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  1. Article ; Online: Insights Into the Role of Tetrahydrobiopterin Deficiency in the Pathogenesis of Gestational Hypertension.

    Dupont, Vincent / Karumanchi, S Ananth

    Hypertension (Dallas, Tex. : 1979)

    2021  Volume 78, Issue 6, Page(s) 1885–1887

    MeSH term(s) Biopterins ; Female ; Humans ; Hypertension, Pregnancy-Induced/etiology ; Phenylketonurias ; Pregnancy
    Chemical Substances Biopterins
    Language English
    Publishing date 2021-11-10
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 423736-5
    ISSN 1524-4563 ; 0194-911X ; 0362-4323
    ISSN (online) 1524-4563
    ISSN 0194-911X ; 0362-4323
    DOI 10.1161/HYPERTENSIONAHA.121.17996
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    Zs.A 1488: Show issues Location:
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  2. Article: Correction to: Difficulties interpreting concentrations in fatal cases: example of 2,5-dimethoxy-4-chloroamphetamine.

    Lelievre, Benedicte / Dupont, Vincent / Buchaillet, Celine / Jousset, Nathalie / Deguigne, Marie / Cirimele, Vincent

    Forensic toxicology

    2022  Volume 41, Issue 1, Page(s) 185

    Language English
    Publishing date 2022-04-13
    Publishing country Japan
    Document type Published Erratum
    ZDB-ID 2274095-8
    ISSN 1860-8965
    ISSN 1860-8965
    DOI 10.1007/s11419-022-00648-4
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    Zs.A 3901: Show issues Location:
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  3. Article ; Online: Urine-to-plasma creatinine ratio and fractional excretion of urea performance in acute-on-chronic kidney disease patients.

    Lievre, Loïc / Dupont, Vincent / Kanagaratnam, Lukshe / Faroux, Laurent / Debrumetz, Alexandre / Rieu, Philippe / Wynckel, Alain

    Journal of nephrology

    2023  Volume 36, Issue 9, Page(s) 2661–2663

    MeSH term(s) Humans ; Acute Kidney Injury ; Biomarkers ; Creatinine ; Kidney Function Tests ; Renal Insufficiency ; Renal Insufficiency, Chronic/diagnosis ; Urea ; Urinalysis
    Chemical Substances Biomarkers ; Creatinine (AYI8EX34EU) ; Urea (8W8T17847W)
    Language English
    Publishing date 2023-07-04
    Publishing country Italy
    Document type Letter
    ZDB-ID 1093991-x
    ISSN 1724-6059 ; 1120-3625 ; 1121-8428
    ISSN (online) 1724-6059
    ISSN 1120-3625 ; 1121-8428
    DOI 10.1007/s40620-023-01700-1
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    Zs.A 3369: Show issues Location:
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  4. Article ; Online: Simultaneous, dual continuous veno-venous haemofiltration for refractory metformin-induced lactic acidosis: a case report.

    Seube, Pierre-Antoine / Djerada, Zoubir / Konecki, Céline / Dupont, Vincent / Goury, Antoine

    Clinical toxicology (Philadelphia, Pa.)

    2023  Volume 61, Issue 2, Page(s) 134–136

    MeSH term(s) Humans ; Metformin/adverse effects ; Continuous Renal Replacement Therapy ; Acidosis, Lactic/chemically induced ; Acidosis, Lactic/therapy ; Hypoglycemic Agents/adverse effects ; Diabetes Mellitus, Type 2
    Chemical Substances Metformin (9100L32L2N) ; Hypoglycemic Agents
    Language English
    Publishing date 2023-02-03
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 204476-6
    ISSN 1556-9519 ; 0009-9309 ; 0731-3810 ; 1556-3650
    ISSN (online) 1556-9519
    ISSN 0009-9309 ; 0731-3810 ; 1556-3650
    DOI 10.1080/15563650.2022.2163900
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    Zs.B 419: Show issues Location:
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  5. Article: Difficulties interpreting concentrations in fatal cases: example of 2,5-dimethoxy-4-chloroamphetamine.

    Lelievre, Benedicte / Dupont, Vincent / Buchaillet, Celine / Jousset, Nathalie / Deguigne, Marie / Cirimele, Vincent

    Forensic toxicology

    2022  Volume 40, Issue 2, Page(s) 383–392

    Abstract: Purpose: Death related to the use of drugs is evident when drugs are detected in biological matrices within toxic levels, but sometimes it can be less obvious. Intoxications after 2,5-dimethoxy-4-chloroamphetamine (DOC) use are occurring but up to date, ...

    Abstract Purpose: Death related to the use of drugs is evident when drugs are detected in biological matrices within toxic levels, but sometimes it can be less obvious. Intoxications after 2,5-dimethoxy-4-chloroamphetamine (DOC) use are occurring but up to date, only one fatality has been reported. Here we present the case of a young woman admitted to hospital as she presented vomiting, convulsions and cardiorespiratory arrest.
    Methods: Blood ethanol concentration was determined using gas chromatography with flame ionization detection and toxicological screenings (blood, gastric content and hair samples) were performed using liquid chromatography with diode array detection, gas chromatography or liquid chromatography with mass spectrometry detection.
    Results: Her health state declined with cardiac troubles, organs failure and cerebral edema till death occurring 4 days later. The autopsy revealed the presence of hemorrhagic infiltration inside the left ventricle, pulmonary edema and hemorrhagic infiltration of the terminal ileum. The analysis of biological fluids confirmed the presence of DOC (< 10 ng/mL in cardiac blood sample), buprenorphine, cocaine and cannabis metabolites. The analysis of hair highlighted a history of drugs abuse.
    Conclusion: In the absence of evident identified cause, the hypothesis of a death due to acute drugs use within a history of chronic consumption of drugs has been put forward. The concentration of some substances such as new psychoactive substances can be low in biological matrices but the toxic effects can be additive and lead to death even within young people, hence the importance of the knowledge of consumption history.
    MeSH term(s) Humans ; Female ; Adolescent ; Gas Chromatography-Mass Spectrometry ; Amphetamine ; Flame Ionization ; Chromatography, Liquid ; Brain Death
    Chemical Substances 4-chloro-2,5-dimethoxyamphetamine (8Y1C6K0PCA) ; Amphetamine (CK833KGX7E)
    Language English
    Publishing date 2022-05-17
    Publishing country Japan
    Document type Case Reports ; Journal Article
    ZDB-ID 2274095-8
    ISSN 1860-8965
    ISSN 1860-8965
    DOI 10.1007/s11419-022-00628-8
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    Zs.A 3901: Show issues Location:
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  6. Article ; Online: The temporal pole: From anatomy to function-A literature appraisal.

    Herlin, Bastien / Navarro, Vincent / Dupont, Sophie

    Journal of chemical neuroanatomy

    2021  Volume 113, Page(s) 101925

    Abstract: Historically, the anterior part of the temporal lobe was labelled as a unique structure named Brain Area 38 by Brodmann or Temporopolar Area TG by Von Economo, but its functions were unknown at that time. Later on, a few studies proposed to divide the ... ...

    Abstract Historically, the anterior part of the temporal lobe was labelled as a unique structure named Brain Area 38 by Brodmann or Temporopolar Area TG by Von Economo, but its functions were unknown at that time. Later on, a few studies proposed to divide the temporal pole in several different subparts, based on distinct cytoarchitectural structure or connectivity patterns, while a still growing number of studies have associated the temporal pole with many cognitive functions. In this review, we provide an overview of the temporal pole anatomical and histological structure and its various functions. We performed a literature review of articles published prior to September 30, 2020 that included 112 articles. The temporal pole has thereby been associated with several high-level cognitive processes: visual processing for complex objects and face recognition, autobiographic memory, naming and word-object labelling, semantic processing in all modalities, and socio-emotional processing, as demonstrated in healthy subjects and in patients with neurological or psychiatric diseases, especially in the field of neurodegenerative disorders. A good knowledge of those functions and the symptoms associated with temporal pole lesions or dysfunctions is helpful to identify these diseases, whose diagnosis may otherwise be difficult.
    MeSH term(s) Animals ; Brain Mapping ; Humans ; Memory/physiology ; Neural Pathways/anatomy & histology ; Neural Pathways/physiology ; Social Cognition ; Temporal Lobe/anatomy & histology ; Temporal Lobe/physiology
    Language English
    Publishing date 2021-02-11
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 639443-7
    ISSN 1873-6300 ; 0891-0618
    ISSN (online) 1873-6300
    ISSN 0891-0618
    DOI 10.1016/j.jchemneu.2021.101925
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    Zs.A 2363: Show issues Location:
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  7. Article ; Online: Analyse empirique de la relation entre la biodiversité marine et l’activité touristique dans les petits et micro-États de la Caraïbe

    Louis Dupont

    Études Caribéennes, Vol

    2022  Volume 53

    Abstract: ... St Kitts and Nevis, Saint Lucia, and St Vincent and Grenadines. In this function, marine biodiversity plays a key ...

    Abstract Small islands of Caribbean are facing important marine, environmental, and terrestrial challenges. The biodiversities in this region are considered as the most threated of the world. Simultaneously, the tourism sector plays a key role in these economies. The objective of this paper is to analyze and evaluate economically the relationship among marine biodiversity and tourism, on the one hand, and inversely between tourism and marine biodiversity, on the other hand. As the result, a panel data is used, also Hausman-Taylor estimator (HT) to investigate a tourism demand function, applied to six small islands of Caribbean, members of Organization of Eastern Caribbean States (OECS): Antigua and Barbuda, Dominica, Grenada, St Kitts and Nevis, Saint Lucia, and St Vincent and Grenadines. In this function, marine biodiversity plays a key role, in addition to the traditional economic and price variables. Levels of biodiversity are found to have a significant influence on tourism. This justifies their inclusion in a tourism demand function, and points to the importance of national policy in protecting the biodiversity of the Caribbean islands. Finally, the results show an urgent need to impose an optimal carrying capacity for these destinations in order to reach tourism sustainable development. panel data, Hausman-Taylor estimator (HP), marine biodiversity, OECS, economic impact
    Keywords données de panel ; biodiversités maritime et côtière ; test de Hausman-Taylor(HT) ; OECO ; impact économique ; Latin America. Spanish America ; F1201-3799 ; Social Sciences ; H
    Subject code 910
    Language English
    Publishing date 2022-12-01T00:00:00Z
    Publisher Université des Antilles
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Negative Impact of

    Lassalle, Fanny / Duployez, Nicolas / Vincent, Flavien / Rauch, Antoine / Denimal, Tom / Rosa, Mickael / Labreuche, Julien / Dombrowicz, David / Staels, Bart / Preudhomme, Claude / Susen, Sophie / Van Belle, Eric / Dupont, Annabelle

    JACC. Basic to translational science

    2023  Volume 8, Issue 11, Page(s) 1424–1435

    Abstract: Clonal hematopoiesis of indeterminate potential (CHIP) is considered as being a novel age-related risk factor for cardiovascular diseases. By capture-sequencing of a 67-gene panel, we established a large spectrum of CHIP in 258 patients with aortic valve ...

    Abstract Clonal hematopoiesis of indeterminate potential (CHIP) is considered as being a novel age-related risk factor for cardiovascular diseases. By capture-sequencing of a 67-gene panel, we established a large spectrum of CHIP in 258 patients with aortic valve stenosis undergoing transcatheter aortic valve replacement (TAVR) and assessed their association with long-term survival after TAVR. One or several CHIP variants in 35 genes were identified in 68% of the cohort,
    Language English
    Publishing date 2023-07-19
    Publishing country United States
    Document type Journal Article
    ISSN 2452-302X
    ISSN (online) 2452-302X
    DOI 10.1016/j.jacbts.2023.04.010
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  9. Article ; Online: Plasma membrane nanodeformations promote actin polymerization through CIP4/CDC42 recruitment and regulate type II IFN signaling.

    Ledoux, Benjamin / Zanin, Natacha / Yang, Jinsung / Mercier, Vincent / Coster, Charlotte / Dupont-Gillain, Christine / Alsteens, David / Morsomme, Pierre / Renard, Henri-François

    Science advances

    2023  Volume 9, Issue 50, Page(s) eade1660

    Abstract: In their environment, cells must cope with mechanical stresses constantly. Among these, nanoscale deformations of plasma membrane induced by substrate nanotopography are now largely accepted as a biophysical stimulus influencing cell behavior and ... ...

    Abstract In their environment, cells must cope with mechanical stresses constantly. Among these, nanoscale deformations of plasma membrane induced by substrate nanotopography are now largely accepted as a biophysical stimulus influencing cell behavior and function. However, the mechanotransduction cascades involved and their precise molecular effects on cellular physiology are still poorly understood. Here, using homemade fluorescent nanostructured cell culture surfaces, we explored the role of Bin/Amphiphysin/Rvs (BAR) domain proteins as mechanosensors of plasma membrane geometry. Our data reveal that distinct subsets of BAR proteins bind to plasma membrane deformations in a membrane curvature radius-dependent manner. Furthermore, we show that membrane curvature promotes the formation of dynamic actin structures mediated by the Rho GTPase CDC42, the F-BAR protein CIP4, and the presence of PI(4,5)P
    MeSH term(s) Actins/metabolism ; Mechanotransduction, Cellular ; Polymerization ; Cell Membrane/metabolism ; rho GTP-Binding Proteins/metabolism
    Chemical Substances Actins ; rho GTP-Binding Proteins (EC 3.6.5.2)
    Language English
    Publishing date 2023-12-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.ade1660
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  10. Article ; Online: Improvement of Lipid Detection in Mouse Brain and Human Uterine Tissue Sections Using In Situ Matrix Enhanced Secondary Ion Mass Spectrometry.

    Daphnis, Thomas / Tomasetti, Benjamin / Delmez, Vincent / Vanvarenberg, Kevin / Préat, Véronique / Thieffry, Charlotte / Henriet, Patrick / Dupont-Gillain, Christine / Delcorte, Arnaud

    Journal of the American Society for Mass Spectrometry

    2023  Volume 34, Issue 10, Page(s) 2259–2268

    Abstract: The potential of mass spectrometry imaging, and especially ToF-SIMS 2D and 3D imaging, for submicrometer-scale, label-free molecular localization in biological tissues is undisputable. Nevertheless, sensitivity issues remain, especially when one wants to ...

    Abstract The potential of mass spectrometry imaging, and especially ToF-SIMS 2D and 3D imaging, for submicrometer-scale, label-free molecular localization in biological tissues is undisputable. Nevertheless, sensitivity issues remain, especially when one wants to achieve the best lateral and vertical (nanometer-scale) resolution. In this study, the interest of in situ matrix transfer for tissue analysis with cluster ion beams (Bi
    MeSH term(s) Mice ; Animals ; Humans ; Spectrometry, Mass, Secondary Ion/methods ; Imaging, Three-Dimensional ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization/methods ; Phosphatidylcholines ; Ions ; Brain
    Chemical Substances Phosphatidylcholines ; Ions
    Language English
    Publishing date 2023-09-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1073671-2
    ISSN 1879-1123 ; 1044-0305
    ISSN (online) 1879-1123
    ISSN 1044-0305
    DOI 10.1021/jasms.3c00195
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    Zs.MO 241: Show issues

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