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  1. Article ; Online: Triggered - does maternal COVID-19 program an exaggerated immune response in neonates?

    Bradley, Todd / Tucker, Megan / Sampath, Venkatesh

    Pediatric research

    2024  

    Language English
    Publishing date 2024-01-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 4411-8
    ISSN 1530-0447 ; 0031-3998
    ISSN (online) 1530-0447
    ISSN 0031-3998
    DOI 10.1038/s41390-023-03007-0
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    Zs.A 564: Show issues Location:
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  2. Article ; Online: Correction: Triggered - does maternal COVID-19 program an exaggerated immune response in neonates?

    Bradley, Todd / Tucker, Megan / Sampath, Venkatesh

    Pediatric research

    2024  Volume 95, Issue 5, Page(s) 1383

    Language English
    Publishing date 2024-01-18
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 4411-8
    ISSN 1530-0447 ; 0031-3998
    ISSN (online) 1530-0447
    ISSN 0031-3998
    DOI 10.1038/s41390-024-03052-3
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  3. Article ; Online: Excess Mortality From Non-COVID-19 Causes During the COVID-19 Pandemic in Philadelphia, Pennsylvania, 2020-2021.

    Todd, Megan / Scheeres, Annaka

    American journal of public health

    2022  Volume 112, Issue 12, Page(s) 1800–1803

    Abstract: Objectives. ...

    Abstract Objectives.
    MeSH term(s) Male ; Female ; Humans ; Pandemics ; COVID-19 ; SARS-CoV-2 ; Philadelphia/epidemiology ; Drug Overdose
    Language English
    Publishing date 2022-11-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 121100-6
    ISSN 1541-0048 ; 0090-0036 ; 0002-9572
    ISSN (online) 1541-0048
    ISSN 0090-0036 ; 0002-9572
    DOI 10.2105/AJPH.2022.307096
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  4. Article ; Online: Neuromuscular Electrical Stimulation for Children With Stroke.

    Metzler, Megan J / Blaufuss, Megan / Dean, Shelley / Levy, Todd J / Duff, Susan V

    Archives of physical medicine and rehabilitation

    2023  Volume 105, Issue 1, Page(s) 191–195

    MeSH term(s) Child ; Humans ; Stroke/therapy ; Stroke Rehabilitation ; Electric Stimulation ; Electric Stimulation Therapy
    Language English
    Publishing date 2023-07-11
    Publishing country United States
    Document type Practice Guideline
    ZDB-ID 80057-0
    ISSN 1532-821X ; 0003-9993
    ISSN (online) 1532-821X
    ISSN 0003-9993
    DOI 10.1016/j.apmr.2023.01.029
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  5. Article ; Online: Pediatric musculoskeletal infections.

    Hannon, Megan / Lyons, Todd

    Current opinion in pediatrics

    2023  Volume 35, Issue 3, Page(s) 309–315

    Abstract: Purpose of review: The aim of this article is to review the recent guidelines and literature regarding the diagnosis and the treatment of common pediatric musculoskeletal infections: septic arthritis, osteomyelitis, pyomyositis, and Lyme disease.: ... ...

    Abstract Purpose of review: The aim of this article is to review the recent guidelines and literature regarding the diagnosis and the treatment of common pediatric musculoskeletal infections: septic arthritis, osteomyelitis, pyomyositis, and Lyme disease.
    Recent findings: In the last decade, a better understanding of the causative organisms of common bacterial infections, including Kingella , leads to prompt targeted antimicrobial coverage in all musculoskeletal infections. Prompt diagnosis and treatment continues to be the mainstay in the treatment of children with osteoarticular infections. Efforts to improve early detection have lead to improving rapid lab diagnostic testing; however, more advanced diagnostics such as arthrocentesis for septic arthritis and MRI for osteomyelitis and pyomyositis, remain the gold standard. Shorter and narrowed antibiotic courses, with appropriate transition to outpatient oral treatment provide effective infection clearance and reduction in complications of disease.
    Summary: Advances in diagnostics, including pathogen identification as well as imaging continues to improve our ability to diagnose and treat these infections, although still lack ability to provide definitive diagnosis without more invasive nor advanced techniques.
    MeSH term(s) Child ; Humans ; Pyomyositis/diagnosis ; Pyomyositis/therapy ; Pyomyositis/microbiology ; Osteomyelitis/diagnosis ; Osteomyelitis/therapy ; Arthritis, Infectious/diagnosis ; Arthritis, Infectious/therapy ; Anti-Bacterial Agents/therapeutic use ; Bacterial Infections
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-02-22
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1049374-8
    ISSN 1531-698X ; 1040-8703
    ISSN (online) 1531-698X
    ISSN 1040-8703
    DOI 10.1097/MOP.0000000000001234
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  6. Article ; Online: Improving communication at NHS Nightingale Hospital North West: Medical updates to next of kin.

    Woolford, Megan / Todd, James

    The International journal of risk & safety in medicine

    2022  Volume 33, Issue S1, Page(s) S111–S115

    Abstract: Background: The Nightingale North West (NNW) was a UK temporary field hospital set up during the COVID-19 pandemic. Policies and standard operating procedures were undeveloped. Visitors were permitted only in exceptional circumstances, resulting in ... ...

    Abstract Background: The Nightingale North West (NNW) was a UK temporary field hospital set up during the COVID-19 pandemic. Policies and standard operating procedures were undeveloped. Visitors were permitted only in exceptional circumstances, resulting in heightened anxiety for patients and next of kin (NOK).
    Objective: Recognising the importance of effective NOK communication, a quality improvement project (QIP) was undertaken to improve communication between doctors and NOK.
    Method: NOK satisfaction with communication received from doctors (scored 1-5) was the primary outcome measure and data was collected through standardised phone-calls.A wide four point (1-5) variability in satisfaction was identified.PDSA methodology was used to introduce interventions: (1) 'Gold standard' for frequency of NOK updates; (2) Record date of NOK update on the doctors' list.
    Results: Early post-intervention data showed reduced variability in satisfaction with 82% of NOK scoring '4' or '5'. Process measures demonstrated excellent uptake of interventions.
    Conclusion: Conclusions are limited by the project's short time-frame but there is a promising role for these interventions in enhancing doctor-NOK communication.
    MeSH term(s) Humans ; Pandemics ; State Medicine ; COVID-19/epidemiology ; Communication ; Hospitals
    Language English
    Publishing date 2022-07-21
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1055458-0
    ISSN 1878-6847 ; 0924-6479
    ISSN (online) 1878-6847
    ISSN 0924-6479
    DOI 10.3233/JRS-227034
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  7. Article ; Online: Seeing science

    Megan Perra / Todd Brinkman

    Ecosphere, Vol 12, Iss 10, Pp n/a-n/a (2021)

    using graphics to communicate research

    2021  

    Abstract: Abstract Proper science communication is quickly becoming a professional imperative in ecology, but many researchers are not practiced in diverse and effective communication strategies. Academic jargon and text‐heavy content are often cited as barriers ... ...

    Abstract Abstract Proper science communication is quickly becoming a professional imperative in ecology, but many researchers are not practiced in diverse and effective communication strategies. Academic jargon and text‐heavy content are often cited as barriers for laypeople trying to access and understand research results. Here, we have presented scientific visualizations (infographics, figures, and illustrations) as a useful tool to reduce the information transfer gaps between researchers and the public. The graphics we have proposed are images with minimal text that convey ecological research concepts, methods, processes, and results. They are more captivating than text alone and more efficient at disseminating information to a broad audience because they reduce cognitive load. We applied tools and best practices from the fields of marketing and design to explain graphic construction and demonstrated how to build a visualization that is both aesthetic and effective. The basic principles of design are paramount to image composition, and we reviewed experimental literature to support the notions that the proper use of color, proximity, and balance helps to illuminate the main message or story that we wanted to communicate. We presented examples from wildlife ecology research in Alaska to highlight how researchers can use graphics for their own communication efforts, and emphasized the power of visual narratives to explain complex techniques and ecosystem processes. The best practices we outlined here are meant to help researchers understand the composition of science visualizations, build productive collaborations with artists, and ultimately create appealing and informative images that communicate research.
    Keywords graphic design ; infographics ; interdisciplinary ; science communication ; science outreach ; scientific illustration ; Ecology ; QH540-549.5
    Subject code 306
    Language English
    Publishing date 2021-10-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Reply to Z.R. McCaw et al.

    Farrar, Jason E / Othus, Megan / Wang, Yi-Cheng / Alonzo, Todd A / Meshinchi, Soheil

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2023  Volume 41, Issue 27, Page(s) 4447

    Language English
    Publishing date 2023-06-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.23.00986
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  9. Article ; Online: Potentially inappropriate medication use among older adults with lower-limb loss.

    Stauffer, Samantha Jeanne / Pohlig, Ryan Todd / Horne, John Robert / Sarlo, Frank Bernard / Sions, Jaclyn Megan

    Geriatric nursing (New York, N.Y.)

    2024  Volume 56, Page(s) 218–224

    Abstract: Objective: The aim of this study was to evaluate the prevalence of, and explore factors related to, prescription of potentially inappropriate medications (PIMs) among older adults with lower-limb loss (LLL).: Methods: This was a secondary analysis of ...

    Abstract Objective: The aim of this study was to evaluate the prevalence of, and explore factors related to, prescription of potentially inappropriate medications (PIMs) among older adults with lower-limb loss (LLL).
    Methods: This was a secondary analysis of a cross-sectional dataset collected through an interdisciplinary limb loss clinic between September 2013 and November 2022. Self-report medication lists were reviewed during in-clinic face-to-face interviews and compared to the American Geriatrics Society Beers Criteria corresponding to the patient's evaluation year.
    Results: Of 82 participants (72.9 ± 6.6 years-old; 78.0 % male), n = 41 (50.0 %) reported using one or more PIM. PIM prescription was significantly associated with presence of phantom limb pain, history of upper gastrointestinal issues, and a greater number of medications.
    Discussion: Polypharmacy and PIM use are common among older adults with LLL. Greater attention should be paid to medications post-amputation, especially pain management medications, to minimize potential adverse side-effects.
    MeSH term(s) Humans ; Male ; Aged ; Female ; Potentially Inappropriate Medication List ; Inappropriate Prescribing ; Cross-Sectional Studies ; Geriatrics ; Polypharmacy
    Language English
    Publishing date 2024-02-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632559-2
    ISSN 1528-3984 ; 0197-4572
    ISSN (online) 1528-3984
    ISSN 0197-4572
    DOI 10.1016/j.gerinurse.2024.02.018
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  10. Article ; Online: Inflammation and Cognition in Older Adults: Evidence from Taiwan.

    Todd, Megan A

    Biodemography and social biology

    2017  Volume 63, Issue 4, Page(s) 309–323

    Abstract: Inflammation has been linked to clinical cognitive impairment, including Alzheimer's disease. Less is known, however, about the relationship between inflammation and normal, age-associated cognitive decline. An understanding of the determinants of all ... ...

    Abstract Inflammation has been linked to clinical cognitive impairment, including Alzheimer's disease. Less is known, however, about the relationship between inflammation and normal, age-associated cognitive decline. An understanding of the determinants of all types of cognitive decline is important for improving quality of life in an aging world. This study investigated whether biomarkers of inflammation were associated with cognitive function and decline in older Taiwanese adults. Data were from the Taiwan Longitudinal Study of Aging and the Social Environment and Biomarkers of Aging Study. Inflammation was measured in 2000 and 2006 as C-reactive protein, interleukin-6, soluble e-selectin, soluble intercellular adhesion molecule-1, and white blood cell count. Cognition was assessed by 10 cognitive and memory tasks, measured in 2006, 2007, and 2011. Growth curve models were used to examine the relationship between inflammation and cognitive score over this time period. Higher levels of inflammation were associated with lower baseline cognitive scores, but not with longitudinal change in cognitive score. This study did not support a causal link between inflammation and cognitive decline among this older cohort. The observed cross-sectional relationship could reflect a causal relationship that arises earlier in life, or confounding; additional research across the life course is warranted.
    MeSH term(s) Aged ; Aged, 80 and over ; Aging/physiology ; Biomarkers/analysis ; C-Reactive Protein/analysis ; Cognition Disorders/etiology ; Cohort Studies ; Cross-Sectional Studies ; E-Selectin/analysis ; E-Selectin/blood ; Enzyme-Linked Immunosorbent Assay/methods ; Female ; Humans ; Inflammation/complications ; Intercellular Adhesion Molecule-1/analysis ; Intercellular Adhesion Molecule-1/blood ; Interleukin-6/analysis ; Interleukin-6/blood ; Leukocyte Count/methods ; Longitudinal Studies ; Male ; Middle Aged ; Neuropsychological Tests ; Surveys and Questionnaires ; Taiwan
    Chemical Substances Biomarkers ; E-Selectin ; Interleukin-6 ; SELE protein, human ; Intercellular Adhesion Molecule-1 (126547-89-5) ; C-Reactive Protein (9007-41-4)
    Language English
    Publishing date 2017-10-04
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2482287-5
    ISSN 1948-5573 ; 0037-766X ; 1948-5565
    ISSN (online) 1948-5573
    ISSN 0037-766X ; 1948-5565
    DOI 10.1080/19485565.2017.1403305
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