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  1. Article ; Online: Response by Forte and Sattler to Letter Regarding Article, "Cross-Priming Dendritic Cells Exacerbate Immunopathology After Ischemic Tissue Damage in the Heart".

    Forte, Elvira / Sattler, Susanne

    Circulation

    2021  Volume 144, Issue 5, Page(s) e94–e95

    MeSH term(s) CD8-Positive T-Lymphocytes ; Cross-Priming ; Dendritic Cells
    Language English
    Publishing date 2021-08-02
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.121.055584
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui IV Zs.60: Show issues Location:
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  2. Article: Editorial: Fibrosis and Inflammation in Tissue Pathophysiology.

    Chimenti, Isotta / Sattler, Susanne / Del Monte-Nieto, Gonzalo / Forte, Elvira

    Frontiers in physiology

    2022  Volume 12, Page(s) 830683

    Language English
    Publishing date 2022-01-21
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2021.830683
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  3. Article ; Online: Protocol for Isolation of Cardiac Interstitial Cells from Adult Murine Hearts for Unbiased Single Cell Profiling.

    Forte, Elvira / Daigle, Sandra / Rosenthal, Nadia A

    STAR protocols

    2020  Volume 1, Issue 2, Page(s) 100077

    Abstract: ... For complete details on the use and execution of this protocol, please refer to Forte et al. (2020). ...

    Abstract Interstitial cells have a crucial role in cardiac fibrosis and repair of the mammalian heart. Single-cell profiling using droplet-based technology has revolutionized the investigation of cell states and identities. Here, we present a protocol for the efficient isolation of high-quality live nucleated non-cardiomyocytes from adult murine heart, for unbiased single-cell RNA sequencing using 10× Chromium technology. This protocol has been applied to homeostatic and injured hearts from different mouse strains. For complete details on the use and execution of this protocol, please refer to Forte et al. (2020).
    MeSH term(s) Animals ; Cell Culture Techniques/methods ; Cells, Cultured/cytology ; Mice ; Myocardium/cytology ; Single-Cell Analysis/methods
    Language English
    Publishing date 2020-09-18
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 2666-1667
    ISSN (online) 2666-1667
    DOI 10.1016/j.xpro.2020.100077
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  4. Article ; Online: Protocol for Isolation of Cardiac Interstitial Cells from Adult Murine Hearts for Unbiased Single Cell Profiling

    Elvira Forte / Sandra Daigle / Nadia A. Rosenthal

    STAR Protocols, Vol 1, Iss 2, Pp 100077- (2020)

    2020  

    Abstract: ... strains.For complete details on the use and execution of this protocol, please refer to Forte et al. (2020). ...

    Abstract Summary: Interstitial cells have a crucial role in cardiac fibrosis and repair of the mammalian heart. Single-cell profiling using droplet-based technology has revolutionized the investigation of cell states and identities. Here, we present a protocol for the efficient isolation of high-quality live nucleated non-cardiomyocytes from adult murine heart, for unbiased single-cell RNA sequencing using 10× Chromium technology. This protocol has been applied to homeostatic and injured hearts from different mouse strains.For complete details on the use and execution of this protocol, please refer to Forte et al. (2020).
    Keywords Science (General) ; Q1-390
    Language English
    Publishing date 2020-09-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Nursing appeals on social media in times of coronavirus.

    Forte, Elaine Cristina Novatzki / Pires, Denise Elvira Pires de

    Revista brasileira de enfermagem

    2020  Volume 73 Suppl 2, Page(s) e20200225

    Abstract: Objective: to know and analyze the nursing appeals on social media during the COVID-19 pandemic.: Method: it is a documentary, qualitative, descriptive, and exploratory research with data collected in publications in two social media. Two hundred ... ...

    Abstract Objective: to know and analyze the nursing appeals on social media during the COVID-19 pandemic.
    Method: it is a documentary, qualitative, descriptive, and exploratory research with data collected in publications in two social media. Two hundred ninety-five publications of nursing professionals published on Twitter and Instagram between March 11 and 20, 2020 were submitted to content analysis using ATLAS.ti resources.
    Results: four thematic categories emerged: #stayathome, #whereismyPPE, #nowweareheroes, #nothingnewinthefrontline, according to frequency of communications. The appeals show a relationship with the social relevance of nursing professional work and with the conditions required for its exercise. Final considerations: old and new challenges of the profession were placed on the agenda in social media, especially related to the workforce and instruments of labor. These speeches can serve as a foundation for policies to improve working conditions and promote appreciation of the profession.
    MeSH term(s) Adult ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/nursing ; Female ; Humans ; Male ; Middle Aged ; Nursing Staff/statistics & numerical data ; Nursing Staff/supply & distribution ; Pandemics ; Personnel Selection/methods ; Personnel Selection/statistics & numerical data ; Pneumonia, Viral/nursing ; SARS-CoV-2 ; Social Media/statistics & numerical data ; Workforce/statistics & numerical data
    Keywords covid19
    Language English
    Publishing date 2020-07-10
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 731983-6
    ISSN 1984-0446 ; 0034-7167
    ISSN (online) 1984-0446
    ISSN 0034-7167
    DOI 10.1590/0034-7167-2020-0225
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3392: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  6. Article ; Online: Murine MHC-Deficient Nonobese Diabetic Mice Carrying Human HLA-DQ8 Develop Severe Myocarditis and Myositis in Response to Anti-PD-1 Immune Checkpoint Inhibitor Cancer Therapy.

    Racine, Jeremy J / Bachman, John F / Zhang, Ji-Gang / Misherghi, Adel / Khadour, Raheem / Kaisar, Sana / Bedard, Olivia / Jenkins, Catherine / Abbott, Annie / Forte, Elvira / Rainer, Peter / Rosenthal, Nadia / Sattler, Susanne / Serreze, David V

    Journal of immunology (Baltimore, Md. : 1950)

    2024  Volume 212, Issue 8, Page(s) 1287–1306

    Abstract: Myocarditis has emerged as an immune-related adverse event of immune checkpoint inhibitor (ICI) cancer therapy associated with significant mortality. To ensure patients continue to safely benefit from life-saving cancer therapy, an understanding of ... ...

    Abstract Myocarditis has emerged as an immune-related adverse event of immune checkpoint inhibitor (ICI) cancer therapy associated with significant mortality. To ensure patients continue to safely benefit from life-saving cancer therapy, an understanding of fundamental immunological phenomena underlying ICI myocarditis is essential. We recently developed the NOD-cMHCI/II-/-.DQ8 mouse model that spontaneously develops myocarditis with lower mortality than observed in previous HLA-DQ8 NOD mouse strains. Our strain was rendered murine MHC class I and II deficient using CRISPR/Cas9 technology, making it a genetically clean platform for dissecting CD4+ T cell-mediated myocarditis in the absence of classically selected CD8+ T cells. These mice are highly susceptible to myocarditis and acute heart failure following anti-PD-1 ICI-induced treatment. Additionally, anti-PD-1 administration accelerates skeletal muscle myositis. Using histology, flow cytometry, adoptive transfers, and RNA sequencing analyses, we performed a thorough characterization of cardiac and skeletal muscle T cells, identifying shared and unique characteristics of both populations. Taken together, this report details a mouse model with features of a rare, but highly lethal clinical presentation of overlapping myocarditis and myositis following ICI therapy. This study sheds light on underlying immunological mechanisms in ICI myocarditis and provides the basis for further detailed analyses of diagnostic and therapeutic strategies.
    MeSH term(s) Humans ; Mice ; Animals ; Myocarditis ; Mice, Inbred NOD ; Immune Checkpoint Inhibitors/therapeutic use ; Diabetes Mellitus, Experimental ; Neoplasms ; Myositis/chemically induced ; Myositis/pathology ; HLA-DQ Antigens
    Chemical Substances HLA-DQ8 antigen ; Immune Checkpoint Inhibitors ; HLA-DQ Antigens
    Language English
    Publishing date 2024-03-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.2300841
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ud II Zs.37: Show issues Location:
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    Zs.MG 28: Show issues

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  7. Article ; Online: Ex uno, plures

    Forte, Elvira / McLellan, Micheal A / Skelly, Daniel A / Rosenthal, Nadia A

    International journal of molecular sciences

    2021  Volume 22, Issue 4

    Abstract: Recent technological advances have revolutionized the study of tissue biology and garnered a greater appreciation for tissue complexity. In order to understand cardiac development, heart tissue homeostasis, and the effects of stress and injury on the ... ...

    Abstract Recent technological advances have revolutionized the study of tissue biology and garnered a greater appreciation for tissue complexity. In order to understand cardiac development, heart tissue homeostasis, and the effects of stress and injury on the cardiovascular system, it is essential to characterize the heart at high cellular resolution. Single-cell profiling provides a more precise definition of tissue composition, cell differentiation trajectories, and intercellular communication, compared to classical bulk approaches. Here, we aim to review how recent single-cell multi-omic studies have changed our understanding of cell dynamics during cardiac development, and in the healthy and diseased adult myocardium.
    MeSH term(s) Animals ; COVID-19/genetics ; COVID-19/pathology ; Cardiovascular System/cytology ; Cellular Reprogramming/genetics ; Embryonic Development/genetics ; Humans ; Single-Cell Analysis ; Transcriptome/genetics
    Language English
    Publishing date 2021-02-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22042071
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  8. Article ; Online: The voice of those who provide care during the pandemic - a lexicographic study in Brazil-Portugal.

    Forte, Elaine Cristina Novatzki / Ribeiro, Olga Maria Pimenta Lopes / Amadigi, Felipa Rafaela / Pires, Denise Elvira Pires de

    Revista gaucha de enfermagem

    2021  Volume 42, Issue spe, Page(s) e20200336

    Abstract: Objective: To analyze the most frequent words in interviews given by nurses during the coronavirus pandemic.: Method: This is a qualitative, exploratory, descriptive study, carried out with 45 interviews granted by nurses to newspapers of great ... ...

    Abstract Objective: To analyze the most frequent words in interviews given by nurses during the coronavirus pandemic.
    Method: This is a qualitative, exploratory, descriptive study, carried out with 45 interviews granted by nurses to newspapers of great circulation in Brazil and Portugal. The data were processed using the ATLAS.ti® software and analyzed using the word cloud tool.
    Results: The seven most frequent words were: "home" (respect for isolation), "nurses" (valuing of the profession and structural problems), "patients/diseased" and "care" (referring to the severity of the disease), "family" (missing her own family/emotional stress) and "fear" (fear of contamination of oneself and others).
    Final considerations: The word cloud revealed how straining nurses' experiences have been and reinforced the urgent need to rethink nursing work and the risks faced. Reflections like this contribute to the construction of more valued nursing and public policies for the protection of nurses.
    MeSH term(s) Brazil/epidemiology ; COVID-19/epidemiology ; COVID-19/nursing ; COVID-19/psychology ; Critical Care/psychology ; Emotions ; Female ; Humans ; Interviews as Topic ; Nurses/psychology ; Pandemics ; Portugal/epidemiology ; Qualitative Research ; Stress, Physiological
    Language Portuguese
    Publishing date 2021-11-12
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2639673-7
    ISSN 1983-1447 ; 1983-1447
    ISSN (online) 1983-1447
    ISSN 1983-1447
    DOI 10.1590/1983-1447.2021.20200336
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Ex uno, plures –From One Tissue to Many Cells

    Elvira Forte / Micheal A. McLellan / Daniel A. Skelly / Nadia A. Rosenthal

    International Journal of Molecular Sciences, Vol 22, Iss 4, p

    A Review of Single-Cell Transcriptomics in Cardiovascular Biology

    2021  Volume 2071

    Abstract: Recent technological advances have revolutionized the study of tissue biology and garnered a greater appreciation for tissue complexity. In order to understand cardiac development, heart tissue homeostasis, and the effects of stress and injury on the ... ...

    Abstract Recent technological advances have revolutionized the study of tissue biology and garnered a greater appreciation for tissue complexity. In order to understand cardiac development, heart tissue homeostasis, and the effects of stress and injury on the cardiovascular system, it is essential to characterize the heart at high cellular resolution. Single-cell profiling provides a more precise definition of tissue composition, cell differentiation trajectories, and intercellular communication, compared to classical bulk approaches. Here, we aim to review how recent single-cell multi-omic studies have changed our understanding of cell dynamics during cardiac development, and in the healthy and diseased adult myocardium.
    Keywords heart ; cardiac ; single-cell ; scRNAseq ; differentiation ; development ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Language English
    Publishing date 2021-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Nursing appeals on social media in times of coronavirus

    Forte, Elaine Cristina Novatzki / Pires, Denise Elvira Pires de

    Revista Brasileira de Enfermagem v.73 suppl.2 2020

    2020  

    Abstract: ABSTRACT Objective: to know and analyze the nursing appeals on social media during the COVID-19 pandemic. Method: it is a documentary, qualitative, descriptive, and exploratory research with data collected in publications in two social media. Two hundred ...

    Abstract ABSTRACT Objective: to know and analyze the nursing appeals on social media during the COVID-19 pandemic. Method: it is a documentary, qualitative, descriptive, and exploratory research with data collected in publications in two social media. Two hundred ninety-five publications of nursing professionals published on Twitter and Instagram between March 11 and 20, 2020 were submitted to content analysis using ATLAS.ti resources. Results: four thematic categories emerged: #stayathome, #whereismyPPE, #nowweareheroes, #nothingnewinthefrontline, according to frequency of communications. The appeals show a relationship with the social relevance of nursing professional work and with the conditions required for its exercise. Final considerations: old and new challenges of the profession were placed on the agenda in social media, especially related to the workforce and instruments of labor. These speeches can serve as a foundation for policies to improve working conditions and promote appreciation of the profession.
    Keywords Nursing ; Working Conditions ; Communications Media ; Coronavirus Infections ; SARS Virus ; covid19
    Subject code 070
    Language English
    Publishing date 2020-01-01
    Publisher Associação Brasileira de Enfermagem
    Publishing country br
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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