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  1. Article ; Online: Vaccination: Special populations are not all the same.

    Khasnis, Atul

    Cleveland Clinic journal of medicine

    2015  Volume 82, Issue 6, Page(s) 348–349

    MeSH term(s) Humans ; Vaccination
    Language English
    Publishing date 2015-06
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 639116-3
    ISSN 1939-2869 ; 0891-1150
    ISSN (online) 1939-2869
    ISSN 0891-1150
    DOI 10.3949/ccjm.82a.14137
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  2. Article ; Online: Update rheumatologists about the rheumatologic face of these diseases.

    Khasnis, Atul

    Current opinion in rheumatology

    2013  Volume 25, Issue 1, Page(s) 35–36

    MeSH term(s) Endocrine System Diseases/complications ; Humans ; Neoplasms/complications ; Paraneoplastic Syndromes/etiology ; Rheumatic Diseases/etiology
    Language English
    Publishing date 2013-01
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 1045317-9
    ISSN 1531-6963 ; 1040-8711
    ISSN (online) 1531-6963
    ISSN 1040-8711
    DOI 10.1097/BOR.0b013e32835b541b
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    Zs.A 3028: Show issues Location:
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  3. Article ; Online: Venous thromboembolism in systemic autoimmune diseases: A narrative review with emphasis on primary systemic vasculitides.

    Tamaki, Hiromichi / Khasnis, Atul

    Vascular medicine (London, England)

    2015  Volume 20, Issue 4, Page(s) 369–376

    Abstract: Venous thromboembolism (VTE) is a prevalent multifactorial health condition associated with significant morbidity and mortality. Population-based epidemiological studies have revealed an association between systemic autoimmune diseases and deep venous ... ...

    Abstract Venous thromboembolism (VTE) is a prevalent multifactorial health condition associated with significant morbidity and mortality. Population-based epidemiological studies have revealed an association between systemic autoimmune diseases and deep venous thrombosis (DVT)/VTE. The etiopathogenesis of increased risk of VTE in systemic autoimmune diseases is not entirely clear but multiple contributors have been explored, especially in the context of systemic inflammation and disordered thrombogenesis. Epidemiologic data on increased risk of VTE in patients with primary systemic vasculitides (PSV) have accumulated in recent years and some of these studies suggest the increased risk while patients have active diseases. This could lead us to hypothesize that venous vascular inflammation has a role to play in this phenomenon, but this is unproven. The role of immunosuppressive agents in modulating the risk of VTE in patients with PSV is not yet clear except for Behçet's disease, where most of the studies are retrospective. Sensitizing physicians to this complication has implications for prevention and optimal management of patients with these complex diseases. This review will focus on the epidemiology and available evidence regarding pathogenesis, and will attempt to summarize the best available data regarding evaluation and treatment of these patients.
    MeSH term(s) Autoimmune Diseases/diagnosis ; Autoimmune Diseases/drug therapy ; Autoimmune Diseases/epidemiology ; Autoimmune Diseases/immunology ; Humans ; Immunosuppressive Agents/therapeutic use ; Incidence ; Inflammation Mediators/immunology ; Prevalence ; Pulmonary Embolism/diagnosis ; Pulmonary Embolism/epidemiology ; Pulmonary Embolism/immunology ; Pulmonary Embolism/prevention & control ; Risk Assessment ; Risk Factors ; Signal Transduction ; Systemic Vasculitis/diagnosis ; Systemic Vasculitis/drug therapy ; Systemic Vasculitis/epidemiology ; Systemic Vasculitis/immunology ; Treatment Outcome ; Venous Thromboembolism/diagnosis ; Venous Thromboembolism/epidemiology ; Venous Thromboembolism/immunology ; Venous Thromboembolism/prevention & control ; Venous Thrombosis/diagnosis ; Venous Thrombosis/epidemiology ; Venous Thrombosis/immunology ; Venous Thrombosis/prevention & control
    Chemical Substances Immunosuppressive Agents ; Inflammation Mediators
    Language English
    Publishing date 2015-08
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1311628-9
    ISSN 1477-0377 ; 1358-863X
    ISSN (online) 1477-0377
    ISSN 1358-863X
    DOI 10.1177/1358863X15573838
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  4. Article ; Online: Paraneoplastic rheumatologic syndromes.

    Azar, Lama / Khasnis, Atul

    Current opinion in rheumatology

    2013  Volume 25, Issue 1, Page(s) 44–49

    Abstract: Purpose of review: To describe rheumatic syndromes that can be a paraneoplastic manifestation of an underlying malignancy. The pathogenesis of paraneoplastic rheumatologic diseases is complex and not fully understood in the majority of instances. In the ...

    Abstract Purpose of review: To describe rheumatic syndromes that can be a paraneoplastic manifestation of an underlying malignancy. The pathogenesis of paraneoplastic rheumatologic diseases is complex and not fully understood in the majority of instances. In the absence of a defined pathogenic link between the malignancy and the rheumatic syndrome, the association between these diseases has been based on concurrence and a parallel clinical course.
    Recent findings: This is an updated review of paraneoplastic presentations of synovitis, bone disease, myositis, and vasculitis.
    Summary: Although paraneoplastic rheumatic syndromes are rare, clinicians should be aware that they can be the first sign of an occult malignancy and that early recognition is vital for early cancer diagnosis and treatment.
    MeSH term(s) Arthritis/etiology ; Humans ; Myositis/etiology ; Neoplasms/complications ; Neoplasms/diagnosis ; Paraneoplastic Syndromes/diagnosis ; Rheumatic Diseases/etiology ; Syndrome ; Synovitis/etiology ; Vasculitis/etiology
    Language English
    Publishing date 2013-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1045317-9
    ISSN 1531-6963 ; 1040-8711
    ISSN (online) 1531-6963
    ISSN 1040-8711
    DOI 10.1097/BOR.0b013e328359e780
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  5. Article ; Online: Left Atrial Appendage Closure in Atrial Fibrillation: A World without Anticoagulation?

    Contractor, Tahmeed / Khasnis, Atul

    Cardiology research and practice

    2011  Volume 2011, Page(s) 752808

    Abstract: Atrial Fibrillation (AF) is a common arrhythmia with an incidence that is as high as 10% in the elderly population. Given the large proportion of strokes caused by AF as well as the associated morbidity and mortality, reducing stroke burden is the most ... ...

    Abstract Atrial Fibrillation (AF) is a common arrhythmia with an incidence that is as high as 10% in the elderly population. Given the large proportion of strokes caused by AF as well as the associated morbidity and mortality, reducing stroke burden is the most important part of AF management. While warfarin significantly reduces the risk of AF-related stroke, perceived bleeding risks and compliance limit its widespread use in the high-risk AF population. The left atrial appendage is believed to be the "culprit" for thrombogenesis in nonvalvular AF and is a new therapeutic target for stroke prevention. The purpose of this review is to explore the evolving field of percutaneous LAA occlusion. After briefly highlighting the risk of stroke with AF, problems with warfarin, and the role of the LAA in clot formation, this article discusses the feasibility and efficacy of various devices which have been developed for percutaneous LAA occlusion.
    Language English
    Publishing date 2011-03-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2506187-2
    ISSN 2090-0597 ; 2090-8016
    ISSN (online) 2090-0597
    ISSN 2090-8016
    DOI 10.4061/2011/752808
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  6. Article ; Online: Tumor necrosis factor inhibitors and lung disease: a paradox of efficacy and risk.

    Khasnis, Atul A / Calabrese, Leonard H

    Seminars in arthritis and rheumatism

    2010  Volume 40, Issue 2, Page(s) 147–163

    Abstract: Objective: Tumor necrosis factor inhibitors (TNFi) are being increasingly used for a wide range of indications. There are increasing reports of pulmonary toxicity related to the use of TNFi. In this review, we have attempted to synthesize the available ... ...

    Abstract Objective: Tumor necrosis factor inhibitors (TNFi) are being increasingly used for a wide range of indications. There are increasing reports of pulmonary toxicity related to the use of TNFi. In this review, we have attempted to synthesize the available literature regarding noninfectious complications related to TNFi use.
    Methods: We reviewed case reports, case series, and clinical trials accessed from the PubMed database (www.pubmed.gov), European League Against Rheumatism web archive (http://www.abstracts2view.com/eular/index.php), and the British Society of Rheumatology Biologics Register Newsletter website (http://www.rheumatology.org.uk/publications) using 23 search terms.
    Results: There are increasing data available about use of TNFi in treatment of systemic inflammatory rheumatologic disorders and their attempted use for various pulmonary indications. Currently reported noninfectious pulmonary complications related to TNFi use include most commonly granulomatous disease and pulmonary fibrosis/interstitial lung disease and rarely alveolar hemorrhage and antisynthetase syndrome. De novo granulomatous disease seems to be mostly reversible, whereas pulmonary fibrosis carries the worst prognosis especially in the setting of prior lung fibrosis.
    Conclusions: Serious and potentially fatal pulmonary toxicity has been reported during the use of TNFi, specifically from pulmonary fibrosis. Increased awareness during trial design and increased postmarketing surveillance is needed to provide more information about the epidemiology of these complications. Early recognition of these complications may help avert therapeutic misadventures.
    MeSH term(s) Antirheumatic Agents/adverse effects ; Databases, Factual ; Humans ; Lung Diseases/chemically induced ; Rheumatic Diseases/drug therapy ; Risk Factors ; Tumor Necrosis Factor-alpha/antagonists & inhibitors
    Chemical Substances Antirheumatic Agents ; Tumor Necrosis Factor-alpha
    Language English
    Publishing date 2010-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 120247-9
    ISSN 1532-866X ; 0049-0172
    ISSN (online) 1532-866X
    ISSN 0049-0172
    DOI 10.1016/j.semarthrit.2009.09.001
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  7. Article ; Online: Left Atrial Appendage Closure in Atrial Fibrillation

    Tahmeed Contractor / Atul Khasnis

    Cardiology Research and Practice, Vol

    A World without Anticoagulation?

    2011  Volume 2011

    Keywords Diseases of the circulatory (Cardiovascular) system ; RC666-701 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Cardiovascular ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Language English
    Publishing date 2011-01-01T00:00:00Z
    Publisher Hindawi Publishing Corporation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Left Atrial Appendage Closure in Atrial Fibrillation

    Atul Khasnis / Tahmeed Contractor

    Cardiology Research and Practice, Vol

    A World without Anticoagulation?

    2011  Volume 2011

    Keywords Diseases of the circulatory (Cardiovascular) system ; RC666-701 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Cardiovascular ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Language English
    Publishing date 2011-01-01T00:00:00Z
    Publisher Hindawi Publishing Corporation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Update on vasculitis.

    Khasnis, Atul / Langford, Carol A

    The Journal of allergy and clinical immunology

    2009  Volume 123, Issue 6, Page(s) 1226–1236

    Abstract: The primary systemic vasculitides comprise a broad group of diseases identified by their clinical, histopathologic, and therapeutic characteristics. These unique entities have a broad spectrum of organ involvement and severity, which influences the ... ...

    Abstract The primary systemic vasculitides comprise a broad group of diseases identified by their clinical, histopathologic, and therapeutic characteristics. These unique entities have a broad spectrum of organ involvement and severity, which influences the approach to diagnosis and treatment. Immunosuppressive and cytotoxic agents are used to manage most vasculitic diseases. Long-term outcome is influenced by chronic sequelae from organ damage, disease relapses, and medication side effects. Further research is needed to understand these diseases and discover more efficacious yet less toxic therapeutic options. This review will focus on vasculitic syndromes more likely to be presented to an allergist/immunologist in an outpatient setting.
    MeSH term(s) Angiography ; Antibodies, Antineutrophil Cytoplasmic/blood ; Diagnosis, Differential ; Drug Therapy, Combination ; Glucocorticoids/therapeutic use ; Histamine Antagonists/therapeutic use ; Humans ; Immunosuppressive Agents/therapeutic use ; Vasculitis/diagnosis ; Vasculitis/drug therapy ; Vasculitis/immunology
    Chemical Substances Antibodies, Antineutrophil Cytoplasmic ; Glucocorticoids ; Histamine Antagonists ; Immunosuppressive Agents
    Language English
    Publishing date 2009-06
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2009.04.024
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  10. Article ; Online: Atrial fibrillation: a historical perspective.

    Khasnis, Atul / Thakur, Ranjan K

    Cardiology clinics

    2009  Volume 27, Issue 1, Page(s) 1–12, vii

    Abstract: Atrial fibrillation (AF) has undoubtedly become one of the most well-studied arrhythmias today in terms of pathophysiology and diagnostic and therapeutic (interventional) electrophysiology. Although it lends itself to an apparently easy diagnosis on the ... ...

    Abstract Atrial fibrillation (AF) has undoubtedly become one of the most well-studied arrhythmias today in terms of pathophysiology and diagnostic and therapeutic (interventional) electrophysiology. Although it lends itself to an apparently easy diagnosis on the surface electrocardiography, myriad electromechanical mechanisms underlie its origin. We have now reached an era of technology that makes AF not only "treatable" but potentially "curable." This article aims at walking through the historical "corridors" and "mazes" that led to the present day understanding of this common yet complex arrhythmia.
    MeSH term(s) Anti-Arrhythmia Agents/history ; Anti-Arrhythmia Agents/therapeutic use ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/history ; Atrial Fibrillation/therapy ; Cardiac Surgical Procedures/history ; Cardiac Surgical Procedures/methods ; Cardiology/history ; Diagnostic Techniques, Cardiovascular/history ; History, 17th Century ; History, 18th Century ; History, 19th Century ; History, 20th Century ; Humans ; Portraits as Topic
    Chemical Substances Anti-Arrhythmia Agents
    Language English
    Publishing date 2009-02
    Publishing country Netherlands
    Document type Historical Article ; Journal Article
    ZDB-ID 1196385-2
    ISSN 1558-2264 ; 0733-8651
    ISSN (online) 1558-2264
    ISSN 0733-8651
    DOI 10.1016/j.ccl.2008.09.013
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