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Article ; Online: Exertional compartment syndrome: review of the literature and proposed rehabilitation guidelines following surgical release.

Schubert, Amy G

International journal of sports physical therapy

2011 Volume 6, Issue 2, Page(s) 126–141

Abstract: Background: There is little published information regarding postoperative management of patients with Chronic Exertional Compartment Syndrome (CECS). Reports of recurrence of symptoms following surgical decompression exist, and are not uncommon ... ...

Abstract	Background: There is little published information regarding postoperative management of patients with Chronic Exertional Compartment Syndrome (CECS). Reports of recurrence of symptoms following surgical decompression exist, and are not uncommon depending on the specific technique used. Recurrence suggests that more time and effort may need to be spent on implementing strategic post-operative rehabilitation management in order to avoid repeat surgical intervention or prolonged symptoms. Objective: To summarize relevant literature regarding CECS and propose scientifically-based guidelines for rehab following compartment release with the rationale based on tissue healing, muscle loading, and scar tissue formation and consideration of all tissues contained in the involved compartment. Literature review: A LITERATURE SEARCH WAS PERFORMED IN PUBMED, SPORTDISCUS, CINAHL, PEDRO, AND GOOGLE SCHOLAR USING THE PHRASE: "chronic exertional compartment syndrome." Results: No specific rehabilitation guidelines following surgical compartment release for lower extremity CECS were found in the literature search performed for this clinical commentary. Discussion: The development of the proposed post-operative guidelines may allow for improved long-term outcomes following anterior compartment release. Summary: Adequate description of long-term follow-up of outcomes following compartment release for CECS is lacking in current literature. The proposed guidelines for rehab following compartment release include consideration of tissue healing, muscle loading, scar tissue formation, and consideration of soft tissues contained in the involved compartment. Utilization of the proposed guidelines may allow for future research to be performed in order to assess outcomes following surgical intervention for CECS.
Language	English
Publishing date	2011-02-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	2628664-6
ISSN	2159-2896 ; 2159-2896
ISSN (online)	2159-2896
ISSN	2159-2896
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Collaborative Approach to Reach Everyone with Familial Hypercholesterolemia: CARE-FH Protocol.

Jones, Laney K / Williams, Marc S / Ladd, Ilene G / Cawley, Dylan / Ge, Shuping / Hao, Jing / Hassen, Dina / Hu, Yirui / Kirchner, H Lester / Kobylinski, Maria / Lesko, Michael G / Nelson, Matthew C / Rahm, Alanna K / Rolston, David D / Romagnoli, Katrina M / Schubert, Tyler J / Shuey, Timothy C / Sturm, Amy C / Gidding, Samuel S

Journal of personalized medicine

2022 Volume 12, Issue 4

Abstract: The Collaborative Approach to Reach Everyone with Familial Hypercholesterolemia (CARE-FH) study aims to improve diagnostic evaluation rates for FH at Geisinger, an integrated health delivery system. This clinical trial relies upon implementation science ... ...

Abstract	The Collaborative Approach to Reach Everyone with Familial Hypercholesterolemia (CARE-FH) study aims to improve diagnostic evaluation rates for FH at Geisinger, an integrated health delivery system. This clinical trial relies upon implementation science to transition the initial evaluation for FH into primary care, attempting to identify individuals prior to the onset of atherosclerotic cardiovascular disease events. The protocol for the CARE-FH study of this paper is available online. The first phase of the project focuses on trial design, including the development of implementation strategies to deploy evidence-based guidelines. The second phase will study the intervention, rolled out regionally to internal medicine, community medicine, and pediatric care clinicians using a stepped-wedge design, and analyzing data on diagnostic evaluation rates, and implementation, service, and health outcomes.
Language	English
Publishing date	2022-04-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm12040606
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Article: Influence of stride frequency and length on running mechanics: a systematic review.

Schubert, Amy G / Kempf, Jenny / Heiderscheit, Bryan C

Sports health

2014 Volume 6, Issue 3, Page(s) 210–217

Abstract: Context: A high number of recreational runners sustain a running-related injury each year. To reduce injury risk, alterations in running form have been suggested. One simple strategy for running stride frequency or length has been commonly advocated.: ...

Abstract	Context: A high number of recreational runners sustain a running-related injury each year. To reduce injury risk, alterations in running form have been suggested. One simple strategy for running stride frequency or length has been commonly advocated. Objective: To characterize how running mechanics change when stride frequency and length are manipulated. Data sources: In January 2012, a comprehensive search of PubMed, CINAHL Plus, SPORTDiscus, PEDro, and Cochrane was performed independently by 2 reviewers. A second search of the databases was repeated in June 2012 to ensure that no additional studies met the criteria after the initial search. Study selection: Inclusion criteria for studies were an independent variable including manipulation of stride frequency or length at a constant speed with outcome measures of running kinematics or kinetics. Study design: Systematic review. Level of evidence: Level 3. Data extraction: Two reviewers independently appraised each article using a modified version of the Quality Index, designed for assessing bias of nonrandomized studies. Results: Ten studies met the criteria for this review. There was consistent evidence that increased stride rate resulted in decreased center of mass vertical excursion, ground reaction force, shock attenuation, and energy absorbed at the hip, knee, and ankle joints. All but 1 study had a limited number of participants, with several methodological differences existing among studies (eg, overground and treadmill running, duration of test conditions). Although speed was held constant during testing, it was individually self-selected or fixed. Most studies used only male participants. Conclusion: Despite procedural differences among studies, an increased stride rate (reduced stride length) appears to reduce the magnitude of several key biomechanical factors associated with running injuries.
Language	English
Publishing date	2014-04-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	2508802-6
ISSN	1941-0921 ; 1941-7381
ISSN (online)	1941-0921
ISSN	1941-7381
DOI	10.1177/1941738113508544
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Article ; Online: Collaborative Approach to Reach Everyone with Familial Hypercholesterolemia

Laney K. Jones / Marc S. Williams / Ilene G. Ladd / Dylan Cawley / Shuping Ge / Jing Hao / Dina Hassen / Yirui Hu / H. Lester Kirchner / Maria Kobylinski / Michael G. Lesko / Matthew C. Nelson / Alanna K. Rahm / David D. Rolston / Katrina M. Romagnoli / Tyler J. Schubert / Timothy C. Shuey / Amy C. Sturm / Samuel S. Gidding

Journal of Personalized Medicine, Vol 12, Iss 606, p

CARE-FH Protocol

2022 Volume 606

Abstract	The Collaborative Approach to Reach Everyone with Familial Hypercholesterolemia (CARE-FH) study aims to improve diagnostic evaluation rates for FH at Geisinger, an integrated health delivery system. This clinical trial relies upon implementation science to transition the initial evaluation for FH into primary care, attempting to identify individuals prior to the onset of atherosclerotic cardiovascular disease events. The protocol for the CARE-FH study of this paper is available online. The first phase of the project focuses on trial design, including the development of implementation strategies to deploy evidence-based guidelines. The second phase will study the intervention, rolled out regionally to internal medicine, community medicine, and pediatric care clinicians using a stepped-wedge design, and analyzing data on diagnostic evaluation rates, and implementation, service, and health outcomes.
Keywords	familial hypercholesterolemia ; prevention ; primary care ; implementation science ; cholesterol screening ; Medicine ; R
Subject code	360
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Exome Sequencing Identifies Candidate Genetic Modifiers of Syndromic and Familial Thoracic Aortic Aneurysm Severity.

Landis, Benjamin J / Schubert, Jeffrey A / Lai, Dongbing / Jegga, Anil G / Shikany, Amy R / Foroud, Tatiana / Ware, Stephanie M / Hinton, Robert B

Journal of cardiovascular translational research

2017 Volume 10, Issue 4, Page(s) 423–432

Abstract: Thoracic aortic aneurysm (TAA) is a genetic disease predisposing to aortic dissection. It is important to identify the genetic modifiers controlling penetrance and expressivity to improve clinical prognostication. Exome sequencing was performed in 27 ... ...

Abstract	Thoracic aortic aneurysm (TAA) is a genetic disease predisposing to aortic dissection. It is important to identify the genetic modifiers controlling penetrance and expressivity to improve clinical prognostication. Exome sequencing was performed in 27 subjects with syndromic or familial TAA presenting with extreme phenotypes (15 with severe TAA; 12 with mild or absent TAA). Family-based analysis of a subset of the cohort identified variants, genes, and pathways segregating with TAA severity among three families. A rare missense variant in ADCK4 (p.Arg63Trp) segregated with mild TAA in each family. Genes and pathways identified in families were further investigated in the entire cohort using the optimal unified sequence kernel association test, finding significance for the gene COL15A1 (p = 0.025) and the retina homeostasis pathway (p = 0.035). Thus, we identified candidate genetic modifiers of TAA severity by exome-based study of extreme phenotypes, which may lead to improved risk stratification and development of new medical therapies.
MeSH term(s)	Adolescent ; Adult ; Aortic Aneurysm, Thoracic/diagnostic imaging ; Aortic Aneurysm, Thoracic/genetics ; Collagen/genetics ; Female ; Gene Regulatory Networks ; Genes, Modifier ; Genetic Association Studies ; Genetic Predisposition to Disease ; Heredity ; Humans ; Male ; Middle Aged ; Pedigree ; Phenotype ; Predictive Value of Tests ; Prospective Studies ; Risk Factors ; Severity of Illness Index ; Syndrome ; Whole Exome Sequencing ; Young Adult
Chemical Substances	COL15A1 protein, human ; Collagen (9007-34-5)
Language	English
Publishing date	2017-05-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	2422411-X
ISSN	1937-5395 ; 1937-5387
ISSN (online)	1937-5395
ISSN	1937-5387
DOI	10.1007/s12265-017-9753-1
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Article: Nicotinic Receptors in the Brainstem Ascending Arousal System in SIDS With Analysis of Pre-natal Exposures to Maternal Smoking and Alcohol in High-Risk Populations of the Safe Passage Study.

Vivekanandarajah, Arunnjah / Nelson, Morgan E / Kinney, Hannah C / Elliott, Amy J / Folkerth, Rebecca D / Tran, Hoa / Cotton, Jacob / Jacobs, Perri / Minter, Megan / McMillan, Kristin / Duncan, Jhodie R / Broadbelt, Kevin G / Schissler, Kathryn / Odendaal, Hein J / Angal, Jyoti / Brink, Lucy / Burger, Elsie H / Coldrey, Jean A / Dempers, Johan /

Boyd, Theonia K / Fifer, William P / Geldenhuys, Elaine / Groenewald, Coen / Holm, Ingrid A / Myers, Michael M / Randall, Bradley / Schubert, Pawel / Sens, Mary Ann / Wright, Colleen A / Roberts, Drucilla J / Nelsen, Laura / Wadee, Shabbir / Zaharie, Dan / Haynes, Robin L

Frontiers in neurology

2021 Volume 12, Page(s) 636668

Abstract: Pre-natal exposures to nicotine and alcohol are known risk factors for sudden infant death syndrome (SIDS), the leading cause of post-neonatal infant mortality. Here, we present data on nicotinic receptor binding, as determined ... ...

Abstract	Pre-natal exposures to nicotine and alcohol are known risk factors for sudden infant death syndrome (SIDS), the leading cause of post-neonatal infant mortality. Here, we present data on nicotinic receptor binding, as determined by
Language	English
Publishing date	2021-03-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2021.636668
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Article: Social Media Engagement at Academic Conferences: Report of the Association of Pathology Chairs 2018 and 2019 Annual Meeting Social Media Committee.

Ziemba, Yonah C / Razzano, Dana / Allen, Timothy C / Booth, Adam L / Anderson, Scott R / Champeaux, Anne / Feldman, Michael D / Fitzhugh, Valerie / Gittens, Simone / Grider, Marilea / Gupta, Mary / Hanos, Christina / Kelly, Karen / Kothari, Tarush / Laudadio, Jennifer / Lin, Amy Y / Mirza, Kamran M / Montone, Kathleen T / Prieto, Victor G /

Remick, Daniel G / Riddle, Nicole D / Schubert, Michael / Suskie, Kelley / Zafar, Nadeem / Robboy, Stanley J / Markwood, Priscilla S

Academic pathology

2020 Volume 7, Page(s) 2374289520934019

Abstract: The use of social media at academic conferences is expanding, and platforms such as Twitter are used to share meeting content with the world. Pathology conferences are no exception, and recently, pathology organizations have promoted social media as a ... ...

Abstract	The use of social media at academic conferences is expanding, and platforms such as Twitter are used to share meeting content with the world. Pathology conferences are no exception, and recently, pathology organizations have promoted social media as a way to enhance meeting exposure. A social media committee was formed ad hoc to implement strategies to enhance social media involvement and coverage at the 2018 and 2019 annual meetings of the Association of Pathology Chairs. This organized approach resulted in an 11-fold increase in social media engagement compared to the year prior to committee formation (2017). In this article, the social media committee reviews the strategies that were employed and the resultant outcome data. In addition, we categorize tweets by topic to identify the topics of greatest interest to meeting participants, and we discuss the differences between Twitter and other social media platforms. Lastly, we review the existing literature on this topic from 23 medical specialties and health care fields.
Language	English
Publishing date	2020-07-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2819382-9
ISSN	2374-2895
ISSN	2374-2895
DOI	10.1177/2374289520934019
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Article ; Online: Treatment of thoracolumbar kyphosis in patients with mucopolysaccharidosis type I: results of an international consensus procedure.

Orphanet journal of rare diseases

2019 Volume 14, Issue 1, Page(s) 17

Abstract: ... the utility of bracing and required additional assessments (e.g. radiographs). Most importantly, it was ...

Abstract	Background: In all patients with mucopolysaccharidosis type I (MPS I), skeletal disease (dysostosis multiplex) is a prominent, debilitating, condition related complication that may impact strongly on activities of daily living. Unfortunately, it is not alleviated by treatment with hematopoietic cell transplantation (HCT) or enzyme replacement therapy (ERT). Although early kyphosis is one of the key features of dysostosis multiplex, there is no international consensus on the optimal management. Therefore, an international consensus procedure was organized with the aim to develop the first clinical practice guideline for the management of thoracolumbar kyphosis in MPS I patients. Methods: A literature review was conducted to identify all available information about kyphosis and related surgery in MPS I patients. Subsequently, a modified Delphi procedure was used to develop consensus statements. The expert panel included 10 spinal orthopedic surgeons, 6 pediatricians and 3 physiotherapists, all experienced in MPS I. The procedure consisted of 2 written rounds, a face-to-face meeting and a final written round. The first 2 rounds contained case histories, general questions and draft statements. During the face-to-face meeting consensus statements were developed. In the final round, the panel had the opportunity to anonymously express their opinion about the proposed statements. Results: Eighteen case series and case reports were retrieved from literature reporting on different surgical approaches and timing of thoracolumbar kyphosis surgery in MPS I. During the face-to-face meeting 16 statements were discussed and revised. Consensus was reached on all statements. Conclusion: This international consensus procedure resulted in the first clinical practice guideline for the management of thoracolumbar kyphosis in MPS I patients, focusing on the goals and timing of surgery, as well as the optimal surgical approach, the utility of bracing and required additional assessments (e.g. radiographs). Most importantly, it was concluded that the decision for surgery depends not only on the kyphotic angle, but also on additional factors such as the progression of the deformity and its flexibility, the presence of symptoms, growth potential and comorbidities. The eventual goal of treatment is the maintenance or improvement of quality of life. Further international collaborative research related to long-term outcome of kyphosis surgery in MPS I is essential as prognostic information is lacking.
MeSH term(s)	Consensus ; Enzyme Replacement Therapy ; Hematopoietic Stem Cell Transplantation ; Humans ; Kyphosis/drug therapy ; Kyphosis/therapy ; Mucopolysaccharidosis I/drug therapy ; Mucopolysaccharidosis I/therapy
Language	English
Publishing date	2019-01-18
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ISSN	1750-1172
ISSN (online)	1750-1172
DOI	10.1186/s13023-019-0997-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Multicountry study of SARS-CoV-2 and associated risk factors among healthcare workers in Côte d'Ivoire, Burkina Faso and South Africa.

Kribi, Sarah / Touré, Fidèle / Mendes, Adriano / Sanou, Soufiane / Some, Arsène / Aminou, Abdoul M / Belarbi, Essia / Griessel, Rosemary / Hema, Arsène / Kabore, Firmin / Pitzinger, Paul / Strydom, Amy / Vietor, Ann Christin / Traoré, Korotimi / Zongo, Arsène / Anoh, Etilé A / Grossegesse, Marica / Hofmann, Natalie / Ouangraoua, Soumeya /

Poda, Armel / Kagone, Thérèse / Schubert, Grit / Eckmanns, Tim / Venter, Marietjie / Leendertz, Fabian / Akoua-Koffi, Chantal / Tomczyk, Sara

Transactions of the Royal Society of Tropical Medicine and Hygiene

2022 Volume 117, Issue 3, Page(s) 179–188

Abstract: Background: Reports on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spread across Africa have varied, including among healthcare workers (HCWs). This study assessed the comparative SARS-CoV-2 burden and associated risk factors among HCWs ...

Abstract	Background: Reports on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spread across Africa have varied, including among healthcare workers (HCWs). This study assessed the comparative SARS-CoV-2 burden and associated risk factors among HCWs in three African countries. Methods: A multicentre study was conducted at regional healthcare facilities in Côte d'Ivoire (CIV), Burkina Faso (BF) and South Africa (SA) from February to May 2021. HCWs provided blood samples for SARS-CoV-2 serology and nasopharyngeal/oropharyngeal swabs for testing of acute infection by polymerase chain reaction and completed a questionnaire. Factors associated with seropositivity were assessed with logistic regression. Results: Among 719 HCWs, SARS-CoV-2 seroprevalence was 34.6% (95% confidence interval 31.2 to 38.2), ranging from 19.2% in CIV to 45.7% in BF. A total of 20 of 523 (3.8%) were positive for acute SARS-CoV-2 infection. Female HCWs had higher odds of SARS-CoV-2 seropositivity compared with males, and nursing staff, allied health professionals, non-caregiver personnel and administration had higher odds compared with physicians. HCWs also reported infection prevention and control (IPC) gaps, including 38.7% and 29% having access to respirators and IPC training, respectively, in the last year. Conclusions: This study was a unique comparative HCW SARS-CoV-2 investigation in Africa. Seroprevalence estimates varied, highlighting distinctive population/facility-level factors affecting COVID-19 burden and the importance of established IPC programmes to protect HCWs and patients.
MeSH term(s)	Male ; Humans ; Female ; Burkina Faso ; Cote d'Ivoire ; South Africa ; SARS-CoV-2 ; Seroepidemiologic Studies ; COVID-19 ; Health Personnel
Language	English
Publishing date	2022-12-19
Publishing country	England
Document type	Multicenter Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	441375-1
ISSN	1878-3503 ; 0035-9203
ISSN (online)	1878-3503
ISSN	0035-9203
DOI	10.1093/trstmh/trac089
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Article ; Online: Serotonin Receptors in the Medulla Oblongata of the Human Fetus and Infant: The Analytic Approach of the International Safe Passage Study.

Haynes, Robin L / Folkerth, Rebecca D / Paterson, David S / Broadbelt, Kevin G / Dan Zaharie, S / Hewlett, Richard H / Dempers, Johan J / Burger, Elsie / Wadee, Shabbir / Schubert, Pawel / Wright, Colleen / Sens, Mary Ann / Nelsen, Laura / Randall, Bradley B / Tran, Hoa / Geldenhuys, Elaine / Elliott, Amy J / Odendaal, Hein J / Kinney, Hannah C

Journal of neuropathology and experimental neurology

2016 Volume 75, Issue 11, Page(s) 1048–1057

Abstract: The Safe Passage Study is an international, prospective study of approximately 12 000 pregnancies to determine the effects of prenatal alcohol exposure (PAE) upon stillbirth and the sudden infant death syndrome (SIDS). A key objective of the study is to ... ...

Abstract	The Safe Passage Study is an international, prospective study of approximately 12 000 pregnancies to determine the effects of prenatal alcohol exposure (PAE) upon stillbirth and the sudden infant death syndrome (SIDS). A key objective of the study is to elucidate adverse effects of PAE upon binding to serotonin (5-HT) 1A receptors in brainstem homeostatic networks postulated to be abnormal in unexplained stillbirth and/or SIDS. We undertook a feasibility assessment of 5-HT1A receptor binding using autoradiography in the medulla oblongata (6 nuclei in 27 cases). 5-HT1A binding was compared to a reference dataset from the San Diego medical examiner's system. There was no adverse effect of postmortem interval ≤100 h. The distribution and quantitated values of 5-HT1A binding in Safe Passage Study cases were essentially identical to those in the reference dataset, and virtually identical between stillbirths and live born fetal cases in grossly non-macerated tissues. The pattern of binding was present at mid-gestation with dramatic changes in binding levels in the medullary 5-HT nuclei over the second half of gestation; there was a plateau at lower levels in the neonatal period and into infancy. This study demonstrates feasibility of 5-HT1A binding analysis in the medulla in the Safe Passage Study.
Language	English
Publishing date	2016-09-15
Publishing country	England
Document type	Journal Article
ZDB-ID	3088-0
ISSN	1554-6578 ; 0022-3069
ISSN (online)	1554-6578
ISSN	0022-3069
DOI	10.1093/jnen/nlw080
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