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Article: Commentary: Urinary Neopterin, a New Marker of the Neuroinflammatory Status in Amyotrophic Lateral Sclerosis.

Espíndola, Gisele / Scheffer, Débora da Luz / Latini, Alexandra

2021 Volume 15, Page(s) 645694

Language	English
Publishing date	2021-03-23
Publishing country	Switzerland
Document type	Journal Article ; Comment
ZDB-ID	2411902-7
ISSN	1662-453X ; 1662-4548
ISSN (online)	1662-453X
ISSN	1662-4548
DOI	10.3389/fnins.2021.645694
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Exercise-induced immune system response: Anti-inflammatory status on peripheral and central organs.

Scheffer, Débora da Luz / Latini, Alexandra

Biochimica et biophysica acta. Molecular basis of disease

2020 Volume 1866, Issue 10, Page(s) 165823

Abstract: A wide array of molecular pathways has been investigated during the past decade in order to understand the mechanisms by which the practice of physical exercise promotes neuroprotection and reduces the risk of developing communicable and non-communicable ...

Abstract	A wide array of molecular pathways has been investigated during the past decade in order to understand the mechanisms by which the practice of physical exercise promotes neuroprotection and reduces the risk of developing communicable and non-communicable chronic diseases. While a single session of physical exercise may represent a challenge for cell homeostasis, repeated physical exercise sessions will improve immunosurveillance and immunocompetence. Additionally, immune cells from the central nervous system will acquire an anti-inflammatory phenotype, protecting central functions from age-induced cognitive decline. This review highlights the exercise-induced anti-inflammatory effect on the prevention or treatment of common chronic clinical and experimental settings. It also suggests the use of pterins in biological fluids as sensitive biomarkers to follow the anti-inflammatory effect of physical exercise.
MeSH term(s)	Animals ; Anti-Inflammatory Agents/pharmacology ; Biomarkers ; Blood-Brain Barrier/immunology ; Chronic Disease ; Communicable Diseases/immunology ; Cytokines ; Databases, Factual ; Exercise/physiology ; Humans ; Immune System/drug effects ; Immune System/immunology ; Immunity, Innate/immunology ; Inflammation/immunology ; Neopterin/pharmacology ; Neuroprotection/immunology
Chemical Substances	Anti-Inflammatory Agents ; Biomarkers ; Cytokines ; Neopterin (670-65-5)
Keywords	covid19
Language	English
Publishing date	2020-04-29
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	60-7
ISSN	1879-260X ; 1879-2596 ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
ISSN (online)	1879-260X ; 1879-2596 ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
ISSN	0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
DOI	10.1016/j.bbadis.2020.165823
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Article ; Online: Mitochondrial Fusion, Fission, and Mitophagy in Cardiac Diseases: Challenges and Therapeutic Opportunities.

Scheffer, Débora da Luz / Garcia, Adriana Ann / Lee, Lucia / Mochly-Rosen, Daria / Ferreira, Julio Cesar Batista

Antioxidants & redox signaling

2022 Volume 36, Issue 13-15, Page(s) 844–863

Abstract: Significance: ...

Abstract	Significance:
MeSH term(s)	Heart Failure/metabolism ; Humans ; Mitochondria/metabolism ; Mitochondrial Dynamics ; Mitophagy ; Myocardial Infarction/metabolism
Language	English
Publishing date	2022-04-18
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	1483836-9
ISSN	1557-7716 ; 1523-0864
ISSN (online)	1557-7716
ISSN	1523-0864
DOI	10.1089/ars.2021.0145
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Article: Exercise-induced immune system response: Anti-inflammatory status on peripheral and central organs

Scheffer, Débora da Luz / Latini, Alexandra

Biochim Biophys Acta Mol Basis Dis

Abstract	A wide array of molecular pathways has been investigated during the past decade in order to understand the mechanisms by which the practice of physical exercise promotes neuroprotection and reduces the risk of developing communicable and non-communicable chronic diseases. While a single session of physical exercise may represent a challenge for cell homeostasis, repeated physical exercise sessions will improve immunosurveillance and immunocompetence. Additionally, immune cells from the central nervous system will acquire an anti-inflammatory phenotype, protecting central functions from age-induced cognitive decline. This review highlights the exercise-induced anti-inflammatory effect on the prevention or treatment of common chronic clinical and experimental settings. It also suggests the use of pterins in biological fluids as sensitive biomarkers to follow the anti-inflammatory effect of physical exercise.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #133265
Database	COVID19

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Article ; Online: Muscle-specific ER-associated degradation maintains postnatal muscle hypertrophy and systemic energy metabolism.

Abdon, Benedict / Liang, Yusheng / da Luz Scheffer, Débora / Torres, Mauricio / Shrestha, Neha / Reinert, Rachel B / Lu, You / Pederson, Brent / Bugarin-Lapuz, Amara / Kersten, Sander / Qi, Ling

JCI insight

2023 Volume 8, Issue 17

Abstract: The growth of skeletal muscle relies on a delicate equilibrium between protein synthesis and degradation; however, how proteostasis is managed in the endoplasmic reticulum (ER) is largely unknown. Here, we report that the SEL1L-HRD1 ER-associated ... ...

Abstract	The growth of skeletal muscle relies on a delicate equilibrium between protein synthesis and degradation; however, how proteostasis is managed in the endoplasmic reticulum (ER) is largely unknown. Here, we report that the SEL1L-HRD1 ER-associated degradation (ERAD) complex, the primary molecular machinery that degrades misfolded proteins in the ER, is vital to maintain postnatal muscle growth and systemic energy balance. Myocyte-specific SEL1L deletion blunts the hypertrophic phase of muscle growth, resulting in a net zero gain of muscle mass during this developmental period and a 30% reduction in overall body growth. In addition, myocyte-specific SEL1L deletion triggered a systemic reprogramming of metabolism characterized by improved glucose sensitivity, enhanced beigeing of adipocytes, and resistance to diet-induced obesity. These effects were partially mediated by the upregulation of the myokine FGF21. These findings highlight the pivotal role of SEL1L-HRD1 ERAD activity in skeletal myocytes for postnatal muscle growth, and its physiological integration in maintaining whole-body energy balance.
MeSH term(s)	Humans ; Endoplasmic Reticulum-Associated Degradation ; Ubiquitin-Protein Ligases/metabolism ; Proteins/genetics ; Muscles/metabolism ; Energy Metabolism ; Hypertrophy/metabolism
Chemical Substances	Ubiquitin-Protein Ligases (EC 2.3.2.27) ; Proteins ; SEL1L protein, human
Language	English
Publishing date	2023-08-03
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	2379-3708
ISSN (online)	2379-3708
DOI	10.1172/jci.insight.170387
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Article: Physical-Exercise-Induced Antioxidant Effects on the Brain and Skeletal Muscle.

Souza, Jennyffer / da Silva, Rodrigo Augusto / da Luz Scheffer, Débora / Penteado, Rafael / Solano, Alexandre / Barros, Leonardo / Budde, Henning / Trostchansky, Andrés / Latini, Alexandra

Antioxidants (Basel, Switzerland)

2022 Volume 11, Issue 5

Abstract: Erythroid-related nuclear factor 2 (NRF2) and the antioxidant-responsive-elements (ARE) signaling pathway are the master regulators of cell antioxidant defenses, playing a key role in maintaining cellular homeostasis, a scenario in which proper ... ...

Abstract	Erythroid-related nuclear factor 2 (NRF2) and the antioxidant-responsive-elements (ARE) signaling pathway are the master regulators of cell antioxidant defenses, playing a key role in maintaining cellular homeostasis, a scenario in which proper mitochondrial function is essential. Increasing evidence indicates that the regular practice of physical exercise increases cellular antioxidant defenses by activating NRF2 signaling. This manuscript reviewed classic and ongoing research on the beneficial effects of exercise on the antioxidant system in both the brain and skeletal muscle.
Language	English
Publishing date	2022-04-23
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox11050826
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Article ; Online: Muscle Fatigue Is Attenuated When Applying Intermittent Compared With Continuous Blood Flow Restriction During Endurance Cycling.

Corvino, Rogério Bulhões / Scheffer, Débora da Luz / Penteado Dos Santos, Rafael / Latini, Alexandra / Oliveira, Anderson Souza / Caputo, Fabrizio

International journal of sports physiology and performance

2022 Volume 17, Issue 7, Page(s) 1126–1131

Abstract: Purpose: The aim of this study was to identify a blood-flow-restriction (BFR) endurance exercise protocol that maximizes metabolic strain and minimizes muscle fatigue.: Methods: Twelve healthy participants accomplished 5 different interval cycling ... ...

Abstract	Purpose: The aim of this study was to identify a blood-flow-restriction (BFR) endurance exercise protocol that maximizes metabolic strain and minimizes muscle fatigue. Methods: Twelve healthy participants accomplished 5 different interval cycling endurance exercises (2-min work, 1-min rest) in a randomized order: (1) control, low intensity with unrestricted blood flow (CON30); (2) low intensity with intermittent BFR (i-BFR30, ∼150 mm Hg); (3) low intensity with continuous BFR (c-BFR, ∼100 mm Hg); (4) unloaded cycling with i-BFR0 (∼150 mm Hg); and (5) high intensity (HI) with unrestricted blood flow. Force production, creatine kinase activity, antioxidant markers, blood pH, and potassium (K+) were measured in a range of 5 minutes before and after each cycling exercise protocol. Results: HI showed the highest reduction (Δ = -0.26 [0.05], d = 5.6) on blood pH. Delta pH for c-BRF30 (Δ = -0.02 [0.03], d = 0.8) and Δ pH for i-BRF30 (Δ = -0.04 [0.03], d = 1.6) were different from each other, and both were higher compared with CON30 (Δ = 0.03 [0.03]). There was significant before-to-after force loss following HI (Δ = 55 [40] N·m-1, d = 1.5) and c-BFR30 (Δ = 27 [21] N·m-1, d = 0.7) protocols only, which were accompanied by significant increases in K+ (HI: Δ = 0.94 [0.65] mmol·L-1, d = 1.8; c-BFR30: Δ = 0.72 [0.85] mmol·L-1, d = 1.2). Moreover, all BFR conditions elicited slight increases in plasma creatine kinase, but not for HI and CON30. Glutathione changes from before to after were significant for all BFR conditions and HI, but not for CON30. Conclusions: The attenuation in fatigue-induced reductions in maximal force suggests that i-BFR exercise could be preferable to c-BFR in improving exercise capacity, with considerably less biologic stress elicited from HI exercises.
MeSH term(s)	Creatine Kinase/metabolism ; Humans ; Muscle Fatigue ; Muscle, Skeletal/physiology ; Regional Blood Flow/physiology ; Resistance Training/methods
Chemical Substances	Creatine Kinase (EC 2.7.3.2)
Language	English
Publishing date	2022-05-12
Publishing country	United States
Document type	Journal Article
ISSN	1555-0273
ISSN (online)	1555-0273
DOI	10.1123/ijspp.2021-0523
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Article ; Online: Muscle-specific ER-associated degradation maintains postnatal muscle hypertrophy and systemic energy metabolism

Benedict Abdon / Yusheng Liang / Débora da Luz Scheffer / Mauricio Torres / Neha Shrestha / Rachel B. Reinert / You Lu / Brent Pederson / Amara Bugarin-Lapuz / Sander Kersten / Ling Qi

JCI Insight, Vol 8, Iss

2023 Volume 17

Abstract	The growth of skeletal muscle relies on a delicate equilibrium between protein synthesis and degradation; however, how proteostasis is managed in the endoplasmic reticulum (ER) is largely unknown. Here, we report that the SEL1L-HRD1 ER-associated degradation (ERAD) complex, the primary molecular machinery that degrades misfolded proteins in the ER, is vital to maintain postnatal muscle growth and systemic energy balance. Myocyte-specific SEL1L deletion blunts the hypertrophic phase of muscle growth, resulting in a net zero gain of muscle mass during this developmental period and a 30% reduction in overall body growth. In addition, myocyte-specific SEL1L deletion triggered a systemic reprogramming of metabolism characterized by improved glucose sensitivity, enhanced beigeing of adipocytes, and resistance to diet-induced obesity. These effects were partially mediated by the upregulation of the myokine FGF21. These findings highlight the pivotal role of SEL1L-HRD1 ERAD activity in skeletal myocytes for postnatal muscle growth, and its physiological integration in maintaining whole-body energy balance.
Keywords	Cell biology ; Muscle biology ; Medicine ; R
Subject code	610
Language	English
Publishing date	2023-09-01T00:00:00Z
Publisher	American Society for Clinical investigation
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Moderate running exercise prevents excessive immune system activation.

Scheffer, Débora da Luz / Ghisoni, Karina / Aguiar, Aderbal Silva / Latini, Alexandra

Physiology & behavior

2019 Volume 204, Page(s) 248–255

Abstract: Benefits of exercise have been documented for many diseases with a chronic progression, including obesity, diabetes mellitus, cardiovascular diseases, neurodegenerative diseases, certain types of cancers, and overall mortality. Low-grade systemic ... ...

Abstract	Benefits of exercise have been documented for many diseases with a chronic progression, including obesity, diabetes mellitus, cardiovascular diseases, neurodegenerative diseases, certain types of cancers, and overall mortality. Low-grade systemic inflammation is a key component of these pathologies and it has been demonstrated that can be prevented by performing regularly physical exercise. The aim of this study was to examine the effect of lipopolysaccharide (LPS)-induced inflammation on glucose and insulin tolerance, exercise performance, production of urinary neopterin and striatal neurotransmitters levels in adult male C57BL/6 mice. Increased blood glucose clearance and insulin sensitivity were observed after a single administration of glucose (2 g/kg, p.o.) or insulin (0.5 U/kg, i.p.). However, the repeated injection of LPS (0.33 mg/kg/day, i.p.) decreased glucose tolerance and increase urinary neopterin levels, pointing to systemic inflammation. In parallel to the urinary-increased neopterin, it was observed a significant reduction in the striatal dopamine levels and an increase in the serotonin/dopamine ratio. While a single LPS injection (0.33 mg/kg, i.p.) showed impaired performance in the incremental loading test (10 m/min, with 2 m/min increment every 3 min, at 9% grade), a moderate physical exercise protocol (treadmill for three weeks; 5 sessions/week; up to 50 min/day) prevented the exacerbation of immune system activation and preserved mitochondrial activity in skeletal muscle from mice with continuous LPS infusion (infusion pumps: 0.83 mg/kg/day, i.p.). In conclusion, the peripheral-induced inflammation elicited metabolic alterations that provoked impairment in striatal dopamine metabolism. The moderate exercise prevented the increase of urinary neopterin and preserved mitochondrial activity under LPS-induced inflammatory conditions.
MeSH term(s)	Animals ; Corpus Striatum/metabolism ; Dopamine/metabolism ; Inflammation/metabolism ; Insulin Resistance/physiology ; Lipopolysaccharides/pharmacology ; Male ; Mice ; Mice, Inbred C57BL ; Mitochondria/metabolism ; Muscle, Skeletal/drug effects ; Muscle, Skeletal/metabolism ; Neopterin/urine ; Physical Conditioning, Animal/physiology ; Running/physiology ; Serotonin/metabolism
Chemical Substances	Lipopolysaccharides ; Serotonin (333DO1RDJY) ; Neopterin (670-65-5) ; Dopamine (VTD58H1Z2X)
Language	English
Publishing date	2019-02-19
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3907-x
ISSN	1873-507X ; 0031-9384
ISSN (online)	1873-507X
ISSN	0031-9384
DOI	10.1016/j.physbeh.2019.02.023
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Article ; Online: Muscle-specific ER-associated degradation maintains postnatal muscle hypertrophy and systemic energy metabolism

Abdon, Benedict / Liang, Yusheng / da Luz Scheffer, Débora / Torres, Mauricio / Shrestha, Neha / Reinert, Rachel / Lu, You / Pederson, Brent / Bugarin-Lapuz, Amara / Kersten, Sander / Qi, Ling

JCI Insight

2023 Volume 8, Issue 17

Abstract	The growth of skeletal muscle relies on a delicate equilibrium between protein synthesis and degradation; however, how proteostasis is managed in the endoplasmic reticulum (ER) is largely unknown. Here, we report that the SEL1L-HRD1 ER-associated degradation (ERAD) complex, the primary molecular machinery that degrades misfolded proteins in the ER, is vital to maintain postnatal muscle growth and systemic energy balance. Myocyte-specific SEL1L deletion blunts the hypertrophic phase of muscle growth, resulting in a net zero gain of muscle mass during this developmental period and a 30% reduction in overall body growth. In addition, myocyte-specific SEL1L deletion triggered a systemic reprogramming of metabolism characterized by improved glucose sensitivity, enhanced beigeing of adipocytes, and resistance to diet-induced obesity. These effects were partially mediated by the upregulation of the myokine FGF21. These findings highlight the pivotal role of SEL1L-HRD1 ERAD activity in skeletal myocytes for postnatal muscle growth, and its physiological integration in maintaining whole-body energy balance.
Keywords	Life Science
Subject code	610
Language	English
Publishing country	nl
Document type	Article ; Online
ISSN	2379-3708
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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