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Article ; Online: Pipes and puddles framework

José Costas Gual / Rafael Pastor Climent / Julio César Puche Regaliza / Francisco Javier Puente García

Journal of Industrial Engineering and Management, Vol 17, Iss 1, Pp 35-

Risk management in manufacturing processes to reduce the total cost of quality

2024 Volume 62

Abstract: Purpose: Decentralize standards to each process owner is an open issue. Centralized standards are a common situation which puts a big amount of chore tasks against continual improvement. The pipes and puddles framework was born to solve this problem. ... ...

Abstract	Purpose: Decentralize standards to each process owner is an open issue. Centralized standards are a common situation which puts a big amount of chore tasks against continual improvement. The pipes and puddles framework was born to solve this problem. Design/methodology/approach: Pipes and puddles framework takes its ground in risk management, which is carried out from the perspective of the physics of the process. Findings: Putting a clear difference among reactive and preventive problem-solving is the first observable change when adopting this framework, which drives to keep cost of poor quality (COPQ) permanently close to zero. Another important consequence of adopting this framework is that there is no person responsible for the continuous improvement process, but each process owner is responsible for the continuous improvement of their process. Research limitations/implications: This research is still limited to a few empirical cases of use; the diffusion of its benefits and guidelines to its real implementation is an opportunity for a massive adoption. A formal representation is also necessary. Practical implications: Pipes and puddles framework brings to management a roadmap to foster the role of process owner, providing a decentralized approach towards risk management, to react to non-conformities and to implement effective channels for continual improvement. Social implications: Approach to a green factory as a direct consequence of elimination of COPQ and the empowerment of all employees by having specific roles and regular channels to effectively act as agents of continual improvement. Originality/value: The vision of each process in the firm as the interconnection of three pipes (sub-processes) is a novelty that completely solves common issues for all processes that are transversal to all others (risk management, non-conformant products, customer claims, change management, etc.).
Keywords	risk management ; cost of quality ; pipes and puddles framework ; continual improvement ; process-centric principle ; Industrial engineering. Management engineering ; T55.4-60.8 ; Social Sciences ; H ; Commerce ; HF1-6182 ; Business ; HF5001-6182
Subject code	650
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	OmniaScience
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effectiveness of eHealth therapeutic education interventions in the management of fibromyalgia: protocol for a systematic review and meta-analysis.

Martínez-Navarro, Oriol / Climent-Sanz, Carolina / Lletjà-Guijarro, Ariadna / Adel El Arab, Rabie / Verdejo-Amengual, Francisco José / Valenzuela-Pascual, Fran

BMJ open

2023 Volume 13, Issue 5, Page(s) e070012

Abstract: Introduction: Non-pharmacological approaches have shown promising results in improving symptoms and quality of life of patients with fibromyalgia. However, these approaches may not be easily accessible or feasible for everyone. eHealth interventions may ...

Abstract	Introduction: Non-pharmacological approaches have shown promising results in improving symptoms and quality of life of patients with fibromyalgia. However, these approaches may not be easily accessible or feasible for everyone. eHealth interventions may offer a more convenient and cost-effective approach to reach a wider range of patients with fibromyalgia and improve their outcomes. As eHealth tools become more prevalent in clinical practice, it is crucial to understand their effectiveness, limitations and how they can be integrated into standard care to optimise clinical outcomes. This systematic review aims to evaluate the effectiveness of eHealth therapeutic education interventions in managing fibromyalgia. Methods and analysis: Randomised controlled trials including eHealth therapeutic education interventions for individuals ≥18 years old with fibromyalgia, published in English or Spanish, will be retrieved by searching the databases PubMed, CINAHL Plus, EMBASE, Scopus, ISI Web of Science, PsycINFO and the Cochrane Central Register of Controlled Trials. Covidence software will be used for the selection of studies and data extraction. The risk of bias and the certainty of evidence will be assessed using the Cochrane Risk of Bias Assessment tool. We plan to perform a meta-analysis contingent on the number of studies retrieved and the interstudy heterogeneity, which will be explored with I Ethics and dissemination: This protocol and the subsequent systematic review will not collect individual-level data and do not require approval by an ethical committee. We intend to disseminate the study results via peer-reviewed scientific journals and relevant (inter)national conferences. Prospero registration number: CRD42022343373.
MeSH term(s)	Humans ; Fibromyalgia/therapy ; Meta-Analysis as Topic ; Quality of Life ; Systematic Reviews as Topic ; Telemedicine/methods
Language	English
Publishing date	2023-05-10
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2022-070012
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Article ; Online: El niño con patología crónica y complejidad: ¿cuál es el camino?

Monroy Tapiador, Miguel Ángel / Climent Alcalá, Francisco José / Rodríguez Alonso, Aroa / Calvo Rey, Cristina

Anales de pediatria

2021 Volume 95, Issue 4, Page(s) 284–285

Title translation	Children with medical complexity. What is the way?
Language	Spanish
Publishing date	2021-03-01
Publishing country	Spain
Document type	Letter
ZDB-ID	2830901-7
ISSN	2341-2879 ; 2341-2879
ISSN (online)	2341-2879
ISSN	2341-2879
DOI	10.1016/j.anpedi.2021.01.011
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Article ; Online: Incidence of Peri-Implantitis and Relationship with Different Conditions: A Retrospective Study.

Astolfi, Víctor / Ríos-Carrasco, Blanca / Gil-Mur, Francisco Javier / Ríos-Santos, José Vicente / Bullón, Beatriz / Herrero-Climent, Mariano / Bullón, Pedro

International journal of environmental research and public health

2022 Volume 19, Issue 7

Abstract: Articles on the prevalence of peri-implant diseases showed that 90% of peri-implant tissues had some form of inflammatory response and a prevalence of peri-implantitis from 28% to 51% according to various publications. Objective: To provide an overview ... ...

Abstract	Articles on the prevalence of peri-implant diseases showed that 90% of peri-implant tissues had some form of inflammatory response and a prevalence of peri-implantitis from 28% to 51% according to various publications. Objective: To provide an overview of how risk factors can be related with peri-implantitis. Methods: A retrospective longitudinal study including 555 implants placed in 132 patients was evaluated based on the presence of peri-implantitis following the criteria of Renvert et al. 2018. Results: In total, 21 patients (15.9%) suffered peri-implantitis (PPG) and 111 patients (84.1%) did not suffer peri-implantitis (NPG). The results reveal that smokers have a high incidence of peri-implantitis (72.7%) compared to non-smokers (27.3%) (p < 0.0005). Another variable with significant results (p < 0.01) was periodontitis: 50% PPG and 23.9% NPG suffered advanced periodontitis. Systemic diseases such as arterial hypertension, diabetes mellitus, osteoporosis, and cardiovascular diseases do not show a statistically significant influence on the incidence of peri-implantitis. Patients who did not attend their maintenance therapy appointment had an incidence of peri-implantitis of 61.4%, compared to 27.3% in those who attend (p < 0.0001). From the results obtained, we can conclude that relevant factors affect peri-implantitis, such as tobacco habits, moderate and severe periodontitis, and attendance in maintenance therapy.
MeSH term(s)	Humans ; Incidence ; Longitudinal Studies ; Peri-Implantitis/epidemiology ; Peri-Implantitis/etiology ; Periodontitis/complications ; Periodontitis/epidemiology ; Retrospective Studies ; Risk Factors
Language	English
Publishing date	2022-03-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph19074147
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Article ; Online: Optimal dosing of bemiparin for deep vein thrombosis treatment in children: a retrospective study.

García-Boyano, Miguel / Caballero-Caballero, José Manuel / Escosa García, Luis / Gutiérrez Alvariño, Mar / Blanco Bañares, María Jesús / Climent Alcalá, Francisco José

Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis

2021 Volume 32, Issue 7, Page(s) 526–527

MeSH term(s)	Child ; Heparin, Low-Molecular-Weight ; Humans ; Retrospective Studies ; Venous Thrombosis/drug therapy
Chemical Substances	Heparin, Low-Molecular-Weight ; bemiparin (PUE0TO3XDR)
Language	English
Publishing date	2021-10-14
Publishing country	England
Document type	Journal Article
ZDB-ID	1033551-1
ISSN	1473-5733 ; 0957-5235
ISSN (online)	1473-5733
ISSN	0957-5235
DOI	10.1097/MBC.0000000000001066
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Article ; Online: Venetoclax improves CD20 immunotherapy in a mouse model of MYC/BCL2 double-expressor diffuse large B-cell lymphoma.

Melchor, Javier / Garcia-Lacarte, Marcos / Grijalba, Sara C / Arnaiz-Leché, Adrián / Pascual, Marién / Panizo, Carlos / Blanco, Oscar / Segura, Victor / Novo, Francisco J / Valero, Juan Garcia / Pérez-Galán, Patricia / Martinez-Climent, Jose A / Roa, Sergio

Journal for immunotherapy of cancer

2023 Volume 11, Issue 2

Abstract: Background: Approximately one-third of diffuse large B cell lymphoma (DLBCL) patients exhibit co-expression of MYC and BCL2 (double-expressor lymphoma, DEL) and have a dismal prognosis. Targeted inhibition of the anti-apoptotic protein BCL2 with ... ...

Abstract	Background: Approximately one-third of diffuse large B cell lymphoma (DLBCL) patients exhibit co-expression of MYC and BCL2 (double-expressor lymphoma, DEL) and have a dismal prognosis. Targeted inhibition of the anti-apoptotic protein BCL2 with venetoclax (ABT-199) has been approved in multiple B-cell malignancies and is currently being investigated in clinical trials for DLBCL. Whether BCL2 anti-apoptotic function represents a multifaceted vulnerability for DEL-DLBCL, affecting both lymphoma B cells and T cells within the tumor microenvironment, remains to be elucidated. Methods: Here, we present novel genetically engineered mice that preclinically recapitulate DEL-DLBCL lymphomagenesis, and evaluate their sensitivity ex vivo and in vivo to the promising combination of venetoclax with anti-CD20-based standard immunotherapy. Results: Venetoclax treatment demonstrated specific killing of MYC Conclusions: These results suggest that the combination of anti-CD20-based immunotherapy and BCL2 inhibition leads to cooperative immunomodulatory effects and improved preclinical responses, which may offer promising therapeutic opportunities for DEL-DLBCL patients.
MeSH term(s)	Animals ; Mice ; Bridged Bicyclo Compounds, Heterocyclic/pharmacology ; Bridged Bicyclo Compounds, Heterocyclic/therapeutic use ; Disease Models, Animal ; Immunotherapy/methods ; Lymphoma, Large B-Cell, Diffuse/drug therapy ; Proto-Oncogene Proteins c-bcl-2 ; Tumor Microenvironment ; Proto-Oncogene Proteins c-myc
Chemical Substances	Bridged Bicyclo Compounds, Heterocyclic ; Proto-Oncogene Proteins c-bcl-2 ; venetoclax (N54AIC43PW) ; Proto-Oncogene Proteins c-myc
Language	English
Publishing date	2023-02-28
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2719863-7
ISSN	2051-1426 ; 2051-1426
ISSN (online)	2051-1426
ISSN	2051-1426
DOI	10.1136/jitc-2022-006113
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Article ; Online: Comparing lung aeration and respiratory effort using two different spontaneous breathing trial: T-piece vs pressure support ventilation.

Bosch-Compte, Raquel / Parrilla, Francisco José / Muñoz-Bermúdez, Rosana / Dot, Irene / Climent, Cristina / Masclans, Joan Ramon / Marin-Corral, Judith / Pérez-Terán, Purificación

Medicina intensiva

2023

Abstract: Objective: To assess the changes in lung aeration and respiratory effort generated by two different spontaneous breathing trial (SBT): T-piece (T-T) vs pressure support ventilation (PSV).: Design: Prospective, interventionist and randomized study.: ...

Abstract	Objective: To assess the changes in lung aeration and respiratory effort generated by two different spontaneous breathing trial (SBT): T-piece (T-T) vs pressure support ventilation (PSV). Design: Prospective, interventionist and randomized study. Setting: Intensive Care Unit (ICU) of Hospital del Mar. Participants: Forty-three ventilated patients for at least 24 h and considered eligible for an SBT were included in the study between October 2017 and March 2020. Interventions: 30-min SBT with T-piece (T-T group, 20 patients) or 8-cmH Main variables of interest: Demographics, clinical data, physiological variables, lung aeration evaluated with electrical impedance tomography (EIT) and lung ultrasound (LUS), and respiratory effort using diaphragmatic ultrasonography (DU) were collected at different timepoints: basal (BSL), end of SBT (EoSBT) and one hour after extubation (OTE). Results: There were a loss of aeration measured with EIT and LUS in the different study timepoints, without statistical differences from BSL to OTE, between T-T and PSV [LUS: 3 (1, 5.5) AU vs 2 (1, 3) AU; p = 0.088; EELI: -2516.41 (-5871.88, 1090.46) AU vs -1992.4 (-3458.76, -5.07) AU; p = 0.918]. Percentage of variation between BSL and OTE, was greater when LUS was used compared to EIT (68.1% vs 4.9%, p ≤ 0.001). Diaphragmatic excursion trend to decrease coinciding with a loss of aeration during extubation. Conclusion: T-T and PSV as different SBT strategies in ventilated patients do not show differences in aeration loss, nor estimated respiratory effort or tidal volume measured by EIT, LUS and DU.
Language	English
Publishing date	2023-10-03
Publishing country	Spain
Document type	Journal Article
ISSN	2173-5727
ISSN (online)	2173-5727
DOI	10.1016/j.medine.2023.07.010
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Article ; Online: New contributions on chronic low back pain: disc infection or contaminated cultures?

Victoria, Monge-García / Gimeno-Gascón, Adelina / Ventero, Maria Paz / Climent-Barberá, Jose M / Cholbi-Llobell, Francisco / Rodríguez, Juan Carlos / Baño-Ruiz, Elena / Caminero-Canas, Miguel Angel / Reus-Bañuls, Sergio

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica

2023 Volume 131, Issue 6, Page(s) 277–283

Abstract: There is controversy about the likely infectious origin of chronic low back pain, because it has been suggested the possibility of a relationship with infection by Cutibacterium acnes (C. acnes). The aim of this study is to compare four methods to ... ...

Abstract	There is controversy about the likely infectious origin of chronic low back pain, because it has been suggested the possibility of a relationship with infection by Cutibacterium acnes (C. acnes). The aim of this study is to compare four methods to determine the presence of a likely infection caused by C. acnes in surgical disc samples. This work is a cross-sectional observational study in which there are included 23 patients with microdiscectomy indication. Disc samples were taken during surgery and analysis was done by culture, Sanger sequencing, next-generation sequencing (NGS), and real-time PCR (qPCR). Furthermore, clinical data collection was conducted, and it was analyzed the presence of the Modic-like changes on the magnetic resonance imaging. In 5 of the samples from among the 23 patients (21.7%), C. acnes was isolated by culture. However, in none of the samples could its genome be detected through Sanger sequencing, the less sensitive method. Only the qPCR and NGS were able to detect very few copies of the genome of this microorganism in all the samples, with no significant quantitative differences being observed between the patients in whom isolation of the microorganism by culture was evident or not. Furthermore, there were no significant relationships identified between the clinical variables, including Modic alterations and positive cultures. The most sensitive methods to the detect C. acnes were NGS and qPCR. The data obtained do not suggest association between the presence of C. acnes and the clinical process and support the hypothesis that C. acnes is found in these samples only because it is a contamination from the skin microbiome.
MeSH term(s)	Humans ; Low Back Pain/diagnosis ; Low Back Pain/microbiology ; Low Back Pain/pathology ; Intervertebral Disc/microbiology ; Intervertebral Disc/pathology ; Intervertebral Disc/surgery ; Cross-Sectional Studies ; Gram-Positive Bacterial Infections/microbiology ; Magnetic Resonance Imaging ; Propionibacterium acnes/genetics
Language	English
Publishing date	2023-03-27
Publishing country	Denmark
Document type	Observational Study ; Journal Article
ZDB-ID	93340-5
ISSN	1600-0463 ; 0903-4641
ISSN (online)	1600-0463
ISSN	0903-4641
DOI	10.1111/apm.13307
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Article ; Online: Hemobilia and acute hemocolecyst as an unusual presentation of gallbladder cancer.

Motos-Micó, José J / Cortés-Climent, Javier / Ferri-Candela, Lirios / Arlandis-Félix, Francisco / Serra-Díaz, Carlos

Cirugia y cirujanos

2021 Volume 89, Issue S1, Page(s) 54–56

Abstract: Gallbladder cancer that presents as acute cholecystitis associated with hemocholecyst and hemobilia is a rare entity. There are few cases reported in the literature. We present a case of gallbladder carcinoma diagnosed after emergency cholecystectomy, ... ...

Title translation	Hemobilia y hemocolecisto agudo como forma de presentación inusual del cáncer de vesícula biliar.
Abstract	Gallbladder cancer that presents as acute cholecystitis associated with hemocholecyst and hemobilia is a rare entity. There are few cases reported in the literature. We present a case of gallbladder carcinoma diagnosed after emergency cholecystectomy, performed due to hemobilia and acute cholecystitis due to hemocholecyst.
MeSH term(s)	Cholecystectomy ; Cholecystitis, Acute/complications ; Gallbladder Diseases/complications ; Gallbladder Diseases/diagnostic imaging ; Gallbladder Neoplasms/complications ; Gallbladder Neoplasms/diagnostic imaging ; Gallbladder Neoplasms/surgery ; Hemobilia/etiology ; Hemobilia/surgery ; Humans
Language	English
Publishing date	2021-11-11
Publishing country	Mexico
Document type	Case Reports ; Journal Article
ZDB-ID	730699-4
ISSN	2444-054X ; 0009-7411
ISSN (online)	2444-054X
ISSN	0009-7411
DOI	10.24875/CIRU.20001120
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Article ; Online: Influence of Implant Design and Under-Preparation of the Implant Site on Implant Primary Stability. An In Vitro Study.

Herrero-Climent, Mariano / Lemos, Bernardo Ferreira / Herrero-Climent, Federico / Falcao, Carlos / Oliveira, Helder / Herrera, Manuela / Gil, Francisco Javier / Ríos-Carrasco, Blanca / Ríos-Santos, José-Vicente

International journal of environmental research and public health

2020 Volume 17, Issue 12

Abstract: The aim of this study was to evaluate the effects of different implant sites an under-preparation sequence associated with two different implant designs on implant primary stability measured by two parameters: insertion torque (IT) and implant stability ... ...

Abstract	The aim of this study was to evaluate the effects of different implant sites an under-preparation sequence associated with two different implant designs on implant primary stability measured by two parameters: insertion torque (IT) and implant stability quotient (ISQ). It used two different implants: one cylindrical as a control and another one with a tapered design. The implants were inserted in type III fresh humid bovine bone and four drilling sequences were used: one control, the one proposed by the implant company (P1), and three different undersized (P2, P3 and P4). P2 was the same as P1 without the cortical drill, P3 was without the last pilot drill and P4 was without both of them. The sample size was
MeSH term(s)	Animals ; Base Sequence ; Bone and Bones ; Cattle ; Prostheses and Implants ; Research Design ; Torque
Language	English
Publishing date	2020-06-20
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1660-4601
ISSN (online)	1660-4601
DOI	10.3390/ijerph17124436
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