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  1. Article ; Online: The synaptic basis for sexual dimorphism in the invertebrate nervous system.

    Salzberg, Yehuda / Haque, Rizwanul / Oren-Suissa, Meital

    Current opinion in neurobiology

    2023  Volume 82, Page(s) 102757

    Abstract: Many animal behaviors are manifested differently in the two sexes of a given species, but how such sexual dimorphism is imprinted in the nervous system is not always clear. One mechanism involved is synaptic dimorphism, by which the same neurons exist in ...

    Abstract Many animal behaviors are manifested differently in the two sexes of a given species, but how such sexual dimorphism is imprinted in the nervous system is not always clear. One mechanism involved is synaptic dimorphism, by which the same neurons exist in the two sexes, but form synapses that differ in features such as anatomy, molecular content or fate. While some evidence for synaptic dimorphism exists in humans and mammals, identifying these mechanisms in invertebrates has proven simpler, due to their smaller nervous systems and absence of external regulation by sex hormones. This review aims to present the current status of the field in invertebrates, the available toolkit for the study of synaptic dimorphism, and the standing questions that still remain incompletely answered.
    MeSH term(s) Animals ; Humans ; Sex Characteristics ; Invertebrates ; Neurons/physiology ; Synapses/physiology ; Mammals
    Language English
    Publishing date 2023-08-10
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1078046-4
    ISSN 1873-6882 ; 0959-4388
    ISSN (online) 1873-6882
    ISSN 0959-4388
    DOI 10.1016/j.conb.2023.102757
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3260: Show issues Location:
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  2. Article ; Online: Environmental experiences shape sexually dimorphic neuronal circuits and behaviour.

    Peedikayil-Kurien, Sonu / Setty, Hagar / Oren-Suissa, Meital

    The FEBS journal

    2023  Volume 291, Issue 6, Page(s) 1080–1101

    Abstract: Dimorphic traits, shaped by both natural and sexual selection, ensure optimal fitness and survival of the organism. This includes neuronal circuits that are largely affected by different experiences and environmental conditions. Recent evidence suggests ... ...

    Abstract Dimorphic traits, shaped by both natural and sexual selection, ensure optimal fitness and survival of the organism. This includes neuronal circuits that are largely affected by different experiences and environmental conditions. Recent evidence suggests that sexual dimorphism of neuronal circuits extends to different levels such as neuronal activity, connectivity and molecular topography that manifest in response to various experiences, including chemical exposures, starvation and stress. In this review, we propose some common principles that govern experience-dependent sexually dimorphic circuits in both vertebrate and invertebrate organisms. While sexually dimorphic neuronal circuits are predetermined, they have to maintain a certain level of fluidity to be adaptive to different experiences. The first layer of dimorphism is at the level of the neuronal circuit, which appears to be dictated by sex-biased transcription factors. This could subsequently lead to differences in the second layer of regulation namely connectivity and synaptic properties. The third regulator of experience-dependent responses is the receptor level, where dimorphic expression patterns determine the primary sensory encoding. We also highlight missing pieces in this field and propose future directions that can shed light onto novel aspects of sexual dimorphism with potential benefits to sex-specific therapeutic approaches. Thus, sexual identity and experience simultaneously determine behaviours that ultimately result in the maximal survival success.
    MeSH term(s) Male ; Female ; Humans ; Sex Characteristics
    Language English
    Publishing date 2023-01-18
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2173655-8
    ISSN 1742-4658 ; 1742-464X
    ISSN (online) 1742-4658
    ISSN 1742-464X
    DOI 10.1111/febs.16714
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    In stock of ZB MED Cologne/Königswinter

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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  3. Article ; Online: Automated dual olfactory device for studying head/tail chemosensation in

    Karimi, Shadi / Gat, Asaf / Agazzi, Costanza / Oren-Suissa, Meital / Krieg, Michael

    APL bioengineering

    2024  Volume 8, Issue 2, Page(s) 26104

    Abstract: The correct interpretation of threat and reward is important for animal survival. Often, the decisions underlying these behavioral programs are mediated by volatile compounds in the animal's environment, which they detect and discriminate with ... ...

    Abstract The correct interpretation of threat and reward is important for animal survival. Often, the decisions underlying these behavioral programs are mediated by volatile compounds in the animal's environment, which they detect and discriminate with specialized olfactory neurons along their body.
    Language English
    Publishing date 2024-04-18
    Publishing country United States
    Document type Journal Article
    ISSN 2473-2877
    ISSN (online) 2473-2877
    DOI 10.1063/5.0187441
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  4. Article ; Online: DNAJB6 mutants display toxic gain of function through unregulated interaction with Hsp70 chaperones.

    Abayev-Avraham, Meital / Salzberg, Yehuda / Gliksberg, Dar / Oren-Suissa, Meital / Rosenzweig, Rina

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 7066

    Abstract: Molecular chaperones are essential cellular components that aid in protein folding and preventing the abnormal aggregation of disease-associated proteins. Mutations in one such chaperone, DNAJB6, were identified in patients with LGMDD1, a dominant ... ...

    Abstract Molecular chaperones are essential cellular components that aid in protein folding and preventing the abnormal aggregation of disease-associated proteins. Mutations in one such chaperone, DNAJB6, were identified in patients with LGMDD1, a dominant autosomal disorder characterized by myofibrillar degeneration and accumulations of aggregated protein within myocytes. The molecular mechanisms through which such mutations cause this dysfunction, however, are not well understood. Here we employ a combination of solution NMR and biochemical assays to investigate the structural and functional changes in LGMDD1 mutants of DNAJB6. Surprisingly, we find that DNAJB6 disease mutants show no reduction in their aggregation-prevention activity in vitro, and instead differ structurally from the WT protein, affecting their interaction with Hsp70 chaperones. While WT DNAJB6 contains a helical element regulating its ability to bind and activate Hsp70, in LGMDD1 disease mutants this regulation is disrupted. These variants can thus recruit and hyperactivate Hsp70 chaperones in an unregulated manner, depleting Hsp70 levels in myocytes, and resulting in the disruption of proteostasis. Interfering with DNAJB6-Hsp70 binding, however, reverses the disease phenotype, suggesting future therapeutic avenues for LGMDD1.
    MeSH term(s) Humans ; Gain of Function Mutation ; Molecular Chaperones/genetics ; Molecular Chaperones/metabolism ; HSP40 Heat-Shock Proteins/metabolism ; HSP70 Heat-Shock Proteins/genetics ; HSP70 Heat-Shock Proteins/metabolism ; Protein Folding ; Nerve Tissue Proteins/genetics
    Chemical Substances Molecular Chaperones ; HSP40 Heat-Shock Proteins ; HSP70 Heat-Shock Proteins ; DNAJB6 protein, human ; Nerve Tissue Proteins
    Language English
    Publishing date 2023-11-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-42735-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: DNAJB6 mutants display toxic gain of function through unregulated interaction with Hsp70 chaperones

    Meital Abayev-Avraham / Yehuda Salzberg / Dar Gliksberg / Meital Oren-Suissa / Rina Rosenzweig

    Nature Communications, Vol 14, Iss 1, Pp 1-

    2023  Volume 16

    Abstract: Abstract Molecular chaperones are essential cellular components that aid in protein folding and preventing the abnormal aggregation of disease-associated proteins. Mutations in one such chaperone, DNAJB6, were identified in patients with LGMDD1, a ... ...

    Abstract Abstract Molecular chaperones are essential cellular components that aid in protein folding and preventing the abnormal aggregation of disease-associated proteins. Mutations in one such chaperone, DNAJB6, were identified in patients with LGMDD1, a dominant autosomal disorder characterized by myofibrillar degeneration and accumulations of aggregated protein within myocytes. The molecular mechanisms through which such mutations cause this dysfunction, however, are not well understood. Here we employ a combination of solution NMR and biochemical assays to investigate the structural and functional changes in LGMDD1 mutants of DNAJB6. Surprisingly, we find that DNAJB6 disease mutants show no reduction in their aggregation-prevention activity in vitro, and instead differ structurally from the WT protein, affecting their interaction with Hsp70 chaperones. While WT DNAJB6 contains a helical element regulating its ability to bind and activate Hsp70, in LGMDD1 disease mutants this regulation is disrupted. These variants can thus recruit and hyperactivate Hsp70 chaperones in an unregulated manner, depleting Hsp70 levels in myocytes, and resulting in the disruption of proteostasis. Interfering with DNAJB6-Hsp70 binding, however, reverses the disease phenotype, suggesting future therapeutic avenues for LGMDD1.
    Keywords Science ; Q
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: One template, two outcomes: How does the sex-shared nervous system generate sex-specific behaviors?

    Salzberg, Yehuda / Gat, Asaf / Oren-Suissa, Meital

    Current topics in developmental biology

    2020  Volume 144, Page(s) 245–268

    Abstract: Sex-specific behaviors are common in nature and are crucial for reproductive fitness and species survival. A key question in the field of sex/gender neurobiology is whether and to what degree the sex-shared nervous system differs between the sexes in the ...

    Abstract Sex-specific behaviors are common in nature and are crucial for reproductive fitness and species survival. A key question in the field of sex/gender neurobiology is whether and to what degree the sex-shared nervous system differs between the sexes in the anatomy, connectivity and molecular identity of its components. An equally intriguing issue is how does the same sex-shared neuronal template diverge to mediate distinct behavioral outputs in females and males. This chapter aims to present the most up-to-date understanding of how this task is achieved in C. elegans. The vast majority of neurons in C. elegans are shared among the two sexes in terms of their lineage history, anatomical position and neuronal identity. Yet a substantial amount of evidence points to the hermaphrodite-male counterparts of some neurons expressing different genes and forming different synaptic connections. This, in turn, enables the same cells and circuits to transmit discrete signals in the two sexes and ultimately execute different functions. We review the various sex-shared behavioral paradigms that have been shown to be sexually dimorphic in recent years, discuss the mechanisms that underlie these examples, refer to the developmental regulation of neuronal dimorphism and suggest evolutionary concepts that emerge from the data.
    MeSH term(s) Animals ; Caenorhabditis elegans/genetics ; Female ; Genetic Fitness ; Male ; Nervous System ; Neurobiology ; Neurons ; Sex Characteristics
    Language English
    Publishing date 2020-09-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ISSN 1557-8933 ; 0070-2153
    ISSN (online) 1557-8933
    ISSN 0070-2153
    DOI 10.1016/bs.ctdb.2020.08.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Integration of spatially opposing cues by a single interneuron guides decision-making in C. elegans.

    Gat, Asaf / Pechuk, Vladyslava / Peedikayil-Kurien, Sonu / Karimi, Shadi / Goldman, Gal / Sela, Sapir / Lubliner, Jazz / Krieg, Michael / Oren-Suissa, Meital

    Cell reports

    2023  Volume 42, Issue 9, Page(s) 113075

    Abstract: The capacity of animals to respond to hazardous stimuli in their surroundings is crucial for their survival. In mammals, complex evaluations of the environment require large numbers and different subtypes of neurons. The nematode C. elegans avoids ... ...

    Abstract The capacity of animals to respond to hazardous stimuli in their surroundings is crucial for their survival. In mammals, complex evaluations of the environment require large numbers and different subtypes of neurons. The nematode C. elegans avoids hazardous chemicals they encounter by reversing their direction of movement. How does the worms' compact nervous system process the spatial information and direct motion change? We show here that a single interneuron, AVA, receives glutamatergic excitatory and inhibitory signals from head and tail sensory neurons, respectively. AVA integrates the spatially distinct and opposing cues, whose output instructs the animal's behavioral decision. We further find that the differential activation of AVA stems from distinct localization of inhibitory and excitatory glutamate-gated receptors along AVA's process and from different threshold sensitivities of the sensory neurons. Our results thus uncover a cellular mechanism that mediates spatial computation of nociceptive cues for efficient decision-making in C. elegans.
    Language English
    Publishing date 2023-09-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2023.113075
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  8. Article ; Online: Sexually dimorphic architecture and function of a mechanosensory circuit in C. elegans.

    Setty, Hagar / Salzberg, Yehuda / Karimi, Shadi / Berent-Barzel, Elisheva / Krieg, Michael / Oren-Suissa, Meital

    Nature communications

    2022  Volume 13, Issue 1, Page(s) 6825

    Abstract: How sensory perception is processed by the two sexes of an organism is still only partially understood. Despite some evidence for sexual dimorphism in auditory and olfactory perception, whether touch is sensed in a dimorphic manner has not been addressed. ...

    Abstract How sensory perception is processed by the two sexes of an organism is still only partially understood. Despite some evidence for sexual dimorphism in auditory and olfactory perception, whether touch is sensed in a dimorphic manner has not been addressed. Here we find that the neuronal circuit for tail mechanosensation in C. elegans is wired differently in the two sexes and employs a different combination of sex-shared sensory neurons and interneurons in each sex. Reverse genetic screens uncovered cell- and sex-specific functions of the alpha-tubulin mec-12 and the sodium channel tmc-1 in sensory neurons, and of the glutamate receptors nmr-1 and glr-1 in interneurons, revealing the underlying molecular mechanisms that mediate tail mechanosensation. Moreover, we show that only in males, the sex-shared interneuron AVG is strongly activated by tail mechanical stimulation, and accordingly is crucial for their behavioral response. Importantly, sex reversal experiments demonstrate that the sexual identity of AVG determines both the behavioral output of the mechanosensory response and the molecular pathways controlling it. Our results present extensive sexual dimorphism in a mechanosensory circuit at both the cellular and molecular levels.
    MeSH term(s) Animals ; Male ; Female ; Caenorhabditis elegans/metabolism ; Caenorhabditis elegans Proteins/metabolism ; Interneurons/metabolism ; Sensory Receptor Cells/metabolism ; Sex Characteristics ; Ion Channels/genetics ; Ion Channels/metabolism
    Chemical Substances Caenorhabditis elegans Proteins ; TMC-1 protein, C elegans ; Ion Channels
    Language English
    Publishing date 2022-11-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-022-34661-3
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  9. Article ; Online: FENS-Kavli Network of Excellence: Mentorship during the COVID-19 pandemic: Perspectives, challenges and opportunities.

    Sela-Vasiliu, Sapir / Miehl, Christoph / Huygelier, Hanne / Oren-Suissa, Meital / Gjorgjieva, Julijana / Gillebert, Celine R

    The European journal of neuroscience

    2022  Volume 58, Issue 12, Page(s) 4429–4437

    MeSH term(s) Humans ; COVID-19 ; Mentors ; Pandemics
    Language English
    Publishing date 2022-08-31
    Publishing country France
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 645180-9
    ISSN 1460-9568 ; 0953-816X
    ISSN (online) 1460-9568
    ISSN 0953-816X
    DOI 10.1111/ejn.15797
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2548: Show issues Location:
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  10. Article ; Online: Sexually dimorphic architecture and function of a mechanosensory circuit in C. elegans

    Hagar Setty / Yehuda Salzberg / Shadi Karimi / Elisheva Berent-Barzel / Michael Krieg / Meital Oren-Suissa

    Nature Communications, Vol 13, Iss 1, Pp 1-

    2022  Volume 15

    Abstract: Mechanosensation is crucial for survival in many organisms. Here, authors reveal that the two sexes of C. elegans show dramatic differences in circuit architecture, neuronal activity and molecular components to drive mechanosensory behavior. ...

    Abstract Mechanosensation is crucial for survival in many organisms. Here, authors reveal that the two sexes of C. elegans show dramatic differences in circuit architecture, neuronal activity and molecular components to drive mechanosensory behavior.
    Keywords Science ; Q
    Language English
    Publishing date 2022-11-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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