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  1. Article ; Online: Emerging Frontiers of Therapeutic Strategies for Brain Tumors: A NeuroMolecular Medicine Special Issue.

    Iyer, Vishwanath R / Kuo, John S

    Neuromolecular medicine

    2022  Volume 24, Issue 1, Page(s) 1–2

    MeSH term(s) Brain Neoplasms/drug therapy ; Humans
    Language English
    Publishing date 2022-01-07
    Publishing country United States
    Document type Editorial
    ZDB-ID 2077809-0
    ISSN 1559-1174 ; 1535-1084
    ISSN (online) 1559-1174
    ISSN 1535-1084
    DOI 10.1007/s12017-021-08699-3
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5818: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: The specificity of H2A.Z occupancy in the yeast genome and its relationship to transcription.

    Iyer, Vishwanath R

    Current genetics

    2020  Volume 66, Issue 5, Page(s) 939–944

    Abstract: The incorporation of histone variants into nucleosomes has important functional consequences in all aspects of eukaryotic chromatin biology. H2A.Z is a conserved histone variant found in all eukaryotes from yeast to mammals. Recent studies in yeast have ... ...

    Abstract The incorporation of histone variants into nucleosomes has important functional consequences in all aspects of eukaryotic chromatin biology. H2A.Z is a conserved histone variant found in all eukaryotes from yeast to mammals. Recent studies in yeast have shed light on the questions of where and how nucleosomes containing this variant are situated at promoters and in relation to genes, and what its specificity implies with regard to transcription. In yeast, H2A.Z appears to be primarily incorporated into the first nucleosome in the direction of transcription initiation, either of an mRNA transcript or a divergently transcribed upstream antisense non-coding RNA. This specificity of H2A.Z is due in part to the localization at promoters of SWR1, the ATP-dependent chromatin remodeler that incorporates H2A.Z into nucleosomes. Replacement of H2A.Z with canonical H2A is dependent on the function of the transcription pre-initiation complex. The recent studies summarized in this review reveal that the directionality of H2A.Z occupancy in relation to transcription thus reflects a balance of incorporation and eviction activities, which likely have varying contributions at distinct sets of genes across the genome.
    MeSH term(s) Adenosine Triphosphatases/genetics ; Adenosine Triphosphatases/metabolism ; Genetic Variation ; Genome, Fungal ; Histones/chemistry ; Histones/genetics ; Histones/metabolism ; Nucleosomes/genetics ; Nucleosomes/metabolism ; Promoter Regions, Genetic ; Ribosomal Proteins/genetics ; Ribosomal Proteins/metabolism ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/genetics ; Saccharomyces cerevisiae Proteins/metabolism ; Transcription, Genetic
    Chemical Substances Histones ; Nucleosomes ; Ribosomal Proteins ; Saccharomyces cerevisiae Proteins ; Adenosine Triphosphatases (EC 3.6.1.-) ; Swr1 protein, S cerevisiae (EC 3.6.1.3)
    Language English
    Publishing date 2020-06-14
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 282876-5
    ISSN 1432-0983 ; 0172-8083
    ISSN (online) 1432-0983
    ISSN 0172-8083
    DOI 10.1007/s00294-020-01087-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2586: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Dermoscopic Perspective of Pityriasis Versicolor in a Cross-Sectional Study.

    Vishwanath, Tejas / Kapadia, Farida M / Mahajan, Sunanda A / Kharkar, Vidya D / Chikhalkar, Siddhi B / Gole, Prachi V / Iyer, Mihir / Shah, Avani J

    Indian dermatology online journal

    2024  Volume 15, Issue 2, Page(s) 218–225

    Abstract: Background: Pityriasis versicolor is a common superficial fungal infection which is usually easily diagnosed with Wood's lamp examination and 10% potassium hydroxide mount. However, these modalities have varying sensitivity and specificity.: Aims and ... ...

    Abstract Background: Pityriasis versicolor is a common superficial fungal infection which is usually easily diagnosed with Wood's lamp examination and 10% potassium hydroxide mount. However, these modalities have varying sensitivity and specificity.
    Aims and objectives: This study aimed to ascertain the dermoscopic features of pityriasis versicolor lesionally as well as perilesionally using dermoscopy, a non-invasive diagnostic tool.
    Materials and methods: In this cross-sectional study, consecutive patients with pityriasis versicolor underwent dermoscopic examination of lesions and 2 cm around lesions, noting lesional and perilesional features. Semi-objective grading of pigmentation, scaling, and vascularity was done. The association between parameters was determined using heat maps and violin plots with Kolmogorov-Smirnov test. Lesional analysis was performed since lesions at different sides showed disparate features.
    Results: A total of 353 lesions from 233 patients (males = 150/233; 64.38% and females = 84/234; 36.05%) were studied. On lesional dermoscopy, pigmentary and scaling abnormalities were universal. 258/353 (73.1%) of lesions showed vascular abnormalities. Perilesionally, scaling (223/353; 63.17%) followed by pigmentation (205/353; 58.07%) and vascular changes (111/353; 31.44%) constituted the most common dermoscopic abnormalities and were noted in 294/353 (83.29%) of lesions overall. Increased disease duration corresponded with increased intensity of perilesional pigmentation alterations, perifollicular (
    Conclusion: Awareness of dermoscopic features could improve the diagnostic accuracy in doubtful cases of pityriasis versicolor. Vascular findings are common and may point to an underlying inflammatory pathogenesis. Perilesional findings constitute early dermoscopic features of pityriasis versicolor and hint at the need for treatment beyond the confines of lesions. Larger follow-up studies and research into immunopathogenesis may be of further benefit.
    Language English
    Publishing date 2024-02-13
    Publishing country India
    Document type Journal Article
    ZDB-ID 2585814-2
    ISSN 2249-5673 ; 2229-5178
    ISSN (online) 2249-5673
    ISSN 2229-5178
    DOI 10.4103/idoj.idoj_319_23
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  4. Article: A Prospective Observational Study Comparing Oxygen Saturation/Fraction of Inspired Oxygen Ratio with Partial Pressure of Oxygen in Arterial Blood/Fraction of Inspired Oxygen Ratio among Critically Ill Patients Requiring Different Modes of Oxygen Supplementation in Intensive Care Unit.

    Alur, T Rakesh / Iyer, Shivakumar S / Shah, Jignesh N / Kulkarni, Sampada / Jedge, Prashant / Patil, Vishwanath

    Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine

    2024  Volume 28, Issue 3, Page(s) 251–255

    Abstract: ... supplementation modes.: How to cite this article: Alur TR, Iyer SS, Shah JN, Kulkarni S, Jedge P, Patil V ...

    Abstract Background: Intensive care unit (ICU) patients face a significant rise in mortality rates due to acute hypoxemic respiratory failure (AHRF). The diagnosis of AHRF is based on the PF ratio, but it has limitations in resource-constrained settings. Instead, the Kigali modification suggests using the oxygen saturation/fraction of inspired oxygen (SF) ratio. This study aims to correlate SF ratio and arterial oxygen pressure (PF) ratio in critically ill adults with hypoxemic respiratory failure, who required O
    Materials and methods: In an ICU, a prospective observational study included 125 adult AHRF patients receiving oxygen therapy, with data collected on FiO
    Results: Data from a total of 250 samples were collected. The study showed a positive correlation (
    Conclusion: For patients with AHRF, the noninvasive SF ratio can effectively serve as a substitute for the invasive PF ratio across all oxygen supplementation modes.
    How to cite this article: Alur TR, Iyer SS, Shah JN, Kulkarni S, Jedge P, Patil V. A Prospective Observational Study Comparing Oxygen Saturation/Fraction of Inspired Oxygen Ratio with Partial Pressure of Oxygen in Arterial Blood/Fraction of Inspired Oxygen Ratio among Critically Ill Patients Requiring Different Modes of Oxygen Supplementation in Intensive Care Unit. Indian J Crit Care Med 2024; 28(3):251-255.
    Language English
    Publishing date 2024-02-26
    Publishing country India
    Document type Journal Article
    ZDB-ID 2121263-6
    ISSN 1998-359X ; 0972-5229
    ISSN (online) 1998-359X
    ISSN 0972-5229
    DOI 10.5005/jp-journals-10071-24652
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: The specificity of H2A.Z occupancy in the yeast genome and its relationship to transcription

    Iyer, Vishwanath R

    Current genetics. 2020 Oct., v. 66, no. 5

    2020  

    Abstract: The incorporation of histone variants into nucleosomes has important functional consequences in all aspects of eukaryotic chromatin biology. H2A.Z is a conserved histone variant found in all eukaryotes from yeast to mammals. Recent studies in yeast have ... ...

    Abstract The incorporation of histone variants into nucleosomes has important functional consequences in all aspects of eukaryotic chromatin biology. H2A.Z is a conserved histone variant found in all eukaryotes from yeast to mammals. Recent studies in yeast have shed light on the questions of where and how nucleosomes containing this variant are situated at promoters and in relation to genes, and what its specificity implies with regard to transcription. In yeast, H2A.Z appears to be primarily incorporated into the first nucleosome in the direction of transcription initiation, either of an mRNA transcript or a divergently transcribed upstream antisense non-coding RNA. This specificity of H2A.Z is due in part to the localization at promoters of SWR1, the ATP-dependent chromatin remodeler that incorporates H2A.Z into nucleosomes. Replacement of H2A.Z with canonical H2A is dependent on the function of the transcription pre-initiation complex. The recent studies summarized in this review reveal that the directionality of H2A.Z occupancy in relation to transcription thus reflects a balance of incorporation and eviction activities, which likely have varying contributions at distinct sets of genes across the genome.
    Keywords eukaryotic cells ; histones ; non-coding RNA ; nucleosomes ; transcription initiation ; yeasts
    Language English
    Dates of publication 2020-10
    Size p. 939-944.
    Publishing place Springer Berlin Heidelberg
    Document type Article
    Note NAL-AP-2-clean ; Review
    ZDB-ID 282876-5
    ISSN 1432-0983 ; 0172-8083
    ISSN (online) 1432-0983
    ISSN 0172-8083
    DOI 10.1007/s00294-020-01087-7
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    In stock of ZB MED Bonn / Germany

    Z 81/707: Show issues

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  6. Book ; Thesis: Bedeutung des Serum-Phosphat und des sekundären Hyperparathyreoidismus für die Entwicklung der Gefäßsklerose

    Iyer, Vishwanath

    1993  

    Author's details vorgelegt von Vishwanath Iyer
    Size 1 Mikrofiche : 24x
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Erlangen-Nürnberg, Univ., Diss., 1993
    Note Mikroreprod. eines Ms. 48, [5] Bl.: graph. Darst.
    HBZ-ID HT004941230
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1993 MB 1102 order for loan Magazin

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  7. Article: Assessment of the quality, content, and reliability of the information in CoMICs videos in comparison to YouTube videos on diabetes mellitus and PCOS.

    Baig, Shams Ali / Banerjee, Anagh Josh / Rahman, Fazna / Batul, Syeda Sabbah / Kowsik, Mukunth / Kumar, Khushi / Saiyad, Mohammed Faraaz / Venkatesh, Vardhan / Iyer, Pranav Vishwanath / Kempegowda, Punith

    Future healthcare journal

    2024  Volume 10, Issue Suppl 3, Page(s) 63

    Language English
    Publishing date 2024-04-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 3016427-8
    ISSN 2514-6653 ; 2514-6645
    ISSN (online) 2514-6653
    ISSN 2514-6645
    DOI 10.7861/fhj.10-3-s63
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  8. Article ; Online: The selfish yeast plasmid exploits a SWI/SNF-type chromatin remodeling complex for hitchhiking on chromosomes and ensuring high-fidelity propagation.

    Ma, Chien-Hui / Kumar, Deepanshu / Jayaram, Makkuni / Ghosh, Santanu K / Iyer, Vishwanath R

    PLoS genetics

    2023  Volume 19, Issue 10, Page(s) e1010986

    Abstract: Extra-chromosomal selfish DNA elements can evade the risk of being lost at every generation by behaving as chromosome appendages, thereby ensuring high fidelity segregation and stable persistence in host cell populations. The yeast 2-micron plasmid and ... ...

    Abstract Extra-chromosomal selfish DNA elements can evade the risk of being lost at every generation by behaving as chromosome appendages, thereby ensuring high fidelity segregation and stable persistence in host cell populations. The yeast 2-micron plasmid and episomes of the mammalian gammaherpes and papilloma viruses that tether to chromosomes and segregate by hitchhiking on them exemplify this strategy. We document for the first time the utilization of a SWI/SNF-type chromatin remodeling complex as a conduit for chromosome association by a selfish element. One principal mechanism for chromosome tethering by the 2-micron plasmid is the bridging interaction of the plasmid partitioning proteins (Rep1 and Rep2) with the yeast RSC2 complex and the plasmid partitioning locus STB. We substantiate this model by multiple lines of evidence derived from genomics, cell biology and interaction analyses. We describe a Rep-STB bypass system in which a plasmid engineered to non-covalently associate with the RSC complex mimics segregation by chromosome hitchhiking. Given the ubiquitous prevalence of SWI/SNF family chromatin remodeling complexes among eukaryotes, it is likely that the 2-micron plasmid paradigm or analogous ones will be encountered among other eukaryotic selfish elements.
    MeSH term(s) Animals ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/genetics ; Saccharomyces cerevisiae Proteins/metabolism ; Chromatin Assembly and Disassembly/genetics ; Chromosomes/metabolism ; Plasmids/genetics ; Chromatin/genetics ; Chromatin/metabolism ; Mammals/genetics
    Chemical Substances Saccharomyces cerevisiae Proteins ; Chromatin
    Language English
    Publishing date 2023-10-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2186725-2
    ISSN 1553-7404 ; 1553-7390
    ISSN (online) 1553-7404
    ISSN 1553-7390
    DOI 10.1371/journal.pgen.1010986
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Comparison of admission GCS score to admission GCS-P and FOUR scores for prediction of outcomes among patients with traumatic brain injury in the intensive care unit in India.

    Agrawal, Nishant / Iyer, Shivakumar S / Patil, Vishwanath / Kulkarni, Sampada / Shah, Jignesh N / Jedge, Prashant

    Acute and critical care

    2023  Volume 38, Issue 2, Page(s) 226–233

    Abstract: Background: This study aimed to determine the predictive power of the Full Outline of Unresponsiveness (FOUR) score and the Glasgow Coma Scale Pupil (GCS-P) score in determining outcomes for traumatic brain injury (TBI) patients. The Glasgow Outcome ... ...

    Abstract Background: This study aimed to determine the predictive power of the Full Outline of Unresponsiveness (FOUR) score and the Glasgow Coma Scale Pupil (GCS-P) score in determining outcomes for traumatic brain injury (TBI) patients. The Glasgow Outcome Scale (GOS) was used to evaluate patients at 1 month and 6 months after the injury.
    Methods: We conducted a 15-month prospective observational study. It included 50 TBI patients admitted to the ICU who met our inclusion criteria. We used Pearson's correlation coefficient to relate coma scales and outcome measures. The predictive value of these scales was determined using the receiver operating characteristic (ROC) curve, calculating the area under the curve with a 99% confidence interval. All hypotheses were two-tailed, and significance was defined as P<0.01.
    Results: In the present study, the GCS-P and FOUR scores among all patients on admission as well as in the subset of patients who were mechanically ventilated were statistically significant and strongly correlated with patient outcomes. The correlation coefficient of the GCS score compared to GCS-P and FOUR scores was higher and statistically significant. The areas under the ROC curve for the GCS, GCS-P, and FOUR scores and the number of computed tomography abnormalities were 0.912, 0.905, 0.937, and 0.324, respectively.
    Conclusions: The GCS, GCS-P, and FOUR scores are all excellent predictors with a strong positive linear correlation with final outcome prediction. In particular, the GCS score has the best correlation with final outcome.
    Language English
    Publishing date 2023-05-25
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 3003021-3
    ISSN 2586-6060 ; 2586-6052
    ISSN (online) 2586-6060
    ISSN 2586-6052
    DOI 10.4266/acc.2023.00570
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  10. Article: Endotracheal Intubation with King Vision Video Laryngoscope vs Macintosh Direct Laryngoscope in ICU: A Comparative Evaluation of Performance and Outcomes.

    Dharanindra, Moturu / Jedge, Prashant Pandurang / Patil, Vishwanath Chandrashekhar / Kulkarni, Sampada Sameer / Shah, Jignesh / Iyer, Shivakumar / Dhanasekaran, Krishna Shriram

    Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine

    2023  Volume 27, Issue 2, Page(s) 101–106

    Abstract: ... Dharanindra M, Jedge PP, Patil VC, Kulkarni SS, Shah J, Iyer S, ...

    Abstract Background: Endotracheal intubation to protect airway patency in critically ill patients with the use of videolaryngoscopes has been emerging and their expertise to handle is crucial. Our study focuses on the performance and outcomes of King Vision video laryngoscope (KVVL) in intensive care unit (ICU) compared to Macintosh direct laryngoscope (DL).
    Materials and methods: This comparative study was conducted by randomizing 143 critically ill patients in ICU into two groups: KVVL and Macintosh DL (
    Results: The KVVL group showed the primary endpoint of significantly improved glottic visualization measured in terms of CL grading compared with the Macintosh DL group (
    Conclusion: We found that the performance and outcomes of KVVL in intubating critically ill ICU patients were promising when handled by experienced operators who are experts in anesthesiology and airway management.
    How to cite this article: Dharanindra M, Jedge PP, Patil VC, Kulkarni SS, Shah J, Iyer S,
    Language English
    Publishing date 2023-02-21
    Publishing country India
    Document type Journal Article
    ZDB-ID 2121263-6
    ISSN 1998-359X ; 0972-5229
    ISSN (online) 1998-359X
    ISSN 0972-5229
    DOI 10.5005/jp-journals-10071-24398
    Database MEDical Literature Analysis and Retrieval System OnLINE

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