LIVIVO - Search results -

Search results

Result 1 - 10 of total 14

Search options

Article ; Online: Evaluation of an artificial intelligence U-net algorithm for pulmonary nodule tracking on chest computed tomography images.

Takeshita, Yuhei / Onozawa, Shiro / Katase, Shichiro / Shirakawa, Yuya / Yamashita, Kouji / Shudo, Jun / Nakanishi, Akihito / Akahori, Sadato / Yokoyama, Kenichi

The Journal of international medical research

2024 Volume 52, Issue 2, Page(s) 3000605241230033

Abstract: Objectives: To apply image registration in the follow up of lung nodules and verify the feasibility of automatic tracking of lung nodules using an artificial intelligence (AI) method.: Methods: For this retrospective, observational study, patients ... ...

Abstract	Objectives: To apply image registration in the follow up of lung nodules and verify the feasibility of automatic tracking of lung nodules using an artificial intelligence (AI) method. Methods: For this retrospective, observational study, patients with pulmonary nodules 5-30 mm in diameter on computed tomography (CT) and who had at least six months follow-up were identified. Two radiologists defined a 'correct' cuboid circumscribing each nodule which was used to judge the success/failure of nodule tracking. An AI algorithm was applied in which a U-net type neural network model was trained to predict the deformation vector field between two examinations. When the estimated position was within a defined cuboid, the AI algorithm was judged a success. Results: In total, 49 lung nodules in 40 patients, with a total of 368 follow-up CT examinations were examined. The success rate for each time evaluation was 94% (345/368) and for 'nodule-by-nodule evaluation' was 78% (38/49). Reasons for a decrease in success rate were related to small nodules and those that decreased in size. Conclusion: Automatic tracking of lung nodules is highly feasible.
MeSH term(s)	Humans ; Artificial Intelligence ; Retrospective Studies ; Lung Neoplasms ; Solitary Pulmonary Nodule ; Algorithms ; Tomography, X-Ray Computed/methods
Language	English
Publishing date	2024-02-06
Publishing country	England
Document type	Observational Study ; Journal Article
ZDB-ID	184023-x
ISSN	1473-2300 ; 0300-0605 ; 0142-2596
ISSN (online)	1473-2300
ISSN	0300-0605 ; 0142-2596
DOI	10.1177/03000605241230033
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 925: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article: No Relationships between Psychosis and the Diazepam Binding Inhibitor rs2276596 (C/A) Polymorphism in Japanese: An Exploratory Study.

Yoshiharia, Eiji / Narita, Shin / Waga, Chikako / Numajiri, Maki / Onozawa, Yuya / Iwahashi, Kazuhiko

Rinsho byori. The Japanese journal of clinical pathology

2019 Volume 64, Issue 9, Page(s) 1007–1011

Abstract: Objective: Our recent study for the first time reported genotyping method of the diazepam binding inhibitor (DBI) rs2276596 polymorphism using a Polymerase Chain Reaction-Restriction Fragment Length Polymor- phism (PCR-RFLP), and revealed a significant ... ...

Abstract	Objective: Our recent study for the first time reported genotyping method of the diazepam binding inhibitor (DBI) rs2276596 polymorphism using a Polymerase Chain Reaction-Restriction Fragment Length Polymor- phism (PCR-RFLP), and revealed a significant relationships between this polymorphism and alcohol depend- ence. In this study, to facilitate elucidation of the pathogeneses of psychoses including schizophrenia and mood (affective) disorders, we investigated the relationship between the DBI rs2276596 polymorphism (C/A) and psychoses. Method: We analyzed the DBI genotypes using the PCR-RFLP method in healthy controls, and psychotics including schizophrenia and mood (affective) disorders (including recurrent depressive disorder and bipolar affective disorder) (ICD-10: F31, F33). Result: There was no significant difference in the rs2276596 genotype and allele frequencies of the DBI gene between these psychoses and healthy controls. Conclusion: The present data suggested that a mutated allele of the DBI was not one of the risk factors for schizophrenia and mood (affective) disorders, as for the rs2276596 polymorphism. [Original].
MeSH term(s)	Adult ; Alleles ; Asian Continental Ancestry Group/genetics ; Diazepam Binding Inhibitor/genetics ; Female ; Genotype ; Humans ; Male ; Middle Aged ; Polymorphism, Single Nucleotide ; Psychotic Disorders/genetics
Chemical Substances	Diazepam Binding Inhibitor
Language	English
Publishing date	2019-01-04
Publishing country	Japan
Document type	Journal Article
ZDB-ID	604196-6
ISSN	0047-1860 ; 0485-1404
ISSN	0047-1860 ; 0485-1404
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 437: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Development and performance evaluation of a deep learning lung nodule detection system.

Katase, Shichiro / Ichinose, Akimichi / Hayashi, Mahiro / Watanabe, Masanaka / Chin, Kinka / Takeshita, Yuhei / Shiga, Hisae / Tateishi, Hidekatsu / Onozawa, Shiro / Shirakawa, Yuya / Yamashita, Koji / Shudo, Jun / Nakamura, Keigo / Nakanishi, Akihito / Kuroki, Kazunori / Yokoyama, Kenichi

BMC medical imaging

2022 Volume 22, Issue 1, Page(s) 203

Abstract: Background: Lung cancer is the leading cause of cancer-related deaths throughout the world. Chest computed tomography (CT) is now widely used in the screening and diagnosis of lung cancer due to its effectiveness. Radiologists must identify each small ... ...

Abstract	Background: Lung cancer is the leading cause of cancer-related deaths throughout the world. Chest computed tomography (CT) is now widely used in the screening and diagnosis of lung cancer due to its effectiveness. Radiologists must identify each small nodule shadow from 3D volume images, which is very burdensome and often results in missed nodules. To address these challenges, we developed a computer-aided detection (CAD) system that automatically detects lung nodules in CT images. Methods: A total of 1997 chest CT scans were collected for algorithm development. The algorithm was designed using deep learning technology. In addition to evaluating detection performance on various public datasets, its robustness to changes in radiation dose was assessed by a phantom study. To investigate the clinical usefulness of the CAD system, a reader study was conducted with 10 doctors, including inexperienced and expert readers. This study investigated whether the use of the CAD as a second reader could prevent nodular lesions in lungs that require follow-up examinations from being overlooked. Analysis was performed using the Jackknife Free-Response Receiver-Operating Characteristic (JAFROC). Results: The CAD system achieved sensitivity of 0.98/0.96 at 3.1/7.25 false positives per case on two public datasets. Sensitivity did not change within the range of practical doses for a study using a phantom. A second reader study showed that the use of this system significantly improved the detection ability of nodules that could be picked up clinically (p = 0.026). Conclusions: We developed a deep learning-based CAD system that is robust to imaging conditions. Using this system as a second reader increased detection performance.
MeSH term(s)	Humans ; Deep Learning ; Tomography, X-Ray Computed ; Lung Neoplasms/diagnostic imaging ; Phantoms, Imaging ; Lung/diagnostic imaging
Language	English
Publishing date	2022-11-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2061975-3
ISSN	1471-2342 ; 1471-2342
ISSN (online)	1471-2342
ISSN	1471-2342
DOI	10.1186/s12880-022-00938-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: [Intraoperative ABR Monitoring in Neurosurgery].

Sato, Sumito / Onozawa, Yuya / Kumabe, Toshihiro / Okamoto, Hirotsugu

Masui. The Japanese journal of anesthesiology

2015 Volume 64, Issue 5, Page(s) 502–507

Abstract: Monitoring of the intraoperative auditory brainstem response (ABR) is a less invasive, easy, and useful method for hearing preservation in patient undergoing cerebellopontine angle surgery such as microvascular decompression (MVD) and excision of an ... ...

Abstract	Monitoring of the intraoperative auditory brainstem response (ABR) is a less invasive, easy, and useful method for hearing preservation in patient undergoing cerebellopontine angle surgery such as microvascular decompression (MVD) and excision of an acoustic neurinoma. The ABR is tolerant of both inhalation and intravenous anesthesia. However, ABR recordings are highly susceptible to electrical noise from surgical devices. Therefore, for ABR recordings to be reliable, noise must be minimized and appropriate evaluation of waveform changes is critical. Electrode setting with low contact impedance and bilateral derivation effectively address these issues. Prolongation of the wave V latency alerts to surgical stress on the cochlear nerve due to nerve stretching from cerebellar retraction. According to Sekiya, the surgeon performing MVD or acoustic neurinoma excision should be warned as soon as latency prolongation exceeds 1.5 msec or characteristics of ABR must be understood. even less than 0.5 msec, respectively. However, hearing was preserved in some patients with false-positive results with respect to intraoperative wave V diminution. To use it as a useful intraoperative modality, the Characteristics of ABR must be understood.
MeSH term(s)	Evoked Potentials, Auditory, Brain Stem ; Humans ; Monitoring, Intraoperative ; Neurosurgical Procedures
Language	Japanese
Publishing date	2015-05
Publishing country	Japan
Document type	English Abstract ; Journal Article
ZDB-ID	391878-6
ISSN	0021-4892
ISSN	0021-4892
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 360: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Evoked potential studies for predicting functional recovery in a case of acute necrotizing encephalopathy.

Onozawa, Yuya / Iwasaki, Toshiyuki / Iizuka, Takahiro / Nonoda, Yutaka / Toki, Taira / Obata, Susumu / Munekata, Shinichi / Kanoh, Yuhsaku

Clinical case reports

2018 Volume 6, Issue 5, Page(s) 813–816

Abstract: Normal-appearing evoked potentials during the acute stage of the disease despite persistent coma may predict subsequent functional recovery of the brain in a pediatric case of acute necrotizing encephalopathy, indicating that evoked potential studies are ...

Abstract	Normal-appearing evoked potentials during the acute stage of the disease despite persistent coma may predict subsequent functional recovery of the brain in a pediatric case of acute necrotizing encephalopathy, indicating that evoked potential studies are useful for predicting functional outcome of the brain.
Language	English
Publishing date	2018-03-08
Publishing country	England
Document type	Case Reports
ZDB-ID	2740234-4
ISSN	2050-0904
ISSN	2050-0904
DOI	10.1002/ccr3.1473
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Status epilepticus suspected autoimmune: Neuronal surface antibodies and main clinical features.

Suga, Hiroki / Yanagida, Atsuko / Kanazawa, Naomi / Ohara, Hiroya / Kitagawa, Tadashi / Hayashi, Masahiro / Onozawa, Yuya / Nagata, Naomi / Kaneko, Juntaro / Kitamura, Eiji / Nishiyama, Kazutoshi / Iizuka, Takahiro

Epilepsia

2021 Volume 62, Issue 11, Page(s) 2719–2731

Abstract: Objectives: Status epilepticus (SE) can be associated with neuronal surface antibodies (NS-Abs) but NS-Ab detection rate remains unknown in patients with SE of unclear etiology at symptom presentation but suspected of having an autoimmune etiology (SE ... ...

Abstract	Objectives: Status epilepticus (SE) can be associated with neuronal surface antibodies (NS-Abs) but NS-Ab detection rate remains unknown in patients with SE of unclear etiology at symptom presentation but suspected of having an autoimmune etiology (SE suspected autoimmune). We aimed to determine the NS-Ab detection rate and the clinical features that predict the presence of NS-Abs in patients with SE suspected autoimmune. Methods: We retrospectively reviewed the clinical information of 137 patients with SE suspected autoimmune who underwent testing for NS-Abs between January 2007 and September 2020. NS-Abs were examined in both serum and cerebrospinal fluid (CSF) obtained at symptom onset with established assays. We classified brain magnetic resonance imaging (MRI) findings into unremarkable, autoimmune limbic encephalitis (ALE) (bilateral abnormalities highly restricted to the medial temporal lobes), ALE-Plus (ALE pattern and additional extramedial temporal lobe abnormalities), multifocal cortico-subcortical (MCS), or other pattern. We compared the clinical features between patients with and without NS-Abs. Results: Forty-four patients (32.1%) had NS-Abs, including 35 N-methyl-d-aspartate receptor (NMDAR) (one with concurrent γ-aminobutyric acid B receptor [GABAbR] and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor [AMPAR]), 5 γ-aminobutyric acid A receptor (GABAaR), 2 leucine-rich glioma-inactivated 1(LGI1), 1 GABAbR, and 1 unknown antigens. Compared with NS-Ab-negative patients, NS-Ab-positive patients were more likely to have a preceding headache (56.8% vs 26.7%), preceding psychobehavioral or memory alterations (65.9% vs 20.4%), involuntary movements (79.5% vs 16.1%), CSF pleocytosis (81.8% vs 62.0%), elevated immunoglobulin G (IgG) index (45.2% vs 15.6%), oligoclonal bands (51.5% vs 9.5%), tumor (47.7% vs 8.6%), and higher APE2 score (median of 9 vs 7), and they were less likely to have an ALE-Plus pattern (2.3% vs 23.7%). However, preceding fever and ALE or MCS pattern were not different between the two groups of patients. Significance: When an autoimmune etiology was suspected, there was a relatively high likelihood (one of three patients) of identifying NS-Abs. Some clinical features (preceding symptoms, inflammatory CSF) predict a higher likelihood of finding NS-Ab positivity, but the ALE-Plus MRI pattern is more likely suggestive of NS-Ab negativity.
MeSH term(s)	Autoantibodies ; Autoimmune Diseases ; Humans ; Limbic Encephalitis ; Retrospective Studies ; Status Epilepticus/diagnostic imaging ; gamma-Aminobutyric Acid
Chemical Substances	Autoantibodies ; gamma-Aminobutyric Acid (56-12-2)
Language	English
Publishing date	2021-08-31
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	216382-2
ISSN	1528-1167 ; 0013-9580
ISSN (online)	1528-1167
ISSN	0013-9580
DOI	10.1111/epi.17055
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 517: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 475: Show issues

Order via subito

Details ▾

Article ; Online: Correction to: A cluster of disseminated small cortical lesions in MELAS: its distinctive clinical and neuroimaging features.

Hongo, Yu / Kaneko, Juntaro / Suga, Hiroki / Ishima, Daisuke / Kitamura, Eiji / Akutsu, Tsugio / Onozawa, Yuya / Kanazawa, Naomi / Goto, Tomohide / Nishiyama, Kazutoshi / Iizuka, Takahiro

Journal of neurology

2019 Volume 266, Issue 6, Page(s) 1473

Abstract: The author would like to correct the errors in the publication of the original article. The corrected details are given below for your reading. ...

Abstract	The author would like to correct the errors in the publication of the original article. The corrected details are given below for your reading.
Language	English
Publishing date	2019-03-11
Publishing country	Germany
Document type	Published Erratum
ZDB-ID	187050-6
ISSN	1432-1459 ; 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
ISSN (online)	1432-1459
ISSN	0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
DOI	10.1007/s00415-019-09314-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Ui II Zs.40: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Clinically based score predicting cryptogenic NORSE at the early stage of status epilepticus.

Yanagida, Atsuko / Kanazawa, Naomi / Kaneko, Juntaro / Kaneko, Atsushi / Iwase, Ryoko / Suga, Hiroki / Nonoda, Yutaka / Onozawa, Yuya / Kitamura, Eiji / Nishiyama, Kazutoshi / Iizuka, Takahiro

Neurology(R) neuroimmunology & neuroinflammation

2020 Volume 7, Issue 5

Abstract: Objective: To determine whether a clinically based score predicts cryptogenic new-onset refractory status epilepticus (C-NORSE) at the early stage of status epilepticus (SE) with prominent motor symptoms (SE-M) of unclear etiology.: Methods: The ... ...

Abstract	Objective: To determine whether a clinically based score predicts cryptogenic new-onset refractory status epilepticus (C-NORSE) at the early stage of status epilepticus (SE) with prominent motor symptoms (SE-M) of unclear etiology. Methods: The score (range 0-6) included 6 clinical features: highly refractoriness to antiseizure drugs, previously healthy individual, presence of prodromal fever, absence of prodromal psychobehavioral or memory alterations, absence of dyskinesias, and symmetric brain MRI abnormalities (the first 2 mandatory). We retrospectively assessed the usefulness of a high scale score (≥5) in predicting C-NORSE in 83 patients with SE-M of unclear etiology, who underwent testing for neuronal surface antibodies (NS-Abs) between January 2007, and December 2019. Results: Thirty-one (37.3%) patients had a high score. Patients with a high score had more frequent prodromal fever (28/31 vs 24/52), mechanical ventilatory support (31/31 vs 36/52), and symmetric MRI abnormalities (26/31 vs 12/52), had less frequent involuntary movements (2/31 vs 30/52), and had absent prodromal psychobehavioral alterations (0/31 vs 27/52), CSF oligoclonal band detection (0/27 vs 11/38), tumor association (0/31 vs 13/52), or NS-Abs (0/31 vs 29/52) than those with a low score (<5). Thirty-three patients (median age, 27 years; 18 [54.5%] female) were finally regarded as C-NORSE. The sensitivity and specificity of a high score for predicting C-NORSE were 93.9% (95% CI 0.87-0.94) and 100% (95% CI 0.95-1.00), respectively. Conclusions: Patients with a high score in the indicated scale are more likely to have C-NORSE, making it a useful diagnostic tool at the early stage of SE-M before antibody test results become available.
MeSH term(s)	Adolescent ; Adult ; Aged ; Child ; Drug Resistant Epilepsy/diagnosis ; Drug Resistant Epilepsy/immunology ; Drug Resistant Epilepsy/pathology ; Drug Resistant Epilepsy/physiopathology ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Practice Guidelines as Topic ; Prognosis ; Retrospective Studies ; Severity of Illness Index ; Status Epilepticus/diagnosis ; Status Epilepticus/immunology ; Status Epilepticus/pathology ; Status Epilepticus/physiopathology ; Young Adult
Language	English
Publishing date	2020-07-29
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2767740-0
ISSN	2332-7812 ; 2332-7812
ISSN (online)	2332-7812
ISSN	2332-7812
DOI	10.1212/NXI.0000000000000849
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Autoimmune brachial amyotrophic diplegia and sensory neuronopathy with Sjögren's syndrome: A case report.

Tominaga, Naomi / Iizuka, Takahiro / Kaneko, Juntaro / Nagai, Makiko / Hara, Atsuko / Onozawa, Yuya / Kanazawa, Naomi / Nishiyama, Kazutoshi

Journal of the neurological sciences

2016 Volume 368, Page(s) 1–3

MeSH term(s)	Cervical Cord/diagnostic imaging ; Diagnosis, Differential ; Disease Progression ; Humans ; Male ; Middle Aged ; Motor Neuron Disease/diagnosis ; Motor Neuron Disease/diagnostic imaging ; Motor Neuron Disease/pathology ; Motor Neuron Disease/physiopathology ; Sjogren's Syndrome/diagnosis ; Sjogren's Syndrome/diagnostic imaging ; Sjogren's Syndrome/pathology ; Sjogren's Syndrome/physiopathology
Language	English
Publishing date	2016-09-15
Publishing country	Netherlands
Document type	Case Reports ; Letter
ZDB-ID	80160-4
ISSN	1878-5883 ; 0022-510X ; 0374-8642
ISSN (online)	1878-5883
ISSN	0022-510X ; 0374-8642
DOI	10.1016/j.jns.2016.06.053
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 308: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: A cluster of disseminated small cortical lesions in MELAS: its distinctive clinical and neuroimaging features.

Hongo, Yu / Kaneko, Juntaro / Suga, Hiroki / Ishima, Daisuke / Kitamura, Eiji / Akutsu, Tsugio / Onozawa, Yuya / Kanazawa, Naomi / Goto, Tomohide / Nishiyama, Kazutoshi / Iizuka, Takahiro

Journal of neurology

2019 Volume 266, Issue 6, Page(s) 1459–1472

Abstract: Objectives: To investigate a diversity of stroke-like episodes (SLEs) in mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS), and report a disseminated form of SLEs (D-SLEs) attributed to a cluster of disseminated small ... ...

Abstract	Objectives: To investigate a diversity of stroke-like episodes (SLEs) in mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS), and report a disseminated form of SLEs (D-SLEs) attributed to a cluster of disseminated small cortical lesions. Methods: We retrospectively reviewed the clinical information of 27 MELAS patients seen at Kitasato University Hospital between January 1990 and April 2018. Among those, we selected 13 patients with m.3243A>G mutation [median age at onset, 35 years (11-68 years), two pediatric onset < 17 years] who had at least one SLE. SLEs were classified into classic or non-classic based on characteristic features of stroke-like lesions. Results: 44 SLEs were identified during a median observational period of 119 months (3-240 months). Among those, 29 (65.9%) were classic SLEs (C-SLEs) mainly attributed to a single continuous lobular lesion incongruent to vascular territory and occasionally accompanied by a gradual spread associated with hyperperfusion and persistent seizure activity. The remaining 15 were non-classic attributed to sparsely distributed (n = 10), disseminated (n = 4) or cerebellar lesions (n = 1). C-SLEs developed in all patients but non-classic SLEs in 5; D-SLEs developed in 4 patients accounting for 4 of 44 SLEs (9.1%). Non-classic SLEs developed more frequently in pediatric-onset than in adult-onset patients (12/15 vs. 3/29, p < 0.0001). SLEs began with acute onset of symptoms in 42 SLEs (95.5%), but D-SLEs of 2 adult-onset patients began with ill-defined subacute-onset fluctuating encephalopathy. Conclusions: This study showed a diversity of SLEs in patients with m.3243A>G mutation. Further studies are required to elucidate the pathophysiological mechanisms of non-classic SLEs including D-SLEs.
MeSH term(s)	Adolescent ; Adult ; Aged ; Child ; Female ; Humans ; MELAS Syndrome/complications ; MELAS Syndrome/genetics ; MELAS Syndrome/physiopathology ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Retrospective Studies ; Stroke/diagnostic imaging ; Stroke/etiology ; Stroke/physiopathology ; Young Adult
Language	English
Publishing date	2019-03-19
Publishing country	Germany
Document type	Journal Article
ZDB-ID	187050-6
ISSN	1432-1459 ; 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
ISSN (online)	1432-1459
ISSN	0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
DOI	10.1007/s00415-019-09283-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Ui II Zs.40: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito