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  1. Article: Kaiserschnitt: Ja! Nein! Vielleicht? Sarah Faubel und Damaris Lahmann berichten von einer interdisziplinären Tagung zum Thema Sectio

    Faubel, Sarah / Lahmann, Damaris

    Deutsche Hebammen-Zeitschrift

    2013  Volume -, Issue 12, Page(s) 71

    Language German
    Document type Article
    ZDB-ID 80218-9
    ISSN 0012-026x
    Database Current Contents Medicine

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    Zs.A 457: Show issues Location:
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  2. Article ; Online: Acute kidney injury causes and exacerbates cardiac dysfunction.

    Faubel, Sarah

    American journal of physiology. Renal physiology

    2023  Volume 324, Issue 6, Page(s) F568–F570

    MeSH term(s) Humans ; Acute Kidney Injury ; Kidney ; Heart Diseases ; Cardio-Renal Syndrome
    Language English
    Publishing date 2023-05-11
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 603837-2
    ISSN 1522-1466 ; 0363-6127
    ISSN (online) 1522-1466
    ISSN 0363-6127
    DOI 10.1152/ajprenal.00305.2022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The author replies.

    Faubel, Sarah

    Kidney international

    2020  Volume 97, Issue 6, Page(s) 1301–1302

    MeSH term(s) Acute Kidney Injury ; Body Fluids ; Hepatocytes ; Humans ; Interleukin-6 ; Lipocalin-2
    Chemical Substances Interleukin-6 ; Lipocalin-2
    Language English
    Publishing date 2020-05-19
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2020.03.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: SuPAR: a potential predictive biomarker for acute kidney injury.

    Faubel, Sarah

    Nature reviews. Nephrology

    2020  Volume 16, Issue 7, Page(s) 375–376

    MeSH term(s) Acute Kidney Injury ; Biomarkers ; Humans ; Receptors, Urokinase Plasminogen Activator ; Urokinase-Type Plasminogen Activator
    Chemical Substances Biomarkers ; Receptors, Urokinase Plasminogen Activator ; Urokinase-Type Plasminogen Activator (EC 3.4.21.73)
    Language English
    Publishing date 2020-04-06
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2490366-8
    ISSN 1759-507X ; 1759-5061
    ISSN (online) 1759-507X
    ISSN 1759-5061
    DOI 10.1038/s41581-020-0276-7
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  5. Article ; Online: Acute Kidney Injury and Acute Respiratory Distress Syndrome.

    Park, Bryan D / Faubel, Sarah

    Critical care clinics

    2021  Volume 37, Issue 4, Page(s) 835–849

    Abstract: Acute kidney injury (AKI) complicates approximately a third of all acute respiratory distress syndrome (ARDS) cases, and the combination of the two drastically worsens prognosis. Recent advances in ARDS supportive care have led to improved outcomes; ... ...

    Abstract Acute kidney injury (AKI) complicates approximately a third of all acute respiratory distress syndrome (ARDS) cases, and the combination of the two drastically worsens prognosis. Recent advances in ARDS supportive care have led to improved outcomes; however, much less is known on how to prevent and support patients with AKI and ARDS together. Understanding the dynamic relationship between the kidneys and lungs is crucial for the practicing intensivist to prevent injury. This article summarizes key concepts for the critical care physician managing a patient with ARDS complicated by AKI. Also provided is a discussion of AKI in the COVID-19 era.
    MeSH term(s) Acute Kidney Injury/complications ; Acute Kidney Injury/therapy ; COVID-19 ; Critical Care ; Humans ; Respiratory Distress Syndrome/complications ; Respiratory Distress Syndrome/therapy ; SARS-CoV-2
    Language English
    Publishing date 2021-05-27
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1006423-0
    ISSN 1557-8232 ; 0749-0704
    ISSN (online) 1557-8232
    ISSN 0749-0704
    DOI 10.1016/j.ccc.2021.05.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Infection Post-AKI: Should We Worry?

    Gist, Katja M / Faubel, Sarah

    Nephron

    2020  Volume 144, Issue 12, Page(s) 673–676

    Abstract: Acute kidney injury (AKI) continues to be a major problem among hospitalized patients, and there is a growing appreciation that the high mortality in AKI may be due to its deleterious systemic effects. Recent research has begun to disentangle kidney- ... ...

    Abstract Acute kidney injury (AKI) continues to be a major problem among hospitalized patients, and there is a growing appreciation that the high mortality in AKI may be due to its deleterious systemic effects. Recent research has begun to disentangle kidney-organ cross talk, wherein the host response to AKI becomes maladaptive, resulting in effects on numerous remote organs such as the lung, heart, liver, spleen, and brain. AKI also adversely affects immune function and is widely considered an immunosuppressed state. A wealth of data has accumulated that patients with AKI have a substantial increased risk of subsequent infection and sepsis. Indeed, sepsis is the leading cause of death in patients with established AKI. Unfortunately, little is known regarding the nature of the abnormal immune response that increases the risk for septic complications which may be persistent and prolonged. Until mechanistic pathways that drive the AKI-immune system-infection process are identified, and physicians should attempt to minimize AKI, its severity, and duration and anticipate infectious complications.
    MeSH term(s) Acute Kidney Injury/complications ; Humans ; Infections/complications ; Sepsis/complications
    Language English
    Publishing date 2020-06-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 207121-6
    ISSN 2235-3186 ; 1423-0186 ; 1660-8151 ; 0028-2766
    ISSN (online) 2235-3186 ; 1423-0186
    ISSN 1660-8151 ; 0028-2766
    DOI 10.1159/000508101
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 169: Show issues Location:
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  7. Article ; Online: Renal relevant radiology: introduction.

    Faubel, Sarah

    Clinical journal of the American Society of Nephrology : CJASN

    2014  Volume 9, Issue 2, Page(s) 371–372

    MeSH term(s) Diagnostic Imaging/methods ; Humans ; Kidney/diagnostic imaging ; Kidney/pathology ; Kidney Diseases/diagnosis ; Kidney Diseases/diagnostic imaging ; Kidney Diseases/pathology ; Magnetic Resonance Imaging ; Predictive Value of Tests ; Prognosis ; Radiography ; Severity of Illness Index ; Ultrasonography
    Language English
    Publishing date 2014-02-07
    Publishing country United States
    Document type Introductory Journal Article
    ZDB-ID 2226665-3
    ISSN 1555-905X ; 1555-9041
    ISSN (online) 1555-905X
    ISSN 1555-9041
    DOI 10.2215/CJN.10211013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Have we reached the limit of mortality benefit with our approach to renal replacement therapy in acute kidney injury?

    Faubel, Sarah

    American journal of kidney diseases : the official journal of the National Kidney Foundation

    2013  Volume 62, Issue 6, Page(s) 1030–1033

    MeSH term(s) Acute Kidney Injury/therapy ; Developing Countries ; Early Medical Intervention ; Female ; Humans ; Male ; Renal Dialysis
    Language English
    Publishing date 2013-12
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 604539-x
    ISSN 1523-6838 ; 0272-6386
    ISSN (online) 1523-6838
    ISSN 0272-6386
    DOI 10.1053/j.ajkd.2013.09.004
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    Zs.A 1669: Show issues Location:
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  9. Article ; Online: The Nephrologist Has Great Potential to Have an Important Role in the Intensive Care Unit: Reply to the Letter to the Editor of David J.R. Morgan.

    Askenazi, David J / Faubel, Sarah

    Blood purification

    2017  Volume 44, Issue 4, Page(s) 269–270

    MeSH term(s) Intensive Care Units ; Nephrologists
    Language English
    Publishing date 2017-10-12
    Publishing country Switzerland
    Document type Letter ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, P.H.S. ; Comment
    ZDB-ID 605548-5
    ISSN 1421-9735 ; 0253-5068
    ISSN (online) 1421-9735
    ISSN 0253-5068
    DOI 10.1159/000478974
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    Zs.A 1872: Show issues Location:
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  10. Article ; Online: Acute kidney injury decreases pulmonary vascular growth and alveolarization in neonatal rat pups.

    Liberio, Brianna M / Seedorf, Gregory / Soranno, Danielle E / Montford, John R / Faubel, Sarah G / Hernandez, Andres / Abman, Steven H / Gien, Jason

    Pediatric research

    2023  Volume 94, Issue 4, Page(s) 1308–1316

    Abstract: Background: Acute kidney injury (AKI) is common in sick neonates and associated with poor pulmonary outcomes, however, the mechanisms responsible remain unknown. We present two novel neonatal rodent models of AKI to investigate the pulmonary effects of ... ...

    Abstract Background: Acute kidney injury (AKI) is common in sick neonates and associated with poor pulmonary outcomes, however, the mechanisms responsible remain unknown. We present two novel neonatal rodent models of AKI to investigate the pulmonary effects of AKI.
    Methods: In rat pups, AKI was induced surgically via bilateral ischemia-reperfusion injury (bIRI) or pharmacologically using aristolochic acid (AA). AKI was confirmed with plasma blood urea nitrogen and creatinine measurements and kidney injury molecule-1 staining on renal immunohistochemistry. Lung morphometrics were quantified with radial alveolar count and mean linear intercept, and angiogenesis investigated by pulmonary vessel density (PVD) and vascular endothelial growth factor (VEGF) protein expression. For the surgical model, bIRI, sham, and non-surgical pups were compared. For the pharmacologic model, AA pups were compared to vehicle controls.
    Results: AKI occurred in bIRI and AA pups, and they demonstrated decreased alveolarization, PVD, and VEGF protein expression compared controls. Sham pups did not experience AKI, however, demonstrated decreased alveolarization, PVD, and VEGF protein expression compared to controls.
    Conclusion: Pharmacologic AKI and surgery in neonatal rat pups, with or without AKI, decreased alveolarization and angiogenesis, producing a bronchopulmonary dysplasia phenotype. These models provide a framework for elucidating the relationship between AKI and adverse pulmonary outcomes.
    Impact: There are no published neonatal rodent models investigating the pulmonary effects after neonatal acute kidney injury, despite known clinical associations. We present two novel neonatal rodent models of acute kidney injury to study the impact of acute kidney injury on the developing lung. We demonstrate the pulmonary effects of both ischemia-reperfusion injury and nephrotoxin-induced AKI on the developing lung, with decreased alveolarization and angiogenesis, mimicking the lung phenotype of bronchopulmonary dysplasia. Neonatal rodent models of acute kidney injury provide opportunities to study mechanisms of kidney-lung crosstalk and novel therapeutics in the context of acute kidney injury in a premature infant.
    MeSH term(s) Humans ; Infant, Newborn ; Animals ; Rats ; Animals, Newborn ; Bronchopulmonary Dysplasia/metabolism ; Vascular Endothelial Growth Factor A/metabolism ; Lung ; Acute Kidney Injury ; Reperfusion Injury/complications ; Reperfusion Injury/metabolism
    Chemical Substances Vascular Endothelial Growth Factor A
    Language English
    Publishing date 2023-05-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 4411-8
    ISSN 1530-0447 ; 0031-3998
    ISSN (online) 1530-0447
    ISSN 0031-3998
    DOI 10.1038/s41390-023-02625-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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