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  1. Article ; Online: Telomere flip-flop: an unfolding passage to senescence.

    Price, Carolyn M

    EMBO reports

    2011  Volume 13, Issue 1, Page(s) 5–6

    MeSH term(s) Cellular Senescence/genetics ; Humans ; Telomere/metabolism
    Language English
    Publishing date 2011-12-23
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 2020896-0
    ISSN 1469-3178 ; 1469-221X
    ISSN (online) 1469-3178
    ISSN 1469-221X
    DOI 10.1038/embor.2011.237
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  2. Article ; Online: Seroreduction of syphilis non-treponemal titers during pregnancy for women with and without HIV co-infection.

    Webster, Carolyn M / Kasaro, Margaret P / Price, Joan T / Stringer, Elizabeth M / Wiesen, Christopher A / Vwalika, Bellington / Stringer, Jeffrey S A

    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

    2022  Volume 159, Issue 2, Page(s) 427–434

    Abstract: Objective: To evaluate the effect of HIV co-infection on non-treponemal titers during pregnancy in women with syphilis.: Methods: This is a secondary analysis of pregnant women with syphilis in the prospective, observational Zambian Preterm Birth ... ...

    Abstract Objective: To evaluate the effect of HIV co-infection on non-treponemal titers during pregnancy in women with syphilis.
    Methods: This is a secondary analysis of pregnant women with syphilis in the prospective, observational Zambian Preterm Birth Prevention Study (ZAPPS). Treponemal (Treponema pallidum particle agglutination) and non-treponemal (rapid plasma reagin; RPR) testing were performed on serum biospecimens, resulting in 47 participants with serologically confirmed syphilis (27 HIV-positive, 20 HIV-negative). The primary outcome, achievement of RPR titer seroreduction during pregnancy, was analyzed by logistic regression. Secondary outcomes included overall titer reduction, seroreduction rate, serologic cure, and adverse pregnancy outcomes.
    Results: Seroreduction of RPR titer occurred in 78% (21/27) of women with HIV versus 45% (9/20) of women without (adjusted odds ratio 4.66; 95% confidence interval [CI] 1.14 - 19.08). Overall RPR titer reduction, rate of seroreduction per week, and the proportion achieving serologic cure each trended higher among women with HIV compared with those without HIV. There was a trend toward decreased stillbirth incidence in participants achieving seroreduction (odds ratio 0.15, 95% CI 0.01-1.58).
    Conclusion: HIV co-infection in this cohort of Zambian women with syphilis was associated with greater odds of RPR titer seroreduction during pregnancy. Pregnant women with syphilis and HIV may not be at increased risk for a delayed syphilis treatment response compared with women without HIV.
    MeSH term(s) Coinfection/epidemiology ; Female ; HIV Infections/complications ; HIV Infections/epidemiology ; Humans ; Infant, Newborn ; Pregnancy ; Pregnancy Complications, Infectious/epidemiology ; Pregnancy Outcome/epidemiology ; Premature Birth ; Prospective Studies ; Reagins ; Syphilis/complications ; Syphilis/epidemiology ; Syphilis Serodiagnosis/methods
    Chemical Substances Reagins
    Language English
    Publishing date 2022-02-25
    Publishing country United States
    Document type Journal Article ; Observational Study
    ZDB-ID 80149-5
    ISSN 1879-3479 ; 0020-7292
    ISSN (online) 1879-3479
    ISSN 0020-7292
    DOI 10.1002/ijgo.14131
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    Zs.A 355: Show issues Location:
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  3. Article ; Online: Incidence, Mortality, and Survival of Merkel Cell Carcinoma: A Systematic Review of Population Based-Studies.

    Mohsen, Samiha T / Price, Emma L / Chan, An-Wen / Hanna, Timothy P / Limacher, James J / Nessim, Carolyn / Shiers, Jessica E / Tron, Victor / Wright, Frances C / Drucker, Aaron M

    The British journal of dermatology

    2023  

    Abstract: Background: Merkel Cell Carcinoma (MCC) is a rare, aggressive skin cancer that most commonly occurs in UV-exposed body sites. Its epidemiology in different geographies and populations is not well characterised.: Objective: The objective of this ... ...

    Abstract Background: Merkel Cell Carcinoma (MCC) is a rare, aggressive skin cancer that most commonly occurs in UV-exposed body sites. Its epidemiology in different geographies and populations is not well characterised.
    Objective: The objective of this systematic review is to summarize evidence on the incidence, mortality, and survival rates of MCC from population-based studies.
    Methods: We searched MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials from database inception to June 6th, 2023. No geographic, age or date exclusions were applied. We included population-based studies of MCC that reported the incidence, survival, or mortality rate, and considered systematic reviews. A data-charting form was created and validated to identify variables to extract. Two reviewers then independently charted the data for each included study with patient characteristics, and estimates of incidence rate, mortality rate, and survival rate and assessed the quality of included studies using the Joanna Briggs Institute Checklist for Prevalence studies, Newcastle-Ottawa Scale and Assessment of Multiple Systematic Reviews. We abstracted age-, sex-, stage- and race-stratified outcomes, and synthesized comparisons between strata narratively and using vote counting. We assessed the certainty of evidence for those comparisons using the Grading of Recommendations, Assessments, Developments and Evaluations framework.
    Results: We identified 11,472 citations, of which 52 studies from 24 countries met our inclusion criteria. Stage 1 and the head and neck were the most frequently reported stage and location at diagnosis. The incidence of MCC is increasing over time (high certainty), with the highest reported incidences reported in Southern hemisphere countries (Australia [2.5 per 100,000], New Zealand [0.96 per 100,000]) (high certainty). Male patients generally had higher incidence rates compared to female patients (high certainty), although there were some variations over time periods. Survival rates varied, with lower survival and/or higher mortality associated with male sex (moderate certainty), higher stage at diagnosis (moderate-to-high certainty), older age (moderate certainty), and immunosuppression (low-to-moderate certainty).
    Conclusions: MCC is increasing in incidence and may increase further given the ageing population of many countries. The prognosis of MCC is poor, particularly for males, those who are immunosuppressed, and patients diagnosed at higher stages or at an older age.
    Language English
    Publishing date 2023-10-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 80076-4
    ISSN 1365-2133 ; 0007-0963
    ISSN (online) 1365-2133
    ISSN 0007-0963
    DOI 10.1093/bjd/ljad404
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  4. Article ; Online: Antics at the telomere: uncoupled polymerases solve the end replication problem.

    Price, Carolyn M

    The EMBO journal

    2009  Volume 28, Issue 7, Page(s) 795–796

    MeSH term(s) DNA Polymerase I/metabolism ; DNA Replication/physiology ; DNA-Directed DNA Polymerase/metabolism ; Models, Biological ; Schizosaccharomyces/enzymology ; Schizosaccharomyces/metabolism ; Telomere/metabolism
    Chemical Substances DNA Polymerase I (EC 2.7.7.7) ; DNA-Directed DNA Polymerase (EC 2.7.7.7)
    Language English
    Publishing date 2009-04-08
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 586044-1
    ISSN 1460-2075 ; 0261-4189
    ISSN (online) 1460-2075
    ISSN 0261-4189
    DOI 10.1038/emboj.2009.64
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  5. Article ; Online: Pregnancy-related healthcare utilisation in Agincourt, South Africa, 1993–2018

    Carolyn M Audet / Ryan G Wagner / Jessica Price / Daniel E Sack / Daniel Ohene-Kwofie / Chodziwadziwa W Kabudula / Carren Ginsburg

    BMJ Global Health, Vol 6, Iss

    a longitudinal surveillance study of rural mothers

    2021  Volume 10

    Keywords Medicine (General) ; R5-920 ; Infectious and parasitic diseases ; RC109-216
    Language English
    Publishing date 2021-10-01T00:00:00Z
    Publisher BMJ Publishing Group
    Document type Article ; Online
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  6. Article: Pregnancy-related healthcare utilisation in Agincourt, South Africa, 1993-2018: a longitudinal surveillance study of rural mothers.

    Sack, Daniel E / Wagner, Ryan G / Ohene-Kwofie, Daniel / Kabudula, Chodziwadziwa W / Price, Jessica / Ginsburg, Carren / Audet, Carolyn M

    BMJ global health

    2021  Volume 6, Issue 10

    Abstract: Introduction: Pregnancy-related health services, an important mediator of global health priorities, require robust health infrastructure. We described pregnancy-related healthcare utilisation among rural South African women from 1993 to 2018, a period ... ...

    Abstract Introduction: Pregnancy-related health services, an important mediator of global health priorities, require robust health infrastructure. We described pregnancy-related healthcare utilisation among rural South African women from 1993 to 2018, a period of social, political and economic transition.
    Methods: We included participants enrolled in the Agincourt Health and Socio-Demographic Surveillance System in Mpumalanga Province, South Africa, a population-based longitudinal cohort, who reported pregnancy between 1993 and 2018. We assessed age, antenatal visits, years of education, pregnancy intention, nationality, residency status, previous pregnancies, prepregnancy and postpregnancy contraceptive use, and student status over the study period and modelled predictors of antenatal care utilisation (ordinal), skilled birth attendant presence (logistic) and delivery at a health facility (logistic).
    Results: Between 1993 and 2018, 51 355 pregnancies occurred. Median antenatal visits, skilled birth attendant presence and healthcare facility deliveries increased over time. Delivery in 2018 vs 2004 was associated with an increased likelihood of ≥1 additional antenatal visits (adjusted OR (aOR) 10.81, 95% CI 9.99 to 11.71), skilled birth attendant presence (aOR 4.58, 95% CI 3.70 to 5.67) and delivery at a health facility (aOR 3.78, 95% CI 3.15 to 4.54). Women of Mozambican origin were less likely to deliver with a skilled birth attendant (aOR 0.42, 95% CI 0.39 to 0.45) or at a health facility (aOR 0.43, 95% CI 0.41 to 0.46) versus South Africans. Temporary migrants reported fewer antenatal visits (aOR 0.35, 95% CI 0.33 to 0.38) but were more likely to deliver with a skilled birth attendant (aOR 1.91, 95% CI 1.66 to 2.2) or at a health facility (aOR 1.4, 95% CI 1.24 to 1.58) versus permanent residents.
    Conclusion: Pregnancy-related healthcare utilisation and skilled birth attendant presence at delivery have increased steadily since 1993 in rural northeastern South Africa, aligning with health policy changes enacted during this time. However, mothers of Mozambican descent are still less likely to use free care, which requires further study and policy interventions.
    MeSH term(s) Delivery, Obstetric ; Female ; Humans ; Mothers ; Patient Acceptance of Health Care ; Pregnancy ; Prenatal Care ; South Africa/epidemiology
    Language English
    Publishing date 2021-10-04
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 2059-7908
    ISSN 2059-7908
    DOI 10.1136/bmjgh-2021-006915
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  7. Article ; Online: Supporting the role of universities in leading individual and societal transformation through education for sustainable development

    Elizabeth A. C. Price / Rehema M. White / Kate Mori / James Longhurst / Patrick Baughan / Carolyn S. Hayles / Georgina Gough / Chris Preist

    Discover Sustainability, Vol 2, Iss 1, Pp 1-

    2021  Volume 16

    Abstract: Abstract There is growing recognition of the value of Education for Sustainable Development (ESD) for all learners, and of the unique role that universities play in the transformation of individuals, institutions and societies towards more sustainable ... ...

    Abstract Abstract There is growing recognition of the value of Education for Sustainable Development (ESD) for all learners, and of the unique role that universities play in the transformation of individuals, institutions and societies towards more sustainable futures. Universities engage and even lead in several areas: education, research and community engagement, all of which are essential in this transformation. Further, given their focus and influence, universities are pivotal to action needed to realise the UN Sustainable Development Goals (SDGs) but, to date, UK university integration of ESD and engagement with the SDGs is relatively limited. In recognition that a more urgent and meaningful response is needed to deliver the 2030 targeted socio-economic transformation outlined by the SDGs, the UK ESD Guidance has been comprehensively revised to support universities to deliver education which enables students to acquire sustainability competencies, equipping them to play leadership roles in an increasingly uncertain world. In this case study, we critically analyse the role of universities and explore why ESD needs to be more urgently integrated in teaching and learning. We review the barriers to achieving ESD in UK universities at political and institutional levels. Finally, we explore the policy-practice interface and outline how the new UK ESD Guidance can support universities in leading individual and societal transformation through ESD and act as a stimulus for embedding ESD in university curricula in both UK and international contexts. We conclude that universities have as yet unfulfilled potential to explore and facilitate ESD for sustainability leadership.
    Keywords Environmental sciences ; GE1-350
    Subject code 370
    Language English
    Publishing date 2021-11-01T00:00:00Z
    Publisher Springer
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: wRAPing up the end to prevent telomere fusions.

    Price, Carolyn M

    Molecular cell

    2007  Volume 26, Issue 4, Page(s) 463–464

    MeSH term(s) Base Sequence ; DNA/chemistry ; DNA Repair ; DNA Replication ; Humans ; Models, Biological ; Nuclear Proteins/chemistry ; Nuclear Proteins/metabolism ; TATA Box Binding Protein-Like Proteins/chemistry ; TATA Box Binding Protein-Like Proteins/metabolism ; Telomere/chemistry ; Telomere/metabolism ; Telomere-Binding Proteins/chemistry ; Telomere-Binding Proteins/metabolism ; Telomeric Repeat Binding Protein 2 ; rap1 GTP-Binding Proteins/chemistry ; rap1 GTP-Binding Proteins/metabolism
    Chemical Substances Nuclear Proteins ; TATA Box Binding Protein-Like Proteins ; TERF2 protein, human ; Telomere-Binding Proteins ; Telomeric Repeat Binding Protein 2 ; DNA (9007-49-2) ; rap1 GTP-Binding Proteins (EC 3.6.5.2)
    Language English
    Publishing date 2007-05-25
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 1415236-8
    ISSN 1097-4164 ; 1097-2765
    ISSN (online) 1097-4164
    ISSN 1097-2765
    DOI 10.1016/j.molcel.2007.05.005
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  9. Article: Stirring the POT1: surprises in telomere protection.

    Price, Carolyn M

    Nature structural & molecular biology

    2006  Volume 13, Issue 8, Page(s) 673–674

    MeSH term(s) Animals ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Humans ; Mice ; Telomere ; Telomere-Binding Proteins/metabolism
    Chemical Substances DNA-Binding Proteins ; POT1 protein, human ; POT1 protein, mouse ; POT1b protein, mouse ; Telomere-Binding Proteins
    Language English
    Publishing date 2006-08
    Publishing country United States
    Document type News
    ZDB-ID 2126708-X
    ISSN 1545-9985 ; 1545-9993
    ISSN (online) 1545-9985
    ISSN 1545-9993
    DOI 10.1038/nsmb0806-673
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  10. Article ; Online: 2023 Focused Update of the 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: Developed by the task force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) With the special contribution of the Heart Failure Association (HFA) of the ESC.

    McDonagh, Theresa A / Metra, Marco / Adamo, Marianna / Gardner, Roy S / Baumbach, Andreas / Böhm, Michael / Burri, Haran / Butler, Javed / Čelutkienė, Jelena / Chioncel, Ovidiu / Cleland, John G F / Crespo-Leiro, Maria Generosa / Farmakis, Dimitrios / Gilard, Martine / Heymans, Stephane / Hoes, Arno W / Jaarsma, Tiny / Jankowska, Ewa A / Lainscak, Mitja /
    Lam, Carolyn S P / Lyon, Alexander R / McMurray, John J V / Mebazaa, Alexandre / Mindham, Richard / Muneretto, Claudio / Francesco Piepoli, Massimo / Price, Susanna / Rosano, Giuseppe M C / Ruschitzka, Frank / Skibelund, Anne Kathrine

    European journal of heart failure

    2024  Volume 26, Issue 1, Page(s) 5–17

    Abstract: Document Reviewers: Rudolf A. de Boer (CPG Review Co-ordinator) (Netherlands), P. Christian Schulze (CPG Review Co-ordinator) (Germany), Elena Arbelo (Spain), Jozef Bartunek (Belgium), Johann Bauersachs (Germany), Michael A. Borger (Germany), Sergio ... ...

    Abstract Document Reviewers: Rudolf A. de Boer (CPG Review Co-ordinator) (Netherlands), P. Christian Schulze (CPG Review Co-ordinator) (Germany), Elena Arbelo (Spain), Jozef Bartunek (Belgium), Johann Bauersachs (Germany), Michael A. Borger (Germany), Sergio Buccheri (Sweden), Elisabetta Cerbai (Italy), Erwan Donal (France), Frank Edelmann (Germany), Gloria Färber (Germany), Bettina Heidecker (Germany), Borja Ibanez (Spain), Stefan James (Sweden), Lars Køber (Denmark), Konstantinos C. Koskinas (Switzerland), Josep Masip (Spain), John William McEvoy (Ireland), Robert Mentz (United States of America), Borislava Mihaylova (United Kingdom), Jacob Eifer Møller (Denmark), Wilfried Mullens (Belgium), Lis Neubeck (United Kingdom), Jens Cosedis Nielsen (Denmark), Agnes A. Pasquet (Belgium), Piotr Ponikowski (Poland), Eva Prescott (Denmark), Amina Rakisheva (Kazakhstan), Bianca Rocca (Italy), Xavier Rossello (Spain), Leyla Elif Sade (United States of America/Türkiye), Hannah Schaubroeck (Belgium), Elena Tessitore (Switzerland), Mariya Tokmakova (Bulgaria), Peter van der Meer (Netherlands), Isabelle C. Van Gelder (Netherlands), Mattias Van Heetvelde (Belgium), Christiaan Vrints (Belgium), Matthias Wilhelm (Switzerland), Adam Witkowski (Poland), and Katja Zeppenfeld (Netherlands) All experts involved in the development of this Focused Update have submitted declarations of interest. These have been compiled in a report and simultaneously published in a supplementary document to the Focused Update. The report is also available on the ESC website www.escardio.org/guidelines See the European Heart Journal online for supplementary documents that include evidence tables.
    MeSH term(s) Humans ; Heart Failure/diagnosis ; Heart Failure/therapy ; Poland ; United Kingdom ; Spain ; Cardiology
    Language English
    Publishing date 2024-01-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 1483672-5
    ISSN 1879-0844 ; 1388-9842
    ISSN (online) 1879-0844
    ISSN 1388-9842
    DOI 10.1002/ejhf.3024
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