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Article ; Online: Timely monitoring of total mortality associated with COVID-19: informing public health and the public.

Vestergaard, Lasse S / Mølbak, Kåre

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin

2020 Volume 25, Issue 34

MeSH term(s)	Betacoronavirus ; COVID-19 ; Coronavirus ; Coronavirus Infections/mortality ; Humans ; Mortality ; Pandemics ; Pneumonia, Viral/mortality ; Population Surveillance ; Public Health ; SARS-CoV-2 ; Urban Population
Keywords	covid19
Language	English
Publishing date	2020-08-21
Publishing country	Sweden
Document type	Journal Article
ZDB-ID	1338803-4
ISSN	1560-7917 ; 1025-496X
ISSN (online)	1560-7917
ISSN	1025-496X
DOI	10.2807/1560-7917.ES.2020.25.34.2001591
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Article: Timely monitoring of total mortality associated with COVID-19: informing public health and the public

Vestergaard, Lasse S / Mølbak, Kåre

Euro surveill

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #732929
Database	COVID19

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Article ; Online: Early and intense epidemic of respiratory syncytial virus (RSV) in Denmark, August to December 2022.

Munkstrup, Charlotte / Lomholt, Frederikke Kristensen / Emborg, Hanne-Dorthe / Møller, Karina Lauenborg / Krog, Jesper Schak / Trebbien, Ramona / Vestergaard, Lasse S

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin

2023 Volume 28, Issue 1

Abstract: In the autumn of 2022, Denmark witnessed the second out-of-season epidemic of respiratory syncytial virus (RSV) following widespread societal preventive measures implemented against the coronavirus disease (COVID-19) pandemic during 2020 and 2021. ... ...

Abstract	In the autumn of 2022, Denmark witnessed the second out-of-season epidemic of respiratory syncytial virus (RSV) following widespread societal preventive measures implemented against the coronavirus disease (COVID-19) pandemic during 2020 and 2021. Admissions peaked at twice the level of pre-pandemic seasons. Especially infants below 6 months of age were affected, but also adults over 45 years of age. The current epidemic is dominated by RSV subtype B, unlike the major RSV summer epidemic in 2021 dominated by RSV subtype A.
MeSH term(s)	Infant ; Adult ; Humans ; Middle Aged ; Respiratory Syncytial Virus Infections/epidemiology ; COVID-19/epidemiology ; Respiratory Syncytial Virus, Human ; Seasons ; Pandemics ; Denmark/epidemiology
Language	English
Publishing date	2023-01-24
Publishing country	Sweden
Document type	Journal Article
ZDB-ID	1338803-4
ISSN	1560-7917 ; 1025-496X
ISSN (online)	1560-7917
ISSN	1025-496X
DOI	10.2807/1560-7917.ES.2023.28.1.2200937
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Article ; Online: A late sharp increase in influenza detections and low interim vaccine effectiveness against the circulating A(H3N2) strain, Denmark, 2021/22 influenza season up to 25 March 2022.

Emborg, Hanne-Dorthe / Vestergaard, Lasse S / Botnen, Amanda Bolt / Nielsen, Jens / Krause, Tyra G / Trebbien, Ramona

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin

2022 Volume 27, Issue 15

Abstract: We estimated interim influenza A vaccine effectiveness (VE) following a late sharp rise in cases during an influenza A(H3N2)-dominated 2021/22 season, after lifting COVID-19 restrictions. In children aged 2-6 years offered a live attenuated influenza ... ...

Abstract	We estimated interim influenza A vaccine effectiveness (VE) following a late sharp rise in cases during an influenza A(H3N2)-dominated 2021/22 season, after lifting COVID-19 restrictions. In children aged 2-6 years offered a live attenuated influenza vaccine, adjusted VE was 62.7% (95% CI: 10.9-84.4) in hospitalised and 64.2% (95% CI: 50.5-74.1) in non-hospitalised children. In non-hospitalised patients aged 7-44 years, VE was 24.8% (95% CI: 12.8-35.2); VE was non-significant in remaining age groups and hospital/non-hospital settings.
MeSH term(s)	COVID-19 ; Case-Control Studies ; Child ; Denmark/epidemiology ; Humans ; Influenza A Virus, H3N2 Subtype/genetics ; Influenza B virus ; Influenza Vaccines ; Influenza, Human/epidemiology ; Influenza, Human/prevention & control ; Seasons ; Vaccination ; Vaccine Efficacy
Chemical Substances	Influenza Vaccines
Language	English
Publishing date	2022-04-15
Publishing country	Sweden
Document type	Journal Article
ZDB-ID	1338803-4
ISSN	1560-7917 ; 1025-496X
ISSN (online)	1560-7917
ISSN	1025-496X
DOI	10.2807/1560-7917.ES.2022.27.15.2200278
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Article ; Online: Estimates of mortality attributable to COVID-19: a statistical model for monitoring COVID-19 and seasonal influenza, Denmark, spring 2020.

Nielsen, Jens / Rod, Naja Hulvej / Vestergaard, Lasse S / Lange, Theis

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin

2021 Volume 26, Issue 8

Abstract: BackgroundTimely monitoring of COVID-19 impact on mortality is critical for rapid risk assessment and public health action.AimBuilding upon well-established models to estimate influenza-related mortality, we propose a new statistical Attributable ... ...

Abstract	BackgroundTimely monitoring of COVID-19 impact on mortality is critical for rapid risk assessment and public health action.AimBuilding upon well-established models to estimate influenza-related mortality, we propose a new statistical Attributable Mortality Model (AttMOMO), which estimates mortality attributable to one or more pathogens simultaneously (e.g. SARS-CoV-2 and seasonal influenza viruses), while adjusting for seasonality and excess temperatures.MethodsData from Nationwide Danish registers from 2014-week(W)W27 to 2020-W22 were used to exemplify utilities of the model, and to estimate COVID-19 and influenza attributable mortality from 2019-W40 to 2020-W20.ResultsSARS-CoV-2 was registered in Denmark from 2020-W09. Mortality attributable to COVID-19 in Denmark increased steeply, and peaked in 2020-W14. As preventive measures and national lockdown were implemented from 2020-W12, the attributable mortality started declining within a few weeks. Mortality attributable to COVID-19 from 2020-W09 to 2020-W20 was estimated to 16.2 (95% confidence interval (CI): 12.0 to 20.4) per 100,000 person-years. The 2019/20 influenza season was mild with few deaths attributable to influenza, 3.2 (95% CI: 1.1 to 5.4) per 100,000 person-years.ConclusionAttMOMO estimates mortality attributable to several pathogens simultaneously, providing a fuller picture of mortality by COVID-19 during the pandemic in the context of other seasonal diseases and mortality patterns. Using Danish data, we show that the model accurately estimates mortality attributable to COVID-19 and influenza, respectively. We propose using standardised indicators for pathogen circulation in the population, to make estimates comparable between countries and applicable for timely monitoring.
MeSH term(s)	COVID-19/mortality ; Communicable Disease Control ; Denmark/epidemiology ; Epidemiological Monitoring ; Humans ; Influenza, Human/mortality ; Models, Statistical ; Seasons
Language	English
Publishing date	2021-02-20
Publishing country	Sweden
Document type	Journal Article
ZDB-ID	1338803-4
ISSN	1560-7917 ; 1025-496X
ISSN (online)	1560-7917
ISSN	1025-496X
DOI	10.2807/1560-7917.ES.2021.26.8.2001646
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Article ; Online: COVID-19 mortality attenuated during widespread Omicron transmission, Denmark, 2020 to 2022.

Friis, Nikolaj U / Martin-Bertelsen, Tomas / Pedersen, Rasmus K / Nielsen, Jens / Krause, Tyra G / Andreasen, Viggo / Vestergaard, Lasse S

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin

2023 Volume 28, Issue 3

Abstract: BackgroundIt sparked considerable attention from international media when Denmark lifted restrictions against COVID-19 in February 2022 amidst widespread transmission of the new SARS-CoV-2 Omicron variant and a steep rise in reported COVID-19 mortality ... ...

Abstract	BackgroundIt sparked considerable attention from international media when Denmark lifted restrictions against COVID-19 in February 2022 amidst widespread transmission of the new SARS-CoV-2 Omicron variant and a steep rise in reported COVID-19 mortality based on the 30-day COVID-19 death count.AimOur aim was to investigate how coincidental infections affected COVID-19 mortality estimates following the introduction of the Omicron variant in late 2021.MethodsWe compared the 30-day COVID-19 death count with the observed mortality using three alternative mortality estimation methods; (i) a mathematical model to correct the 30-day COVID-19 death count for coincidental deaths, (ii) the Causes of Death Registry (CDR) and (iii) all-cause excess mortality.ResultsThere was a substantial peak in the 30-day COVID-19 death count following the emergence of the Omicron variant in late 2021. However, there was also a substantial change in the proportion of coincidental deaths, increasing from 10-20% to around 40% of the recorded COVID-19 deaths. The high number of 30-day COVID-19 deaths was not reflected in the number of COVID-19 deaths in the CDR and the all-cause excess mortality surveillance.ConclusionOur analysis showed a distinct change in the mortality pattern following the introduction of Omicron in late 2021 with a markedly higher proportion of people estimated to have died
MeSH term(s)	Humans ; Pandemics ; COVID-19 ; SARS-CoV-2 ; Denmark/epidemiology
Language	English
Publishing date	2023-01-12
Publishing country	Sweden
Document type	Journal Article
ZDB-ID	1338803-4
ISSN	1560-7917 ; 1025-496X
ISSN (online)	1560-7917
ISSN	1025-496X
DOI	10.2807/1560-7917.ES.2023.28.3.2200547
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Article ; Online: Authors' response: Excess all-cause mortality during second wave of COVID-19 - the Polish perspective.

Vestergaard, Lasse S / Nørgaard, Sarah K / Nielsen, Jens / Krause, Tyra G / Mølbak, Kåre

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin

2021 Volume 26, Issue 7

MeSH term(s)	COVID-19 ; Cause of Death ; Humans ; Influenza, Human ; Poland/epidemiology ; SARS-CoV-2
Language	English
Publishing date	2021-02-18
Publishing country	Sweden
Document type	Letter ; Comment
ZDB-ID	1338803-4
ISSN	1560-7917 ; 1025-496X
ISSN (online)	1560-7917
ISSN	1025-496X
DOI	10.2807/1560-7917.ES.2021.26.7.2100191
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Article ; Online: Age-dependent influenza infection patterns and subtype circulation in Denmark, in seasons 2015/16 to 2021/22.

Emborg, Hanne-Dorthe / Bolt Botnen, Amanda / Nielsen, Jens / Vestergaard, Lasse S / Lomholt, Frederikke Kristensen / Munkstrup, Charlotte / Møller, Karina Lauenborg / Kjelsø, Charlotte / Rasmussen, Steen Hulthin / Trebbien, Ramona

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin

2024 Volume 29, Issue 4

Abstract: BackgroundInfluenza was almost absent for 2 years following the implementation of strict public health measures to prevent the spread of SARS-CoV-2. The consequence of this on infections in different age groups is not yet known.AimTo describe the age ... ...

Abstract	BackgroundInfluenza was almost absent for 2 years following the implementation of strict public health measures to prevent the spread of SARS-CoV-2. The consequence of this on infections in different age groups is not yet known.AimTo describe the age groups infected with the influenza virus in 2021/22, the first post-pandemic influenza season in Denmark, compared with the previous six seasons, and subtypes circulating therein.MethodsInfection and hospitalisation incidences per season and age group were estimated from data in Danish registries. Influenza virus subtypes and lineages were available from samples sent to the National Influenza Centre at Statens Serum Institut.ResultsTest incidence followed a similar pattern in all seasons, being highest in 0-1-year-olds and individuals over 75 years, and lowest in 7-14-year-olds and young people 15 years to late twenties. When the influenza A virus subtypes A(H3N2) and A(H1N1)pdm09 co-circulated in seasons 2015/16 and 2017/18 to 2019/20, the proportion of A(H1N1)pdm09 was higher in 0-1-year-olds and lower in the over 85-year-olds compared with the overall proportion of A(H1N1)pdm09 in these seasons. The proportion of A(H3N2) was higher in the over 85 years age group compared with the overall proportion of A(H3N2). The 2016/17 and 2021/22 seasons were dominated by A(H3N2) but differed in age-specific trends, with the over 85 years age group initiating the 2016/17 season, while the 2021/22 season was initiated by the 15-25-year-olds, followed by 7-14-year-olds.ConclusionThe 2021/22 influenza season had a different age distribution compared with pre-COVID-19 pandemic seasons.
MeSH term(s)	Humans ; Adolescent ; Aged, 80 and over ; Influenza, Human/prevention & control ; Seasons ; Influenza A Virus, H1N1 Subtype ; Influenza A Virus, H3N2 Subtype ; Pandemics ; Denmark/epidemiology ; Influenza Vaccines
Chemical Substances	Influenza Vaccines
Language	English
Publishing date	2024-01-11
Publishing country	Sweden
Document type	Journal Article
ZDB-ID	1338803-4
ISSN	1560-7917 ; 1025-496X
ISSN (online)	1560-7917
ISSN	1025-496X
DOI	10.2807/1560-7917.ES.2024.29.4.2300263
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Article ; Online: Sex-differences in COVID-19 associated excess mortality is not exceptional for the COVID-19 pandemic.

Nielsen, Jens / Nørgaard, Sarah K / Lanzieri, Giampaolo / Vestergaard, Lasse S / Moelbak, Kaare

Scientific reports

2021 Volume 11, Issue 1, Page(s) 20815

Abstract: Europe experienced excess mortality from February through June, 2020 due to the COVID-19 pandemic, with more COVID-19-associated deaths in males compared to females. However, a difference in excess mortality among females compared to among males may be a ...

Abstract	Europe experienced excess mortality from February through June, 2020 due to the COVID-19 pandemic, with more COVID-19-associated deaths in males compared to females. However, a difference in excess mortality among females compared to among males may be a more general phenomenon, and should be investigated in none-COVID-19 situations as well. Based on death counts from Eurostat, separate excess mortalities were estimated for each of the sexes using the EuroMOMO model. Sex-differential excess mortality were expressed as differences in excess mortality incidence rates between the sexes. A general relation between sex-differential and overall excess mortality both during the COVID-19 pandemic and in preceding seasons were investigated. Data from 27 European countries were included, covering the seasons 2016/17 to 2019/20. In periods with increased excess mortality, excess was consistently highest among males. From February through May 2020 male excess mortality was 52.7 (95% PI: 56.29; 49.05) deaths per 100,000 person years higher than for females. Increased male excess mortality compared to female was also observed in the seasons 2016/17 to 2018/19. We found a linear relation between sex-differences in excess mortality and overall excess mortality, i.e., 40 additional deaths among males per 100 excess deaths per 100,000 population. This corresponds to an overall female/male mortality incidence ratio of 0.7. In situations with overall excess mortality, excess mortality increases more for males than females. We suggest that the sex-differences observed during the COVID-19 pandemic reflects a general sex-disparity in excess mortality.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Algorithms ; COVID-19/epidemiology ; COVID-19/mortality ; Child ; Child, Preschool ; Europe/epidemiology ; Female ; Humans ; Incidence ; Infant ; Infant, Newborn ; Male ; Middle Aged ; Models, Statistical ; Mortality ; Pandemics ; Poisson Distribution ; Risk Factors ; SARS-CoV-2 ; Sex Factors ; Young Adult
Language	English
Publishing date	2021-10-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-00213-w
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Sex-differences in COVID-19 associated excess mortality is not exceptional for the COVID-19 pandemic

Jens Nielsen / Sarah K. Nørgaard / Giampaolo Lanzieri / Lasse S. Vestergaard / Kaare Moelbak

Scientific Reports, Vol 11, Iss 1, Pp 1-

2021 Volume 9

Abstract: Abstract Europe experienced excess mortality from February through June, 2020 due to the COVID-19 pandemic, with more COVID-19-associated deaths in males compared to females. However, a difference in excess mortality among females compared to among males ...

Abstract	Abstract Europe experienced excess mortality from February through June, 2020 due to the COVID-19 pandemic, with more COVID-19-associated deaths in males compared to females. However, a difference in excess mortality among females compared to among males may be a more general phenomenon, and should be investigated in none-COVID-19 situations as well. Based on death counts from Eurostat, separate excess mortalities were estimated for each of the sexes using the EuroMOMO model. Sex-differential excess mortality were expressed as differences in excess mortality incidence rates between the sexes. A general relation between sex-differential and overall excess mortality both during the COVID-19 pandemic and in preceding seasons were investigated. Data from 27 European countries were included, covering the seasons 2016/17 to 2019/20. In periods with increased excess mortality, excess was consistently highest among males. From February through May 2020 male excess mortality was 52.7 (95% PI: 56.29; 49.05) deaths per 100,000 person years higher than for females. Increased male excess mortality compared to female was also observed in the seasons 2016/17 to 2018/19. We found a linear relation between sex-differences in excess mortality and overall excess mortality, i.e., 40 additional deaths among males per 100 excess deaths per 100,000 population. This corresponds to an overall female/male mortality incidence ratio of 0.7. In situations with overall excess mortality, excess mortality increases more for males than females. We suggest that the sex-differences observed during the COVID-19 pandemic reflects a general sex-disparity in excess mortality.
Keywords	Medicine ; R ; Science ; Q
Subject code	590 ; 310
Language	English
Publishing date	2021-10-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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