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  1. Article ; Online: The adducts of cyano- and aquacobalamin with hypochlorite.

    Lehene, Maria / Brânzanic, Adrian M V / Silaghi-Dumitrescu, Radu

    Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry

    2023  Volume 28, Issue 6, Page(s) 583–589

    Abstract: Hypochlorite is known to oxidatively degrade the corrin ring of cobalamin. Here, transient reaction intermediates are described in the reaction of aqua as well as of cyano-cobalamin with hypochlorite, using stopped-flow UV-vis kinetics. For aqua- ... ...

    Abstract Hypochlorite is known to oxidatively degrade the corrin ring of cobalamin. Here, transient reaction intermediates are described in the reaction of aqua as well as of cyano-cobalamin with hypochlorite, using stopped-flow UV-vis kinetics. For aqua-cobalamin, the intermediate is assigned as arising from substitution of the aqua ligand with hypochlorite. For cyano-cobalamin, the intermediate is proposed to arise from substitution of the benzimidazole ligand trans to the cyanide. In both cases, the intermediates would feature a new Co(III)-OCl
    MeSH term(s) Hypochlorous Acid ; Ligands ; Vitamin B 12/metabolism ; Cyanides
    Chemical Substances aquacobalamin (13422-52-1) ; Hypochlorous Acid (712K4CDC10) ; Ligands ; Vitamin B 12 (P6YC3EG204) ; Cyanides
    Language English
    Publishing date 2023-07-26
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1464026-0
    ISSN 1432-1327 ; 0949-8257
    ISSN (online) 1432-1327
    ISSN 0949-8257
    DOI 10.1007/s00775-023-02015-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Comorbidities of COVID-19 Patients.

    Silaghi-Dumitrescu, Radu / Patrascu, Iulia / Lehene, Maria / Bercea, Iulia

    Medicina (Kaunas, Lithuania)

    2023  Volume 59, Issue 8

    Abstract: The novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) responsible for the coronavirus disease outbreak initiated in 2019 (COVID-19) has been shown to affect the health of infected patients in a manner at times dependent on pre-existing ... ...

    Abstract The novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) responsible for the coronavirus disease outbreak initiated in 2019 (COVID-19) has been shown to affect the health of infected patients in a manner at times dependent on pre-existing comorbidities. Reported here is an overview of the correlation between comorbidities and the exacerbation of the disease in patients with COVID-19, which may lead to poor clinical outcomes or mortality. General medical issues are also reviewed, such as the types of symptoms present in people infected with SARS-CoV-2, the long-term effects of COVID-19 disease, and the types of treatment that are currently used.
    MeSH term(s) Humans ; COVID-19 ; SARS-CoV-2 ; Comorbidity ; Disease Outbreaks ; Patients
    Language English
    Publishing date 2023-07-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina59081393
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6270: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Book ; Online: Designing Trustworthy User Interfaces

    Zieglmeier, Valentin / Lehene, Antonia Maria

    2022  

    Abstract: Interface design can directly influence trustworthiness of a software. Thereby, it affects users' intention to use a tool. Previous research on user trust has not comprehensively addressed user interface design, though. We lack an understanding of what ... ...

    Abstract Interface design can directly influence trustworthiness of a software. Thereby, it affects users' intention to use a tool. Previous research on user trust has not comprehensively addressed user interface design, though. We lack an understanding of what makes interfaces trustworthy (1), as well as actionable measures to improve trustworthiness (2). We contribute to this by addressing both gaps. Based on a systematic literature review, we give a thorough overview over the theory on user trust and provide a taxonomy of factors influencing user interface trustworthiness. Then, we derive concrete measures to address these factors in interface design. We use the results to create a proof of concept interface. In a preliminary evaluation, we compare a variant designed to elicit trust with one designed to reduce it. Our results show that the measures we apply can be effective in fostering trust in users.

    Comment: Peer-reviewed version accepted for publication in the proceedings of the 33rd Australian Conference on Human-Computer Interaction (OzCHI '21)
    Keywords Computer Science - Human-Computer Interaction ; Computer Science - Software Engineering
    Subject code 005
    Publishing date 2022-02-25
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: On the Origin of the Blue Color in The Iodine/Iodide/Starch Supramolecular Complex.

    Pesek, Szilárd / Lehene, Maria / Brânzanic, Adrian M V / Silaghi-Dumitrescu, Radu

    Molecules (Basel, Switzerland)

    2022  Volume 27, Issue 24

    Abstract: The nature of the blue color in the iodine-starch reaction is still a matter of debate. Some textbooks still invoke charge-transfer bands within a chain of neutral ... ...

    Abstract The nature of the blue color in the iodine-starch reaction is still a matter of debate. Some textbooks still invoke charge-transfer bands within a chain of neutral I
    Language English
    Publishing date 2022-12-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27248974
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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  5. Article ; Online: Adduct of Aquacobalamin with Hydrogen Peroxide.

    Lehene, Maria / Plesa, Diana / Ionescu-Zinca, Stefania / Iancu, Stefania D / Leopold, Nicolae / Makarov, Sergei V / Brânzanic, Adrian M V / Silaghi-Dumitrescu, Radu

    Inorganic chemistry

    2021  Volume 60, Issue 17, Page(s) 12681–12684

    Abstract: Aquacobalamin binds hydrogen peroxide reversibly to form a cobalt(III) hydroperoxo adduct with a 0.25 mM dissociation constant, as evidenced by UV-vis absorption spectroscopy and corroborated by NMR, Raman spectroscopy, stopped-flow UV-vis measurements, ... ...

    Abstract Aquacobalamin binds hydrogen peroxide reversibly to form a cobalt(III) hydroperoxo adduct with a 0.25 mM dissociation constant, as evidenced by UV-vis absorption spectroscopy and corroborated by NMR, Raman spectroscopy, stopped-flow UV-vis measurements, and density functional theory calculations.
    Language English
    Publishing date 2021-08-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1484438-2
    ISSN 1520-510X ; 0020-1669
    ISSN (online) 1520-510X
    ISSN 0020-1669
    DOI 10.1021/acs.inorgchem.1c01483
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  6. Article: Excess Ascorbate is a Chemical Stress Agent against Proteins and Cells.

    Lehene, Maria / Fischer-Fodor, Eva / Scurtu, Florina / Hădade, Niculina D / Gal, Emese / Mot, Augustin C / Matei, Alina / Silaghi-Dumitrescu, Radu

    Pharmaceuticals (Basel, Switzerland)

    2020  Volume 13, Issue 6

    Abstract: Excess ascorbate (as expected in intravenous treatment proposed for COVID-19 management, for example) oxidizes and/or degrades hemoglobin and albumin, as evidenced by UV-vis spectroscopy, gel electrophoresis, and mass spectrometry. It also degrades ... ...

    Abstract Excess ascorbate (as expected in intravenous treatment proposed for COVID-19 management, for example) oxidizes and/or degrades hemoglobin and albumin, as evidenced by UV-vis spectroscopy, gel electrophoresis, and mass spectrometry. It also degrades hemoglobin in intact blood or in isolated erythrocytes. The survival rates and metabolic activities of several leukocyte subsets implicated in the antiviral cellular immune response are also affected. Excess ascorbate is thus an unselective biological stress agent.
    Keywords covid19
    Language English
    Publishing date 2020-05-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph13060107
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Excess Ascorbate is a Chemical Stress Agent against Proteins and Cells

    Maria Lehene / Eva Fischer-Fodor / Florina Scurtu / Niculina D. Hădade / Emese Gal / Augustin C. Mot / Alina Matei / Radu Silaghi-Dumitrescu

    Pharmaceuticals, Vol 13, Iss 107, p

    2020  Volume 107

    Abstract: Excess ascorbate (as expected in intravenous treatment proposed for COVID-19 management, for example) oxidizes and/or degrades hemoglobin and albumin, as evidenced by UV-vis spectroscopy, gel electrophoresis, and mass spectrometry. It also degrades ... ...

    Abstract Excess ascorbate (as expected in intravenous treatment proposed for COVID-19 management, for example) oxidizes and/or degrades hemoglobin and albumin, as evidenced by UV-vis spectroscopy, gel electrophoresis, and mass spectrometry. It also degrades hemoglobin in intact blood or in isolated erythrocytes. The survival rates and metabolic activities of several leukocyte subsets implicated in the antiviral cellular immune response are also affected. Excess ascorbate is thus an unselective biological stress agent.
    Keywords hemoglobin ; albumin ; ascorbate ; erythrocyte ; antioxidant ; leukocyte ; Medicine ; R ; Pharmacy and materia medica ; RS1-441 ; covid19
    Language English
    Publishing date 2020-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Book ; Online: Excess Ascorbate is a Chemical Stress Agent against Proteins and Cells

    Maria Lehene / Eva Fischer-Fodor / Florina Scurtu / Niculina D. Hădade / Emese Gal / Augustin C. Mot / Alina Matei / Radu Silaghi-Dumitrescu

    Pharmaceuticals ; Volume 13 ; Issue 6

    2020  

    Abstract: Excess ascorbate (as expected in intravenous treatment proposed for COVID-19 management, for example) oxidizes and/or degrades hemoglobin and albumin, as evidenced by UV-vis spectroscopy, gel electrophoresis, and mass spectrometry. It also degrades ... ...

    Abstract Excess ascorbate (as expected in intravenous treatment proposed for COVID-19 management, for example) oxidizes and/or degrades hemoglobin and albumin, as evidenced by UV-vis spectroscopy, gel electrophoresis, and mass spectrometry. It also degrades hemoglobin in intact blood or in isolated erythrocytes. The survival rates and metabolic activities of several leukocyte subsets implicated in the antiviral cellular immune response are also affected. Excess ascorbate is thus an unselective biological stress agent.
    Keywords hemoglobin ; albumin ; ascorbate ; erythrocyte ; antioxidant ; leukocyte ; COVID-19 ; covid19
    Language English
    Publishing date 2020-05-27
    Publisher Multidisciplinary Digital Publishing Institute
    Publishing country ch
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: On the Stability of Glutaraldehyde in Biocide Compositions.

    Matei, Alina / Puscas, Cristina / Patrascu, Iulia / Lehene, Maria / Ziebro, Julia / Scurtu, Florina / Baia, Monica / Porumb, Dan / Totos, Robert / Silaghi-Dumitrescu, Radu

    International journal of molecular sciences

    2020  Volume 21, Issue 9

    Abstract: Glutaraldehyde (GA) is used as biocide in hospitals. Recent public investigations on the chemical composition of biocides used in Romania have in some cases found GA, as a key ingredient, to be apparently diluted. However, these data did not explicitly ... ...

    Abstract Glutaraldehyde (GA) is used as biocide in hospitals. Recent public investigations on the chemical composition of biocides used in Romania have in some cases found GA, as a key ingredient, to be apparently diluted. However, these data did not explicitly consider the complex chemical equilibria inherent to GA. An investigation of experimental and theoretical data is reported here, assessing the stability of GA solutions relevant for biocide compositions. GA solutions of various chemical composition and under varying circumstances were analyzed using spectroscopy (UV-VIS, Raman, NMR) coupled with density functional theory (DFT) calculations, as well as chemically, such as via the formation of imines in reaction/titration with glycine monitored at 270 nm; using LC-MS; or using SDS-PAGE analysis with GA as reagent in the polymerization of two test proteins- hemoglobin and myoglobin. The spectral properties of GA changed significantly over time, in a temperature-dependent manner; titration with glycine confirmed the spectral data. SDS-PAGE experiments demonstrated a non-linear and apparently unpredictable change in the reactivity of GA over time. The results may be relevant for the determination of GA concentration in various settings such as biocide analysis, hospital wastewaters, and others.
    MeSH term(s) Chromatography, Liquid ; Density Functional Theory ; Disinfectants/analysis ; Glutaral/chemistry ; Glycine/chemistry ; Hemoglobins/chemistry ; Magnetic Resonance Spectroscopy ; Mass Spectrometry ; Romania ; Spectrophotometry, Ultraviolet ; Spectrum Analysis, Raman ; Temperature
    Chemical Substances Disinfectants ; Hemoglobins ; Glutaral (T3C89M417N) ; Glycine (TE7660XO1C)
    Language English
    Publishing date 2020-05-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms21093372
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Excess Ascorbate is a Chemical Stress Agent against Proteins and Cells

    Lehene, Maria / Fischer-Fodor, Eva / Scurtu, Florina / Hadade, Niculina D / Gal, Emese / Mot, Augustin C / Matei, Alina / Silaghi-Dumitrescu, Radu

    Abstract: Excess ascorbate (as expected in intravenous treatment proposed for COVID-19 management, for example) oxidizes and/or degrades hemoglobin and albumin, as evidenced by UV-vis spectroscopy, gel electrophoresis, and mass spectrometry. It also degrades ... ...

    Abstract Excess ascorbate (as expected in intravenous treatment proposed for COVID-19 management, for example) oxidizes and/or degrades hemoglobin and albumin, as evidenced by UV-vis spectroscopy, gel electrophoresis, and mass spectrometry. It also degrades hemoglobin in intact blood or in isolated erythrocytes. The survival rates and metabolic activities of several leukocyte subsets implicated in the antiviral cellular immune response are also affected. Excess ascorbate is thus an unselective biological stress agent.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #381790
    Database COVID19

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