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  1. Book: Von der Schule in den Job - finde deinen Weg

    Becker, Katrin / Lorenz, Anne-Regine / Schöler, Meike

    ein Ratgeber für junge Menschen mit Rheuma

    (Rheumatische Erkrankungen)

    2016  

    Institution Deutsche Rheuma-Liga
    Author's details Deutsche Rheuma-Liga ; die Autorinnen Katrin Becker, Anne-Regine Lorenz, Rechtsanwältin Meike Schoeler
    Series title Rheumatische Erkrankungen
    Language German
    Size 41 Seiten, Illustrationen
    Edition 5. vollständige neu überarbeitete Auflage
    Publisher Deutsche Rheuma-Liga Bundesverband e.V
    Publishing place Bonn
    Publishing country Germany
    Document type Book
    HBZ-ID HT019301052
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2009 A 12488 order for loan Magazin

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  2. Article ; Online: Ceramide and Related Molecules in Viral Infections

    Nadine Beckmann / Katrin Anne Becker

    International Journal of Molecular Sciences, Vol 22, Iss 5676, p

    2021  Volume 5676

    Abstract: Ceramide is a lipid messenger at the heart of sphingolipid metabolism. In concert with its metabolizing enzymes, particularly sphingomyelinases, it has key roles in regulating the physical properties of biological membranes, including the formation of ... ...

    Abstract Ceramide is a lipid messenger at the heart of sphingolipid metabolism. In concert with its metabolizing enzymes, particularly sphingomyelinases, it has key roles in regulating the physical properties of biological membranes, including the formation of membrane microdomains. Thus, ceramide and its related molecules have been attributed significant roles in nearly all steps of the viral life cycle: they may serve directly as receptors or co-receptors for viral entry, form microdomains that cluster entry receptors and/or enable them to adopt the required conformation or regulate their cell surface expression. Sphingolipids can regulate all forms of viral uptake, often through sphingomyelinase activation, and mediate endosomal escape and intracellular trafficking. Ceramide can be key for the formation of viral replication sites. Sphingomyelinases often mediate the release of new virions from infected cells. Moreover, sphingolipids can contribute to viral-induced apoptosis and morbidity in viral diseases, as well as virus immune evasion. Alpha-galactosylceramide, in particular, also plays a significant role in immune modulation in response to viral infections. This review will discuss the roles of ceramide and its related molecules in the different steps of the viral life cycle. We will also discuss how novel strategies could exploit these for therapeutic benefit.
    Keywords ceramide ; acid sphingomyelinase ; sphingolipids ; lipid-rafts ; α-galactosylceramide ; viral infection ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 570
    Language English
    Publishing date 2021-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Ceramide and Related Molecules in Viral Infections.

    Beckmann, Nadine / Becker, Katrin Anne

    International journal of molecular sciences

    2021  Volume 22, Issue 11

    Abstract: Ceramide is a lipid messenger at the heart of sphingolipid metabolism. In concert with its metabolizing enzymes, particularly sphingomyelinases, it has key roles in regulating the physical properties of biological membranes, including the formation of ... ...

    Abstract Ceramide is a lipid messenger at the heart of sphingolipid metabolism. In concert with its metabolizing enzymes, particularly sphingomyelinases, it has key roles in regulating the physical properties of biological membranes, including the formation of membrane microdomains. Thus, ceramide and its related molecules have been attributed significant roles in nearly all steps of the viral life cycle: they may serve directly as receptors or co-receptors for viral entry, form microdomains that cluster entry receptors and/or enable them to adopt the required conformation or regulate their cell surface expression. Sphingolipids can regulate all forms of viral uptake, often through sphingomyelinase activation, and mediate endosomal escape and intracellular trafficking. Ceramide can be key for the formation of viral replication sites. Sphingomyelinases often mediate the release of new virions from infected cells. Moreover, sphingolipids can contribute to viral-induced apoptosis and morbidity in viral diseases, as well as virus immune evasion. Alpha-galactosylceramide, in particular, also plays a significant role in immune modulation in response to viral infections. This review will discuss the roles of ceramide and its related molecules in the different steps of the viral life cycle. We will also discuss how novel strategies could exploit these for therapeutic benefit.
    MeSH term(s) Apoptosis/drug effects ; Apoptosis/immunology ; Ceramides/chemistry ; Ceramides/metabolism ; Gene Expression Regulation, Viral ; HIV-1/metabolism ; HIV-1/pathogenicity ; Humans ; Immunomodulation ; Influenza A virus/metabolism ; Influenza A virus/pathogenicity ; SARS-CoV-2/metabolism ; SARS-CoV-2/pathogenicity ; Virion/growth & development ; Virus Diseases/immunology ; Virus Diseases/metabolism ; Virus Diseases/virology ; Virus Internalization ; Virus Replication/drug effects ; Virus Replication/immunology
    Chemical Substances Ceramides
    Language English
    Publishing date 2021-05-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22115676
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Staphylococcus aureus

    Krones, David / Rühling, Marcel / Becker, Katrin Anne / Kunz, Tobias C / Sehl, Carolin / Paprotka, Kerstin / Gulbins, Erich / Fraunholz, Martin

    Frontiers in microbiology

    2021  Volume 12, Page(s) 694489

    Abstract: Staphylococcus ... ...

    Abstract Staphylococcus aureus
    Language English
    Publishing date 2021-07-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2021.694489
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Highlight: sphingolipids in infectious biology and immunology.

    Carpinteiro, Alexander / Becker, Katrin Anne / Gulbins, Erich

    Biological chemistry

    2018  Volume 399, Issue 10, Page(s) 1113

    MeSH term(s) Animals ; Bacterial Infections/metabolism ; Humans ; Sphingolipids/immunology ; Sphingolipids/metabolism
    Chemical Substances Sphingolipids
    Language English
    Publishing date 2018-09-14
    Publishing country Germany
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 1334659-3
    ISSN 1437-4315 ; 1431-6730 ; 1432-0355
    ISSN (online) 1437-4315
    ISSN 1431-6730 ; 1432-0355
    DOI 10.1515/hsz-2018-0341
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  6. Article ; Online: Sphingosine kills bacteria by binding to cardiolipin.

    Verhaegh, Rabea / Becker, Katrin Anne / Edwards, Michael J / Gulbins, Erich

    The Journal of biological chemistry

    2020  Volume 295, Issue 22, Page(s) 7686–7696

    Abstract: Sphingosine is a long-chain sphingoid base that has been shown to have bactericidal activity against many pathogens, ... ...

    Abstract Sphingosine is a long-chain sphingoid base that has been shown to have bactericidal activity against many pathogens, including
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Cardiolipins/genetics ; Cardiolipins/metabolism ; Cell Membrane/genetics ; Cell Membrane/metabolism ; Escherichia coli/genetics ; Escherichia coli/growth & development ; Pseudomonas aeruginosa/genetics ; Pseudomonas aeruginosa/growth & development ; Sphingosine/pharmacology ; Staphylococcus aureus/genetics ; Staphylococcus aureus/growth & development
    Chemical Substances Anti-Bacterial Agents ; Cardiolipins ; Sphingosine (NGZ37HRE42)
    Language English
    Publishing date 2020-04-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1074/jbc.RA119.012325
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Ex vivo

    Becker, Katrin Anne / Carpinteiro, Alexander / Hoffmann, Markus / Pöhlmann, Stefan / Kornhuber, Johannes / Gulbins, Erich

    STAR protocols

    2021  Volume 2, Issue 1, Page(s) 100356

    Abstract: This protocol enables the testing of drugs against infection of epithelial cells with SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2), using pseudo-typed replication deficient vesicular stomatitis virus particles (pp-VSV) presenting the SARS- ...

    Abstract This protocol enables the testing of drugs against infection of epithelial cells with SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2), using pseudo-typed replication deficient vesicular stomatitis virus particles (pp-VSV) presenting the SARS-CoV-2 spike protein. After treating human volunteers with amitriptyline, an approved antidepressant and inhibitor of the acid sphingomyelinase, freshly isolated nasal epithelial cells were infected
    MeSH term(s) Antiviral Agents/pharmacology ; COVID-19/prevention & control ; Cell Culture Techniques ; Cells, Cultured ; Drug Evaluation, Preclinical/methods ; Epithelial Cells/cytology ; Humans ; Nasal Mucosa/cytology ; SARS-CoV-2/drug effects ; Sphingolipids/metabolism ; Spike Glycoprotein, Coronavirus ; Vesicular stomatitis Indiana virus
    Chemical Substances Antiviral Agents ; Sphingolipids ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
    Language English
    Publishing date 2021-02-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2666-1667
    ISSN (online) 2666-1667
    DOI 10.1016/j.xpro.2021.100356
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Simultaneous targeting of mitochondrial Kv1.3 and lysosomal acid sphingomyelinase amplifies killing of pancreatic ductal adenocarcinoma cells in vitro and in vivo.

    Patel, Sameer H / Bachmann, Magdalena / Kadow, Stephanie / Wilson, Gregory C / Abdel-Salam, Mostafa M L / Xu, Kui / Keitsch, Simone / Soddemann, Matthias / Wilker, Barbara / Becker, Katrin Anne / Carpinteiro, Alexander / Ahmad, Syed A / Szabo, Ildiko / Gulbins, Erich

    Journal of molecular medicine (Berlin, Germany)

    2023  Volume 101, Issue 3, Page(s) 295–310

    Abstract: Pancreas ductal adenocarcinoma (PDAC) remains a malignant tumor with very poor prognosis and low 5-year overall survival. Here, we aimed to simultaneously target mitochondria and lysosomes as a new treatment paradigm of malignant pancreas cancer in vitro ...

    Abstract Pancreas ductal adenocarcinoma (PDAC) remains a malignant tumor with very poor prognosis and low 5-year overall survival. Here, we aimed to simultaneously target mitochondria and lysosomes as a new treatment paradigm of malignant pancreas cancer in vitro and in vivo. We demonstrate that the clinically used sphingosine analog FTY-720 together with PAPTP, an inhibitor of mitochondrial Kv1.3, induce death of pancreas cancer cells in vitro and in vivo. The combination of both drugs results in a marked inhibition of the acid sphingomyelinase and accumulation of cellular sphingomyelin in vitro and in vivo in orthotopic and flank pancreas cancers. Mechanistically, PAPTP and FTY-720 cause a disruption of both mitochondria and lysosomes, an alteration of mitochondrial bioenergetics and accumulation of cytoplasmic Ca
    MeSH term(s) Humans ; Sphingomyelin Phosphodiesterase ; Sphingomyelins/metabolism ; Fingolimod Hydrochloride ; Pancreatic Neoplasms/metabolism ; Carcinoma, Pancreatic Ductal/drug therapy ; Carcinoma, Pancreatic Ductal/metabolism ; Carcinoma, Pancreatic Ductal/pathology ; Lysosomes/metabolism ; Mitochondria/metabolism ; Cell Line, Tumor ; Pancreatic Ducts/metabolism ; Pancreatic Ducts/pathology ; Pancreatic Neoplasms
    Chemical Substances Sphingomyelin Phosphodiesterase (EC 3.1.4.12) ; Sphingomyelins ; Fingolimod Hydrochloride (G926EC510T)
    Language English
    Publishing date 2023-02-15
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1223802-8
    ISSN 1432-1440 ; 0946-2716
    ISSN (online) 1432-1440
    ISSN 0946-2716
    DOI 10.1007/s00109-023-02290-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.36: Show issues Location:
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  9. Book ; Online ; Thesis: Characterization of lungs in a transgenic acid sphingomyelinase mouse model

    Koch, Anne [Verfasser] / Becker-Flegler, Katrin [Akademischer Betreuer]

    2019  

    Author's details Anne Koch ; Betreuer: Katrin Becker-Flegler
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher Duisburg ; Universität Duisburg-Essen
    Publishing place Essen
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  10. Article ; Online: Cell-intrinsic ceramides determine T cell function during melanoma progression.

    Hose, Matthias / Günther, Anne / Naser, Eyad / Schumacher, Fabian / Schönberger, Tina / Falkenstein, Julia / Papadamakis, Athanasios / Kleuser, Burkhard / Becker, Katrin Anne / Gulbins, Erich / Haimovitz-Friedman, Adriana / Buer, Jan / Westendorf, Astrid M / Hansen, Wiebke

    eLife

    2022  Volume 11

    Abstract: Acid sphingomyelinase (Asm) and acid ceramidase (Ac) are parts of the sphingolipid metabolism. Asm hydrolyzes sphingomyelin to ceramide, which is further metabolized to sphingosine by Ac. Ceramide generates ceramide-enriched platforms that are involved ... ...

    Abstract Acid sphingomyelinase (Asm) and acid ceramidase (Ac) are parts of the sphingolipid metabolism. Asm hydrolyzes sphingomyelin to ceramide, which is further metabolized to sphingosine by Ac. Ceramide generates ceramide-enriched platforms that are involved in receptor clustering within cellular membranes. However, the impact of cell-intrinsic ceramide on T cell function is not well characterized. By using T cell-specific Asm- or Ac-deficient mice, with reduced or elevated ceramide levels in T cells, we identified ceramide to play a crucial role in T cell function in vitro and in vivo. T cell-specific ablation of Asm in
    MeSH term(s) Animals ; Mice ; Ceramides/metabolism ; CD8-Positive T-Lymphocytes/metabolism ; Melanoma ; Sphingosine/metabolism ; Receptors, Antigen, T-Cell
    Chemical Substances Ceramides ; Sphingosine (NGZ37HRE42) ; Receptors, Antigen, T-Cell
    Language English
    Publishing date 2022-11-25
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.83073
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