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Article ; Online: Factors affecting activities of daily living among patients with Wilson disease.

Amemiya, Ayumi / Asakura, Keiko / Nishiwaki, Yuji / Shimizu, Norikazu

2023 Volume 46, Issue 4, Page(s) 735–743

Abstract: Wilson disease (WD) is a congenital copper metabolism disorder with various manifestations and can be treated with oral medication. This study examined the factors related to decline in activities of daily living (ADL) in patients with WD as research in ... ...

Abstract	Wilson disease (WD) is a congenital copper metabolism disorder with various manifestations and can be treated with oral medication. This study examined the factors related to decline in activities of daily living (ADL) in patients with WD as research in this area remains limited. We enrolled 308 patients with WD, including patients who participated in a national survey and those who sought cares at the Department of Pediatrics, Toho University Ohashi Medical Center, from 2016 to 2017. We analyzed the association between ADL decline and factors including age at diagnosis, period from diagnosis to survey, hepatic symptoms, neurological signs, and psychiatric presentation at diagnosis. The relative risks (RRs) for ADL decline were estimated for each factor using multivariate modified Poisson regression analysis. Overall, 97 out of 308 (31.5%) patients experienced ADL decline. After adjusting for explanatory variables, regression analysis revealed that factors significantly associated with ADL decline were a period of ≥20 years from diagnosis to survey (adjusted RR = 2.34, 95% confidence interval [CI]: 1.47-3.74), hepatic symptoms with splenomegaly (adjusted RR = 2.57, 95% CI: 1.26-5.24), mild neurological signs (adjusted RR = 3.20, 95% CI: 1.96-5.23), and severe neurological signs (adjusted RR = 3.63, 95% CI: 2.28-5.77). Neurological signs, hepatic symptoms with splenomegaly, and a period of 20 years from diagnosis to survey are associated with ADL decline. Thus, careful assessment of patients for these factors is necessary, and these findings may guide future efforts to improve patient prognosis.
MeSH term(s)	Humans ; Child ; Activities of Daily Living ; Hepatolenticular Degeneration ; Splenomegaly ; Prognosis
Language	English
Publishing date	2023-05-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	438341-2
ISSN	1573-2665 ; 0141-8955
ISSN (online)	1573-2665
ISSN	0141-8955
DOI	10.1002/jimd.12634
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Article ; Online: Relationship between hand-foot skin reaction and external force on patients with hepatocellular carcinoma: A cohort study.

Tahara, Yukie / Amemiya, Ayumi / Kase, Ryutaro / Kitagawa, Yuka / Ogasawara, Sadahisa / Kato, Naoya / Komiyama, Masatoshi

European journal of oncology nursing : the official journal of European Oncology Nursing Society

2024 Volume 70, Page(s) 102576

Abstract: Purpose: Hand-foot skin reaction (HFSR), a side effect of tyrosine kinase inhibitor (TKI) treatment, makes it difficult to walk and perform daily activities because of pain in the limbs. HFSR occurs predominantly in the sites where external forces ( ... ...

Abstract	Purpose: Hand-foot skin reaction (HFSR), a side effect of tyrosine kinase inhibitor (TKI) treatment, makes it difficult to walk and perform daily activities because of pain in the limbs. HFSR occurs predominantly in the sites where external forces (pressure and shear stress) are applied. This study aimed to determine whether pressure or shear stress induces the occurrence of HFSR. Methods: This cohort study was conducted in patients who received TKI treatment for hepatocellular carcinoma. The external forces applied to the sole of the patients' foot while walking was measured, and its association with the occurrence of HFSR was examined. The degree of HFSR was assessed by the patient's response during the examination and by photographs of their feet. The patients' feet were divided into low (grade <2) or high (grade ≥2) HFSR foot group, and the differences in external forces between the groups were analyzed using t-test and Cox hazard analysis. Results: Analysis of the feet of 55 study participants (n = 110) showed no significant difference between the groups on t-test (p ≥ 0.05), however, Cox hazard analysis showed an increased risk of HFSR with higher peak shear stress values at the fifth metatarsal head (hazard ratio = 1.01, p = 0.047; 95% confidence interval = 1.00-1.02). Conclusion: Shear stress is possibly related to HFSR occurrence. Nurses should assess whether patients' shoes fit their feet before initiating TKI treatment. They should instruct patients to wear shoes that are fit of both diameter and width for their feet.
Language	English
Publishing date	2024-03-27
Publishing country	Scotland
Document type	Journal Article
ZDB-ID	2017117-1
ISSN	1532-2122 ; 1462-3889
ISSN (online)	1532-2122
ISSN	1462-3889
DOI	10.1016/j.ejon.2024.102576
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Article ; Online: Study of Alarm Threshold for Assumed Nasogastric Tube Self-removal Action Using a Contact Sensor System.

Matsumura, Aya / Amemiya, Ayumi / Minowa, Takashiro / Ichida, Makoto

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

2022 Volume 2022, Page(s) 4249–4252

Abstract: Physical restraints negatively impact the physical, mental, and social well-being of patients. However, elderly people with dementia are often physically restrained by preventing nasogastric tube (NG tube) self-removal. This study aimed to examine alarm ... ...

Abstract	Physical restraints negatively impact the physical, mental, and social well-being of patients. However, elderly people with dementia are often physically restrained by preventing nasogastric tube (NG tube) self-removal. This study aimed to examine alarm threshold settings limited to the actions that the subject makes contact with the NG tube out of feeling uneasy for the NG tube (assumed self-removal actions) using a contact sensor system in order to achieve non-physical restraint. In this study, subjects with experience in caring for older people with dementia were required to perform an assumed self-removal action along with 15 kinds of non-self-removal actions, while we observed the contact detection and measured the voltage. The alarm thresholds for the assumed self-removal action were examined from the ROC curve using the voltage zero time and the number of times the voltage was up and down during each action as a variable. The system presented in this study allowed us to reduce the false alarm rate from 23.3% to 8.5%. Furthermore, we used this alarm threshold to verify the data of three new subjects, observing a false alarm rate of 0.0%. Our future research would focus on investigating and evaluating elderly with dementia using the alarm threshold of the assumed self-removal action that we examined. In addition, we would use ICT to link contact detection with the nurse call system. Clinical Relevance- In this study, we examined the alarm threshold limited to the expected self-removal action using a contact sensor system. We showed that it is possible to detect the NG tube self-removal with few false alarms.
MeSH term(s)	Aged ; Dementia ; Durable Medical Equipment ; Humans ; Restraint, Physical
Language	English
Publishing date	2022-09-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2694-0604
ISSN (online)	2694-0604
DOI	10.1109/EMBC48229.2022.9871854
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Article ; Online: Formal pump heel height affects the external force exerted on the foot during normal walking.

Kitagawa, Yuka / Umeda, Maho / Nakashima, Yukiko / Kawano, Mio / Amemiya, Ayumi

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

2022 Volume 2022, Page(s) 1797–1800

Abstract: Forefoot pain, hallux valgus, shoe sore, flat foot, and calluses are among the common foot problems encountered by high heel wearers. This study aimed to investigate the external forces associated with shoe sore and callus while wearing formal heel shoes. ...

Abstract	Forefoot pain, hallux valgus, shoe sore, flat foot, and calluses are among the common foot problems encountered by high heel wearers. This study aimed to investigate the external forces associated with shoe sore and callus while wearing formal heel shoes. The external force on the 1
MeSH term(s)	Body Height ; Female ; Foot ; Heel ; Humans ; Lower Extremity ; Pain ; Walking
Language	English
Publishing date	2022-09-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2694-0604
ISSN (online)	2694-0604
DOI	10.1109/EMBC48229.2022.9870998
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Article ; Online: Gait due to difference in Intravenous pole position on the healthy participants.

Shinkawa, Minami / Kitagawa, Yuka / Amemiya, Ayumi

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

2021 Volume 2021, Page(s) 5824–5827

Abstract: Introduction: The gait while using an intravenous (IV) pole is close to the gait of the elderly and fallers. Additionally, one survey has reported that the diagonal position is optimal for transporting an IV pole with a light load. However, in clinical ... ...

Abstract	Introduction: The gait while using an intravenous (IV) pole is close to the gait of the elderly and fallers. Additionally, one survey has reported that the diagonal position is optimal for transporting an IV pole with a light load. However, in clinical practice, carrying a heavier load may be possible. Therefore, this study clarifies the optimum operation position using an IV pole with a weight closer to that in actual clinical practice. Method: Using image analysis software, we investigated several variables indicating gait, such as stride length. Participants walk with an IV pole in three ways: sideways, in front, and diagonally. We investigated two types of IV pole loads, which are 0.5 kg and 5.0 kg. Results and discussion: In 0.5-kg settings, the sideways position is a way to suppress the narrowing of the heel-floor angle. No significant difference in the subjective appraisals was observed between the sideways and diagonal positions. In addition, the sideways position is as optimum as the diagonal position. In 5.0-kg settings, only the sideways position suppressed the narrowing of the step length. Therefore, the sideways position is optimal. However, the participants' impressions suggested that arm strength is required for the sideways position. If a patient has weak arms and cannot maintain the sideways position, the patient may choose the diagonal position. Moreover, the front position is the way to hold the trunk most forward. However, there is a possibility that it is easy for a specific person, such as a rollator user, to choose. Therefore, further investigate of the optimum operation position depending on the walking abilities is needed. Conclusion: It was suggested that the sideways position is optimal for walking with an IV pole when transporting with a total load of approximately 5.0 kg.Clinical Relevance- The results of this study help to prevent people from gait like fallers and the elderly when using IV poles in clinical settings.
MeSH term(s)	Aged ; Gait ; Healthy Volunteers ; Humans ; Torso ; Walking
Language	English
Publishing date	2021-12-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2694-0604
ISSN (online)	2694-0604
DOI	10.1109/EMBC46164.2021.9629564
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Article ; Online: Long-term body weight change assessed by non-contact load cells under the bed in older people with and without eating assistance: a preliminary study.

Ishikawa, Takahiro / Sakai, Ikuko / Amemiya, Ayumi / Komatsu, Ryou / Sakuraba, Shoko / Isono, Shiroh

Scientific reports

2022 Volume 12, Issue 1, Page(s) 8107

Abstract: Utilizing automatic daily body weight (BW) measurements may be helpful for assessing nutritional status and detecting underlying diseases particularly in older people who require nursing care. This preliminary study aimed to verify effectiveness of ... ...

Abstract	Utilizing automatic daily body weight (BW) measurements may be helpful for assessing nutritional status and detecting underlying diseases particularly in older people who require nursing care. This preliminary study aimed to verify effectiveness of eating assistance for maintaining BW in older people using a contact-free load cells under the bed (Bed Sensor System: BSS). BW was measured every night for 3 months in eight nursing home older people with severe cognitive and physical dysfunctions. Body composition of the subject's trunk and each limb was measured using a segmented multi-frequency bioelectrical impedance analyzer (BIA). A monthly BW loss was estimated as a slope of linear regression of the daily BW plot. BSS successfully measured daily BW for the study period in all participants. The 4 residents with eating assistance gained slightly more weight, while the 4 residents without eating assistance lost weight. There was a significant difference between the two groups in the monthly BW change (- 0.79 ± 0.51 kg/month versus 0.20 ± 0.49 kg/month, P = 0.030). None of the BIA-derived parameters was associated with the monthly BW change. BSS revealed effectiveness of eating assistance to maintain BW in nursing home residents with severe cognitive and physical dysfunctions.
MeSH term(s)	Aged ; Body Composition ; Body Weight ; Electric Impedance ; Humans ; Nursing Homes ; Nutritional Status
Language	English
Publishing date	2022-05-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-12291-5
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Article ; Online: Quality of life in Werner syndrome and associated subjective foot/ankle symptoms: A cross-sectional survey.

Kitagawa, Yuka / Amemiya, Ayumi / Ogata, Hideyuki / Koshizaka, Masaya / Shoji, Mayumi / Maezawa, Yoshiro / Akita, Shinsuke / Mitsukawa, Nobuyuki / Yokote, Koutaro

Geriatrics & gerontology international

2023 Volume 23, Issue 3, Page(s) 188–193

Abstract: Aim: The aims of this study were to assess the general quality of life and foot/ankle health-related quality of life among subjects with Werner syndrome (WS) and to determine subjective foot/ankle symptoms associated with quality of life.: Methods: ... ...

Abstract	Aim: The aims of this study were to assess the general quality of life and foot/ankle health-related quality of life among subjects with Werner syndrome (WS) and to determine subjective foot/ankle symptoms associated with quality of life. Methods: Using a questionnaire survey, patients were asked to provide information on age, sex and presence of subjective symptoms and complete both the 36-Item Short Form Health Survey (SF-36) questionnaire and the Self-Administered Foot Evaluation Questionnaire (SAFE-Q). Statistical analyses were performed using Student's t-test, the Mann-Whitney U test, Fisher's exact test and Spearman's rank correlation. Results: Data from 12 patients with an average age of 54 ± 8.6 years were analyzed. The mean SF-36 score for the domain of physical functioning was 21.2; for role-physical function, 32.6; for bodily pain, 38.5; for general health, 34.4; for vitality, 44.8; for social function, 38.5; for role-emotional function and for mental health, 46.7. The mean mental component summary was as high as the national standard, but it was low in men. The mean SAFE-Q scores were also low. Patients with ulcers had significantly more pain and low general health perception. As compared with the national standard, the role/social component score was not low, and there was a correlation in most domains of the SAFE-Q. Conclusion: In WS, the general health-related quality of life was low overall in the physical domain and low only in men for the mental domain, whereas it was low in the social domain when foot/ankle health-related quality of life was low. Geriatr Gerontol Int 2023; 23: 188-193.
MeSH term(s)	Male ; Humans ; Quality of Life/psychology ; Cross-Sectional Studies ; Ankle ; Werner Syndrome ; Surveys and Questionnaires ; Pain
Language	English
Publishing date	2023-01-20
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2113849-7
ISSN	1447-0594 ; 1444-1586
ISSN (online)	1447-0594
ISSN	1444-1586
DOI	10.1111/ggi.14541
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Article ; Online: Long-term body weight change assessed by non-contact load cells under the bed in older people with and without eating assistance

Takahiro Ishikawa / Ikuko Sakai / Ayumi Amemiya / Ryou Komatsu / Shoko Sakuraba / Shiroh Isono

Scientific Reports, Vol 12, Iss 1, Pp 1-

a preliminary study

2022 Volume 5

Abstract: Abstract Utilizing automatic daily body weight (BW) measurements may be helpful for assessing nutritional status and detecting underlying diseases particularly in older people who require nursing care. This preliminary study aimed to verify effectiveness ...

Abstract	Abstract Utilizing automatic daily body weight (BW) measurements may be helpful for assessing nutritional status and detecting underlying diseases particularly in older people who require nursing care. This preliminary study aimed to verify effectiveness of eating assistance for maintaining BW in older people using a contact-free load cells under the bed (Bed Sensor System: BSS). BW was measured every night for 3 months in eight nursing home older people with severe cognitive and physical dysfunctions. Body composition of the subject's trunk and each limb was measured using a segmented multi-frequency bioelectrical impedance analyzer (BIA). A monthly BW loss was estimated as a slope of linear regression of the daily BW plot. BSS successfully measured daily BW for the study period in all participants. The 4 residents with eating assistance gained slightly more weight, while the 4 residents without eating assistance lost weight. There was a significant difference between the two groups in the monthly BW change (− 0.79 ± 0.51 kg/month versus 0.20 ± 0.49 kg/month, P = 0.030). None of the BIA-derived parameters was associated with the monthly BW change. BSS revealed effectiveness of eating assistance to maintain BW in nursing home residents with severe cognitive and physical dysfunctions.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Examination of a contact detection sensor to prevent self-removal of peripheral intravenous catheters

Amemiya, Ayumi / Matsumura, Aya / Kase, Ryutaro / Sugasawa, Yasuhisa / Minowa, Takashiro / Ichida, Makoto

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

2021 Volume 2021, Page(s) 4965–4968

Abstract: If patients are at risk of self-removal of a catheter, it is necessary to check the condition of the catheter frequently. If this is the only way to prevent self-removal, physical restraint of the patient is required. Furthermore, it is currently ... ...

Abstract	If patients are at risk of self-removal of a catheter, it is necessary to check the condition of the catheter frequently. If this is the only way to prevent self-removal, physical restraint of the patient is required. Furthermore, it is currently necessary to reduce human-to-human contact to prevent COVID-19 infection. Therefore, the development of a sensor system to prevent self-removal of a catheter and reduce human-to-human contact is urgent. The purpose of this study is to examine a sensor system that detects the contact of a patient's hand to a peripheral intravenous catheter in order to prevent self-removal in patients with dementia. This study analyzes the use of a capacitance sensor and an energization sensor to detect the contact of a patient's hand to a catheter. Additionally, the time required from the start of peeling the sensor sheet to the removal of the needle was measured. As the results, the capacitance sensor was difficult to use in a clinical setting because the connection between the seat and cable could be unstable depending on the condition of the connections. The energization sensor was able to recognize the contact of a hand to the catheter by detecting its contact with the sensor. It took at least 28 seconds from detection of the hand contact to the beginning of needle removal. Therefore, it is possible for the caregiver to visit the patient's bedside and stop the self-removal when the sensor sheet detects hand contact. This study is the first step in developing the system that prevents self-removal by detecting hand contact and requires several more steps for clinical use. In the future, we will conduct surveys on more subjects and clinical trials on elderly with dementia to examine accuracy, precision, and repeatability. Using the energization sensor, a self-removal prevention system for dementia patients will be further developed.Clinical Relevance- Developing this self-removal prevention system in the future will allow many dementia patients to no longer be physically restrained, and it will make it possible to remotely detect their actions to prevent self-removal while also minimizing the risk of COVID-19 infection.
MeSH term(s)	Aged ; COVID-19 ; Catheters ; Hand ; Humans ; SARS-CoV-2 ; Upper Extremity
Language	English
Publishing date	2021-12-10
Publishing country	United States
Document type	Journal Article
ISSN	2694-0604
ISSN (online)	2694-0604
DOI	10.1109/EMBC46164.2021.9630388
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Article ; Online: Factors Associated with Callus Formation in the Plantar Region through Gait Measurement in Patients with Diabetic Neuropathy: An Observational Case-Control Study.

Amemiya, Ayumi / Noguchi, Hiroshi / Oe, Makoto / Takehara, Kimie / Ohashi, Yumiko / Suzuki, Ryo / Yamauchi, Toshimasa / Kadowaki, Takashi / Sanada, Hiromi / Mori, Taketoshi

Sensors (Basel, Switzerland)

2020 Volume 20, Issue 17

Abstract: Callus has been identified as a risk factor leading to severe diabetic foot ulcer; thus, it is necessary to prevent its formation. Callus formation under the first, second, and fifth metatarsal heads (MTHs) is associated with external forces (pressure ... ...

Abstract	Callus has been identified as a risk factor leading to severe diabetic foot ulcer; thus, it is necessary to prevent its formation. Callus formation under the first, second, and fifth metatarsal heads (MTHs) is associated with external forces (pressure and shear stress) during walking. However, the gait factors increasing the external forces remain undetermined. Thus, this study aims to identify the factors increasing the external forces to prevent callus formation. In 59 patients with diabetic neuropathy wearing their usual shoes, the external forces, and the lower extremity joint angles were measured using MEMS force sensors and motion sensors. The external forces and their relationship with the lower extremity joint angles and footwear size were determined. Risk factors causing high external forces on the first MTH included small flexion of the knee joint (
MeSH term(s)	Biomechanical Phenomena ; Case-Control Studies ; Diabetes Mellitus ; Diabetic Neuropathies/diagnosis ; Female ; Gait ; Humans ; Male ; Pressure ; Shoes ; Walking
Language	English
Publishing date	2020-08-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s20174863
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