ; Social Stigma
    Language English
    Publishing date 2022-01-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1491194-2
    ISSN 1520-6629 ; 0090-4392
    ISSN (online) 1520-6629
    ISSN 0090-4392
    DOI 10.1002/jcop.22801
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  6. Article ; Online: Strategies for identifying dynamic regions in protein complexes: Flexibility changes accompany methylation in chemotaxis receptor signaling states.

    Malik, Nikita / Wahlbeck, Katherine A / Thompson, Lynmarie K

    Biochimica et biophysica acta. Biomembranes

    2020  Volume 1862, Issue 9, Page(s) 183312

    Abstract: Bacterial chemoreceptors are organized in arrays composed of helical receptors arranged as trimers of dimers, coupled to a histidine kinase CheA and a coupling protein CheW. Ligand binding to the external domain inhibits the kinase activity, leading to a ...

    Abstract Bacterial chemoreceptors are organized in arrays composed of helical receptors arranged as trimers of dimers, coupled to a histidine kinase CheA and a coupling protein CheW. Ligand binding to the external domain inhibits the kinase activity, leading to a change in the swimming behavior. Adaptation to an ongoing stimulus involves reversible methylation and demethylation of specific glutamate residues. However, the exact mechanism of signal propagation through the helical receptor to the histidine kinase remains elusive. Dynamics of the receptor cytoplasmic domain is thought to play an important role in the signal transduction, and current models propose inverse dynamic changes in different regions of the receptor. We hypothesize that the adaptational modification (methylation) controls the dynamics by stabilizing a partially ordered domain, which in turn modulates the binding of the kinase, CheA. We investigated the difference in dynamics between the methylated and unmethylated states of the chemoreceptor using solid-state NMR. The unmethylated receptor (CF4E) shows increased flexibility relative to the methylated mimic (CF4Q). Methylation helix 1 (MH1) has been shown to be flexible in the methylated mimic receptor. Our analysis indicates that in addition to MH1, methylation helix 2 also becomes flexible in the unmethylated receptor. In addition, we have demonstrated that both states of the receptor have a rigid region and segments with intermediate timescale dynamics. The strategies used in this study for identifying dynamic regions are applicable to a broad class of proteins and protein complexes with intrinsic disorder and dynamics spanning multiple timescales.
    MeSH term(s) Chemotaxis/genetics ; Escherichia coli Proteins/chemistry ; Escherichia coli Proteins/genetics ; Histidine Kinase/chemistry ; Histidine Kinase/genetics ; Intrinsically Disordered Proteins/chemistry ; Intrinsically Disordered Proteins/genetics ; Magnetic Resonance Spectroscopy ; Methyl-Accepting Chemotaxis Proteins/chemistry ; Methyl-Accepting Chemotaxis Proteins/genetics ; Methylation ; Multiprotein Complexes/chemistry ; Multiprotein Complexes/genetics ; Phosphorylation/genetics ; Protein Binding/genetics ; Protein Conformation ; Signal Transduction/genetics
    Chemical Substances Escherichia coli Proteins ; Intrinsically Disordered Proteins ; Methyl-Accepting Chemotaxis Proteins ; Multiprotein Complexes ; Histidine Kinase (EC 2.7.13.1) ; cheA protein, E coli (EC 2.7.13.3)
    Language English
    Publishing date 2020-04-15
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 60-7
    ISSN 1879-2642 ; 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    ISSN (online) 1879-2642 ; 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2618 ; 1879-2650
    ISSN 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    DOI 10.1016/j.bbamem.2020.183312
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  7. Article ; Online: European mental health policy should target everybody.

    Wahlbeck, Kristian

    European journal of public health

    2011  Volume 21, Issue 5, Page(s) 551–553

    MeSH term(s) Biomedical Research ; Health Policy ; Humans ; Mental Health/legislation & jurisprudence
    Language English
    Publishing date 2011-10
    Publishing country England
    Document type Comment ; Journal Article
    ZDB-ID 1129243-x
    ISSN 1464-360X ; 1101-1262
    ISSN (online) 1464-360X
    ISSN 1101-1262
    DOI 10.1093/eurpub/ckr122
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  8. Article: European comparisons between mental health services.

    Wahlbeck, K

    Epidemiology and psychiatric sciences

    2008  Volume 20, Issue 1, Page(s) 15–18

    Abstract: When developing accessible, affordable and effective mental health systems, exchange of data between countries is an important moving force towards better mental health care. Unfortunately, health information systems in most countries are weak in the ... ...

    Abstract When developing accessible, affordable and effective mental health systems, exchange of data between countries is an important moving force towards better mental health care. Unfortunately, health information systems in most countries are weak in the field of mental health, and comparability of data is low. Special international data collection exercises, such as the World Health Organization (WHO) Atlas Project and the WHO Baseline Project have provided valuable insights in the state of mental health systems in countries, but such single-standing data collections are not sustainable solutions. Improvements in routine data collection are urgently needed. The European Commission has initiated major improvements to ensure harmonized and comprehensive health data collection, by introducing the European Community Health Indicators set and the European Health Interview Survey. However, both of these initiatives lack strength in the field of mental health. The neglect of the need for relevant and valid comparable data on mental health systems is in conflict with the importance of mental health for European countries and the objectives of the 'Europe 2020' strategy. The need for valid and comparable mental health services data is today addressed only by single initiatives, such as the Organisation for Economic Co-operation and Development work to establish quality indicators for mental health care. Real leadership in developing harmonized mental health data across Europe is lacking. A European Mental Health Observatory is urgently needed to lead development and implementation of monitoring of mental health and mental health service provision in Europe.
    MeSH term(s) Cross-Cultural Comparison ; Data Collection/statistics & numerical data ; Europe ; European Union ; Humans ; Information Dissemination ; Mental Disorders/epidemiology ; Mental Health Services/statistics & numerical data ; Quality Indicators, Health Care ; World Health Organization
    Language English
    Publishing date 2008-06-06
    Publishing country England
    Document type Comparative Study ; Editorial
    ZDB-ID 2607964-1
    ISSN 2045-7979 ; 2045-7960
    ISSN (online) 2045-7979
    ISSN 2045-7960
    DOI 10.1017/s2045796011000060
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  9. Article ; Online: The Economic Case for the Prevention of Mental Illness.

    McDaid, David / Park, A-La / Wahlbeck, Kristian

    Annual review of public health

    2019  Volume 40, Page(s) 373–389

    Abstract: Poor mental health has profound economic consequences. Given the burden of poor mental health, the economic case for preventing mental illness and promoting better mental health may be very strong, but too often prevention attracts little attention and ... ...

    Abstract Poor mental health has profound economic consequences. Given the burden of poor mental health, the economic case for preventing mental illness and promoting better mental health may be very strong, but too often prevention attracts little attention and few resources. This article describes the potential role that can be played by economic evidence alongside experimental trials and observational studies, or through modeling, to substantiate the need for increased investment in prevention. It illustrates areas of action across the life course where there is already a good economic case. It also suggests some further areas of substantive public health concern, with promising effectiveness evidence, that may benefit from economic analysis. Financial and economic barriers to implementation are then presented, and strategies to address the barriers and increase investment in the prevention of mental illness are suggested.
    MeSH term(s) Health Promotion/economics ; Health Promotion/organization & administration ; Humans ; Mental Disorders/economics ; Mental Disorders/prevention & control ; Mental Health ; Mental Health Services/economics ; Mental Health Services/organization & administration
    Language English
    Publishing date 2019-01-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 760917-6
    ISSN 1545-2093 ; 0163-7525
    ISSN (online) 1545-2093
    ISSN 0163-7525
    DOI 10.1146/annurev-publhealth-040617-013629
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  10. Article: Cochrane-katsausten pätevyys.

    Wahlbeck, Kristian

    Duodecim; laaketieteellinen aikakauskirja

    2007  Volume 123, Issue 3, Page(s) 245–247

    Language Finnish
    Publishing date 2007
    Publishing country Finland
    Document type Journal Article
    ZDB-ID 127604-9
    ISSN 0012-7183
    ISSN 0012-7183
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