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  1. Article ; Online: TRMT13 inhibits the growth of papillary thyroid cancer by targeting ANAPC4.

    Liu, Lianyong / Wang, Yan / Zou, Mei / Chen, Shiwei / Wu, Fengying / Li, Xiangqi

    Acta biochimica et biophysica Sinica

    2024  

    Abstract: The recently discovered ... ...

    Abstract The recently discovered gene
    Language English
    Publishing date 2024-03-01
    Publishing country China
    Document type Journal Article
    ZDB-ID 2175256-4
    ISSN 1745-7270 ; 0582-9879 ; 1672-9145
    ISSN (online) 1745-7270
    ISSN 0582-9879 ; 1672-9145
    DOI 10.3724/abbs.2024010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Deciphering GABBR1-centered drug targets to fight viral infection with preexisting diabetes.

    Li, Xiangqi / Zhao, Xuemei / Peng, Li / Du, Hong / Chen, Shiwei / Chen, Xia

    Acta biochimica et biophysica Sinica

    2024  Volume 55, Issue 12, Page(s) 1999–2003

    MeSH term(s) Humans ; Genetic Predisposition to Disease ; Diabetes Mellitus/drug therapy ; Virus Diseases
    Language English
    Publishing date 2024-01-11
    Publishing country China
    Document type Journal Article
    ZDB-ID 2175256-4
    ISSN 1745-7270 ; 0582-9879 ; 1672-9145
    ISSN (online) 1745-7270
    ISSN 0582-9879 ; 1672-9145
    DOI 10.3724/abbs.2023249
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  3. Article ; Online: Joint inference of clonal structure using single-cell genome and transcriptome sequencing data.

    Bai, Xiangqi / Duren, Zhana / Wan, Lin / Xia, Li C

    NAR genomics and bioinformatics

    2024  Volume 6, Issue 1, Page(s) lqae017

    Abstract: Latest advancements in the high-throughput single-cell genome (scDNA) and transcriptome (scRNA) sequencing technologies enabled cell-resolved investigation of tissue clones. However, it remains challenging to cluster and couple single cells for ... ...

    Abstract Latest advancements in the high-throughput single-cell genome (scDNA) and transcriptome (scRNA) sequencing technologies enabled cell-resolved investigation of tissue clones. However, it remains challenging to cluster and couple single cells for heterogeneous scRNA and scDNA data generated from the same specimen. In this study, we present a computational framework called CCNMF, which employs a novel Coupled-Clone Non-negative Matrix Factorization technique to jointly infer clonal structure for matched scDNA and scRNA data. CCNMF couples multi-omics single cells by linking copy number and gene expression profiles through their general concordance. It successfully resolved the underlying coexisting clones with high correlations between the clonal genome and transcriptome from the same specimen. We validated that CCNMF can achieve high accuracy and robustness using both simulated benchmarks and real-world applications, including an ovarian cancer cell lines mixture, a gastric cancer cell line, and a primary gastric cancer. In summary, CCNMF provides a powerful tool for integrating multi-omics single-cell data, enabling simultaneous resolution of genomic and transcriptomic clonal architecture. This computational framework facilitates the understanding of how cellular gene expression changes in conjunction with clonal genome alternations, shedding light on the cellular genomic difference of subclones that contributes to tumor evolution.
    Language English
    Publishing date 2024-02-13
    Publishing country England
    Document type Journal Article
    ISSN 2631-9268
    ISSN (online) 2631-9268
    DOI 10.1093/nargab/lqae017
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  4. Article ; Online: Structural characteristics and paste properties of wheat starch in natural fermentation during traditional Chinese Mianpi processing.

    Zhao, Guiting / Liu, Chong / Li, Limin / Li, Jie / Wang, Jiasheng / Fan, Xiangqi / Zheng, Xueling

    International journal of biological macromolecules

    2024  Volume 262, Issue Pt 1, Page(s) 129993

    Abstract: Fermentation plays a crucial role in traditional Chinese mianpi processing, where short-term natural fermentation (within 24 h) is considered advantageous for mianpi production. However, the influence of short-term natural fermentation on the properties ... ...

    Abstract Fermentation plays a crucial role in traditional Chinese mianpi processing, where short-term natural fermentation (within 24 h) is considered advantageous for mianpi production. However, the influence of short-term natural fermentation on the properties of wheat starch is not explored yet. Hence, structural characteristics and paste properties of wheat starch during natural fermentation were investigated in this study. The findings revealed that fermenting for 24 h had a slight effect on the morphology of wheat starch but significantly decreased the particle size of starch. Compared to native wheat starch, the enzyme activity produced during fermentation may destroy the integrity of starch granules, resulting in a lower molecular weight but higher relative crystallinity and orderliness of starch. After 24 h of natural fermentation, higher solubility and swelling power were obtained compared to non-fermentation. Regarding paste properties, fermented starches exhibited higher peak viscosity and breakdown, along with lower final viscosity, tough viscosity, and setback. Furthermore, the hardness, gel strength, G', and G" decreased after fermentation. Clarifying changes in starch during the short-term natural fermentation process could provide theoretical guidance for improving the quality and production of short-term naturally fermented foods such as mianpi, as discussed in this study.
    MeSH term(s) Starch/chemistry ; Triticum/chemistry ; Fermentation ; Viscosity ; China
    Chemical Substances Starch (9005-25-8)
    Language English
    Publishing date 2024-02-05
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2024.129993
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  5. Article ; Online: Mast cell activation may contribute to adverse health transitions in COVID-19 patients with frailty.

    Li, Xiangqi / Zhang, Chaobao / Bao, Zhijun

    Emerging microbes & infections

    2023  Volume 12, Issue 2, Page(s) 2251589

    Abstract: A prominent aspect of the post-coronavirus disease-2019 (post-COVID-19) era is long-COVID. Therefore, precise patient classification and exploration of the corresponding factors affecting long-COVID are crucial for tailored treatment strategies. Frailty ... ...

    Abstract A prominent aspect of the post-coronavirus disease-2019 (post-COVID-19) era is long-COVID. Therefore, precise patient classification and exploration of the corresponding factors affecting long-COVID are crucial for tailored treatment strategies. Frailty is a common age-related clinical syndrome characterized by deteriorated physiological functions of multiple organ systems, which increases susceptibility to stressors. Herein, we performed an inclusion and exclusion analysis (definite COVID-19 infection diagnosis, clear underlying disease information, ≥60 years old, and repeated sampling of clinical cases) of 10,613 blood samples and identified frailty cases for further investigation. RNA-Seq data were used for differential gene expression and functional and pathway analyses. The results revealed that patients with frailty were more prone to poor health conversions and more sequelae, and the blood transcriptome had obvious disturbances in pathways associated with immune regulation, metabolism, and stress response. These adverse health transitions were significantly associated with mast cell activation. Additionally, NCAPG, MCM10, and CDC25C were identified as hub genes in the peripheral blood differential gene cluster, which could be used as diagnostic markers of poor health conversion. Our results indicate that healthcare measures should be prioritized to mitigate adverse health outcomes in this vulnerable patient group, COVID-19 patients with frailty, in post-COVID era.
    MeSH term(s) Humans ; Middle Aged ; COVID-19 ; Post-Acute COVID-19 Syndrome ; Frailty ; Health Transition ; Mast Cells
    Language English
    Publishing date 2023-08-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2681359-2
    ISSN 2222-1751 ; 2222-1751
    ISSN (online) 2222-1751
    ISSN 2222-1751
    DOI 10.1080/22221751.2023.2251589
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  6. Article ; Online: PIWIL1 Promotes Malignant Progression of Papillary Thyroid Carcinoma by Inducing EVA1A Expression.

    Liu, Lianyong / Wu, Fengying / Zhang, Xiaoying / Li, Xiangqi

    Current cancer drug targets

    2023  Volume 24, Issue 2, Page(s) 192–203

    Abstract: Introduction: Papillary thyroid carcinoma (PTC) is the most common subtype of thyroid cancer. Previous studies have reported on the ectopic expression of P-element-induced wimpy testis ligand 1 (PIWIL1) in various human cancers, but its role in PTC ... ...

    Abstract Introduction: Papillary thyroid carcinoma (PTC) is the most common subtype of thyroid cancer. Previous studies have reported on the ectopic expression of P-element-induced wimpy testis ligand 1 (PIWIL1) in various human cancers, but its role in PTC progression has not been investigated.
    Methods: In this study, we measured the expression levels of PIWIL1 and Eva-1 homolog A (EVA1A) in PTC using qPCR and WB. We performed a viability assay to evaluate PTC cell proliferation and used flow cytometry to investigate apoptosis. Moreover, we conducted a Transwell invasion assay to quantify cell invasion and assessed PTC growth
    Results: Our findings showed PIWIL1 to be highly expressed in PTC and promote cell proliferation, cell cycle activity, and cell invasion, while suppressing apoptosis. Additionally, PIWIL1 accelerated tumor growth in PTC xenografts by modulating the EVA1A expression.
    Conclusion: Our study suggests that PIWIL1 contributes to the progression of PTC through EVA1A signaling, indicating its potential role as a therapeutic target for PTC. These results provide valuable insights into PIWIL1 function and may lead to more effective treatments for PTC.
    MeSH term(s) Male ; Humans ; Thyroid Cancer, Papillary ; Carcinoma, Papillary/genetics ; Carcinoma, Papillary/metabolism ; Carcinoma, Papillary/pathology ; Cell Line, Tumor ; Thyroid Neoplasms/metabolism ; Apoptosis ; Cell Proliferation ; Gene Expression Regulation, Neoplastic ; MicroRNAs ; Cell Movement ; Argonaute Proteins/genetics ; Argonaute Proteins/metabolism
    Chemical Substances MicroRNAs ; PIWIL1 protein, human ; Argonaute Proteins
    Language English
    Publishing date 2023-07-04
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2064824-8
    ISSN 1873-5576 ; 1568-0096
    ISSN (online) 1873-5576
    ISSN 1568-0096
    DOI 10.2174/1568009623666230703140510
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5589: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Experimental Study on the Mechanical Behavior of Sandy Soil Reinforced by Disposable Face Mask Chips under Different Stress Paths

    Xiangqi Hu / Mingliang Chen / Bo Hu / Guangzhen Du / Kaihui Li

    Sustainability, Vol 15, Iss 4059, p

    2023  Volume 4059

    Abstract: Since 2020, with the global spread of major respiratory infectious diseases, such as COVID–19, the demand and consumption of personal protective equipment, such as masks, have increased dramatically worldwide. The environmental pollution caused by ... ...

    Abstract Since 2020, with the global spread of major respiratory infectious diseases, such as COVID–19, the demand and consumption of personal protective equipment, such as masks, have increased dramatically worldwide. The environmental pollution caused by numerous waste disposable face masks has gradually attracted people’s attention. In this study, the mechanical properties of mask–chip–reinforced soil are evaluated from a new perspective, through the uniaxial, biaxial, conventional triaxial, and true triaxial compression tests on reshaped sandy soil samples mixed with different contents of mask chips. The experimental results show that the mechanical properties of the sandy soil can be improved by the mask chips. With the proper content of mask chips, the failure strength is substantially improved, and the failure of soil is delayed. Meanwhile, the strength and stiffness are significantly affected by the stress path and the content of mask chips, even if the soil samples with the same mask–chip content can also show different mechanical properties under different stress paths. Additionally, the mechanical properties of soil are not necessarily improved constantly with the increasing content of mask chips. The failure strength of sandy soil samples under conventional and true triaxial stress paths decreases when the mass content of mask chips exceeds 0.3% and 0.5%, respectively. This study confirms the potential of mask chips applied to subgrade, slope, and other engineering construction fields in a sustainable way.
    Keywords mechanical properties ; reinforced soil ; stress paths ; true triaxial compression test ; waste masks ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
    Subject code 630
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Trends in Atmospheric CO 2 Fertilization Effects with Stand Age Based on Tree Rings

    Yanxi Chen / Bin Wang / Mingze Li / Xiangqi Kong / Shaojie Bian

    Forests, Vol 14, Iss 12, p

    2023  Volume 2441

    Abstract: The increase in global carbon emissions has intensified the effects of CO 2 fertilization on the carbon cycle. CO 2 fertilization is shaped by several factors, including the physiological differences among trees of varied forest ages and types, as well ... ...

    Abstract The increase in global carbon emissions has intensified the effects of CO 2 fertilization on the carbon cycle. CO 2 fertilization is shaped by several factors, including the physiological differences among trees of varied forest ages and types, as well as the influence of different climatic conditions. It is essential to investigate the differences in CO 2 fertilization effects across diverse climate zones and delve into the association between these effects and forest age and type. Such exploration will deepen our knowledge of forest responses to environmental changes. This study used annual ring width data from the International Tree-Ring Data Bank, employing the generalized additive mixed models and the Random Forest model to discern the pattern of the CO 2 fertilization effect concerning forest age in the Northern Hemisphere. This study also explored the variations in the effect of CO 2 fertilization across unique climate zones and the disparities among various forest types within the same climatic zone. The results indicated a link between forest age and the CO 2 fertilization effect: it tends to increase in sapling forests and middle-aged forests and diminish in mature forests. Warmer, drier environments had a more marked effect of increased CO 2 on tree fertilization. Additionally, coniferous forests demonstrated a more substantial CO 2 fertilization effect than broadleaf forests, and deciduous needle-leaf forests surpassed evergreen needle-leaf forests in this regard. This research is pivotal in understanding the shifting patterns of CO 2 fertilization effects and how forests respond to atmospheric changes.
    Keywords CO 2 fertilization effect ; ring width ; stand age ; northern hemisphere ; Plant ecology ; QK900-989
    Subject code 580
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Corrosion Protection of Q235 Steel Using Epoxy Coatings Loaded with Calcium Carbonate Microparticles Modified by Sodium Lignosulfonate in Simulated Concrete Pore Solutions.

    Liu, Weilin / Li, Jiansan / Huang, Xiangqi / Bi, Jinye

    Materials (Basel, Switzerland)

    2021  Volume 14, Issue 8

    Abstract: In this study, calcium carbonate ( ... ...

    Abstract In this study, calcium carbonate (CaCO
    Language English
    Publishing date 2021-04-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma14081982
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  10. Article: Molecular cloning and functional analysis of Chinese bayberry

    Wu, Xiangqi / Zhang, Shuwen / Yu, Zheping / Sun, Li / Liang, Senmiao / Zheng, Xiliang / Qi, Xingjiang / Ren, Haiying

    Frontiers in plant science

    2023  Volume 14, Page(s) 1127228

    Abstract: Chinese bayberry ( ...

    Abstract Chinese bayberry (
    Language English
    Publishing date 2023-02-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2613694-6
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2023.1127228
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