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  1. Article ; Online: Correction to: Multiparametric Analysis Combining DSC-MR Perfusion and [18F]FET-PET is Superior to a Single Parameter Approach for Differentiation of Progressive Glioma from Radiation Necrosis.

    Panholzer, Jürgen / Malsiner-Walli, Gertraud / Grün, Bettina / Kalev, Ognian / Sonnberger, Michael / Pichler, Robert

    Clinical neuroradiology

    2024  

    Language English
    Publishing date 2024-04-05
    Publishing country Germany
    Document type Published Erratum
    ZDB-ID 2234662-4
    ISSN 1869-1447 ; 0939-7116 ; 1869-1439
    ISSN (online) 1869-1447
    ISSN 0939-7116 ; 1869-1439
    DOI 10.1007/s00062-024-01398-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3413: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  2. Article: Neoadjuvante Radiochemotherapie für Mundhöhlenkarzinome-INVERT. Prospektive, unizentrische, einarmige, Proof-of-Principle-Studie (ARO 2022-4)

    von der Grün, J. / Winkelmann, R. / Burck, I.

    Forum / Deutsche Krebsgesellschaft

    2022  Volume 37, Issue 4, Page(s) 311

    Language German
    Document type Article
    ZDB-ID 1218650-8
    ISSN 0947-0255
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2355: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  3. Article ; Online: Cross-Polarization Schemes for Improved Heteronuclear Transfers Involving Labile Protons in Biomolecular Solution NMR.

    Kim, Jihyun / Grün, J Tassilo / Novakovic, Mihajlo / Kupce, Eriks / Rosenzweig, Rina / Frydman, Lucio

    Angewandte Chemie (International ed. in English)

    2023  Volume 62, Issue 35, Page(s) e202304900

    Abstract: INEPT-based experiments are widely used ... ...

    Abstract INEPT-based experiments are widely used for
    Language English
    Publishing date 2023-07-18
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202304900
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Multiparametric Analysis Combining DSC-MR Perfusion and [18F]FET-PET is Superior to a Single Parameter Approach for Differentiation of Progressive Glioma from Radiation Necrosis.

    Panholzer, Jürgen / Malsiner-Walli, Gertraud / Grün, Bettina / Kalev, Ognian / Sonnberger, Michael / Pichler, Robert

    Clinical neuroradiology

    2023  

    Abstract: ... maps (r(relative)CBV, rCBF, rMTT, rTTP). Static [18F]FET-PET parameters including mean and maximum ...

    Abstract Purpose: Perfusion-weighted (PWI) magnetic resonance imaging (MRI) and O‑(2-[18F]fluoroethyl-)-l-tyrosine ([18F]FET) positron emission tomography (PET) are both useful for discrimination of progressive disease (PD) from radiation necrosis (RN) in patients with gliomas. Previous literature showed that the combined use of FET-PET and MRI-PWI is advantageous; hhowever the increased diagnostic performances were only modest compared to the use of a single modality. Hence, the goal of this study was to further explore the benefit of combining MRI-PWI and [18F]FET-PET for differentiation of PD from RN. Secondarily, we evaluated the usefulness of cerebral blood flow (CBF), mean transit time (MTT) and time to peak (TTP) as previous studies mainly examined cerebral blood volume (CBV).
    Methods: In this single center study, we retrospectively identified patients with WHO grades II-IV gliomas with suspected tumor recurrence, presenting with ambiguous findings on structural MRI. For differentiation of PD from RN we used both MRI-PWI and [18F]FET-PET. Dynamic susceptibility contrast MRI-PWI provided normalized parameters derived from perfusion maps (r(relative)CBV, rCBF, rMTT, rTTP). Static [18F]FET-PET parameters including mean and maximum tumor to brain ratios (TBR
    Results: After application of inclusion and exclusion criteria, we included 37 patients in this study. Regarding the in-sample based approach, in single parameter analysis rTBR
    Conclusion: A multiparametric MRI-PWI and [18F]FET-PET model consisting of TBR
    Language English
    Publishing date 2023-12-29
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2234662-4
    ISSN 1869-1447 ; 0939-7116 ; 1869-1439
    ISSN (online) 1869-1447
    ISSN 0939-7116 ; 1869-1439
    DOI 10.1007/s00062-023-01372-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3413: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: 1024-channel electrophysiological recordings in macaque V1 and V4 during resting state.

    Chen, Xing / Morales-Gregorio, Aitor / Sprenger, Julia / Kleinjohann, Alexander / Sridhar, Shashwat / van Albada, Sacha J / Grün, Sonja / Roelfsema, Pieter R

    Scientific data

    2022  Volume 9, Issue 1, Page(s) 77

    Abstract: Co-variations in resting state activity are thought to arise from a variety of correlated inputs to neurons, such as bottom-up activity from lower areas, feedback from higher areas, recurrent processing in local circuits, and fluctuations in ... ...

    Abstract Co-variations in resting state activity are thought to arise from a variety of correlated inputs to neurons, such as bottom-up activity from lower areas, feedback from higher areas, recurrent processing in local circuits, and fluctuations in neuromodulatory systems. Most studies have examined resting state activity throughout the brain using MRI scans, or observed local co-variations in activity by recording from a small number of electrodes. We carried out electrophysiological recordings from over a thousand chronically implanted electrodes in the visual cortex of non-human primates, yielding a resting state dataset with unprecedentedly high channel counts and spatiotemporal resolution. Such signals could be used to observe brain waves across larger regions of cortex, offering a temporally detailed picture of brain activity. In this paper, we provide the dataset, describe the raw and processed data formats and data acquisition methods, and indicate how the data can be used to yield new insights into the 'background' activity that influences the processing of visual information in our brain.
    MeSH term(s) Animals ; Brain/physiology ; Electrophysiological Phenomena ; Macaca ; Neurons/physiology ; Visual Cortex/physiology
    Language English
    Publishing date 2022-03-11
    Publishing country England
    Document type Dataset ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2775191-0
    ISSN 2052-4463 ; 2052-4463
    ISSN (online) 2052-4463
    ISSN 2052-4463
    DOI 10.1038/s41597-022-01180-1
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  6. Article ; Online: Piezo1 stretch-activated channel activity differs between murine bone marrow-derived and cardiac tissue-resident macrophages.

    Simon-Chica, Ana / Klesen, Alexander / Emig, Ramona / Chan, Andy / Greiner, Joachim / Grün, Dominic / Lother, Achim / Hilgendorf, Ingo / Rog-Zielinska, Eva A / Ravens, Ursula / Kohl, Peter / Schneider-Warme, Franziska / Peyronnet, Rémi

    The Journal of physiology

    2024  

    Abstract: Macrophages (MΦ) play pivotal roles in tissue homeostasis and repair. Their mechanical environment has been identified as a key modulator of various cell functions, and MΦ mechanosensitivity is likely to be critical - in particular in a rhythmically ... ...

    Abstract Macrophages (MΦ) play pivotal roles in tissue homeostasis and repair. Their mechanical environment has been identified as a key modulator of various cell functions, and MΦ mechanosensitivity is likely to be critical - in particular in a rhythmically contracting organ such as the heart. Cultured MΦ, differentiated in vitro from bone marrow (MΦ
    Language English
    Publishing date 2024-04-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/JP284805
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.65: Show issues Location:
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  7. Article ; Online: Investigation on the thermal budget and flow field of a manikin and comparison with human subject in different scenarios

    Sankaran, Abhilash / Hain, Rainer / Matheis, Christina / Fuchs, Thomas / Norrefeldt, Victor / Grün, Gunnar / Kähler, Christian J.

    2024  

    Abstract: The thermal plume from a human significantly influences indoor air flows, impacting the dispersion of air constituents and consequently affecting indoor air quality. This is also relevant in the transport of respiratory particles, which results in spread ...

    Abstract The thermal plume from a human significantly influences indoor air flows, impacting the dispersion of air constituents and consequently affecting indoor air quality. This is also relevant in the transport of respiratory particles, which results in spread of respiratory diseases including COVID-19 caused by SARS-CoV-2. Our focus is on the sitting condition, a common scenario in various ventilated spaces. Prior human thermal plume studies employed predominantly anemometers to measure flow field which lack spatial resolution and detailed flow field. Here, Particle Image Velocimetry (PIV) is utilized to directly visualize and analyze the human thermal plume. No direct comparison of thermal manikin and real human subject is considered in previous studies. Such experiments were performed with a thermal manikin and comparisons were made with a real human. The results show that the thermal plume from manikin without breathing function and the real person have similarities including bi-lobe structure of the flow field. The integral fluxes like volumetric flux, momentum flux, buoyancy force flux, and enthalpy flux were determined and compared. The average volume flux of real person and the thermal manikin was found to be 153 m3/h and 125 m3/h, respectively. The momentum flux was 0.005 N for both the cases. The estimation of enthalpy flux revealed that radiative heat transfer dominates and less than 50 % of the total flux is convected in the human thermal plume. In addition, a zonal simulation model was created and the volumetric flux was determined by simulation and is compared to the measured values.

    252
    Subject code 551
    Language English
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  8. Article ; Online: The Rosetta Phenotype Harmonization Method Facilitates Finding a Relationship Quantitative Trait Locus for a Complex Cognitive Trait.

    Petrill, Stephen A / Klamer, Brett G / Buyske, Steven / Willcutt, Erik G / Gruen, Jeffrey R / Francis, David J / Flax, Judy F / Brzustowicz, Linda M / Bartlett, Christopher W

    Genes

    2023  Volume 14, Issue 9

    Abstract: Genetics researchers increasingly combine data across many sources to increase power and to conduct analyses that cross multiple individual studies. However, there is often a lack of alignment on outcome measures when the same constructs are examined ... ...

    Abstract Genetics researchers increasingly combine data across many sources to increase power and to conduct analyses that cross multiple individual studies. However, there is often a lack of alignment on outcome measures when the same constructs are examined across studies. This inhibits comparison across individual studies and may impact the findings from meta-analysis. Using a well-characterized genotypic (brain-derived neurotrophic factor: BDNF) and phenotypic constructs (working memory and reading comprehension), we employ an approach called Rosetta, which allows for the simultaneous examination of primary studies that employ related but incompletely overlapping data. We examined four studies of BDNF, working memory, and reading comprehension with a combined sample size of 1711 participants. Although the correlation between working memory and reading comprehension over all participants was high, as expected (ρ = 0.45), the correlation between working memory and reading comprehension was attenuated in the BDNF Met/Met genotype group (ρ = 0.18, n.s.) but not in the Val/Val (ρ = 0.44) or Val/Met (ρ = 0.41) groups. These findings indicate that Met/Met carriers may be a unique and robustly defined subgroup in terms of memory and reading comprehension. This study demonstrates the utility of the Rosetta method when examining complex phenotypes across multiple studies, including psychiatric genetic studies, as shown here, and also for the mega-analysis of cohorts generally.
    MeSH term(s) Humans ; Brain-Derived Neurotrophic Factor/genetics ; Quantitative Trait Loci ; Magnetic Resonance Imaging ; Phenotype ; Cognition
    Chemical Substances Brain-Derived Neurotrophic Factor
    Language English
    Publishing date 2023-08-31
    Publishing country Switzerland
    Document type Meta-Analysis ; Journal Article
    ZDB-ID 2527218-4
    ISSN 2073-4425 ; 2073-4425
    ISSN (online) 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes14091748
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  9. Article: Systems Medicine Disease: Disease Classification and Scalability Beyond Networks and Boundary Conditions.

    Berlin, Richard / Gruen, Russell / Best, James

    Frontiers in bioengineering and biotechnology

    2018  Volume 6, Page(s) 112

    Abstract: In order to accommodate the forthcoming wealth of health and disease related information, from genome to body sensors to population and the environment, the approach to disease description and definition demands re-examination. Traditional classification ...

    Abstract In order to accommodate the forthcoming wealth of health and disease related information, from genome to body sensors to population and the environment, the approach to disease description and definition demands re-examination. Traditional classification methods remain trapped by history; to provide the descriptive features that are required for a comprehensive description of disease, systems science, which realizes dynamic processes, adaptive response, and asynchronous communication channels, must be applied (Wolkenhauer et al., 2013). When Disease is viewed beyond the thresholds of lines and threshold boundaries, disease definition is not only the result of reductionist, mechanistic categories which reluctantly face re-composition. Disease is process and synergy as the characteristics of Systems Biology and Systems Medicine are included. To capture the wealth of information and contribute meaningfully to medical practice and biology research, Disease classification goes beyond a single spatial biologic level or static time assignment to include the interface of Disease process and organism response (Bechtel, 2017a; Green et al., 2017).
    Language English
    Publishing date 2018-08-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2719493-0
    ISSN 2296-4185
    ISSN 2296-4185
    DOI 10.3389/fbioe.2018.00112
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Mechanism matters: mortality and endothelial cell damage marker differences between blunt and penetrating traumatic injuries across three prehospital clinical trials.

    Donohue, Jack K / Gruen, Danielle S / Iyanna, Nidhi / Lorence, John M / Brown, Joshua B / Guyette, Francis X / Daley, Brian J / Eastridge, Brian J / Miller, Richard S / Nirula, Raminder / Harbrecht, Brian G / Claridge, Jeffrey A / Phelan, Herb A / Vercruysse, Gary A / O'Keeffe, Terence / Joseph, Bellal / Neal, Matthew D / Billiar, Timothy R / Sperry, Jason L

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 2747

    Abstract: Injury mechanism is an important consideration when conducting clinical trials in trauma. Mechanisms of injury may be associated with differences in mortality risk and immune response to injury, impacting the potential success of the trial. We sought to ... ...

    Abstract Injury mechanism is an important consideration when conducting clinical trials in trauma. Mechanisms of injury may be associated with differences in mortality risk and immune response to injury, impacting the potential success of the trial. We sought to characterize clinical and endothelial cell damage marker differences across blunt and penetrating injured patients enrolled in three large, prehospital randomized trials which focused on hemorrhagic shock. In this secondary analysis, patients with systolic blood pressure < 70 or systolic blood pressure < 90 and heart rate > 108 were included. In addition, patients with both blunt and penetrating injuries were excluded. The primary outcome was 30-day mortality. Mortality was characterized using Kaplan-Meier and Cox proportional-hazards models. Generalized linear models were used to compare biomarkers. Chi squared tests and Wilcoxon rank-sum were used to compare secondary outcomes. We characterized data of 696 enrolled patients that met all secondary analysis inclusion criteria. Blunt injured patients had significantly greater 24-h (18.6% vs. 10.7%, log rank p = 0.048) and 30-day mortality rates (29.7% vs. 14.0%, log rank p = 0.001) relative to penetrating injured patients with a different time course. After adjusting for confounders, blunt mechanism of injury was independently predictive of mortality at 30-days (HR 1.84, 95% CI 1.06-3.20, p = 0.029), but not 24-h (HR 1.65, 95% CI 0.86-3.18, p = 0.133). Elevated admission levels of endothelial cell damage markers, VEGF, syndecan-1, TM, S100A10, suPAR and HcDNA were associated with blunt mechanism of injury. Although there was no difference in multiple organ failure (MOF) rates across injury mechanism (48.4% vs. 42.98%, p = 0.275), blunt injured patients had higher Denver MOF score (p < 0.01). The significant increase in 30-day mortality and endothelial cell damage markers in blunt injury relative to penetrating injured patients highlights the importance of considering mechanism of injury within the inclusion and exclusion criteria of future clinical trials.
    MeSH term(s) Humans ; Wounds, Penetrating/complications ; Wounds, Nonpenetrating/complications ; Proportional Hazards Models ; Emergency Medical Services ; Endothelial Cells ; Retrospective Studies
    Language English
    Publishing date 2024-02-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-53398-1
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