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  1. Article ; Online: Adult-onset ornithine transcarbamylase deficiency as a rare cause of fatal hyperammonaemia.

    Durer, Seren / Durer, Ceren / Hoilat, Gilles Jadd

    Lancet (London, England)

    2021  Volume 398, Issue 10302, Page(s) e11

    MeSH term(s) Adult ; Brain/diagnostic imaging ; Brain/pathology ; Emergency Service, Hospital ; Fatal Outcome ; Humans ; Hyperammonemia/etiology ; Hyperammonemia/genetics ; Hyperammonemia/pathology ; Male ; Neuroimaging ; Ornithine Carbamoyltransferase Deficiency Disease/complications ; Ornithine Carbamoyltransferase Deficiency Disease/genetics ; Tomography, X-Ray Computed
    Language English
    Publishing date 2021-08-19
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(21)01606-8
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    In stock of ZB MED Cologne/Königswinter

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  2. Article: Percutaneous Mechanical Pulmonary Thrombectomy in a Patient With Pulmonary Embolism as a First Presentation of COVID-19.

    Hoilat, Gilles J / Durer, Ceren / Durer, Seren / Gupta, Pratishtha

    Cureus

    2020  Volume 12, Issue 8, Page(s) e9506

    Abstract: There has been a high incidence of thromboembolic diseases in patients with coronavirus disease 2019 (COVID-19) pneumonia. We present a case of a healthy 32-year-old male with no past medical history who presented with shortness of breath, tested ... ...

    Abstract There has been a high incidence of thromboembolic diseases in patients with coronavirus disease 2019 (COVID-19) pneumonia. We present a case of a healthy 32-year-old male with no past medical history who presented with shortness of breath, tested positive for COVID-19, and was found to have a large acute saddle pulmonary embolism.
    Keywords covid19
    Language English
    Publishing date 2020-08-01
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.9506
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  3. Article: Percutaneous Mechanical Pulmonary Thrombectomy in a Patient With Pulmonary Embolism as a First Presentation of COVID-19

    Hoilat, Gilles J. / Durer, Ceren / Durer, Seren / Gupta, Pratishtha

    Cureus

    Abstract: There has been a high incidence of thromboembolic diseases in patients with coronavirus disease 2019 (COVID-19) pneumonia We present a case of a healthy 32-year-old male with no past medical history who presented with shortness of breath, tested positive ...

    Abstract There has been a high incidence of thromboembolic diseases in patients with coronavirus disease 2019 (COVID-19) pneumonia We present a case of a healthy 32-year-old male with no past medical history who presented with shortness of breath, tested positive for COVID-19, and was found to have a large acute saddle pulmonary embolism
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #705571
    Database COVID19

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  4. Article: Polyethylene glycol versus lactulose in the treatment of hepatic encephalopathy: a systematic review and meta-analysis.

    Hoilat, Gilles Jadd / Ayas, Mohamad Fekredeen / Hoilat, Judie Noemie / Abu-Zaid, Ahmed / Durer, Ceren / Durer, Seren / Adhami, Talal / John, Savio

    BMJ open gastroenterology

    2021  Volume 8, Issue 1

    Abstract: Background: Hepatic encephalopathy (HE) is defined as brain dysfunction that occurs because of acute liver failure or liver cirrhosis and is associated with significant morbidity and mortality. Lactulose is the standard of care till this date; however, ... ...

    Abstract Background: Hepatic encephalopathy (HE) is defined as brain dysfunction that occurs because of acute liver failure or liver cirrhosis and is associated with significant morbidity and mortality. Lactulose is the standard of care till this date; however, polyethylene glycol (PEG) has gained the attention of multiple investigators.
    Methods: We screened five databases namely PubMed, Scopus, Web of Science, Cochrane Library and Embase from inception to 10 February 2021. Dichotomous and continuous data were analysed using the Mantel-Haenszel and inverse variance methods, respectively, which yielded a meta-analysis comparing PEG versus lactulose in the treatment of HE.
    Results: Four trials with 229 patients were included. Compared with lactulose, the pooled effect size demonstrated a significantly lower average HE Scoring Algorithm (HESA) Score at 24 hours (Mean difference (MD)=-0.68, 95% CI (-1.05 to -0.31), p<0.001), a higher proportion of patients with reduction of HESA Score by ≥1 grade at 24 hours (risk ratio (RR)=1.40, 95% CI (1.17 to 1.67), p<0.001), a higher proportion of patients with a HESA Score of grade 0 at 24 hours (RR=4.33, 95% CI (2.27 to 8.28), p<0.0010) and a shorter time to resolution of HE group (MD=-1.45, 95% CI (-1.72 to -1.18), p<0.001) in favour of patients treated with PEG.
    Conclusion: PEG leads to a higher drop in the HESA Score and thus leads to a faster resolution of HE compared with lactulose.
    MeSH term(s) Hepatic Encephalopathy/drug therapy ; Humans ; Lactulose/therapeutic use ; Liver Cirrhosis ; Polyethylene Glycols/therapeutic use
    Chemical Substances Polyethylene Glycols (3WJQ0SDW1A) ; Lactulose (4618-18-2)
    Language English
    Publishing date 2021-04-06
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Review ; Systematic Review
    ISSN 2054-4774
    ISSN 2054-4774
    DOI 10.1136/bmjgast-2021-000648
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  5. Article: Seminoma metastasized to the prostate: A case report and literature review.

    Durer, Ceren / Comba, Isin Yagmur / Durer, Seren / Torres Luna, Nancy / Jignesh, Parikh / Carilli, Allison

    Urology case reports

    2019  Volume 29, Page(s) 101096

    Abstract: The testicular seminomas are germ-cell tumors which account for approximately 50% of all testicular tumors. Most primary testicular germ cell tumors metastasize through a lymphatic system in a predictable pattern with the retroperitoneal lymph nodes ... ...

    Abstract The testicular seminomas are germ-cell tumors which account for approximately 50% of all testicular tumors. Most primary testicular germ cell tumors metastasize through a lymphatic system in a predictable pattern with the retroperitoneal lymph nodes being the most common initial metastatic site. Hematological metastasis to the distant organs is less common, and except for pulmonary metastasis, changes the classification from good to intermediate prognosis. Metastasis of testicular seminoma to the prostate is an extremely rare entity with only five reported cases in the literature. In this report, we present a 63-year-old male with recurrent testicular seminoma presenting in prostate.
    Language English
    Publishing date 2019-12-13
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2745459-9
    ISSN 2214-4420
    ISSN 2214-4420
    DOI 10.1016/j.eucr.2019.101096
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  6. Article: Fecal Calprotectin as a Diagnostic and Prognostic Biomarker for Gastrointestinal Graft Versus Host Disease: A Systematic Review of Literature.

    Malik, Mustafa N / Rafae, Abdul / Durer, Ceren / Durer, Seren / Anwer, Faiz

    Cureus

    2019  Volume 11, Issue 2, Page(s) e4143

    Abstract: The current practice for diagnosing graft versus host disease (GVHD) includes clinical or endoscopic evaluation of the patient. Clinical diagnosis is limited by an overlapping symptomatic spectrum with infectious causes, a common scenario in the post- ... ...

    Abstract The current practice for diagnosing graft versus host disease (GVHD) includes clinical or endoscopic evaluation of the patient. Clinical diagnosis is limited by an overlapping symptomatic spectrum with infectious causes, a common scenario in the post-transplant setting where an invasive procedure, such as endoscopy, is often impractical. We, therefore, evaluated the role of fecal calprotectin as a diagnostic as well as a prognostic biomarker for gastrointestinal GVHD (GI-GVHD) occurrence and severity in the post-hematopoietic transplant population. Following Prisma guidelines, we performed a systematic search of articles published after 2004 using the PubMed, Embase, Cochrane Library, and Web of Science databases. After a detailed screening, 10 studies involving a total of 494 patients were included. In the cohorts comparing median fecal calprotectin (mFC) level in GI-GVHD vs. non-GI-GVHD patients, the results indicated an increase in the mFC level in patients with GI-GVHD when compared to non-GI-GVHD patients. Similarly, an increase in the mFC level was seen in accordance with the severity of the disease. Moreover, corticosteroid-resistant patients had a higher mFC level as compared to corticosteroid-sensitive patients. Our study indicates that the mFC level can be used for diagnosing as well as predicting the treatment response to GI-GVHD. However, future randomized prospective trials involving larger populations are needed to further explore its significance.
    Language English
    Publishing date 2019-02-27
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.4143
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  7. Article: Duodenal bulb obstruction caused by a gallstone (Bouveret syndrome) successfully treated with endoscopic measures.

    Hoilat, Gilles Jadd / Sostre, Vanessa / Hoilat, Judie N / Durer, Ceren / Durer, Seren / Kanagalingam, Gowthami / Manocha, Divey

    Proceedings (Baylor University. Medical Center)

    2020  Volume 33, Issue 4, Page(s) 630–632

    Abstract: Bouveret syndrome is the rarest variant of gallstone ileus, with a high morbidity and mortality rate as well as life-threatening complications. We present a case of an 86-year-old woman who presented with abdominal pain and was diagnosed with acute ... ...

    Abstract Bouveret syndrome is the rarest variant of gallstone ileus, with a high morbidity and mortality rate as well as life-threatening complications. We present a case of an 86-year-old woman who presented with abdominal pain and was diagnosed with acute cholecystitis. After laparoscopic cholecystectomy, her symptoms did not improve. She then underwent endoscopic retrograde cholangiopancreatography and was found to have a stone causing duodenal bulb obstruction. The stone was removed using a snare, and her symptoms improved greatly. This rare case of Bouveret syndrome with no apparent fistula was successfully treated using endoscopic measures.
    Language English
    Publishing date 2020-07-23
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2703932-8
    ISSN 1525-3252 ; 0899-8280
    ISSN (online) 1525-3252
    ISSN 0899-8280
    DOI 10.1080/08998280.2020.1792757
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Cavernous Hemangioma of the Small Bowel: A Case Report and Literature Review.

    Durer, Ceren / Durer, Seren / Sharbatji, Mohamad / Comba, Isin Y / Aharoni, Ilan / Majeed, Umair

    Cureus

    2018  Volume 10, Issue 8, Page(s) e3113

    Abstract: Hemangiomas of the small intestine are rare and very difficult to diagnose preoperatively. Clinical presentations may include occult or massive gastrointestinal (GI) bleeding, obstruction, intussusception, and perforation. We report a 66-year-old ... ...

    Abstract Hemangiomas of the small intestine are rare and very difficult to diagnose preoperatively. Clinical presentations may include occult or massive gastrointestinal (GI) bleeding, obstruction, intussusception, and perforation. We report a 66-year-old Caucasian male patient with severe anemia secondary to occult GI bleeding from a cavernous hemangioma in the jejunum. A double balloon enteroscopy following capsule endoscopy was performed to obtain biopsy samples, which established the final diagnosis.
    Language English
    Publishing date 2018-08-06
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.3113
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  9. Article: An Overview of Light Chain Multiple Myeloma: Clinical Characteristics and Rarities, Management Strategies, and Disease Monitoring.

    Rafae, Abdul / Malik, Mustafa N / Abu Zar, Muhammad / Durer, Seren / Durer, Ceren

    Cureus

    2018  Volume 10, Issue 8, Page(s) e3148

    Abstract: ... in combination with bendamustine. Monitoring of disease should include serum free light chain levels ... as literature review revealed that serum assays were more sensitive in indicating the disease and predicting PFS ...

    Abstract Light chain multiple myeloma (LCMM) constitutes approximately 15% of patients with multiple myeloma (MM). It has a poorer prognosis when compared to immunoglobulin (Ig) G or IgA variant. We performed a comprehensive literature search on LCMM and identified a total of 390 articles. After a detailed screening, six studies involving a total of 1054 LCMM patients were included. A literature review revealed bone pain and renal failure as the most common initial sign and symptoms while extramedullary disease (EMD) was acquired later during the progression of the disease. Bortezomib has shown superior efficacy in LCMM patients over nonbortezomib regimens as demonstrated by better overall response rate (95.5% vs. 60%), progression-free survival (PFS) (25% vs. 9% at two years), and overall survival (OS) (24% vs. 9% at five years). Moreover, better PFS was seen, when bortezomib was used in combination with bendamustine compared to dexamethasone (95% vs. 25% at two years). Similarly, better OS (90% at two years) was observed with bortezomib in combination with bendamustine. Monitoring of disease should include serum free light chain levels, as literature review revealed that serum assays were more sensitive in indicating the disease and predicting PFS and OS as compared to urine assays. We provide presentation patterns, clinical rarities, management strategies including their efficacy, and disease monitoring in patients with LCMM in our review paper.
    Language English
    Publishing date 2018-08-15
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.3148
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  10. Book ; Thesis: Transmissionselektronenmikroskopische und immunozytochemische Untersuchungen zum Nachweis von Lipoproteinen (VLDL) im Serum und in den Leberparenchymzellen fetaler Ratten

    Dürer, Uwe

    1984  

    Size 89 Bl. : Ill., graph. Darst.
    Publishing country XA-DDDE
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Jena, Univ., Diss., 1984
    HBZ-ID HT003100768
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    85 E 910 order for loan Magazin

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