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  1. Article ; Online: Exilic (Art) Narratives of Queer Refugees Challenging Dominant Hegemonies.

    Holle, Fabian / Rast, Maria Charlotte / Ghorashi, Halleh

    Frontiers in sociology

    2021  Volume 6, Page(s) 641630

    Abstract: Within the Dutch hegemonic discourse, the "migrant other" is portrayed as almost incompatible with "national culture" while it is simultaneously pressured to assimilate. This creates paradoxes for the queer refugee participants in this study. When these ... ...

    Abstract Within the Dutch hegemonic discourse, the "migrant other" is portrayed as almost incompatible with "national culture" while it is simultaneously pressured to assimilate. This creates paradoxes for the queer refugee participants in this study. When these refugees assimilate, they risk reinforcing the dominant discourse considering their group as the "backward other". When they do not assimilate, they are considered not "properly" Dutch. This paper explores how queer refugee artists can unsettle such dominant exclusionary discourses through exilic (art) narratives. Their experiences of exilic positioning (being neither there nor here) and queer liminality (e.g., nonbinary gender identifications) and their intersectional positionalities situate these artists in various "states of in-betweenness". Although these states may be challenging, this paper shows how they can also stimulate agency. Inspired by a feminist approach, this study aimed to co-create knowledge
    Language English
    Publishing date 2021-05-10
    Document type Journal Article
    ISSN 2297-7775
    ISSN (online) 2297-7775
    DOI 10.3389/fsoc.2021.641630
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Die neuralgische Amyotrophie: eine häufige Ursache uni- oder bilateraler Zwerchfellparesen.

    Zimmermann, Maximilian / Wollsching-Strobel, Maximilian / Majorski, Daniel Sebastian / Kroppen, Doreen / Schwarz, Sarah Bettina / Berger, Melanie / Windisch, Wolfram / Holle, Johannes Fabian

    Pneumologie (Stuttgart, Germany)

    2023  Volume 77, Issue 10, Page(s) 814–824

    Abstract: There are several causes for unilateral or bilateral diaphragmatic paresis. The most common cause is an (intraoperative) injury to the phrenic nerve.However, in up to 20% of cases, no explanation can be found despite extensive workup. Neuralgic ... ...

    Title translation Neuralgic amyotrophy: a common cause of unilateral and bilateral diaphragmatic pareses.
    Abstract There are several causes for unilateral or bilateral diaphragmatic paresis. The most common cause is an (intraoperative) injury to the phrenic nerve.However, in up to 20% of cases, no explanation can be found despite extensive workup. Neuralgic amyotrophy (NA, also known as Parsonage-Turner syndrome) is a common underdiagnosed multifocal autoimmune-inflammatory disease that predominantly affects proximal nerve segments of the upper extremities. Classic symptoms include acute onset of severe pain in the shoulder girdle with delayed onset of paresis of the shoulder and arm muscles. In at least 7% of cases, the phrenic nerve is also affected. Based on the annual incidence of NA of 1:1000, the entity as a cause of diaphragmatic dysfunction is probably not as uncommon as previously thought. However, clinical experience shows that this diagnosis is often not considered, and diaphragmatic paresis gets wrongly classified as idiopathic.This is particularly disastrous because in the early stage of NA, medical therapy with corticosteroids is mostly not considered and the possibility that surgical repair of the diaphragm may be performed prematurely, given that the condition may resolve spontaneously many months after symptom onset.The aim of the present article is to raise awareness of the entity of NA as a cause of diaphragmatic paresis and to establish a standardized approach to diagnosis and treatment.
    MeSH term(s) Humans ; Brachial Plexus Neuritis/diagnosis ; Brachial Plexus Neuritis/etiology ; Brachial Plexus Neuritis/therapy ; Diaphragm ; Phrenic Nerve ; Incidence ; Autoimmune Diseases/complications ; Paresis/diagnosis ; Paresis/etiology ; Paresis/therapy
    Language German
    Publishing date 2023-08-30
    Publishing country Germany
    Document type English Abstract ; Journal Article
    ZDB-ID 607630-0
    ISSN 1438-8790 ; 0934-8387
    ISSN (online) 1438-8790
    ISSN 0934-8387
    DOI 10.1055/a-2113-0385
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Plasma Transfusion in Septic Shock-A Secondary Analysis of a Retrospective Single-Center Cohort.

    Dietrich, Maximilian / Hölle, Tobias / Lalev, Lazar Detelinov / Loos, Martin / Schmitt, Felix Carl Fabian / Fiedler, Mascha Onida / Hackert, Thilo / Richter, Daniel Christoph / Weigand, Markus Alexander / Fischer, Dania

    Journal of clinical medicine

    2022  Volume 11, Issue 15

    Abstract: In sepsis, both beneficial and detrimental effects of fresh frozen plasma (FFP) transfusion have been reported. The aim of this study was to analyze the indication for and effect of FFP transfusion in patients with septic shock. We performed a secondary ... ...

    Abstract In sepsis, both beneficial and detrimental effects of fresh frozen plasma (FFP) transfusion have been reported. The aim of this study was to analyze the indication for and effect of FFP transfusion in patients with septic shock. We performed a secondary analysis of a retrospective single-center cohort of all patients treated for septic shock at the interdisciplinary surgical intensive care unit (ICU) of the Heidelberg University Hospital. Septic shock was defined according to sepsis-3 criteria. To assess the effects of FFP administration in the early phase of septic shock, we compared patients with and without FFP transfusion during the first 48 h of septic shock. Patients who died during the first 48 h of septic shock were excluded from the analysis. Primary endpoints were 30- and 90-day mortality. A total of 261 patients were identified, of which 100 (38.3%) received FFP transfusion within the first 48 h after septic shock onset. The unmatched analysis showed a trend toward higher 30- and 90-d mortality in the FFP group (30 d: +7%
    Language English
    Publishing date 2022-07-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11154367
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Die neuralgische Amyotrophie: eine häufige Ursache uni- oder bilateraler Zwerchfellparesen

    Zimmermann, Maximilian / Wollsching-Strobel, Maximilian / Majorski, Daniel Sebastian / Kroppen, Doreen / Schwarz, Sarah Bettina / Berger, Melanie / Windisch, Wolfram / Holle, Johannes Fabian

    Pneumologie

    2023  Volume 77, Issue 10, Page(s) 814–824

    Abstract: Eine ein- oder beidseitige Zwerchfellparese kann verschiedene Ursachen haben, an erster Stelle stehen (intraoperative) Verletzungen des Nervus phrenicus. In bis zu 20% der Fälle lässt sich jedoch trotz umfangreicher Abklärung keine Erklärung finden. Die ... ...

    Abstract Eine ein- oder beidseitige Zwerchfellparese kann verschiedene Ursachen haben, an erster Stelle stehen (intraoperative) Verletzungen des Nervus phrenicus. In bis zu 20% der Fälle lässt sich jedoch trotz umfangreicher Abklärung keine Erklärung finden. Die neuralgische Amyotrophie (NA, syn. Parsonage-Turner-Syndrom) ist eine häufige, im Alltag unterdiagnostizierte, multifokale autoimmun-inflammatorische Erkrankung, die überwiegend proximale Nervenabschnitte der oberen Extremitäten betrifft. Klassische Symptome sind akut einsetzende, starke Schmerzen im Bereich des Schultergürtels mit zeitverzögert auftretenden Paresen der Schulter- und Armmuskulatur. In mindestens 7% der Fälle ist der N. phrenicus (mit-)betroffen. Legt man die jährliche Inzidenz einer NA von 1:1000 zugrunde, ist die Entität als Ursache einer Zwerchfellfunktionsstörung wahrscheinlich nicht so ungewöhnlich, wie bislang angenommen. Die klinische Erfahrung zeigt jedoch, dass diese Diagnose oft nicht in Betracht gezogen und die Zwerchfellparese somit fälschlicherweise als idiopathisch klassifiziert wird. Fatal ist dies v.a. im Hinblick auf die Möglichkeit einer medikamentösen Therapie mittels Kortikosteroiden im Akutstadium einer NA sowie einer möglicherweise zu frühen operativen Zwerchfellraffung aufgrund des Potenzials der Erkrankung einer spontanen Heilung auch viele Monate nach Symptombeginn. Ziel des vorliegenden Artikels ist es, das Bewusstsein für die Entität der NA als Ursache einer Zwerchfellparese zu schärfen und einen standardisierten Ansatz für die Diagnostik und Behandlung zu etablieren.
    Keywords Zwerchfellparese ; Atemmuskuläre Diagnostik ; Seltene Erkrankungen ; Parsonage Turner Syndrom ; Neuralgische Amyotrophie ; Diaphragmatic paresis ; Respiratory muscular diagnostics ; Rare diseases ; Parsonage-Turner syndrome ; Neuralgic amyotrophy
    Language German
    Publishing date 2023-08-30
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 607630-0
    ISSN 1438-8790 ; 0934-8387
    ISSN (online) 1438-8790
    ISSN 0934-8387
    DOI 10.1055/a-2113-0385
    Database Thieme publisher's database

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  5. Article ; Online: Plasma Transfusion in Septic Shock—A Secondary Analysis of a Retrospective Single-Center Cohort

    Maximilian Dietrich / Tobias Hölle / Lazar Detelinov Lalev / Martin Loos / Felix Carl Fabian Schmitt / Mascha Onida Fiedler / Thilo Hackert / Daniel Christoph Richter / Markus Alexander Weigand / Dania Fischer

    Journal of Clinical Medicine, Vol 11, Iss 4367, p

    2022  Volume 4367

    Abstract: In sepsis, both beneficial and detrimental effects of fresh frozen plasma (FFP) transfusion have been reported. The aim of this study was to analyze the indication for and effect of FFP transfusion in patients with septic shock. We performed a secondary ... ...

    Abstract In sepsis, both beneficial and detrimental effects of fresh frozen plasma (FFP) transfusion have been reported. The aim of this study was to analyze the indication for and effect of FFP transfusion in patients with septic shock. We performed a secondary analysis of a retrospective single-center cohort of all patients treated for septic shock at the interdisciplinary surgical intensive care unit (ICU) of the Heidelberg University Hospital. Septic shock was defined according to sepsis-3 criteria. To assess the effects of FFP administration in the early phase of septic shock, we compared patients with and without FFP transfusion during the first 48 h of septic shock. Patients who died during the first 48 h of septic shock were excluded from the analysis. Primary endpoints were 30- and 90-day mortality. A total of 261 patients were identified, of which 100 (38.3%) received FFP transfusion within the first 48 h after septic shock onset. The unmatched analysis showed a trend toward higher 30- and 90-d mortality in the FFP group (30 d: +7% p = 0.261; 90 d: +11.9% p = 0.061). In the propensity-matched analysis, 30- and 90-day mortality were similar between groups. Plasma administration did not influence fluid or vasopressor need, lactate levels, ICU stay, or days on a ventilator. We found no significant harm or associated benefit of FFP use in the early phase of septic shock. Finally, plasma should only be used in patients with a strong indication according to current recommendations, as a conclusive evaluation of the risk-benefit ratio for plasma transfusion in septic shock cannot be made based on the current data.
    Keywords plasma transfusion ; fresh frozen plasma ; sepsis ; shock ; resuscitation ; coagulopathy ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2022-07-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Post-COVID-19 Syndrome is Rarely Associated with Damage of the Nervous System: Findings from a Prospective Observational Cohort Study in 171 Patients.

    Fleischer, Michael / Szepanowski, Fabian / Tovar, Muriel / Herchert, Klaas / Dinse, Hannah / Schweda, Adam / Mausberg, Anne K / Holle-Lee, Dagny / Köhrmann, Martin / Stögbauer, Julia / Jokisch, Daniel / Jokisch, Martha / Deuschl, Cornelius / Skoda, Eva-Maria / Teufel, Martin / Stettner, Mark / Kleinschnitz, Christoph

    Neurology and therapy

    2022  Volume 11, Issue 4, Page(s) 1637–1657

    Abstract: Introduction: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can affect multiple organs. Reports of persistent or newly emergent symptoms, including those related to the nervous system, have increased over the course of the pandemic, ... ...

    Abstract Introduction: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can affect multiple organs. Reports of persistent or newly emergent symptoms, including those related to the nervous system, have increased over the course of the pandemic, leading to the introduction of post-COVID-19 syndrome. However, this novel syndrome is still ill-defined and structured objectification of complaints is scarce. Therefore, we performed a prospective observational cohort study to better define and validate subjective neurological disturbances in patients with post-COVID-19 syndrome.
    Methods: A total of 171 patients fulfilling the post-COVID-19 WHO Delphi consensus criteria underwent a comprehensive neurological diagnostic work-up including neurovascular, electrophysiological, and blood analysis. In addition, magnetic resonance imaging (MRI) and lumbar puncture were conducted in subgroups of patients. Furthermore, patients underwent neuropsychological, psychosomatic, and fatigue assessment.
    Results: Patients were predominantly female, middle-aged, and had incurred mostly mild-to-moderate acute COVID-19. The most frequent post-COVID-19 complaints included fatigue, difficulties in concentration, and memory deficits. In most patients (85.8%), in-depth neurological assessment yielded no pathological findings. In 97.7% of the cases, either no diagnosis other than post COVID-19 syndrome, or no diagnosis likely related to preceding acute COVID-19 could be established. Sensory or motor complaints were more often associated with a neurological diagnosis other than post-COVID-19 syndrome. Previous psychiatric conditions were identified as a risk factor for developing post-COVID-19 syndrome. We found high somatization scores in our patient group that correlated with cognitive deficits and the extent of fatigue.
    Conclusions: Albeit frequently reported by patients, objectifiable affection of the nervous system is rare in post-COVID-19 syndrome. Instead, elevated levels of somatization point towards a pathogenesis potentially involving psychosomatic factors. However, thorough neurological assessment is important in this patient group in order to not miss neurological diseases other than post-COVID-19.
    Language English
    Publishing date 2022-08-26
    Publishing country New Zealand
    Document type Journal Article
    ISSN 2193-8253
    ISSN 2193-8253
    DOI 10.1007/s40120-022-00395-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: A Tablet App- and Sensor-Based Assistive Technology Intervention for Informal Caregivers to Manage the Challenging Behavior of People With Dementia (the insideDEM Study): Protocol for a Feasibility Study.

    Kernebeck, Sven / Holle, Daniela / Pogscheba, Patrick / Jordan, Felix / Mertl, Fabian / Huldtgren, Alina / Bader, Sebastian / Kirste, Thomas / Teipel, Stefan / Holle, Bernhard / Halek, Margareta

    JMIR research protocols

    2019  Volume 8, Issue 2, Page(s) e11630

    Abstract: Background: Despite the enormous number of assistive technologies (ATs) in dementia care, the management of challenging behavior (CB) of persons with dementia (PwD) by informal caregivers in home care is widely disregarded. The first-line strategy to ... ...

    Abstract Background: Despite the enormous number of assistive technologies (ATs) in dementia care, the management of challenging behavior (CB) of persons with dementia (PwD) by informal caregivers in home care is widely disregarded. The first-line strategy to manage CB is to support the understanding of the underlying causes of CB to formulate individualized nonpharmacological interventions. App- and sensor-based approaches combining multimodal sensors (actimetry and other modalities) and caregiver information are innovative ways to support the understanding of CB for family caregivers.
    Objective: The main aim of this study is to describe the design of a feasibility study consisting of an outcome and a process evaluation of a newly developed app- and sensor-based intervention to manage CB of PwD for family caregivers at home.
    Methods: In this feasibility study, we perform an outcome and a process evaluation with a pre-post descriptive design over an 8-week intervention period. The Medical Research Council framework guides the design of this feasibility study. The data on 20 dyads (primary caregiver and PwD) are gathered through standardized questionnaires, protocols, and log files as well as semistructured qualitative interviews. The outcome measures (neuropsychiatric inventory and Cohen-Mansfield agitation inventory) are analyzed by using descriptive statistics and statistical tests relevant to the individual assessments (eg, chi-square test and Wilcoxon signed-rank test). For the analysis of the process data, the Unified Theory of Acceptance and Use of Technology is used. Log files are analyzed by using descriptive statistics, protocols are analyzed by using documentary analysis, and semistructured interviews are analyzed deductively using content analysis.
    Results: The newly developed app- and sensor-based AT has been developed and was evaluated until July in 2018. The recruitment of dyads started in September 2017 and was concluded in March 2018. The data collection was completed at the end of July 2018.
    Conclusions: This study presents the protocol of the first feasibility study to encompass an outcome and process evaluation to assess a complex app- and sensor-based AT combining multimodal actimetry sensors for informal caregivers to manage CB. The feasibility study will provide in-depth information about the study procedure and on how to optimize the design of the intervention and its delivery.
    International registered report identifier (irrid): DERR1-10.2196/11630.
    Language English
    Publishing date 2019-02-26
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 2719222-2
    ISSN 1929-0748
    ISSN 1929-0748
    DOI 10.2196/11630
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Serum immunoglobulin G4 in giant cell arteritis and polymyalgia rheumatica.

    Burkel, Mara / Arndt, Fabian / Schirmer, Jan-Henrik / Moosig, Frank / Holle, Julia U

    Clinical and experimental rheumatology

    2017  Volume 35 Suppl 103, Issue 1, Page(s) 94–97

    Abstract: Objectives: To date, no specific serum marker for giant cell arteritis and polymyalgia rheumatica has been established in routine practice. Therefore, the aim of this study was to examine whether immunoglobulin G4 serum concentrations could be a ... ...

    Abstract Objectives: To date, no specific serum marker for giant cell arteritis and polymyalgia rheumatica has been established in routine practice. Therefore, the aim of this study was to examine whether immunoglobulin G4 serum concentrations could be a potential biomarker for the differentiation of both diseases.
    Methods: Serum immunoglobulin G4 (IgG4) concentrations were measured in patients with giant cell arteritis (n=41) and polymyalgia rheumatica (n=27) by an in-house enzyme-linked immunosorbent assay. In the subgroup of untreated patients with disease activity (polymyalgia rheumatica n=27, giant cell arteritis n=19) additional parameters of T-helper 2 cell inflammatory responses were analysed.
    Results: IgG4-values above the prior determined cut-off value of 1400 μg/ml in giant cell arteritis were rare and also significantly less frequent in giant cell arteritis than in polymyalgia rheumatica patients (7.3% vs. 44.4%; p<0.001). The relative risk that patients with clinical features of PMR, presenting without elevated IgG4 levels, have simultaneously GCA was 5.8 compared to those patients with elevated IgG4 levels. In untreated patients absolute counts of eosinophilic leukocytes were lower in giant cell arteritis than in polymyalgia rheumatica (p=0.002) and the cytokines interleukin-4 (p=0.013) and interleukin-10 (p=0.033) were less frequently detectable in giant cell arteritis than in polymyalgia rheumatica.
    Conclusions: In giant cell arteritis serum levels of IgG4 usually are within the normal range. In polymyalgia rheumatica however, increased IgG4 serum levels are frequently found. Normal IgG4 serum levels in polymyalgia rheumatica may have predictive value in identifying patients with additional, clinically non-apparent giant cell arteritis.
    MeSH term(s) Aged ; Biomarkers/blood ; Diagnosis, Differential ; Enzyme-Linked Immunosorbent Assay ; Female ; Giant Cell Arteritis/blood ; Giant Cell Arteritis/diagnostic imaging ; Giant Cell Arteritis/immunology ; Humans ; Immunoglobulin G/blood ; Male ; Middle Aged ; Polymyalgia Rheumatica/blood ; Polymyalgia Rheumatica/diagnostic imaging ; Polymyalgia Rheumatica/immunology ; Predictive Value of Tests ; Up-Regulation
    Chemical Substances Biomarkers ; Immunoglobulin G
    Language English
    Publishing date 2017-03
    Publishing country Italy
    Document type Comparative Study ; Journal Article
    ZDB-ID 605886-3
    ISSN 1593-098X ; 0392-856X
    ISSN (online) 1593-098X
    ISSN 0392-856X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book ; Online ; Thesis: Tierexperimentelle Studie am Schwein zum Vergleich des Blutverlustes nach perkutaner Schneidbiopsie der Milz mit und ohne Okklusion des Punktionskanals durch Gelatineschwamm

    Holle, Johannes Fabian [Verfasser]

    2008  

    Author's details vorgelegt von Johannes Fabian Holle
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  10. Article ; Online: Inflammation in Children with CKD Linked to Gut Dysbiosis and Metabolite Imbalance.

    Holle, Johannes / Bartolomaeus, Hendrik / Löber, Ulrike / Behrens, Felix / Bartolomaeus, Theda U P / Anandakumar, Harithaa / Wimmer, Moritz I / Vu, Dai Long / Kuhring, Mathias / Brüning, Ulrike / Maifeld, Andras / Geisberger, Sabrina / Kempa, Stefan / Schumacher, Fabian / Kleuser, Burkhard / Bufler, Philip / Querfeld, Uwe / Kitschke, Stefanie / Engler, Denise /
    Kuhrt, Leonard D / Drechsel, Oliver / Eckardt, Kai-Uwe / Forslund, Sofia K / Thürmer, Andrea / McParland, Victoria / Kirwan, Jennifer A / Wilck, Nicola / Müller, Dominik

    Journal of the American Society of Nephrology : JASN

    2022  Volume 33, Issue 12, Page(s) 2259–2275

    Abstract: Background: CKD is characterized by a sustained proinflammatory response of the immune system, promoting hypertension and cardiovascular disease. The underlying mechanisms are incompletely understood but may be linked to gut dysbiosis. Dysbiosis has ... ...

    Abstract Background: CKD is characterized by a sustained proinflammatory response of the immune system, promoting hypertension and cardiovascular disease. The underlying mechanisms are incompletely understood but may be linked to gut dysbiosis. Dysbiosis has been described in adults with CKD; however, comorbidities limit CKD-specific conclusions.
    Methods: We analyzed the fecal microbiome, metabolites, and immune phenotypes in 48 children (with normal kidney function, CKD stage G3-G4, G5 treated by hemodialysis [HD], or kidney transplantation) with a mean±SD age of 10.6±3.8 years.
    Results: Serum TNF-
    Conclusions: Gut barrier dysfunction and microbial metabolite imbalance apparently mediate the proinflammatory immune phenotype, thereby driving the susceptibility to cardiovascular disease. The data highlight the importance of the microbiota-immune axis in CKD, irrespective of confounding comorbidities.
    MeSH term(s) Humans ; Cardiovascular Diseases ; Dysbiosis/microbiology ; Gastrointestinal Microbiome/physiology ; Inflammation ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/therapy ; Renal Insufficiency, Chronic/metabolism ; Tumor Necrosis Factor-alpha ; Child ; Adolescent
    Chemical Substances Tumor Necrosis Factor-alpha
    Language English
    Publishing date 2022-08-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.2022030378
    Database MEDical Literature Analysis and Retrieval System OnLINE

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