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  1. Article ; Online: The role of hypermutation and collateral sensitivity in antimicrobial resistance diversity of

    Vanderwoude, Jelly / Azimi, Sheyda / Read, Timothy D / Diggle, Stephen P

    mBio

    2024  Volume 15, Issue 2, Page(s) e0310923

    Abstract: Pseudomonas ... ...

    Abstract Pseudomonas aeruginosa
    MeSH term(s) Humans ; Cystic Fibrosis/microbiology ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Pseudomonas aeruginosa ; Drug Collateral Sensitivity ; Drug Resistance, Bacterial ; Pseudomonas Infections/microbiology ; Tobramycin ; Lung/microbiology
    Chemical Substances Anti-Bacterial Agents ; Tobramycin (VZ8RRZ51VK)
    Language English
    Publishing date 2024-01-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mbio.03109-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Corrigendum: Microbe Profile:

    Diggle, Stephen P / Whiteley, Marvin

    Microbiology (Reading, England)

    2021  Volume 167, Issue 8

    Language English
    Publishing date 2021-08-12
    Publishing country England
    Document type Journal Article ; Published Erratum
    ZDB-ID 1180712-x
    ISSN 1465-2080 ; 1350-0872
    ISSN (online) 1465-2080
    ISSN 1350-0872
    DOI 10.1099/mic.0.001073
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.140: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  3. Article: The Role of Hypermutation and Collateral Sensitivity in Antimicrobial Resistance Diversity of

    Vanderwoude, Jelly / Azimi, Sheyda / Read, Timothy D / Diggle, Stephen P

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Pseudomonas ... ...

    Abstract Pseudomonas aeruginosa
    Language English
    Publishing date 2023-11-22
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.06.14.544983
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: High prevalence of lipopolysaccharide mutants and R2-Pyocin susceptible variants in

    Mei, Madeline / Pheng, Preston / Kurzeja-Edwards, Detriana / Diggle, Stephen P

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Chronic, highly antibiotic-resistant infections in cystic fibrosis (CF) lungs contribute to increasing morbidity and mortality. ...

    Abstract Chronic, highly antibiotic-resistant infections in cystic fibrosis (CF) lungs contribute to increasing morbidity and mortality.
    Language English
    Publishing date 2023-09-06
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.04.26.538445
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: High prevalence of lipopolysaccharide mutants and R2-pyocin susceptible variants in

    Mei, Madeline / Pheng, Preston / Kurzeja-Edwards, Detriana / Diggle, Stephen P

    Microbiology spectrum

    2023  Volume 11, Issue 6, Page(s) e0177323

    Abstract: Importance: Cystic fibrosis (CF) patients often experience chronic, debilitating lung infections caused by antibiotic- ... ...

    Abstract Importance: Cystic fibrosis (CF) patients often experience chronic, debilitating lung infections caused by antibiotic-resistant
    MeSH term(s) Humans ; Pyocins/pharmacology ; Lipopolysaccharides ; Pseudomonas aeruginosa/genetics ; Cystic Fibrosis/complications ; Cystic Fibrosis/microbiology ; Prevalence ; Bacteriocins/genetics ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Pseudomonas Infections/drug therapy ; Pseudomonas Infections/epidemiology ; Pseudomonas Infections/microbiology ; Lung
    Chemical Substances Pyocins ; Lipopolysaccharides ; Bacteriocins ; Anti-Bacterial Agents
    Language English
    Publishing date 2023-10-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.01773-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Frequency of quorum-sensing mutations in

    O'Connor, Kathleen / Zhao, Conan Y / Mei, Madeline / Diggle, Stephen P

    Microbiology (Reading, England)

    2023  Volume 168, Issue 12

    Abstract: Pseudomonas ... ...

    Abstract Pseudomonas aeruginosa
    MeSH term(s) Humans ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Cystic Fibrosis ; Gene Expression Regulation, Bacterial ; Mutation ; Pseudomonas aeruginosa/genetics ; Pseudomonas Infections ; Quorum Sensing/genetics ; Trans-Activators/genetics ; Trans-Activators/metabolism
    Chemical Substances Bacterial Proteins ; Trans-Activators
    Language English
    Publishing date 2023-02-03
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1180712-x
    ISSN 1465-2080 ; 1350-0872
    ISSN (online) 1465-2080
    ISSN 1350-0872
    DOI 10.1099/mic.0.001265
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.140: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  7. Article ; Online: Microbial Primer: LuxR-LuxI Quorum Sensing.

    Soto-Aceves, Martin P / Diggle, Stephen P / Greenberg, E Peter

    Microbiology (Reading, England)

    2023  Volume 169, Issue 9

    Abstract: Quorum sensing is a term describing bacterial cell-to-cell communication systems for monitoring and responding to changes in population density. This primer serves as an introduction to the canonical LuxR-LuxI-type quorum sensing circuits common to many ... ...

    Abstract Quorum sensing is a term describing bacterial cell-to-cell communication systems for monitoring and responding to changes in population density. This primer serves as an introduction to the canonical LuxR-LuxI-type quorum sensing circuits common to many species of Gram-negative bacteria. Quorum sensing can synchronize behaviours across a community. Different species employ quorum sensing strategies to control specific behaviours such as bioluminescence, virulence factor production, secondary metabolite production, and biofilm formation.
    MeSH term(s) Quorum Sensing ; Virulence Factors ; Trans-Activators/genetics
    Chemical Substances Virulence Factors ; Trans-Activators
    Language English
    Publishing date 2023-08-25
    Publishing country England
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1180712-x
    ISSN 1465-2080 ; 1350-0872
    ISSN (online) 1465-2080
    ISSN 1350-0872
    DOI 10.1099/mic.0.001343
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.140: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Clostridium beijerinckii

    Humphreys, Jonathan R / Debebe, Bisrat J / Diggle, Stephen P / Winzer, Klaus

    Frontiers in microbiology

    2023  Volume 13, Page(s) 1075609

    Abstract: Solventogenic clostridia represent a diverse group of anaerobic, spore-forming bacteria capable of producing acetone, butanol and ethanol through their unique biphasic metabolism. An intrinsic problem with these organisms however is their tendency to ... ...

    Abstract Solventogenic clostridia represent a diverse group of anaerobic, spore-forming bacteria capable of producing acetone, butanol and ethanol through their unique biphasic metabolism. An intrinsic problem with these organisms however is their tendency to degenerate when repeatedly subcultured or when grown continuously. This phenomenon sees cells lose their ability to produce solvents and spores, posing a significant problem for industrial applications. To investigate the mechanistic and evolutionary basis of degeneration we combined comparative genomics, ultra-deep sequencing, and concepts of sociomicrobiology using
    Language English
    Publishing date 2023-01-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2022.1075609
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Exploiting Cooperative Pathogen Behavior for Enhanced Antibiotic Potency: A Trojan Horse Approach.

    Mutlu, Alper / Vanderpool, Emily / Rumbaugh, Kendra P / Diggle, Stephen P / Griffin, Ashleigh S

    Research square

    2023  

    Abstract: Antimicrobial resistance poses an escalating global threat, rendering traditional drug development approaches increasingly ineffective. Thus, novel alternatives to antibiotic-based therapies are needed. Exploiting pathogen cooperation as a strategy for ... ...

    Abstract Antimicrobial resistance poses an escalating global threat, rendering traditional drug development approaches increasingly ineffective. Thus, novel alternatives to antibiotic-based therapies are needed. Exploiting pathogen cooperation as a strategy for combating resistant infections has been proposed but lacks experimental validation. Empirical findings demonstrate the successful invasion of cooperating populations by non-cooperating cheats, effectively reducing virulence
    Language English
    Publishing date 2023-11-06
    Publishing country United States
    Document type Preprint
    DOI 10.21203/rs.3.rs-3466639/v1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Heterogenous Susceptibility to R-Pyocins in Populations of Pseudomonas aeruginosa Sourced from Cystic Fibrosis Lungs.

    Mei, Madeline / Thomas, Jacob / Diggle, Stephen P

    mBio

    2021  Volume 12, Issue 3

    Abstract: Bacteriocins are proteinaceous antimicrobials produced by bacteria that are active against other strains of the same species. R-type pyocins are phage tail-like bacteriocins produced ... ...

    Abstract Bacteriocins are proteinaceous antimicrobials produced by bacteria that are active against other strains of the same species. R-type pyocins are phage tail-like bacteriocins produced by
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Cystic Fibrosis/microbiology ; Humans ; Pseudomonas Infections/microbiology ; Pseudomonas aeruginosa/drug effects ; Pseudomonas aeruginosa/genetics ; Pseudomonas aeruginosa/isolation & purification ; Pyocins/classification ; Pyocins/pharmacology
    Chemical Substances Anti-Bacterial Agents ; Pyocins
    Language English
    Publishing date 2021-05-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mBio.00458-21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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