Article ; Online: Evolutionary analysis of JC polyomavirus in Misiones' population yields insight into the population dynamics of the early human dispersal in the Americas.
2023 Volume 585, Page(s) 100–108
Abstract: Background: JC polyomavirus (JCV) has an ethno-geographical distribution across human populations.: Objective: Study the origins of the population of Misiones (Argentina) by using JCV as genetic marker.: Methods: Viral detection and ... ...
Abstract | Background: JC polyomavirus (JCV) has an ethno-geographical distribution across human populations. Objective: Study the origins of the population of Misiones (Argentina) by using JCV as genetic marker. Methods: Viral detection and characterization was conducted by PCR amplification and evolutionary analysis of the intergenic region sequences. Results: 22 out of 121 samples were positive for JCV, including 5 viral lineages: MY (n = 8), Eu-a (n = 7), B1-c (n = 4), B1-b (n = 2) and Af2 (n = 1). MY sequences clustered within a branch of Native American origin that diverged from its Asian counterpart about 21,914 years ago (HPD 95% interval 15,383-30,177), followed by a sustained demographic expansion around 5000 years ago. Conclusions: JCV in Misiones reflects the multiethnic origin of the current population, with an important Amerindian contribution. Analysis of the MY viral lineage shows a pattern consistent with the arrival of early human migrations to the Americas and a population expansion by the pre-Columbian native societies. |
---|---|
MeSH term(s) | Humans ; JC Virus/genetics ; Biological Evolution ; Population Dynamics ; Human Migration ; Americas/epidemiology ; DNA, Viral/genetics |
Chemical Substances | DNA, Viral |
Language | English |
Publishing date | 2023-06-05 |
Publishing country | United States |
Document type | Journal Article ; Research Support, Non-U.S. Gov't |
ZDB-ID | 200425-2 |
ISSN | 1096-0341 ; 0042-6822 |
ISSN (online) | 1096-0341 |
ISSN | 0042-6822 |
DOI | 10.1016/j.virol.2023.05.009 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
Ud II Zs.172: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.