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  1. Article ; Online: Conflicts with transcription make early replication late.

    Petermann, Eva

    Molecular cell

    2022  Volume 82, Issue 18, Page(s) 3315–3317

    Abstract: By sequencing sites of mitotic DNA synthesis in cells lacking homologous recombination, Groelly, Bhowmick, and colleagues show how conflicts between transcription and replication in early S phase can cause under-replicated DNA to persist into mitosis. ...

    Abstract By sequencing sites of mitotic DNA synthesis in cells lacking homologous recombination, Groelly, Bhowmick, and colleagues show how conflicts between transcription and replication in early S phase can cause under-replicated DNA to persist into mitosis.
    MeSH term(s) DNA ; DNA Replication ; Mitosis/genetics ; Transcription, Genetic
    Chemical Substances DNA (9007-49-2)
    Language English
    Publishing date 2022-09-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1415236-8
    ISSN 1097-4164 ; 1097-2765
    ISSN (online) 1097-4164
    ISSN 1097-2765
    DOI 10.1016/j.molcel.2022.08.026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Conflicts with transcription make early replication late

    Petermann, Eva

    Molecular cell. 2022 Sept. 15, v. 82, no. 18

    2022  

    Abstract: By sequencing sites of mitotic DNA synthesis in cells lacking homologous recombination, Groelly, Bhowmick, and colleagues show how conflicts between transcription and replication in early S phase can cause under-replicated DNA to persist into mitosis. ...

    Abstract By sequencing sites of mitotic DNA synthesis in cells lacking homologous recombination, Groelly, Bhowmick, and colleagues show how conflicts between transcription and replication in early S phase can cause under-replicated DNA to persist into mitosis.
    Keywords DNA ; DNA replication ; homologous recombination ; interphase ; mitosis
    Language English
    Dates of publication 2022-0915
    Size p. 3315-3317.
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 1415236-8
    ISSN 1097-4164 ; 1097-2765
    ISSN (online) 1097-4164
    ISSN 1097-2765
    DOI 10.1016/j.molcel.2022.08.026
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  3. Book ; Thesis: Komplikationen nach partieller Pankreatikoduodenektomie

    Petermann, Eva

    Risikofaktoren und prognostische Bedeutung

    2005  

    Author's details vorgelegt von Eva Petermann
    Language German
    Size IV, 92 Bl., graph. Darst., 30 cm
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Heidelberg, Univ., Diss., 2005
    HBZ-ID HT014938843
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2007 E 260 order for loan Magazin

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  4. Article ; Online: Author Correction: Sources, resolution and physiological relevance of R-loops and RNA-DNA hybrids.

    Petermann, Eva / Lan, Li / Zou, Lee

    Nature reviews. Molecular cell biology

    2022  Volume 23, Issue 6, Page(s) 444

    Language English
    Publishing date 2022-05-05
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2031313-5
    ISSN 1471-0080 ; 1471-0072
    ISSN (online) 1471-0080
    ISSN 1471-0072
    DOI 10.1038/s41580-022-00494-7
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  5. Article ; Online: Sources, resolution and physiological relevance of R-loops and RNA-DNA hybrids.

    Petermann, Eva / Lan, Li / Zou, Lee

    Nature reviews. Molecular cell biology

    2022  Volume 23, Issue 8, Page(s) 521–540

    Abstract: RNA-DNA hybrids are generated during transcription, DNA replication and DNA repair and are crucial intermediates in these processes. When RNA-DNA hybrids are stably formed in double-stranded DNA, they displace one of the DNA strands and give rise to a ... ...

    Abstract RNA-DNA hybrids are generated during transcription, DNA replication and DNA repair and are crucial intermediates in these processes. When RNA-DNA hybrids are stably formed in double-stranded DNA, they displace one of the DNA strands and give rise to a three-stranded structure called an R-loop. R-loops are widespread in the genome and are enriched at active genes. R-loops have important roles in regulating gene expression and chromatin structure, but they also pose a threat to genomic stability, especially during DNA replication. To keep the genome stable, cells have evolved a slew of mechanisms to prevent aberrant R-loop accumulation. Although R-loops can cause DNA damage, they are also induced by DNA damage and act as key intermediates in DNA repair such as in transcription-coupled repair and RNA-templated DNA break repair. When the regulation of R-loops goes awry, pathological R-loops accumulate, which contributes to diseases such as neurodegeneration and cancer. In this Review, we discuss the current understanding of the sources of R-loops and RNA-DNA hybrids, mechanisms that suppress and resolve these structures, the impact of these structures on DNA repair and genome stability, and opportunities to therapeutically target pathological R-loops.
    MeSH term(s) DNA/chemistry ; DNA Repair ; Genomic Instability ; Humans ; R-Loop Structures ; RNA/metabolism
    Chemical Substances RNA (63231-63-0) ; DNA (9007-49-2)
    Language English
    Publishing date 2022-04-22
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2031313-5
    ISSN 1471-0080 ; 1471-0072
    ISSN (online) 1471-0080
    ISSN 1471-0072
    DOI 10.1038/s41580-022-00474-x
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  6. Article ; Online: Reply.

    Böhm, Myriam / Petermann, Kerstin / Hemkeppler, Eva / Kohnen, Thomas

    Journal of cataract and refractive surgery

    2020  Volume 46, Issue 5, Page(s) 803–804

    Language English
    Publishing date 2020-05-08
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 632744-8
    ISSN 1873-4502 ; 0886-3350
    ISSN (online) 1873-4502
    ISSN 0886-3350
    DOI 10.1097/j.jcrs.0000000000000159
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    Zs.A 1806: Show issues Location:
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  7. Article ; Online: Hypertranscription and replication stress in cancer.

    Bowry, Akhil / Kelly, Richard D W / Petermann, Eva

    Trends in cancer

    2021  Volume 7, Issue 9, Page(s) 863–877

    Abstract: Replication stress results from obstacles to replication fork progression, including ongoing transcription, which can cause transcription-replication conflicts. Oncogenic signaling can promote global increases in transcription activity, also termed ... ...

    Abstract Replication stress results from obstacles to replication fork progression, including ongoing transcription, which can cause transcription-replication conflicts. Oncogenic signaling can promote global increases in transcription activity, also termed hypertranscription. Despite the widely accepted importance of oncogene-induced hypertranscription, its study remains neglected compared with other causes of replication stress and genomic instability in cancer. A growing number of recent studies are reporting that oncogenes, such as RAS, and targeted cancer treatments, such as bromodomain and extraterminal motif (BET) bromodomain inhibitors, increase global transcription, leading to R-loop accumulation, transcription-replication conflicts, and the activation of replication stress responses. Here we discuss our mechanistic understanding of hypertranscription-induced replication stress and the resulting cellular responses, in the context of oncogenes and targeted cancer therapies.
    MeSH term(s) DNA Damage ; DNA Replication ; Genomic Instability ; Humans ; Neoplasms/genetics ; Oncogenes ; R-Loop Structures
    Language English
    Publishing date 2021-05-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2852626-0
    ISSN 2405-8025 ; 2405-8033 ; 2405-8033
    ISSN (online) 2405-8025 ; 2405-8033
    ISSN 2405-8033
    DOI 10.1016/j.trecan.2021.04.006
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  8. Article ; Online: Reply: Visual and patient-reported factors leading to satisfaction after implantation of diffractive EDOF and trifocal intraocular lenses.

    Lwowski, Christoph / Pawlowicz, Katarzyna / Petermann, Kerstin / Hemkeppler, Eva / Hinzelmann, Lisa / Böhm, Myriam / Kohnen, Thomas

    Journal of cataract and refractive surgery

    2022  Volume 48, Issue 3, Page(s) 383

    MeSH term(s) Humans ; Lenses, Intraocular ; Multifocal Intraocular Lenses ; Patient Reported Outcome Measures ; Patient Satisfaction ; Personal Satisfaction
    Language English
    Publishing date 2022-01-31
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 632744-8
    ISSN 1873-4502 ; 0886-3350
    ISSN (online) 1873-4502
    ISSN 0886-3350
    DOI 10.1097/j.jcrs.0000000000000894
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  9. Article: Besatzdichte in der Junghennenaufzucht - ein kontrovers diskutiertes Thema

    Moors, Eva / Petermann, Sabine

    Amtstierärztlicher Dienst und Lebensmittelkontrolle

    2018  Volume 25, Issue 3, Page(s) 156

    Language German
    Document type Article
    ZDB-ID 1191273-x
    ISSN 0945-3296
    Database Current Contents Nutrition, Environment, Agriculture

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  10. Article ; Online: Defocus curves of 4 presbyopia-correcting IOL designs: Diffractive panfocal, diffractive trifocal, segmental refractive, and extended-depth-of-focus.

    Böhm, Myriam / Petermann, Kerstin / Hemkeppler, Eva / Kohnen, Thomas

    Journal of cataract and refractive surgery

    2019  Volume 45, Issue 11, Page(s) 1625–1636

    Abstract: Purpose: To evaluate the defocus curves of 4 presbyopia-correcting intraocular lenses (IOLs).: Setting: Department of Ophthalmology, Goethe University, Frankfurt, Germany.: Design: Prospective case series.: Methods: Patients included in the ... ...

    Abstract Purpose: To evaluate the defocus curves of 4 presbyopia-correcting intraocular lenses (IOLs).
    Setting: Department of Ophthalmology, Goethe University, Frankfurt, Germany.
    Design: Prospective case series.
    Methods: Patients included in the study had bilateral surgery with implantation of diffractive panfocal, diffractive trifocal, segmental refractive (SegRef), or extended-depth-of-focus (EDOF) presbyopia-correcting IOLs. The uncorrected (UDVA) and corrected (CDVA) distance visual acuities, uncorrected intermediate and near visual acuities, distance-corrected intermediate (DCIVA) and near (DCNVA) visual acuities, defocus curve, and spectacle independence were measured.
    Results: The UDVA and CDVA were not significantly different between groups (P > .05); however, the EDOF group had worse near CDVA (P < .001). The trifocal and EDOF groups showed better DCIVA than the panfocal and SegRef group at 80 cm (P < .001); the EDOF and panfocal groups had comparable DCIVA at 60 cm (P > .05). Defocus curves showed no significant between-group differences from 4 m to 2 m (P > .05). The EDOF group had better visual acuity from 1 m to 67 cm than the trifocal and SegRef groups and better visual acuity than the panfocal group at 1 m (P > .05). Compared with the other IOLs, the panfocal IOL yielded significantly better visual acuity at 50 cm (P < .001) and the EDOF IOL worse visual acuity at 40 cm (P < .01). There was a significant difference in spectacle independence between the panfocal group and EDOF group (P < .05) but no difference between the other groups.
    Conclusions: The 4 IOLs provided equally good CDVA. The EDOF IOL yielded slightly better DCIVA but worse DCNVA than the other IOLs. Only the panfocal IOL gave better DCIVA at 50 cm.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Depth Perception/physiology ; Female ; Humans ; Lens Implantation, Intraocular ; Lenses, Intraocular ; Male ; Middle Aged ; Multifocal Intraocular Lenses ; Patient Satisfaction ; Presbyopia/surgery ; Prospective Studies ; Prosthesis Design ; Pseudophakia/physiopathology ; Refraction, Ocular/physiology ; Vision, Binocular/physiology ; Visual Acuity/physiology
    Language English
    Publishing date 2019-11-06
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 632744-8
    ISSN 1873-4502 ; 0886-3350
    ISSN (online) 1873-4502
    ISSN 0886-3350
    DOI 10.1016/j.jcrs.2019.07.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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