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  1. Article ; Online: Combination Immunotherapy in Head and Neck Cancer-Checkmate or a Draw?

    Posner, Marshall

    JAMA oncology

    2023  Volume 9, Issue 6, Page(s) 789–790

    MeSH term(s) Humans ; Head and Neck Neoplasms/drug therapy ; Squamous Cell Carcinoma of Head and Neck/drug therapy ; Immunotherapy ; Neoplasm Recurrence, Local
    Language English
    Publishing date 2023-04-05
    Publishing country United States
    Document type Journal Article ; Comment
    ISSN 2374-2445
    ISSN (online) 2374-2445
    DOI 10.1001/jamaoncol.2023.0086
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  2. Article ; Online: Endpoints in human papillomavirus-related oropharyngeal cancer trials.

    Posner, Marshall / Roof, Scott A

    The Lancet. Oncology

    2024  Volume 25, Issue 3, Page(s) 270–272

    MeSH term(s) Humans ; Oropharyngeal Neoplasms/therapy ; Papillomavirus Infections/complications ; Papillomaviridae
    Language English
    Publishing date 2024-03-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/S1470-2045(24)00065-2
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    Zs.A 5696: Show issues Location:
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  3. Article ; Online: Liquid Biopsies for Head and Neck Cancers-Any Hope for Human Papillomavirus-Negative Disease?-Reply.

    Ferrandino, Rocco M / Posner, Marshall R / Roof, Scott A

    JAMA otolaryngology-- head & neck surgery

    2023  Volume 150, Issue 1, Page(s) 83–84

    MeSH term(s) Humans ; Head and Neck Neoplasms ; Squamous Cell Carcinoma of Head and Neck ; Liquid Biopsy ; Human Papillomavirus Viruses ; Papillomavirus Infections ; Papillomaviridae
    Language English
    Publishing date 2023-11-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2701825-8
    ISSN 2168-619X ; 2168-6181
    ISSN (online) 2168-619X
    ISSN 2168-6181
    DOI 10.1001/jamaoto.2023.3633
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  4. Article ; Online: Interdisciplinary case study: from fly-to-bedside, translating basic research to the clinic.

    Posner, Marshall / Cagan, Ross

    iScience

    2021  Volume 24, Issue 4, Page(s) 102279

    Language English
    Publishing date 2021-03-20
    Publishing country United States
    Document type News
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2021.102279
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  5. Article ; Online: Interdisciplinary case study

    Marshall Posner / Ross Cagan

    iScience, Vol 24, Iss 4, Pp 102279- (2021)

    from fly-to-bedside, translating basic research to the clinic

    2021  

    Keywords Science ; Q
    Language English
    Publishing date 2021-04-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Clinical trials in squamous cell carcinoma of the head and neck.

    Posner, Marshall

    Clinical advances in hematology & oncology : H&O

    2012  Volume 10, Issue 6, Page(s) 388–390

    MeSH term(s) Carcinoma, Squamous Cell/therapy ; Clinical Trials as Topic ; Head and Neck Neoplasms/therapy ; Humans
    Language English
    Publishing date 2012-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2271951-9
    ISSN 1543-0790
    ISSN 1543-0790
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    Zs.A 6505: Show issues Location:
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  7. Article ; Online: A proposal for risk-based and strategy-adapted de-escalation in human papillomavirus-positive oropharyngeal squamous cell carcinoma.

    Wotman, Michael T / Miles, Brett A / Bakst, Richard L / Posner, Marshall R

    Cancer

    2021  Volume 127, Issue 23, Page(s) 4330–4338

    MeSH term(s) Alphapapillomavirus ; Head and Neck Neoplasms ; Humans ; Oropharyngeal Neoplasms ; Papillomaviridae ; Papillomavirus Infections/complications ; Squamous Cell Carcinoma of Head and Neck
    Language English
    Publishing date 2021-08-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1429-1
    ISSN 1097-0142 ; 0008-543X ; 1934-662X
    ISSN (online) 1097-0142
    ISSN 0008-543X ; 1934-662X
    DOI 10.1002/cncr.33851
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  8. Article ; Online: Robotic Surgery plus Chemo-Radiation Therapy.

    Posner, Marshall / Gupta, Vishal

    International journal of radiation oncology, biology, physics

    2017  Volume 97, Issue 1, Page(s) 4–5

    Language English
    Publishing date 2017-01-01
    Publishing country United States
    Document type Letter
    ZDB-ID 197614-x
    ISSN 1879-355X ; 0360-3016
    ISSN (online) 1879-355X
    ISSN 0360-3016
    DOI 10.1016/j.ijrobp.2016.09.016
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    Zs.A 1218: Show issues Location:
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  9. Article ; Online: Circulating Tumor HPV DNA in Patients With Head and Neck Carcinoma: Correlation With HPV Genotyping.

    Mijares, Kevin / Ferrandino, Rocco / Chai, Raymond / Roof, Scott / Bhardwaj, Swati / Posner, Marshall / Westra, William H

    The American journal of surgical pathology

    2023  Volume 48, Issue 1, Page(s) 80–87

    Abstract: Circulating tumor human papillomavirus DNA (ctHPVDNA) testing using digital-droplet polymerase chain reaction (PCR) detects fragments of tumor-modified human papillomavirus (HPV) in the plasma of patients with HPV-associated head and neck squamous cell ... ...

    Abstract Circulating tumor human papillomavirus DNA (ctHPVDNA) testing using digital-droplet polymerase chain reaction (PCR) detects fragments of tumor-modified human papillomavirus (HPV) in the plasma of patients with HPV-associated head and neck squamous cell carcinomas (HNSCCs). Its impact on tumor surveillance and primary diagnosis is limited by unresolved issues relating to sensitivity and specificity. The study population consisted of patients with HNSCC who had undergone ctHPVDNA testing. HPV status was determined by p16 immunohistochemistry and PCR-HPV genotyping on the tumor samples. For discrepant cases (HPV-positive/ctHPVDNA-negative), HPV status was confirmed by RNA in situ hybridization and, when possible, targeted single-nucleotide polymorphisms genotyping. A total of 167 patients had ctHPVDNA testing, and 141 tumors were HPV positive by p16 immunohistochemistry and PCR genotyping. Genotypes included types 16 (91.5%), 33 (4.3%), 35 (2.1%), and 18 (2.1%). ctHPVDNA was detected in 133 (94.3%) of HPV-positive HNSCCs but in none of the HPV-negative HNSCCs. Four of the 5 p16-positive cases that were negative by PCR and ctHPVDNA were positive by RNA in situ hybridization, and in 2 of these cases, rare high-risk genotypes were identified. ctHPVDNA had a sensitivity of 91.7%, specificity of 100%, positive predictive value of 100%, and negative predictive value of 63.6%. The likelihood that patients with HPV-positive HNSCC have detectable ctHPVDNA is high. Non-HPV16 genotypes contribute to discrepancies but only in a small subset of cases. This finding validates ongoing efforts to use ctHPVDNA as a surveillance tool, and even as a primary diagnostic assay in patients presenting with masses in the neck and/or oropharynx.
    MeSH term(s) Humans ; Squamous Cell Carcinoma of Head and Neck ; Carcinoma, Squamous Cell/pathology ; Human Papillomavirus Viruses ; Papillomavirus Infections/complications ; Papillomavirus Infections/diagnosis ; Papillomavirus Infections/pathology ; Genotype ; Cyclin-Dependent Kinase Inhibitor p16/analysis ; Papillomaviridae/genetics ; Head and Neck Neoplasms/genetics ; RNA ; DNA ; DNA, Viral/genetics
    Chemical Substances Cyclin-Dependent Kinase Inhibitor p16 ; RNA (63231-63-0) ; DNA (9007-49-2) ; DNA, Viral
    Language English
    Publishing date 2023-09-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 752964-8
    ISSN 1532-0979 ; 0147-5185
    ISSN (online) 1532-0979
    ISSN 0147-5185
    DOI 10.1097/PAS.0000000000002134
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    Zs.A 1356: Show issues Location:
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  10. Article ; Online: Evaluating human papillomavirus testing, prevalence, and association with prognosis in head and neck squamous cell carcinoma by subsite: A national cancer database study.

    Barlow, Joshua / Gilja, Shivee / Ferrandino, Rocco M / Berger, Michael H / Posner, Marshall R / Bakst, Richard L / Khan, Mohemmed N / Teng, Marita S / Genden, Eric M / Chai, Raymond L / Roof, Scott A

    American journal of otolaryngology

    2024  Volume 45, Issue 3, Page(s) 104243

    Abstract: Purpose: To compare human papillomavirus (HPV) testing, prevalence, and association with prognosis between head and neck squamous cell carcinoma (HNSCC) subsites.: Materials and methods: This study utilized the National Cancer Database (NCDB) to ... ...

    Abstract Purpose: To compare human papillomavirus (HPV) testing, prevalence, and association with prognosis between head and neck squamous cell carcinoma (HNSCC) subsites.
    Materials and methods: This study utilized the National Cancer Database (NCDB) to identify patients diagnosed with HNSCC between 2010 and 2017. Rates of HPV testing, HPV-positivity, and changes in these rates over time were measured by subsite. The impact of HPV-positivity on overall survival across six head and neck subsites was assessed using multivariable-adjusted Cox proportional hazards analysis.
    Results: A total of 121,550 patients were included. Of this cohort, 87,575 (72.1%) were tested for HPV, with the oropharynx (55,049/64,158; 85.8%) displaying the highest rates of testing and the sinonasal tract (1519/2853; 53.2%) displaying the lowest testing rates. Of the 86,136 with a definitive result, 46,878 (54.4%) were HPV-positive, with the oropharynx (40,313/54,205; 74.4%) displaying the highest rates of HPV-positivity and the oral cavity (1818/11,505; 15.8%) displaying the lowest. HPV-positive malignancy was associated with significantly improved adjusted overall survival in the oropharynx (HR = 0.42 [95% CI: 0.43-0.47]), oral cavity (HR = 0.86 [95% CI: 0.79-0.95]), sinonasal tract (HR = 0.63 [95% CI: 0.48-0.83]), larynx (HR = 0.78 [95% CI: 0.71-0.87]), and hypopharynx (HR = 0.56 [95% CI: 0.48-0.66]), but not the nasopharynx (HR = 0.93 [95% CI: 0.77-1.14]).
    Conclusion: HPV testing rates were significantly lower in non-oropharyngeal subsites. This is relevant as HPV-associated disease displayed significantly improved overall survival in both the oropharynx and four of five non-oropharyngeal subsites. While validation with prospective studies is necessary, these findings may warrant HPV testing in all HNSCC subsites.
    Language English
    Publishing date 2024-02-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604541-8
    ISSN 1532-818X ; 0196-0709
    ISSN (online) 1532-818X
    ISSN 0196-0709
    DOI 10.1016/j.amjoto.2024.104243
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