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  1. Article ; Online: Author response: the coefficient of determination: what determines a useful R(2) statistic?

    De Moraes, Carlos Gustavo / Liebmann, Jeffrey M / Ritch, Robert / Greenfield, David S / Sehi, Mitra / Chung, Yun S

    Investigative ophthalmology & visual science

    2013  Volume 54, Issue 1, Page(s) 37–38

    MeSH term(s) Data Interpretation, Statistical ; Glaucoma/diagnosis ; Humans ; Models, Statistical ; Visual Field Tests/methods ; Visual Fields
    Language English
    Publishing date 2013-01-02
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 391794-0
    ISSN 1552-5783 ; 0146-0404
    ISSN (online) 1552-5783
    ISSN 0146-0404
    DOI 10.1167/iovs.12-11354
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: PSA Testing in U.S. Immigrants.

    Ritch, Chad R

    The Journal of urology

    2022  Volume 209, Issue 1, Page(s) 25–26

    Language English
    Publishing date 2022-11-02
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 3176-8
    ISSN 1527-3792 ; 0022-5347
    ISSN (online) 1527-3792
    ISSN 0022-5347
    DOI 10.1097/JU.0000000000003047
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  3. Article ; Online: Synthesis, multinuclear NMR spectra, and X-ray structures of tBu2PNP(I)tBu2 and EPR2NP(I)R2 (E = Se, Te; R = iPr, tBu).

    Ritch, Jamie S / Robertson, Stuart D / Risto, Maarit / Chivers, Tristram

    Inorganic chemistry

    2010  Volume 49, Issue 10, Page(s) 4681–4686

    Abstract: Two synthetic routes to bifunctional P(V)/P(V) compounds of the type EPR(2)NP(I)R(2) have been ...

    Abstract Two synthetic routes to bifunctional P(V)/P(V) compounds of the type EPR(2)NP(I)R(2) have been developed. The reaction of Li[EP(i)Pr(2)NP(i)Pr(2)] with one molar equivalent of I(2) produces EP(i)Pr(2)NP(I)(i)Pr(2) (3a-I, E = Se; 3b-I, E = Te). Alternatively, the oxidation of Na[N(P(t)Bu(2))(2)] with I(2) in tetrahydrofuran (THF) generates the P(III)/P(V) compound (t)Bu(2)PNP(I)(t)Bu(2) (6'-I) which, on treatment with elemental selenium or tellurium in THF, yields EP(t)Bu(2)NP(I)(t)Bu(2) (3a'-I, E = Se; 3b'-I, E = Te). The acyclic compounds 3a-I, 3a'-I, 3b-I, 3b'-I, and 6'-I have been characterized in solution by multinuclear ((1)H, (31)P, (77)Se, and (125)Te) NMR spectroscopy and in the solid state by X-ray structural determinations.
    Language English
    Publishing date 2010-05-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1484438-2
    ISSN 1520-510X ; 0020-1669
    ISSN (online) 1520-510X
    ISSN 0020-1669
    DOI 10.1021/ic1005055
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  4. Article ; Online: Ocular Findings in Exfoliation Syndrome.

    Ritch, Robert

    Journal of glaucoma

    2018  Volume 27 Suppl 1, Page(s) S67–S71

    Abstract: Exfoliation syndrome is characterized by numerous ocular manifestations, the most important of these being glaucoma and cataract. Its ocular manifestations affect all of the structures of the anterior segment as well as conjunctiva and orbital structures. ...

    Abstract Exfoliation syndrome is characterized by numerous ocular manifestations, the most important of these being glaucoma and cataract. Its ocular manifestations affect all of the structures of the anterior segment as well as conjunctiva and orbital structures. Exfoliation material is seen most prominently as characteristic white deposits on the anterior surface of the lens and the pupillary border of the iris. Both open-angle and angle-closure glaucoma are intimately associated with exfoliation syndrome. Other findings include zonular disruption, iris sphincter fibrosis, keratopathy, ocular surface disease, and retinal vein occlusion.
    MeSH term(s) Cataract/diagnosis ; Cataract/physiopathology ; Exfoliation Syndrome/diagnosis ; Exfoliation Syndrome/physiopathology ; Glaucoma, Angle-Closure/diagnosis ; Glaucoma, Angle-Closure/physiopathology ; Glaucoma, Open-Angle/diagnosis ; Glaucoma, Open-Angle/physiopathology ; Humans ; Intraocular Pressure
    Language English
    Publishing date 2018-05-21
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 913494-3
    ISSN 1536-481X ; 1057-0829
    ISSN (online) 1536-481X
    ISSN 1057-0829
    DOI 10.1097/IJG.0000000000000986
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    Zs.A 3795: Show issues Location:
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  5. Article ; Online: Homocysteine and Glaucoma.

    Washington, Joshua / Ritch, Robert / Liu, Yutao

    International journal of molecular sciences

    2023  Volume 24, Issue 13

    Abstract: Elevated levels of homocysteine (Hcy), a non-proteinogenic amino acid, may lead to a host of manifestations across the biological systems, particularly the nervous system. Defects in Hcy metabolism have been associated with many neurodegenerative ... ...

    Abstract Elevated levels of homocysteine (Hcy), a non-proteinogenic amino acid, may lead to a host of manifestations across the biological systems, particularly the nervous system. Defects in Hcy metabolism have been associated with many neurodegenerative diseases including glaucoma, i.e., the leading cause of blindness. However, the pathophysiology of elevated Hcy and its eligibility as a risk factor for glaucoma remain unclear. We aimed to provide a comprehensive review of the relationship between elevated Hcy levels and glaucoma. Through a systemic search of the PubMed and Google Scholar databases, we found that elevated Hcy might play an important role in the pathogenesis of glaucoma. Further research will be necessary to help clarify the specific contribution of elevated Hcy in the pathogenesis of glaucoma. A discovery and conceptual understanding of Hcy-associated glaucoma could be the keys to providing better therapeutic treatment, if not prophylactic treatment, for this disease.
    MeSH term(s) Humans ; Glaucoma, Open-Angle/metabolism ; Glaucoma/etiology ; Amino Acids ; Risk Factors ; Homocysteine
    Chemical Substances Amino Acids ; Homocysteine (0LVT1QZ0BA)
    Language English
    Publishing date 2023-06-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241310790
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  6. Article ; Online: Balint autobiography-Ritch Addison.

    Addison, Ritch

    International journal of psychiatry in medicine

    2020  Volume 55, Issue 3, Page(s) 210–213

    Language English
    Publishing date 2020-05-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 220669-9
    ISSN 1541-3527 ; 0091-2174
    ISSN (online) 1541-3527
    ISSN 0091-2174
    DOI 10.1177/0091217420919017
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  7. Article: Optical coherence tomography angiography in glaucoma.

    Aghsaei Fard, Masoud / Ritch, Robert

    Annals of translational medicine

    2021  Volume 8, Issue 18, Page(s) 1204

    Abstract: Assessment of the vasculature within the optic nerve, peripapillary superficial retina, macula, and peripapillary choroid can be determined in glaucoma using optical coherence tomography angiography (OCTA). Decreased perfusion within the pre-laminar ... ...

    Abstract Assessment of the vasculature within the optic nerve, peripapillary superficial retina, macula, and peripapillary choroid can be determined in glaucoma using optical coherence tomography angiography (OCTA). Decreased perfusion within the pre-laminar layer of the optic nerve has been correlated with glaucoma severity. The peripapillary superficial retinal vessel density allows diagnosis and detection of glaucoma progression in a manner similar to the peripapillary retinal nerve fiber layer (RNFL) thickness. Furthermore, decreased peripapillary vessel density of the intact hemiretina or unaffected eye of glaucomatous eyes suggests that vascular changes can occur prior to detectable visual field damage. The accuracy for glaucoma detection of the macular ganglion cell (MGC) thickness compared to macular vessel density has differed among studies. Several studies have reported reduction of macular vessel density as well as its ganglion cell thickness. Results of studies evaluating the parapapillary choroid have shown a greater prevalence of choroidal microvasculature dropout in glaucomatous eyes with a parapapillary gamma zone, which is associated with central visual field defects or glaucoma progression. It remains unclear whether the reduced vessel density in glaucoma is a primary event or secondary to glaucomatous damage. Further studies are warranted to elucidate this question.
    Language English
    Publishing date 2021-01-11
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2893931-1
    ISSN 2305-5847 ; 2305-5839
    ISSN (online) 2305-5847
    ISSN 2305-5839
    DOI 10.21037/atm-20-2828
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Systemic Associations of Exfoliation Syndrome.

    Ritch, Robert

    Asia-Pacific journal of ophthalmology (Philadelphia, Pa.)

    2016  Volume 5, Issue 1, Page(s) 45–50

    Abstract: Exfoliation syndrome (XFS) is an age-related disease characterized by the production, deposition, and progressive accumulation of a white, fibrillar, extracellular material in many ocular tissues, most prominent on the anterior lens surface and pupillary ...

    Abstract Exfoliation syndrome (XFS) is an age-related disease characterized by the production, deposition, and progressive accumulation of a white, fibrillar, extracellular material in many ocular tissues, most prominent on the anterior lens surface and pupillary border. Its prevalence increases steadily with age in all populations. It is the most common identifiable cause of open-angle glaucoma worldwide and is a potentially reversible or even curable disease. First described in Finland in 1917 by Lindberg, it has long been associated with open-angle glaucoma. However, in recent years, it is being increasingly reported in conjunction with a multiplicity of both ocular and systemic disorders, and the number of these is expected to grow, particularly with investigations based on attempts to associate other diseases with those genes known to be associated with XFS. Despite the focus on XFS as a cause of open-angle glaucoma for nearly a century, in reality it is still only an ocular manifestation of a protean systemic disease. It is a unique disorder with extensive and often serious ocular and systemic manifestations and not, as it has long been termed, a "form" or "type" of glaucoma. This misconception has delayed research into the molecular and cellular processes involved in its development, and the underestimation of its overall importance and its underlying causative mechanisms have largely been long ignored. The purpose of this article is to review the systemic disorders which are becoming increasingly associated with XFS. Reviews of epidemiology, genetics, biomarkers, molecular mechanisms of development, and ocular findings may be found elsewhere.
    MeSH term(s) Amino Acid Oxidoreductases/genetics ; Exfoliation Syndrome/complications ; Exfoliation Syndrome/genetics ; Exfoliation Syndrome/metabolism ; Glaucoma, Open-Angle/etiology ; Humans ; Prevalence ; Protein-Lysine 6-Oxidase/metabolism
    Chemical Substances Amino Acid Oxidoreductases (EC 1.4.-) ; LOXL1 protein, human (EC 1.4.3.-) ; Protein-Lysine 6-Oxidase (EC 1.4.3.13)
    Language English
    Publishing date 2016-01-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2756329-7
    ISSN 2162-0989 ; 2162-0989
    ISSN (online) 2162-0989
    ISSN 2162-0989
    DOI 10.1097/APO.0000000000000187
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Editorial Comment.

    Ritch, Chad R

    The Journal of urology

    2016  Volume 196, Issue 4, Page(s) 1059–1060

    Language English
    Publishing date 2016
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 3176-8
    ISSN 1527-3792 ; 0022-5347
    ISSN (online) 1527-3792
    ISSN 0022-5347
    DOI 10.1016/j.juro.2016.04.111
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  10. Article: Annual Reviews in Ophthalmology, a New Feature of the Asia-Pacific Journal of Ophthalmology.

    Ritch, Robert

    Asia-Pacific journal of ophthalmology (Philadelphia, Pa.)

    2015  Volume 1, Issue 6, Page(s) 323–324

    Language English
    Publishing date 2015-05-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2756329-7
    ISSN 2162-0989
    ISSN 2162-0989
    DOI 10.1097/APO.0b013e3182778abc
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