LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 1428

Search options

  1. Article ; Online: Ion-retention properties of graphene oxide/zinc oxide nanocomposite membranes at various pH and temperature conditions.

    Hassanpour, Amir / Gauthier, Marc A / Sun, Shuhui

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 1443

    Abstract: Laminar graphene oxide (GO) is a promising candidate material for next-generation highly water-permeable membranes. Despite extensive research, there is little information known concerning GO's ion-sieving properties at high acidic/basic pH and ... ...

    Abstract Laminar graphene oxide (GO) is a promising candidate material for next-generation highly water-permeable membranes. Despite extensive research, there is little information known concerning GO's ion-sieving properties at high acidic/basic pH and temperatures. In this study, the ion-blockage properties of the pristine GO and GO/zinc oxide (ZnO) nanocomposite membranes were tested using a non-pressure-driven filtration setup over a wide range of pH and temperatures. The ZnO nanoparticles within the composite membranes were synthesized via the room-temperature oxidation of zinc acetate and zinc acrylate precursors and were uniformly distributed across the composite membrane. It is observed that partially replacing the zinc acetate precursor with zinc acrylate improves the blockage performance of the composite membranes under extreme basic conditions by 42%. Moreover, photocatalytically-reduced composite membranes blocked copper sulfate ions 28% more than as-prepared composite membranes. Further, it was discovered that the composition of the membrane plays a vital role in its ion blockage performance at higher temperatures.
    Language English
    Publishing date 2024-01-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-51309-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Microwave-Induced Transient Heating Accelerates Protein PEGylation.

    Meziadi, Ahlem / Greschner, Andrea A / Gauthier, Marc A

    Biomacromolecules

    2023  Volume 24, Issue 6, Page(s) 2856–2863

    Abstract: PEGylation is one of the most widely employed strategies to increase the circulatory half-life of proteins and to reduce immune responses. However, conventional PEGylation protocols often require excess reagents and extended reaction times because of ... ...

    Abstract PEGylation is one of the most widely employed strategies to increase the circulatory half-life of proteins and to reduce immune responses. However, conventional PEGylation protocols often require excess reagents and extended reaction times because of their inefficiency. This study demonstrates that a microwave-induced transient heating phenomenon can be exploited to significantly accelerate protein PEGylation and even increase the degree of PEGylation achievable beyond what is possible at room temperature. This can be accomplished under conditions that do not compromise protein integrity. Several PEGylation chemistries and proteins are tested, and mechanistic insight is provided. Under certain conditions, extremely high levels of PEGylation were achieved in a matter of minutes. Moreover, considering the significantly reduced reaction times, the microwave-induced transient heating concept was adapted for continuous flow manufacturing of bioconjugates.
    MeSH term(s) Microwaves ; Heating/methods ; Proteins
    Chemical Substances Proteins
    Language English
    Publishing date 2023-05-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1526-4602
    ISSN (online) 1526-4602
    DOI 10.1021/acs.biomac.3c00250
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: Correction to "Consecutive Alkylation, "Click", and "Clip" Reactions for the Traceless Methionine-Based Conjugation and Release of Methionine-Containing Peptides".

    Zare, Fatemeh / Potenza, Alessandro / Greschner, Andrea A / Gauthier, Marc A

    Biomacromolecules

    2023  Volume 24, Issue 6, Page(s) 2955–2956

    Language English
    Publishing date 2023-05-04
    Publishing country United States
    Document type Published Erratum
    ISSN 1526-4602
    ISSN (online) 1526-4602
    DOI 10.1021/acs.biomac.3c00378
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Book ; Online: Between Species/Between Spaces

    Sullivan, Kendra / Gauthier, Dylan

    2020  

    Abstract: ... curators Kendra Sullivan and Dylan Gauthier, who organized the residency and culminating exhibition ... Marcel Breuer. An epistolary essay by NPS cartographer Mark Adams, who is also a painter, meditates ...

    Abstract Between Species/Between Spaces assembles text and images resulting from a pilot artistic research residency hosted by the Cape Cod Modern House Trust and the Cape Cod National Seashore in Cape Cod, MA. Artists in the book reflect on the geological forces that are reshaping the landscape and ecology of the Outer Cape which illuminate and to some degree mirror the broader global dynamic of instability, loss, and transition we are facing as a result of anthropogenic climate change. The book collects new artworks in a variety of media by ten contemporary artists whose work investigates the relationships between ecological crisis, communities, individual subjects, and the environment - the result of collaborations between visiting artists and researchers at the NPS field station in the National Seashore. An introductory essay by Peter McMahon, founding director of the Cape Cod Modern House Trust, reflects on the Cape as a site of groundbreaking collaborations between artists, architects, designers, and scientists in the middle of the 20th century, led by visionaries Serge Chermayeff, Bernard Rudofsky, Gyorgy Kepes, and Marcel Breuer. An epistolary essay by NPS cartographer Mark Adams, who is also a painter, meditates on the Outer Cape as a site of community with an uncertain future; Adams' own work has indicated that a predicted 4000 year timeframe for the Cape's dunes and sandy shores to erode entirely into the sea may in fact be accelerating under climate change. Contributions by Adams, along with artists Jean Barberis, Joshua Edwards, Marie Lorenz, Nancy Nowacek, Jeff Williams, Lynn Xu, and Marina Zurkow and artist/curators Kendra Sullivan and Dylan Gauthier, who organized the residency and culminating exhibition, present multimodal research into species extinction, terraforming, ecological restoration and regenerative practices, as a window onto the past, present, and future of this unstable place
    Keywords Arts in general ; Environmental sciences
    Size 1 electronic resource (132 pages)
    Publisher punctum books
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020590228
    ISBN 9781950192953 ; 1950192954
    DOI 10.21983/P3.0325.1.00
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article: Exercise therapy in the treatment of anorexia nervosa: Its effects depending on the type of physical exercise-A systematic review.

    Toutain, Marc / Gauthier, Antoine / Leconte, Pascale

    Frontiers in psychiatry

    2022  Volume 13, Page(s) 939856

    Abstract: Background and purpose: Clinical research focusing on the effectiveness of exercise therapy (ET) in patients with anorexia nervosa (AN) shows increasing interest in the last decade. The aim of this systematic review was to provide an overview of ... ...

    Abstract Background and purpose: Clinical research focusing on the effectiveness of exercise therapy (ET) in patients with anorexia nervosa (AN) shows increasing interest in the last decade. The aim of this systematic review was to provide an overview of quantitative studies that have examined the impact of ET in AN patients and to examine its specific effects on physical and mental health according to the type of physical exercise (PE) practiced.
    Methods: The review was carried out based on the PRISMA 2020. Electronic databases PubMed, Web of Science, Embase, and Wiley were searched from inception to December 2021. Quantitative studies assessing the effects of ET interventions on AN patients were included and study quality was assessed using the PEDro scale.
    Results: A total of 27 studies were selected, including 13 randomized controlled trials. Regarding outcomes measured, results showed that aerobic and resistance exercise improved muscle strength, that mind-body PE decreased main symptoms of AN and mental health, and that combined PE reduced dysfunctional exercise and improved weight gain.
    Conclusion: The findings suggest that ET intervention can induce benefits and has no deleterious effects on patients. In addition, specific effects on anorexia symptoms and physical and mental health have been observed according to the type of PE. However, this review reported several methodological weaknesses, including a lack of control group or randomization and statistical misconduct. Finally, ET intervention parameters were heterogeneous, and ET intervention generally lacked details, making reproducibility and comparability difficult. All these limitations underscore the need for a more rigorous methodology for further research.
    Language English
    Publishing date 2022-10-19
    Publishing country Switzerland
    Document type Systematic Review
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2022.939856
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Citrulline enteral administration markedly reduces immunosuppressive extrafollicular plasma cell differentiation in a preclinical model of sepsis.

    Gauthier, Juliette / Grégoire, Murielle / Reizine, Florian / Lesouhaitier, Mathieu / Desvois, Yoni / Ghukasyan, Gevorg / Moreau, Caroline / Amé, Patricia / Tarte, Karin / Tadié, Jean-Marc / Delaloy, Céline

    European journal of immunology

    2023  Volume 53, Issue 3, Page(s) e2250154

    Abstract: The sustained immunosuppression associated with severe sepsis favors an increased susceptibility to secondary infections and remains incompletely understood. Plasmablast and plasma cell subsets, whose primary function is to secrete antibodies, have ... ...

    Abstract The sustained immunosuppression associated with severe sepsis favors an increased susceptibility to secondary infections and remains incompletely understood. Plasmablast and plasma cell subsets, whose primary function is to secrete antibodies, have emerged as important suppressive populations that expand during sepsis. In particular, sepsis supports CD39
    MeSH term(s) Mice ; Animals ; Citrulline/metabolism ; Coinfection ; Sepsis ; Arginine ; Immunosuppressive Agents ; Cell Differentiation
    Chemical Substances Citrulline (29VT07BGDA) ; Arginine (94ZLA3W45F) ; Immunosuppressive Agents
    Language English
    Publishing date 2023-01-10
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 120108-6
    ISSN 1521-4141 ; 0014-2980
    ISSN (online) 1521-4141
    ISSN 0014-2980
    DOI 10.1002/eji.202250154
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 489: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 85: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Homogenous Scavenging Resolves Low-Purification Yield/Selectivity Caused by Secondary Binding of Protein-A to Antigen-Binding Antibody Fragments.

    Anees, Palapuravan / Gauthier, Marc A

    Biomacromolecules

    2020  Volume 21, Issue 2, Page(s) 825–829

    Abstract: Antigen-binding fragments of antibodies are biotechnologically useful agents for decorating drug delivery systems, for blocking cell-surface receptors in cell culture, for recognizing analytes in biosensors, and potentially as therapeutics. They are ... ...

    Abstract Antigen-binding fragments of antibodies are biotechnologically useful agents for decorating drug delivery systems, for blocking cell-surface receptors in cell culture, for recognizing analytes in biosensors, and potentially as therapeutics. They are typically produced by enzymatic digestion of full antibodies and isolated from the undesirable fragment crystallizable (Fc) by affinity chromatography using Protein-A columns. However, while Protein-A has a strong "classical" interaction with Fc fragments, it can also more weakly bind to an "alternative" site on the heavy chain variable region of antigen-binding fragments. As such, purifying small amounts of antibody fragments by Protein-A chromatography can result in low yield. Moreover, loading larger amounts of antibody fragments onto a Protein-A column can result in poor separation, because of competition of Fc and antigen-binding fragments for immobilized Protein-A. This study demonstrates that Protein-A-based homogeneous scavenging resolves this issue by precisely controlling the stoichiometry of Protein-A to Fc fragments, something that is not possible for conventional flow-type systems, such as affinity chromatography.
    MeSH term(s) Animals ; Antigen-Antibody Complex/isolation & purification ; Antigen-Antibody Complex/metabolism ; Chromatography, Affinity/methods ; Humans ; Immunoglobulin Fab Fragments/isolation & purification ; Immunoglobulin Fab Fragments/metabolism ; Immunoglobulin Fc Fragments/isolation & purification ; Immunoglobulin Fc Fragments/metabolism ; Protein Binding/physiology ; Staphylococcal Protein A/isolation & purification ; Staphylococcal Protein A/metabolism
    Chemical Substances Antigen-Antibody Complex ; Immunoglobulin Fab Fragments ; Immunoglobulin Fc Fragments ; Staphylococcal Protein A
    Language English
    Publishing date 2020-01-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1526-4602
    ISSN (online) 1526-4602
    DOI 10.1021/acs.biomac.9b01516
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Article ; Online: Monoclonal Antibodies for COVID-19 in X-linked Agammaglobulinemia: a Case Series.

    Simard, Marie-Lee / Nadeau, Marc-Antoine / Gauthier, Amélie / Cros, Guilhem / Lavoie, Aubert

    Journal of clinical immunology

    2023  Volume 43, Issue 6, Page(s) 1067–1071

    MeSH term(s) Humans ; COVID-19 ; Antibodies, Monoclonal/therapeutic use ; Agammaglobulinemia/complications ; Agammaglobulinemia/diagnosis ; Genetic Diseases, X-Linked/complications ; Genetic Diseases, X-Linked/diagnosis ; Genetic Diseases, X-Linked/genetics
    Chemical Substances Antibodies, Monoclonal
    Language English
    Publishing date 2023-04-24
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 779361-3
    ISSN 1573-2592 ; 0271-9142
    ISSN (online) 1573-2592
    ISSN 0271-9142
    DOI 10.1007/s10875-023-01480-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1640: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: As-needed β agonist-inhaled corticosteroid in mild asthma.

    Gauthier, Marc / Wenzel, Sally E

    Lancet (London, England)

    2019  Volume 394, Issue 10202, Page(s) 897–898

    MeSH term(s) Adrenal Cortex Hormones ; Adult ; Asthma ; Budesonide ; Formoterol Fumarate ; Humans ; Terbutaline
    Chemical Substances Adrenal Cortex Hormones ; Budesonide (51333-22-3) ; Terbutaline (N8ONU3L3PG) ; Formoterol Fumarate (W34SHF8J2K)
    Language English
    Publishing date 2019-08-23
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(19)31994-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.5: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 94: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article: Strategy to secure the neuraxial route in anaesthesia: Risk mapping and feedback from the application of the ISO 80369-6 standard NRFit® connectors.

    Amiot, Jeanice / Bruge Ansel, Marie Hélène / Bruyas, Mathilde / Rinaudo, Marc / Rulliat, Emilie / Gauthier, Jérôme / Piriou, Vincent / Cabelguenne, Delphine

    Annales pharmaceutiques francaises

    2024  

    Abstract: Introduction: In anesthesia, a medication error would occur every 20 to 133 anesthesia procedures, and 14% is related to a route administration error. To secure neuraxial route, ISO group published a norm in 2016 to develop specific connectors, the " ... ...

    Abstract Introduction: In anesthesia, a medication error would occur every 20 to 133 anesthesia procedures, and 14% is related to a route administration error. To secure neuraxial route, ISO group published a norm in 2016 to develop specific connectors, the "NRFit® connector". The main objective of this work, is to develop a risk mapping related to neuraxial medication errors therefore prepare the NRFit® implementation in anesthesia units in a French Universitary Hospital.
    Methods: Failure modes, effects and criticality analysis (FMECA) methodology was used for our risk mapping which was divided in 3 anesthesia specialities. For each, the analysis was performed for accidental neuraxial administration of intravenous drugs, and its opposite error. Secondly, NRFit® devices were tested for 1 month by 3 experimented anesthetists.
    Results: The majority of reported errors concerns epidural and intrathecal anesthesia, and more frequently in the field of obstetrics. Opioids and tranexamic acid, administered in neuraxial route, are drugs with the highest criticality. The tests were rather conclusive and made it possible to highlight the additional needs in medical devices.
    Discussion: Obstetrics is the riskiest area due to the frequency of epidural anesthesia, the administration of critical drugs in intravenous and neuraxial route. This work increased the awareness of our group, improved the measure of this risk and harmonized practices.
    Conclusion: This work is the first step of the project to prevent administration route error in anesthesia during patient's drug management. The next step will be the NRFit® implementation for epidural and combined spinal-epidural anesthesia in our hospital.
    Language English
    Publishing date 2024-03-05
    Publishing country France
    Document type Journal Article
    ZDB-ID 307-4
    ISSN 0003-4509
    ISSN 0003-4509
    DOI 10.1016/j.pharma.2024.02.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 223: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top