LIVIVO - Search results -

Search results

Result 1 - 10 of total 24

Search options

Article ; Online: Azapeptides -A History of Synthetic Milestones and Key Examples.

Fan Cheng, Kai / VanPatten, Sonya / He, Mingzhu / Al-Abed, Yousef

2022 Volume 29, Issue 42, Page(s) 6336–6358

Abstract: For over 50 years of azapeptide synthetic techniques, developments have renewed the field of peptidomimetic therapeutics. Azapeptides are close surrogates of natural peptides: they contain a substitution of the amino acid α-carbon by a nitrogen atom. ... ...

Abstract	For over 50 years of azapeptide synthetic techniques, developments have renewed the field of peptidomimetic therapeutics. Azapeptides are close surrogates of natural peptides: they contain a substitution of the amino acid α-carbon by a nitrogen atom. Goserelin (1989) and Atazanavir (2003) are two well-known, FDA-approved azapeptide-based drugs for the treatment of cancers and HIV infection, providing evidence for the successful clinical implementation of this class of therapeutic. This review highlights the azapeptides in recent medicinal chemistry applications and synthetic milestones. We describe the current techniques for azapeptide bond formation by introducing azapeptide coupling reagents and chain elongation methods both in solution and solid-phase strategies.
MeSH term(s)	Humans ; Peptidomimetics ; Aza Compounds/chemistry ; Atazanavir Sulfate ; Goserelin ; HIV Infections ; Peptides/chemistry ; Amino Acids/chemistry ; Carbon ; Nitrogen
Chemical Substances	Peptidomimetics ; Aza Compounds ; Atazanavir Sulfate (4MT4VIE29P) ; Goserelin (0F65R8P09N) ; Peptides ; Amino Acids ; Carbon (7440-44-0) ; Nitrogen (N762921K75)
Language	English
Publishing date	2022-05-11
Publishing country	United Arab Emirates
Document type	Review ; Journal Article
ZDB-ID	1319315-6
ISSN	1875-533X ; 0929-8673
ISSN (online)	1875-533X
ISSN	0929-8673
DOI	10.2174/0929867329666220510214402
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4432: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: High Mobility Group Box-1 (HMGb1): Current Wisdom and Advancement as a Potential Drug Target.

VanPatten, Sonya / Al-Abed, Yousef

Journal of medicinal chemistry

2018 Volume 61, Issue 12, Page(s) 5093–5107

Abstract: High mobility group box-1 (HMGb1) protein, a nuclear non-histone protein that is released or secreted from the cell in response to damage or stress, is a sentinel for the immune system that plays a critical role in cell survival/death pathways. This ... ...

Abstract	High mobility group box-1 (HMGb1) protein, a nuclear non-histone protein that is released or secreted from the cell in response to damage or stress, is a sentinel for the immune system that plays a critical role in cell survival/death pathways. This review highlights key features of the endogenous danger-associated molecular pattern (DAMP) protein, HMGb1 in the innate inflammatory response along with various cofactors and receptors that regulate its downstream effects. The evidence demonstrating increased levels of HMGb1 in human inflammatory diseases and conditions is presented, along with a summary of current small molecule or peptide-like antagonists proven to specifically target HMGb1. Additionally, we delineate the measures needed toward validating this protein as a clinically relevant biomarker or bioindicator and as a relevant drug target.
MeSH term(s)	Alarmins/immunology ; Alarmins/metabolism ; Biomarkers/analysis ; Biomarkers/metabolism ; HMGB1 Protein/antagonists & inhibitors ; HMGB1 Protein/metabolism ; Humans ; Immunity, Innate/drug effects ; Immunity, Innate/physiology ; Inflammation/immunology ; Inflammation/metabolism ; Molecular Targeted Therapy/methods ; Pathogen-Associated Molecular Pattern Molecules/immunology ; Pathogen-Associated Molecular Pattern Molecules/metabolism
Chemical Substances	Alarmins ; Biomarkers ; HMGB1 Protein ; HMGB1 protein, human ; Pathogen-Associated Molecular Pattern Molecules
Language	English
Publishing date	2018-01-05
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	218133-2
ISSN	1520-4804 ; 0022-2623
ISSN (online)	1520-4804
ISSN	0022-2623
DOI	10.1021/acs.jmedchem.7b01136
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 151: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MB 1: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: SARS-CoV-2 and interferon blockade.

Diamond, Betty / Volpe, Bruce T / VanPatten, Sonya / Al Abed, Yousef

Molecular medicine (Cambridge, Mass.)

2020 Volume 26, Issue 1, Page(s) 103

Abstract: The response to viral infection generally includes an activation of the adaptive immune response to produce cytotoxic T cells and neutralizing antibodies. We propose that SARS-CoV-2 activates the innate immune system through the renin-angiotensin and ... ...

Abstract	The response to viral infection generally includes an activation of the adaptive immune response to produce cytotoxic T cells and neutralizing antibodies. We propose that SARS-CoV-2 activates the innate immune system through the renin-angiotensin and kallikrein-bradykinin pathways, blocks interferon production and reduces an effective adaptive immune response. This model has therapeutic implications.
MeSH term(s)	Animals ; Betacoronavirus/immunology ; Bradykinin/metabolism ; COVID-19 ; Coronavirus Infections/immunology ; Humans ; Immunity, Innate ; Kallikreins/metabolism ; Models, Immunological ; Pandemics ; Pneumonia, Viral/immunology ; Renin-Angiotensin System ; SARS-CoV-2
Chemical Substances	Kallikreins (EC 3.4.21.-) ; Bradykinin (S8TIM42R2W)
Keywords	covid19
Language	English
Publishing date	2020-11-09
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	1283676-x
ISSN	1528-3658 ; 1076-1551
ISSN (online)	1528-3658
ISSN	1076-1551
DOI	10.1186/s10020-020-00231-w
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4456: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: The challenges of modulating the 'rest and digest' system: acetylcholine receptors as drug targets.

VanPatten, Sonya / Al-Abed, Yousef

Drug discovery today

2017 Volume 22, Issue 1, Page(s) 97–104

Abstract: Acetylcholine, a major neurotransmitter of the parasympathetic and sympathetic nervous systems, was discovered in the early 1900s. Over the years, researchers have revealed much about its regulation, properties of its receptors and features of the ... ...

Abstract	Acetylcholine, a major neurotransmitter of the parasympathetic and sympathetic nervous systems, was discovered in the early 1900s. Over the years, researchers have revealed much about its regulation, properties of its receptors and features of the downstream signaling that influence its terminal effects. The acetylcholine system, traditionally associated with neuromuscular communication, is now known to play a crucial part in modulation of the immune system and other 'rest and digest' effects. Recent research seeks to elucidate the system's role in brain functions including cognition, sleep, arousal, motivation, reward and pain. We highlight clinically approved and experimental drugs that modulate the acetylcholine receptors. The complexities in targeting the acetylcholine receptors are vast and finding future indications for drug development associated with specific acetylcholine receptors remains a challenge.
Language	English
Publishing date	2017-01
Publishing country	England
Document type	Review ; Journal Article
ZDB-ID	1324988-5
ISSN	1878-5832 ; 1359-6446
ISSN (online)	1878-5832
ISSN	1359-6446
DOI	10.1016/j.drudis.2016.09.011
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4725: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Mechanistic insights into high mobility group box-1 (HMGb1)-induced Toll-like receptor 4 (TLR4) dimer formation.

Sun, Shan / He, Mingzhu / VanPatten, Sonya / Al-Abed, Yousef

Journal of biomolecular structure & dynamics

2018 Volume 37, Issue 14, Page(s) 3721–3730

Abstract: Supplemental data for this article can be accessed here.High mobility group box-1 (HMGb1), an endogenous danger-associated molecular pattern protein (DAMP) whose extracellular release has been associated with sterile injury and various inflammatory ... ...

Abstract	Supplemental data for this article can be accessed here.High mobility group box-1 (HMGb1), an endogenous danger-associated molecular pattern protein (DAMP) whose extracellular release has been associated with sterile injury and various inflammatory diseases and conditions, has been shown to be a valuable clinical drug target. Elucidation of the specific interactions with the HMGb1 receptor, Toll-like receptor 4 (TLR4) and adaptor protein myeloid differentiation factor-2 (MD-2), will lead to more precisely targeted therapeutics. We sought to examine detailed interactions and dynamics of the HMGb1 A-box and B-box fragments, as well as the intact protein using
MeSH term(s)	Animals ; Disulfides/metabolism ; HMGB1 Protein/chemistry ; HMGB1 Protein/metabolism ; Humans ; Lymphocyte Antigen 96/metabolism ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Mutant Proteins/chemistry ; Mutant Proteins/metabolism ; Protein Binding ; Protein Multimerization ; Rats ; Toll-Like Receptor 4/chemistry ; Toll-Like Receptor 4/metabolism
Chemical Substances	Disulfides ; HMGB1 Protein ; LY96 protein, human ; Lymphocyte Antigen 96 ; Mutant Proteins ; Toll-Like Receptor 4
Language	English
Publishing date	2018-12-10
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	49157-3
ISSN	1538-0254 ; 0739-1102
ISSN (online)	1538-0254
ISSN	0739-1102
DOI	10.1080/07391102.2018.1526712
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2093: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Rediscovering MIF: New Tricks for an Old Cytokine.

Harris, James / VanPatten, Sonya / Deen, Nadia S / Al-Abed, Yousef / Morand, Eric F

Trends in immunology

2019 Volume 40, Issue 5, Page(s) 447–462

Abstract: Produced by many cell types, macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine with critical and supporting roles in many disease states and conditions. Its disease associations, myriad functions, receptors, and downstream signaling ... ...

Abstract	Produced by many cell types, macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine with critical and supporting roles in many disease states and conditions. Its disease associations, myriad functions, receptors, and downstream signaling have been the subject of considerable research, yet many questions remain. Moreover, the relevance of MIF's partially functionally redundant family member, D-dopachrome tautomerase (D-DT), also remains to be further characterized. Here, we discuss recent discoveries demonstrating direct roles of MIF in supporting NLR Family Pyrin Domain-Containing 3 (NRLP3) inflammasome activation, as well as acting as a molecular chaperone for intracellular proteins. These findings may offer new clues to understanding MIF's multiple functions, and assist the development of putative MIF-targeting therapeutics for a variety of pathologies.
MeSH term(s)	Humans ; Inflammasomes/immunology ; Intramolecular Oxidoreductases/biosynthesis ; Intramolecular Oxidoreductases/immunology ; Macrophage Migration-Inhibitory Factors/biosynthesis ; Macrophage Migration-Inhibitory Factors/immunology ; NLR Family, Pyrin Domain-Containing 3 Protein/immunology
Chemical Substances	Inflammasomes ; Macrophage Migration-Inhibitory Factors ; NLR Family, Pyrin Domain-Containing 3 Protein ; NLRP3 protein, human ; Intramolecular Oxidoreductases (EC 5.3.-) ; MIF protein, human (EC 5.3.2.1)
Language	English
Publishing date	2019-04-05
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2036831-8
ISSN	1471-4981 ; 1471-4906
ISSN (online)	1471-4981
ISSN	1471-4906
DOI	10.1016/j.it.2019.03.002
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1601: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 2: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: SARS-CoV-2 and interferon blockade

Diamond, Betty / Volpe, Bruce T / VanPatten, Sonya / Al Abed, Yousef

Mol Med

Abstract	The response to viral infection generally includes an activation of the adaptive immune response to produce cytotoxic T cells and neutralizing antibodies. We propose that SARS-CoV-2 activates the innate immune system through the renin-angiotensin and kallikrein-bradykinin pathways, blocks interferon production and reduces an effective adaptive immune response. This model has therapeutic implications.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #917917
Database	COVID19

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article ; Online: Evidence supporting the use of peptides and peptidomimetics as potential SARS-CoV-2 (COVID-19) therapeutics.

VanPatten, Sonya / He, Mingzhu / Altiti, Ahmad / F Cheng, Kai / Ghanem, Mustafa H / Al-Abed, Yousef

Future medicinal chemistry

2020 Volume 12, Issue 18, Page(s) 1647–1656

Abstract: During a disease outbreak/pandemic situation such as COVID-19, researchers are in a prime position to identify and develop peptide-based therapies, which could be more rapidly and cost-effectively advanced into a clinical setting. One drawback of natural ...

Abstract	During a disease outbreak/pandemic situation such as COVID-19, researchers are in a prime position to identify and develop peptide-based therapies, which could be more rapidly and cost-effectively advanced into a clinical setting. One drawback of natural peptide drugs, however, is their proteolytic instability; peptidomimetics can help to overcome this caveat. In this review, we summarize peptide and peptide-based therapeutics that target one main entry pathway of SARS-CoV-2, which involves the host ACE2 receptor and viral spike (S) protein interaction. Furthermore, we discuss the advantages of peptidomimetics and other potential targets that have been studied using peptide-based therapeutics for COVID-19.
MeSH term(s)	Angiotensin-Converting Enzyme 2 ; Animals ; Antiviral Agents/therapeutic use ; COVID-19 ; Coronavirus Infections/drug therapy ; Humans ; Pandemics ; Peptides/therapeutic use ; Peptidomimetics/therapeutic use ; Peptidyl-Dipeptidase A/drug effects ; Pneumonia, Viral/drug therapy ; Spike Glycoprotein, Coronavirus/drug effects ; Virus Internalization
Chemical Substances	Antiviral Agents ; Peptides ; Peptidomimetics ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2 ; Peptidyl-Dipeptidase A (EC 3.4.15.1) ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
Keywords	covid19
Language	English
Publishing date	2020-07-16
Publishing country	England
Document type	Journal Article
ISSN	1756-8927
ISSN (online)	1756-8927
DOI	10.4155/fmc-2020-0180
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Multi-Drug Cocktail Therapy Improves Survival and Neurological Function after Asphyxial Cardiac Arrest in Rodents.

Choudhary, Rishabh C / Shoaib, Muhammad / Hayashida, Kei / Yin, Tai / Miyara, Santiago J / d'Abramo, Cristina / Heuser, William G / Shinozaki, Koichiro / Kim, Nancy / Takegawa, Ryosuke / Nishikimi, Mitsuaki / Li, Timmy / Owens, Casey / Molmenti, Ernesto P / He, Mingzhu / Vanpatten, Sonya / Al-Abed, Yousef / Kim, Junhwan / Becker, Lance B

Cells

2023 Volume 12, Issue 11

Abstract: Background: Cardiac arrest (CA) can lead to neuronal degeneration and death through various pathways, including oxidative, inflammatory, and metabolic stress. However, current neuroprotective drug therapies will typically target only one of these ... ...

Abstract	Background: Cardiac arrest (CA) can lead to neuronal degeneration and death through various pathways, including oxidative, inflammatory, and metabolic stress. However, current neuroprotective drug therapies will typically target only one of these pathways, and most single drug attempts to correct the multiple dysregulated metabolic pathways elicited following cardiac arrest have failed to demonstrate clear benefit. Many scientists have opined on the need for novel, multidimensional approaches to the multiple metabolic disturbances after cardiac arrest. In the current study, we have developed a therapeutic cocktail that includes ten drugs capable of targeting multiple pathways of ischemia-reperfusion injury after CA. We then evaluated its effectiveness in improving neurologically favorable survival through a randomized, blind, and placebo-controlled study in rats subjected to 12 min of asphyxial CA, a severe injury model. Results: 14 rats were given the cocktail and 14 received the vehicle after resuscitation. At 72 h post-resuscitation, the survival rate was 78.6% among cocktail-treated rats, which was significantly higher than the 28.6% survival rate among vehicle-treated rats (log-rank test; Conclusions: Our findings demonstrate that, with its ability to target multiple damaging pathways, a multi-drug therapeutic cocktail offers promise both as a conceptual advance and as a specific multi-drug formulation capable of combatting neuronal degeneration and death following cardiac arrest. Clinical implementation of this therapy may improve neurologically favorable survival rates and neurological deficits in patients suffering from cardiac arrest.
MeSH term(s)	Animals ; Rats ; Cardiopulmonary Resuscitation/methods ; Heart Arrest/complications ; Heart Arrest/therapy ; Rats, Sprague-Dawley ; Rodentia
Language	English
Publishing date	2023-06-05
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells12111548
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Multi-Drug Cocktail Therapy Improves Survival and Neurological Function after Asphyxial Cardiac Arrest in Rodents

Rishabh C. Choudhary / Muhammad Shoaib / Kei Hayashida / Tai Yin / Santiago J. Miyara / Cristina d’Abramo / William G. Heuser / Koichiro Shinozaki / Nancy Kim / Ryosuke Takegawa / Mitsuaki Nishikimi / Timmy Li / Casey Owens / Ernesto P. Molmenti / Mingzhu He / Sonya Vanpatten / Yousef Al-Abed / Junhwan Kim / Lance B. Becker

Cells, Vol 12, Iss 1548, p

2023 Volume 1548

Abstract	Background: Cardiac arrest (CA) can lead to neuronal degeneration and death through various pathways, including oxidative, inflammatory, and metabolic stress. However, current neuroprotective drug therapies will typically target only one of these pathways, and most single drug attempts to correct the multiple dysregulated metabolic pathways elicited following cardiac arrest have failed to demonstrate clear benefit. Many scientists have opined on the need for novel, multidimensional approaches to the multiple metabolic disturbances after cardiac arrest. In the current study, we have developed a therapeutic cocktail that includes ten drugs capable of targeting multiple pathways of ischemia–reperfusion injury after CA. We then evaluated its effectiveness in improving neurologically favorable survival through a randomized, blind, and placebo-controlled study in rats subjected to 12 min of asphyxial CA, a severe injury model. Results: 14 rats were given the cocktail and 14 received the vehicle after resuscitation. At 72 h post-resuscitation, the survival rate was 78.6% among cocktail-treated rats, which was significantly higher than the 28.6% survival rate among vehicle-treated rats (log-rank test; p = 0.006). Moreover, in cocktail-treated rats, neurological deficit scores were also improved. These survival and neurological function data suggest that our multi-drug cocktail may be a potential post-CA therapy that deserves clinical translation. Conclusions: Our findings demonstrate that, with its ability to target multiple damaging pathways, a multi-drug therapeutic cocktail offers promise both as a conceptual advance and as a specific multi-drug formulation capable of combatting neuronal degeneration and death following cardiac arrest. Clinical implementation of this therapy may improve neurologically favorable survival rates and neurological deficits in patients suffering from cardiac arrest.
Keywords	brain injury ; cell death ; cardiac arrest ; cardiopulmonary resuscitation ; cardiopulmonary bypass resuscitation ; ischemic damage ; Biology (General) ; QH301-705.5
Subject code	610
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED