LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 492

Search options

  1. Article ; Online: A Zebrafish Genetic Screen Identifies Neuromedin U as a Regulator of Sleep/Wake States.

    Chiu, Cindy N / Rihel, Jason / Lee, Daniel A / Singh, Chanpreet / Mosser, Eric A / Chen, Shijia / Sapin, Viveca / Pham, Uyen / Engle, Jae / Niles, Brett J / Montz, Christin J / Chakravarthy, Sridhara / Zimmerman, Steven / Salehi-Ashtiani, Kourosh / Vidal, Marc / Schier, Alexander F / Prober, David A

    Neuron

    2016  Volume 89, Issue 4, Page(s) 842–856

    Abstract: ... genes that affect larval zebrafish arousal. We found that the neuropeptide neuromedin U (Nmu) promotes ...

    Abstract Neuromodulation of arousal states ensures that an animal appropriately responds to its environment and engages in behaviors necessary for survival. However, the molecular and circuit properties underlying neuromodulation of arousal states such as sleep and wakefulness remain unclear. To tackle this challenge in a systematic and unbiased manner, we performed a genetic overexpression screen to identify genes that affect larval zebrafish arousal. We found that the neuropeptide neuromedin U (Nmu) promotes hyperactivity and inhibits sleep in zebrafish larvae, whereas nmu mutant animals are hypoactive. We show that Nmu-induced arousal requires Nmu receptor 2 and signaling via corticotropin releasing hormone (Crh) receptor 1. In contrast to previously proposed models, we find that Nmu does not promote arousal via the hypothalamic-pituitary-adrenal axis, but rather probably acts via brainstem crh-expressing neurons. These results reveal an unexpected functional and anatomical interface between the Nmu system and brainstem arousal systems that represents a novel wake-promoting pathway.
    MeSH term(s) Age Factors ; Aniline Compounds/pharmacology ; Animals ; Brain Stem/cytology ; Brain Stem/growth & development ; Brain Stem/metabolism ; Gene Expression Regulation/drug effects ; Gene Expression Regulation/genetics ; Humans ; Hypothalamo-Hypophyseal System/metabolism ; Larva ; Mice, Transgenic ; Motor Activity/genetics ; Neurons/drug effects ; Neurons/metabolism ; Neuropeptides/genetics ; Neuropeptides/metabolism ; Pituitary-Adrenal System/metabolism ; Pyrimidines/pharmacology ; Receptors, Complement 3b/metabolism ; Receptors, Neurotransmitter/metabolism ; Signal Transduction/drug effects ; Signal Transduction/genetics ; Sleep/genetics ; Wakefulness/genetics ; Zebrafish ; Zebrafish Proteins/genetics
    Chemical Substances 2-methyl-4-(N-propyl-N-cycloproanemethylamino)-5-chloro-6-(2,4,6-trichloranilino)pyrimidine ; Aniline Compounds ; Neuropeptides ; Pyrimidines ; Receptors, Complement 3b ; Receptors, Neurotransmitter ; Zebrafish Proteins ; neuromedin U receptor ; neuromedin U (117505-80-3)
    Language English
    Publishing date 2016-02-12
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Video-Audio Media
    ZDB-ID 808167-0
    ISSN 1097-4199 ; 0896-6273
    ISSN (online) 1097-4199
    ISSN 0896-6273
    DOI 10.1016/j.neuron.2016.01.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2496: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 92: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Book ; Thesis: Behandlung von schweren Spitzknickfüßen bei Zerebralparese mittels Navikulektomie kombiniert mit Mittelfußarthrodese

    Dussa, Chakravarthy

    2018  

    Author's details vorgelegt von Ugandhar Chakravarthy Dussa
    Language German
    Size 36 Seiten, Illustrationen, 21 cm
    Publishing place Erlangen ; Nürnberg
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Friedrich-Alexander-Universität Erlangen-Nürnberg, 2018
    Note Enthält 1 Sonderabdruck
    HBZ-ID HT019986789
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2019 D 282 order for loan Magazin

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Does the Inhibition of Vacular Endothelial Growth Factor in Neovascular Age-Related Macular Degeneration Result in Macular Atrophy?

    Chakravarthy, Usha

    Ophthalmology

    2020  Volume 127, Issue 4, Page(s) 533–534

    MeSH term(s) Atrophy ; Endothelial Growth Factors ; Humans ; Macular Degeneration ; Prevalence ; Ranibizumab ; Tomography, Optical Coherence
    Chemical Substances Endothelial Growth Factors ; Ranibizumab (ZL1R02VT79)
    Language English
    Publishing date 2020-03-26
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 392083-5
    ISSN 1549-4713 ; 0161-6420
    ISSN (online) 1549-4713
    ISSN 0161-6420
    DOI 10.1016/j.ophtha.2020.01.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ul II Zs.83: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 533: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Counseling Patients about Rare but Serious Harms: The Importance of Absolute as well as Relative Risks.

    Reeves, Barnaby / Chakravarthy, Usha

    Ophthalmology. Retina

    2023  Volume 7, Issue 8, Page(s) 649–651

    MeSH term(s) Humans ; Risk Assessment ; Counseling
    Language English
    Publishing date 2023-08-04
    Publishing country United States
    Document type Editorial ; Comment
    ISSN 2468-6530
    ISSN (online) 2468-6530
    DOI 10.1016/j.oret.2023.04.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article ; Online: The Issue of End Point Discordance in Dry Age-Related Macular Degeneration: How Might Clinical Trials Demonstrate a Functional Benefit?

    Lad, Eleonora M / Chakravarthy, Usha

    Ophthalmology

    2023  Volume 130, Issue 9, Page(s) 890–892

    MeSH term(s) Humans ; Geographic Atrophy ; Macular Degeneration/drug therapy ; Eye Diseases
    Language English
    Publishing date 2023-06-06
    Publishing country United States
    Document type Editorial
    ZDB-ID 392083-5
    ISSN 1549-4713 ; 0161-6420
    ISSN (online) 1549-4713
    ISSN 0161-6420
    DOI 10.1016/j.ophtha.2023.05.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ul II Zs.83: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 533: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Age-Related Macular Degeneration: A Review.

    Fleckenstein, Monika / Schmitz-Valckenberg, Steffen / Chakravarthy, Usha

    JAMA

    2024  Volume 331, Issue 2, Page(s) 147–157

    Abstract: Importance: Age-related macular degeneration (AMD) affects approximately 20 million people in the US and 196 million people worldwide. AMD is a leading cause of severe vision impairment in older people and is expected to affect approximately 288 million ...

    Abstract Importance: Age-related macular degeneration (AMD) affects approximately 20 million people in the US and 196 million people worldwide. AMD is a leading cause of severe vision impairment in older people and is expected to affect approximately 288 million people worldwide by 2040.
    Observations: Older age, genetic factors, and environmental factors, such as cigarette smoking, are associated with development of AMD. AMD occurs when extracellular deposits accumulate in the outer retina, ultimately leading to photoreceptor degeneration and loss of central vision. The late stages of AMD are characterized by outer retinal atrophy, termed geographic atrophy, or neovascularization associated with subretinal and/or intraretinal exudation, termed exudative neovascular AMD. The annual incidence of AMD ranges from 0.3 per 1000 in people who are aged 55 to 59 years to 36.7 per 1000 in people aged 90 years or older. The estimated heritability of late-stage AMD is approximately 71% (95% CI, 18%-88%). Long-term prospective cohort studies show a significantly higher AMD incidence in people who smoke more than 20 cigarettes per day compared with people who never smoked. AMD is diagnosed primarily with clinical examination that includes a special lens that focuses light of the slit lamp through the pupil. Exudative neovascular AMD is best identified using angiography and by optical coherence tomography. Individuals with AMD who take nutritional supplements consisting of high-dose vitamin C, vitamin E, carotenoids, and zinc have a 20% probability to progress to late-stage AMD at 5 years vs a 28% probability for those taking a placebo. In exudative neovascular AMD, 94.6% of patients receiving monthly intravitreal anti-vascular endothelial growth factor (anti-VEGF) injections experience less than a 15-letter visual acuity loss after 12 months compared with 62.2% receiving sham treatment.
    Conclusions and relevance: The prevalence of AMD is anticipated to increase worldwide to 288 million individuals by 2040. Intravitreally administered anti-VEGF treatment is first-line therapy for exudative neovascular AMD.
    MeSH term(s) Aged ; Aged, 80 and over ; Humans ; Middle Aged ; Angiogenesis Inhibitors/administration & dosage ; Angiogenesis Inhibitors/pharmacology ; Angiogenesis Inhibitors/therapeutic use ; Intravitreal Injections ; Macular Degeneration/diagnosis ; Macular Degeneration/drug therapy ; Macular Degeneration/epidemiology ; Macular Degeneration/etiology ; Prospective Studies ; Retina/drug effects ; Retina/pathology ; Vascular Endothelial Growth Factor A/antagonists & inhibitors ; Visual Acuity ; Wet Macular Degeneration/diagnosis ; Wet Macular Degeneration/drug therapy ; Wet Macular Degeneration/epidemiology
    Chemical Substances Angiogenesis Inhibitors ; Vascular Endothelial Growth Factor A
    Language English
    Publishing date 2024-01-09
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2023.26074
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.88: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Clinical, Radiographic and Gait Parameters Associated with Medial Arch Pain in the Flexible Pediatric Flatfoot.

    Böhm, Harald / Dussa, Chakravarthy U

    The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons

    2023  Volume 62, Issue 4, Page(s) 637–643

    Abstract: Pain in the flexible flatfoot is a common complaint, if present it is important to find its exact location and causes Therefore, the study aimed to find differences between children with and without medial arch pain and relate them to the reduction of ... ...

    Abstract Pain in the flexible flatfoot is a common complaint, if present it is important to find its exact location and causes Therefore, the study aimed to find differences between children with and without medial arch pain and relate them to the reduction of pain following surgical treatment. Children with idiopathic flexible flatfeet were retrospectively included in the study. All children underwent a clinical, radiographic, and gait examination. The feet were subdivided into 2 groups: asymptomatic and those with medial arch pain. Factors associated with medial arch pain were identified via t test. Significant radiological and gait parameters were correlated to the change in medial arch pain score following surgery. Included were 322 feet belonging to 177 children, with the mean age of 11.8 (SD = 2.2) years. The pain was perceived in 52% of the feet, of these, 74% in the medial arch. In the group with pain, 31 feet received a gait analysis following surgery. The radiological parameters, talus-1 and -2 metatarsal angles and the gait parameter, calcaneal lateral shift during walking showed a significant difference (p ≤ .004) between the no pain and pain groups and were associated (R
    MeSH term(s) Humans ; Child ; Flatfoot/diagnostic imaging ; Flatfoot/surgery ; Retrospective Studies ; Foot/diagnostic imaging ; Foot/surgery ; Calcaneus/surgery ; Gait ; Pain
    Language English
    Publishing date 2023-02-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1146972-9
    ISSN 1542-2224 ; 1067-2516
    ISSN (online) 1542-2224
    ISSN 1067-2516
    DOI 10.1053/j.jfas.2023.01.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1468: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Epidemiology of geographic atrophy and its precursor features of intermediate age-related macular degeneration.

    Vujosevic, Stela / Alovisi, Camilla / Chakravarthy, Usha

    Acta ophthalmologica

    2023  Volume 101, Issue 8, Page(s) 839–856

    Abstract: Globally age-related macular degeneration (AMD) is a leading cause of blindness with a significant impact on quality of life. Geographic atrophy (GA) is the atrophic late form of AMD and its prevalence increases markedly with age with around 1 in 5 ... ...

    Abstract Globally age-related macular degeneration (AMD) is a leading cause of blindness with a significant impact on quality of life. Geographic atrophy (GA) is the atrophic late form of AMD and its prevalence increases markedly with age with around 1 in 5 persons aged 85 and above having GA in at least one eye. Bilateral GA leads to severe visual impairment thus posing a significant burden on patients, careers and health providers. The incidence and prevalence of GA varies across different geographic regions, with the highest rates in those of European ancestry. Although heterogeneity in definitions of GA and reporting strategy can explain some of the discrepancies, the data overall are consistent in showing a lower prevalence in other ethnicities such as those of Asian heritage. This is at present unexplained but thought to be due to the existence of protective factors such as differences in eye pigmentation, diet, environmental exposures and genetic variability. This review covers key aspects of the prevalence and incidence of the ocular precursor features of GA (large drusen, pigmentary abnormalities and reticular pseudo-drusen), the late stage of GA and factors that have been known to be associated with modifying risk including systemic, demographic, environment, genetic and ocular. Understanding the global epidemiology scenario is crucial for the prevention of and management of patients with GA.
    MeSH term(s) Humans ; Geographic Atrophy ; Retinal Drusen/epidemiology ; Quality of Life ; Macular Degeneration/epidemiology ; Retina
    Language English
    Publishing date 2023-11-07
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2408333-1
    ISSN 1755-3768 ; 1755-375X
    ISSN (online) 1755-3768
    ISSN 1755-375X
    DOI 10.1111/aos.15767
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ul I Zs.90: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Komplexe Achskorrekturen um das Kniegelenk.

    Dussa, Chakravarthy U / Döderlein, Leonhard

    Der Orthopade

    2021  Volume 50, Issue 7, Page(s) 559–569

    Abstract: Complex deformities around the knee joint are usually severe and have several aetiologies. They can be present in one or more planes, with variations in severity between planes. The occurrence and progression of the deformity can be influenced by local ... ...

    Title translation Correction of complex defomities around the Knee Joint.
    Abstract Complex deformities around the knee joint are usually severe and have several aetiologies. They can be present in one or more planes, with variations in severity between planes. The occurrence and progression of the deformity can be influenced by local and systemic factors. Several types of osteotomies and fixation methods are available to correct these complex deformities. The selection of the osteotomy used to correct a deformity depends on the type of deformity, its severity and its aetiology. Therefore, precise planning taking into consideration the above factors is necessary to achieve the goal.
    MeSH term(s) Humans ; Knee Joint/diagnostic imaging ; Knee Joint/surgery ; Osteotomy
    Language German
    Publishing date 2021-06-23
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 121792-6
    ISSN 1433-0431 ; 0085-4530
    ISSN (online) 1433-0431
    ISSN 0085-4530
    DOI 10.1007/s00132-021-04117-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 822: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Health technology assessment of new retinal treatments; the need to capture healthcare capacity issues.

    Gale, Richard / Cox, Oliver / Keenan, Craig / Chakravarthy, Usha

    Eye (London, England)

    2022  Volume 36, Issue 12, Page(s) 2236–2238

    MeSH term(s) Humans ; Technology Assessment, Biomedical ; Delivery of Health Care
    Language English
    Publishing date 2022-06-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 91001-6
    ISSN 1476-5454 ; 0950-222X
    ISSN (online) 1476-5454
    ISSN 0950-222X
    DOI 10.1038/s41433-022-02149-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 3010: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 603: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top